-
1
-
-
2542491777
-
The role of ABC transporter in drug resistance, metabolism and toxicity
-
Glavinas H., Krajcsi P., Cserepes J., Sarkadi B.: The role of ABC transporter in drug resistance, metabolism and toxicity. Curr Drug Deliv 2004 ; 1: 27-42.
-
(2004)
Curr Drug Deliv
, vol.1
, pp. 27-42
-
-
Glavinas, H.1
Krajcsi, P.2
Cserepes, J.3
Sarkadi, B.4
-
2
-
-
33644840984
-
The power of the pump: Mechanisms of action of P-glycoprotein (ABCB1)
-
Ambudkar SV, Kim IW, Sauna ZE: The power of the pump: mechanisms of action of P-glycoprotein (ABCB1). Eur J Pharm Sci 2006 ; 27: 392-400.
-
(2006)
Eur J Pharm Sci
, vol.27
, pp. 392-400
-
-
Ambudkar, S.V.1
Kim, I.W.2
Sauna, Z.E.3
-
3
-
-
4143115811
-
Structure and mechanism of ABC transporters
-
Locher K.: Structure and mechanism of ABC transporters. Curr Opin Struct Biol 2004 ; 14: 426-431.
-
(2004)
Curr Opin Struct Biol
, vol.14
, pp. 426-431
-
-
Locher, K.1
-
4
-
-
0031160517
-
Hepatic canalicular membrane 5: Expression and localization of the conjugate export pump encoded by the MRP2 (cMRP/cMOAT) gene in liver
-
Keppler D., Konig J.: Hepatic canalicular membrane 5: expression and localization of the conjugate export pump encoded by the MRP2 (cMRP/cMOAT) gene in liver. FASEB J 1997 ; 11: 509-516.
-
(1997)
FASEB J
, vol.11
, pp. 509-516
-
-
Keppler, D.1
Konig, J.2
-
5
-
-
0040761368
-
CDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats
-
Buchler M., Konig J., Brom M., Kartenbeck J., Spring H., Horie T.,, et al. cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. J Biol Chem 1996 ; 271: 15091-15098.
-
(1996)
J Biol Chem
, vol.271
, pp. 15091-15098
-
-
Buchler, M.1
Konig, J.2
Brom, M.3
Kartenbeck, J.4
Spring, H.5
Horie, T.6
-
6
-
-
0034119967
-
Expression and localization of multidrug resistant protein mrp2 in rat small intestine
-
Mottino AD, Hoffman T., Jennes L., Vore M.: Expression and localization of multidrug resistant protein mrp2 in rat small intestine. J Pharmacol Exp Ther 2000 ; 293: 717-723.
-
(2000)
J Pharmacol Exp Ther
, vol.293
, pp. 717-723
-
-
Mottino, A.D.1
Hoffman, T.2
Jennes, L.3
Vore, M.4
-
8
-
-
0030063480
-
Transport of glutathione, glucuronide and sulfate conjugates by the MRP gene-encoded conjugate export pump
-
Jedlitschky G., Leier I., Buchholz U., Barnouin G., Keppler D.: Transport of glutathione, glucuronide and sulfate conjugates by the MRP gene-encoded conjugate export pump. Cancer Res 1996 ; 56: 988-994.
-
(1996)
Cancer Res
, vol.56
, pp. 988-994
-
-
Jedlitschky, G.1
Leier, I.2
Buchholz, U.3
Barnouin, G.4
Keppler, D.5
-
9
-
-
0000552161
-
Chronic idiopathic jaundice with unidentified pigment in liver cells: A new clinicopathologic entity with report of 12 cases
-
Dubin IN, Johnson FB: Chronic idiopathic jaundice with unidentified pigment in liver cells: a new clinicopathologic entity with report of 12 cases. Medicine 1954 ; 33: 155-179.
-
(1954)
Medicine
, vol.33
, pp. 155-179
-
-
Dubin, I.N.1
Johnson, F.B.2
-
10
-
-
0029986408
-
Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome
-
Kartenbeck J., Leuschner U., Mayer R., Keppler D.: Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome. Hepatology 1996 ; 23: 1061-1066.
