Synthesis, characterization and biological evaluation of novel 4′-fluoro-2′-hydroxy-chalcone derivatives as antioxidant, anti-inflammatory and analgesic agents

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 30, Issue 3, 2015, Pages 484-491

  Abdellatif, Khaled R A ^a   Elshemy, Heba A H ^a   Salama, Samir A ^b   Omar, Hany A ^a,c  

^a Beni Suef University   (Egypt)

^b Al Azhar University   (Egypt)

^c UNIVERSITY OF SHARJAH   (United Arab Emirates)

Author keywords

4 fluoro 2 hydroxychalcones; Analgesic; Anti inflammatory; Antioxidant; Cyclooxygenase inhibition; Dihydropyrazole

Indexed keywords

5 (3,4 DIMETHOXYPHENYL) 3 (4 FLUORO 2 HYDROXYPHENYL) 4,5 DIHYDRO 1H PYRAZOLE; ALDEHYDE DERIVATIVE; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; CELECOXIB; CHALCONE DERIVATIVE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; FLUORINE DERIVATIVE; HYDRAZINE; PIROXICAM; UNCLASSIFIED DRUG; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN SYNTHASE INHIBITOR;

ALDOL REACTION; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CARRAGEENAN-INDUCED PAW EDEMA; CONTROLLED STUDY; CYCLIZATION; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HOT PLATE TEST; IC50; MOLECULAR DOCKING; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION; WRITHING TEST; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; OXIDATIVE STRESS; SACCHAROMYCES CEREVISIAE; SYNTHESIS; WISTAR RAT;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIOXIDANTS; CHALCONES; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; OXIDATIVE STRESS; RATS; RATS, WISTAR; SACCHAROMYCES CEREVISIAE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84937035967     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.3109/14756366.2014.949255     Document Type: Article

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