Synthesis and pharmacological evaluation of 2-substituted benzo[b]thiophenes as anti-inflammatory and analgesic agents

European Journal of Medicinal Chemistry

Volumn 44, Issue 4, 2009, Pages 1718-1725

  Fakhr, Issa M I ^a   Radwan, Mohamed A A ^a   El Batran, Seham ^a   Abd El Salam, Omar M E ^a   El Shenawy, Siham M ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

Anti inflammatory and analgesic; Benzo b thiophene; Zileuton

Indexed keywords

1 [5 NITROBENZO(B)THIOPHENE 2 CARBONYL] 4 PHENYLTHIOSEMICARBAZIDE; 4 (5 NITROBENZO(B)THIOPHENE 2 YL)SEMICARBAZIDE; 5 NITROBENZO(B)THIOPENE 2 CARBOXYLIC ACID; 5 NITROBENZO(B)THIOPHENE 2 CARBOAZIDE; ALANINE AMINOTRANSFERASE; ALCOHOL; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; ASPARTATE AMINOTRANSFERASE; AZIDE; CARBAMIC ACID; ETHYL(5 NITROBENZO(B)THIOPENE 2 YL)CARBAMATE; HYDRAZIDE; HYDRAZINE; ISOCYANATE; N [(1H INDOL 3 YL)METHYLENE] 5 NITROBENZO(B)THIOPHENE 2 CABOHYDRAZIDE; N [(5 METHYLFURAN 2 YL)METHYLENE] 2 NITROBENZO(B)THIOPHENE 2 CARBOHYDRAZIDE; NITROUS ACID; PHENYL ISOTHIOCYANATE; PIROXICAM; SEMICARBAZIDE DERIVATIVE; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG; ZILEUTON;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; CURTIUS REARRANGEMENT; DRUG DETERMINATION; DRUG SCREENING; DRUG SYNTHESIS; HOT PLATE TEST; NONHUMAN; PAW EDEMA; RAT; ULCEROGENESIS; WRITHING TEST;

ACETIC ACID; ALANINE TRANSAMINASE; ANIMALS; ANTI-INFLAMMATORY AGENTS; ASPARTATE AMINOTRANSFERASES; CARRAGEENAN; EDEMA; LIVER; MICE; PAIN; PAIN THRESHOLD; PIROXICAM; RATS; STOMACH ULCER; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 61349091166     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.02.034     Document Type: Article

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