-
(1996)
Hepatology
, vol.23
, pp. 1061-1066
-
-
Kartenbeck, J.1
Leuschner, U.2
Mayer, R.3
Keppler, D.4
-
11
-
-
33645104459
-
Altered hepatobiliary disposition of 5 (and 6)-carboxy-2, ′7′dichlorofluorescein in Abcg2 (Bcrp1) and Abcc2 (Mrp2) knockout mice
-
Nezasa K., Tian X., Zamek-Gliszczynski MJ, Patel NJ, Raub TJ, Brouwer KL: Altered hepatobiliary disposition of 5 (and 6)-carboxy-2, ′7′dichlorofluorescein in Abcg2 (Bcrp1) and Abcc2 (Mrp2) knockout mice. Drug Metab Dispos 2006 ; 34: 718-723.
-
(2006)
Drug Metab Dispos
, vol.34
, pp. 718-723
-
-
Nezasa, K.1
Tian, X.2
Zamek-Gliszczynski, M.J.3
Patel, N.J.4
Raub, T.J.5
Brouwer, K.L.6
-
12
-
-
0034928631
-
Up-regulation of basolateral multidrug resistance protein 3 (Mrp3) in cholestatic rat liver
-
Donner MG, Keppler D.: Up-regulation of basolateral multidrug resistance protein 3 (Mrp3) in cholestatic rat liver. Hepatology 2001 ; 34: 351-359.
-
(2001)
Hepatology
, vol.34
, pp. 351-359
-
-
Donner, M.G.1
Keppler, D.2
-
13
-
-
0035889601
-
Expression of the multidrug resistance proteins MRP2 and MRP3 in human hepatocellular carcinoma
-
Nies AT, König J., Pfannschmidt M., Klar E., Hofmann WJ, Keppler D.: Expression of the multidrug resistance proteins MRP2 and MRP3 in human hepatocellular carcinoma. Int J Cancer 2001 ; 94: 492-499.
-
(2001)
Int J Cancer
, vol.94
, pp. 492-499
-
-
Nies, A.T.1
König, J.2
Pfannschmidt, M.3
Klar, E.4
Hofmann, W.J.5
Keppler, D.6
-
14
-
-
38849152127
-
Modulation of sinusoidal and canalicular elimination of bilirubinglucuronides by rifampicin and other cholestatic drugs in a sandwich culture of rat hepatocytes
-
Lengyel G., Veres Z., Tugyi R., Vereczkey L., Molnár T., Glavinas H.,, et al. Modulation of sinusoidal and canalicular elimination of bilirubinglucuronides by rifampicin and other cholestatic drugs in a sandwich culture of rat hepatocytes. Hepatology Res 2008 ; 38: 300-309.
-
(2008)
Hepatology Res
, vol.38
, pp. 300-309
-
-
Lengyel, G.1
Veres, Z.2
Tugyi, R.3
Vereczkey, L.4
Molnár, T.5
Glavinas, H.6
-
15
-
-
0037963557
-
Differential modulation of the human liver conjugate transporters MRP2 and MRP3 by bile acids and organic anions
-
Bodo A., Bakos E., Szeri F., Varadi A., Sarkadi B.: Differential modulation of the human liver conjugate transporters MRP2 and MRP3 by bile acids and organic anions. J Biol Chem 2003 ; 278: 23529-23537.
-
(2003)
J Biol Chem
, vol.278
, pp. 23529-23537
-
-
Bodo, A.1
Bakos, E.2
Szeri, F.3
Varadi, A.4
Sarkadi, B.5
-
16
-
-
0034753042
-
Vectorial transport by double-transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2
-
Cui Y., Konig J., Keppler D.: Vectorial transport by double-transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2. Mol Pharmacol 2001 ; 60: 934-943.
-
(2001)
Mol Pharmacol
, vol.60
, pp. 934-943
-
-
Cui, Y.1
Konig, J.2
Keppler, D.3
-
17
-
-
0035028211
-
Charged amino acids in the transmembrane domains are involved in the determination of the substrate specificity of rat Mrp2
-
Ito K., Suzuki H., Sugiyama Y.: Charged amino acids in the transmembrane domains are involved in the determination of the substrate specificity of rat Mrp2. Mol Pharmacol 2001 ; 59: 1077-1085.
-
(2001)
Mol Pharmacol
, vol.59
, pp. 1077-1085
-
-
Ito, K.1
Suzuki, H.2
Sugiyama, Y.3
-
18
-
-
33751547871
-
Functional analysis of mouse and monkey multidrug resistance-associated protein 2 (Mrp2)
-
Ninomiya M., Ito K., Hiramatsu R., Horie T.: Functional analysis of mouse and monkey multidrug resistance-associated protein 2 (Mrp2). Drug Metab Dispos 2006 ; 34: 2056-2063.
-
(2006)
Drug Metab Dispos
, vol.34
, pp. 2056-2063
-
-
Ninomiya, M.1
Ito, K.2
Hiramatsu, R.3
Horie, T.4
-
19
-
-
33845876683
-
Interaction of nonsteroidal anti-inflammatory drugs with multidrug resistance protein (MRP) 2/ABCC2- and MRP4/ABCC4-mediated methotrexate transport
-
El-Sheikh AA, van den Heuvel JJ, Koenderink JB, Russel FG: Interaction of nonsteroidal anti-inflammatory drugs with multidrug resistance protein (MRP) 2/ABCC2- and MRP4/ABCC4-mediated methotrexate transport. J Pharmacol Exp Ther 2007 ; 320: 229-235.
-
(2007)
J Pharmacol Exp Ther
, vol.320
, pp. 229-235
-
-
El-Sheikh, A.A.1
Van Den Heuvel, J.J.2
Koenderink, J.B.3
Russel, F.G.4
-
20
-
-
0032753749
-
Effect of multidrug resistance-reversing agents on transporting activity of human canalicular multispecific organic anion transporter
-
Chen ZS, Kawabe T., Ono M., Aoki S., Sumizawa T., Furukawa T.,, et al. Effect of multidrug resistance-reversing agents on transporting activity of human canalicular multispecific organic anion transporter. Mol Pharmacol 1999 ; 56: 1219-1228.
-
(1999)
Mol Pharmacol
, vol.56
, pp. 1219-1228
-
-
Chen, Z.S.1
Kawabe, T.2
Ono, M.3
Aoki, S.4
Sumizawa, T.5
Furukawa, T.6
-
21
-
-
0032562616
-
Multidrug resistance protein: Identification of regions required for active transport of leukotriene C4
-
Gao M., Yamazaki M., Loe DW, Westlake CJ, Grant CE, Cole SP,, et al. Multidrug resistance protein: identification of regions required for active transport of leukotriene C4. J Biol Chem 1998 ; 273: 10733-10740.
-
(1998)
J Biol Chem
, vol.273
, pp. 10733-10740
-
-
Gao, M.1
Yamazaki, M.2
Loe, D.W.3
Westlake, C.J.4
Grant, C.E.5
Cole, S.P.6
-
22
-
-
0037666795
-
Evidence for two interacting ligand binding sites in human multidrug resistance protein 2 (ATP binding cassette C2)
-
Zelcer N., Huisman MT, Reid G., Wielinga P., Breedveld P., Kuil A.,, et al. Evidence for two interacting ligand binding sites in human multidrug resistance protein 2 (ATP binding cassette C2). J Biol Chem 2003 ; 278: 23538-23544.
-
(2003)
J Biol Chem
, vol.278
, pp. 23538-23544
-
-
Zelcer, N.1
Huisman, M.T.2
Reid, G.3
Wielinga, P.4
Breedveld, P.5
Kuil, A.6
-
23
-
-
0023185436
-
Hereditary defect of hepatobiliary cysteinyl leukotriene elimination in mutant rats with defective hepatic anion excretion
-
Huber M., Guhlmann A., Jansen PLM, Keppler D.: Hereditary defect of hepatobiliary cysteinyl leukotriene elimination in mutant rats with defective hepatic anion excretion. Hepatology 1997 ; 7: 224-228.
-
(1997)
Hepatology
, vol.7
, pp. 224-228
-
-
Huber, M.1
Guhlmann, A.2
Plm, J.3
Keppler, D.4
-
24
-
-
0037310954
-
Pharmacokinetics of 5 (and 6)-Carboxy-2, ′7′dichlorofluorescein and its diacetate promoiety in the liver
-
Zamek-Glyszczyinsky MJ, Xiong H., Patel NJ, Turncliff RZ, Pollack GM, Brouwer KL: Pharmacokinetics of 5 (and 6)-Carboxy-2, ′7′dichlorofluorescein and its diacetate promoiety in the liver. J Pharm Exp Ther 2003 ; 304: 801-809.
-
(2003)
J Pharm Exp Ther
, vol.304
, pp. 801-809
-
-
Zamek-Glyszczyinsky, M.J.1
Xiong, H.2
Patel, N.J.3
Turncliff, R.Z.4
Pollack, G.M.5
Brouwer, K.L.6
-
25
-
-
33644847437
-
Kinetic validation of the use of carboxydichlorofluorescein as a drug surrogate for MRP5-mediated transport
-
Pratt S., Chen V., Perry WI III, Starling JJ, Dantzig AH: Kinetic validation of the use of carboxydichlorofluorescein as a drug surrogate for MRP5-mediated transport. Eur J Pharm Sci 2006 ; 27: 524-532.
-
(2006)
Eur J Pharm Sci
, vol.27
, pp. 524-532
-
-
Pratt, S.1
Chen, V.2
Perry III, W.I.3
Starling, J.J.4
Dantzig, A.H.5
-
26
-
-
0036707615
-
Mechanisms of impaired biliary excretion of acetaminophen glucuronide after acute phenobarbital treatment or phenobarbital pretreatment
-
Xiong H., Suzuki H., Sugiyama Y., Meier PJ, Pollack GM, Brouwer KL: Mechanisms of impaired biliary excretion of acetaminophen glucuronide after acute phenobarbital treatment or phenobarbital pretreatment. Drug Metab Dispos 2002 ; 30: 962-969.
-
(2002)
Drug Metab Dispos
, vol.30
, pp. 962-969
-
-
Xiong, H.1
Suzuki, H.2
Sugiyama, Y.3
Meier, P.J.4
Pollack, G.M.5
Brouwer, K.L.6
-
27
-
-
0034072174
-
Interaction of the human multidrug resistance proteins MRP1 and MRP2 with organic anions
-
Bakos E., Evers R., Sinko E., Varadi A., Borst P., Sarkadi B.: Interaction of the human multidrug resistance proteins MRP1 and MRP2 with organic anions. Mol Pharmacol 2000 ; 57: 760-768.
-
(2000)
Mol Pharmacol
, vol.57
, pp. 760-768
-
-
Bakos, E.1
Evers, R.2
Sinko, E.3
Varadi, A.4
Borst, P.5
Sarkadi, B.6
-
28
-
-
4744347692
-
The role of the conserved glycerin of ATP-binding cassette signature motifs of MRP1 in the communication between the substrate-binding site and the catalytic centers
-
Szentpetery Z., Kern A., Liliom K., Sarkadi B., Varadi A., Bakos E.: The role of the conserved glycerin of ATP-binding cassette signature motifs of MRP1 in the communication between the substrate-binding site and the catalytic centers. J Biol Chem 2004 ; 279: 41670-41678.
-
(2004)
J Biol Chem
, vol.279
, pp. 41670-41678
-
-
Szentpetery, Z.1
Kern, A.2
Liliom, K.3
Sarkadi, B.4
Varadi, A.5
Bakos, E.6
-
29
-
-
0030026629
-
Altered drug-simulated ATPase activity in mutants of the human multidrug resistance protein
-
Muller M., Bakos E., Welker E., Varadi A., Germann UA, Gottesman MM,, et al. Altered drug-simulated ATPase activity in mutants of the human multidrug resistance protein. J Biol Chem 1996 ; 271: 1877-1883.
-
(1996)
J Biol Chem
, vol.271
, pp. 1877-1883
-
-
Muller, M.1
Bakos, E.2
Welker, E.3
Varadi, A.4
Germann, U.A.5
Gottesman, M.M.6
-
30
-
-
0026722467
-
Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase
-
Sarkadi B., Price EM, Boucher RC, Germann UA, Scarborough GA: Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase. J Biol Chem 1992 ; 267: 4854-4858.
-
(1992)
J Biol Chem
, vol.267
, pp. 4854-4858
-
-
Sarkadi, B.1
Price, E.M.2
Boucher, R.C.3
Germann, U.A.4
Scarborough, G.A.5
-
31
-
-
0015861774
-
Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction
-
Cheng Y., Prusoff WH: Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. Biochem Pharmacol 1973 ; 22: 3099-3108.
-
(1973)
Biochem Pharmacol
, vol.22
, pp. 3099-3108
-
-
Cheng, Y.1
Prusoff, W.H.2
-
32
-
-
33846387512
-
Efflux of baicalin, a flavone glucuronide of Scutellariae Radix, on Caco-2 cells through multidrug resistance-associated protein 2
-
Akao T., Hanada M., Sakashita Y., Sato K., Morita M., Imanaka T.: Efflux of baicalin, a flavone glucuronide of Scutellariae Radix, on Caco-2 cells through multidrug resistance-associated protein 2. J Pharm Pharmacol 2007 ; 59: 87-93.
-
(2007)
J Pharm Pharmacol
, vol.59
, pp. 87-93
-
-
Akao, T.1
Hanada, M.2
Sakashita, Y.3
Sato, K.4
Morita, M.5
Imanaka, T.6
-
33
-
-
0037613131
-
The potential for an interaction between MRP2 (ABCC2) and various therapeutic agents: Probenecid as a candidate inhibitor of the biliary excretion of irinotecan metabolites
-
Horikawa M., Kato Y., Tyson CA, Sugiyama Y.: The potential for an interaction between MRP2 (ABCC2) and various therapeutic agents: probenecid as a candidate inhibitor of the biliary excretion of irinotecan metabolites. Drug Metab Pharmacokinet 2002 ; 17: 23-33.
-
(2002)
Drug Metab Pharmacokinet
, vol.17
, pp. 23-33
-
-
Horikawa, M.1
Kato, Y.2
Tyson, C.A.3
Sugiyama, Y.4
-
34
-
-
0035115578
-
The sulphonylurea glibenclamide inhibits multidrug resistance protein (MRP1) activity in human lung cancer cells
-
Payen L., Delugin L., Courtois A., Trinquart Y., Guillouzo A., Fardel O.: The sulphonylurea glibenclamide inhibits multidrug resistance protein (MRP1) activity in human lung cancer cells. Br J Pharmacol 2001 ; 132: 778-784.
-
(2001)
Br J Pharmacol
, vol.132
, pp. 778-784
-
-
Payen, L.1
Delugin, L.2
Courtois, A.3
Trinquart, Y.4
Guillouzo, A.5
Fardel, O.6
-
35
-
-
0034083906
-
ATP-dependent paraaminohippurate transport by apical multidrug resistance protein MRP2
-
Leier I., Hummel-Eisenbeiss J., Cui Y., Keppler D.: ATP-dependent paraaminohippurate transport by apical multidrug resistance protein MRP2. Kidney Int 2000 ; 57: 1636-1642.
-
(2000)
Kidney Int
, vol.57
, pp. 1636-1642
-
-
Leier, I.1
Hummel-Eisenbeiss, J.2
Cui, Y.3
Keppler, D.4
-
36
-
-
0029133131
-
Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes
-
Mayer R., Kartenbeck J., Buchler M., Jeditschky G., Leier I., Keppler D.: Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes. J Cell Biol 1995 ; 131: 137-150.
-
(1995)
J Cell Biol
, vol.131
, pp. 137-150
-
-
Mayer, R.1
Kartenbeck, J.2
Buchler, M.3
Jeditschky, G.4
Leier, I.5
Keppler, D.6
-
37
-
-
0025132673
-
ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane. role of the ATP-dependent transport system for glutathione S-conjugates
-
Ishikawa T., Muller M., Klunemann C., Schaub T., Keppler D.: ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane. role of the ATP-dependent transport system for glutathione S-conjugates. J Biol Chem 1990 ; 265: 19279-19286.
-
(1990)
J Biol Chem
, vol.265
, pp. 19279-19286
-
-
Ishikawa, T.1
Muller, M.2
Klunemann, C.3
Schaub, T.4
Keppler, D.5
-
38
-
-
0029884940
-
Defective hepatobiliary leukotriene elimination in patients with the Dubin-Johnson syndrome
-
Mayatepek E., Lehmann WD: Defective hepatobiliary leukotriene elimination in patients with the Dubin-Johnson syndrome. Clin Chim Acta 1996 ; 249: 37-46.
-
(1996)
Clin Chim Acta
, vol.249
, pp. 37-46
-
-
Mayatepek, E.1
Lehmann, W.D.2
-
39
-
-
0345299165
-
Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells
-
Cui Y., Konig J., Buchholz U., Spring H., Leier I., Keppler D.: Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells. Mol Pharmacol 1999: 55: 929-937.
-
(1999)
Mol Pharmacol
, vol.55
, pp. 929-937
-
-
Cui, Y.1
Konig, J.2
Buchholz, U.3
Spring, H.4
Leier, I.5
Keppler, D.6
|