Celecoxib prodrugs possessing a diazen-1-ium-1,2-diolate nitric oxide donor moiety: Synthesis, biological evaluation and nitric oxide release studies

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 15, 2010, Pages 4544-4549

  Abdellatif, Khaled R A ^a   Chowdhury, Morshed A ^a   Velázquez, Carlos A ^a   Huang, Zhangjian ^a   Dong, Ying ^a   Das, Dipankar ^a   Yu, Gang ^a   Suresh, Mavanur R ^a   Knaus, Edward E ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Anti inflammatory activity; Cyclooxygenase inhibition; Nitric oxide donors

Indexed keywords

5 [4 (DIOXY AMMONIUM DIAZEN 1 IUM 1,2 DIOLATO)PHENYL ] 1 [4 METHYLSULFONYL(SULFAMOYL)PHENYL] 3 TRIFLUOROMETHYL 1H PYRAZOLE DERIVATIVE; 5 [4 (DIOXY AMMONIUM DIAZEN 1 IUM 1,2 DIOLATO)PHENYL] 1 (4 SULFAMOYLPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; 5 [4 (DIOXY METHYL DIAZEN 1 IUM 1,2 DIOLATO)PHENYL ] 1 [4 METHYLSULFONYL(SULFAMOYL)PHENYL] 3 TRIFLUOROMETHYL 1H PYRAZOLE DERIVATIVE; ACETYLSALICYLIC ACID; AMMONIA; ANTIINFLAMMATORY AGENT; CARBON; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2 INHIBITOR; DIOXY METHYL DIAZEN 1 IUM 1,2 DIOLATE; IBUPROFEN; ISOENZYME; NITRIC OXIDE; NITRIC OXIDE DONOR; PHOSPHATE BUFFERED SALINE; PRODRUG; ROFECOXIB; UNCLASSIFIED DRUG; VALDECOXIB;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; COMPETITIVE INHIBITION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HYPERTENSION; IC 50; INFLAMMATION; NONHUMAN; PAW EDEMA; PH; RAT; STOMACH IRRITATION; THROMBOCYTE AGGREGATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; DRUG DESIGN; HUMANS; HYDRAZINES; NITRIC OXIDE; NITRIC OXIDE DONORS; NITROSAMINES; PRODRUGS; PYRAZOLES; RATS; SULFONAMIDES;

RATTUS;

EID: 77955420023     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.06.022     Document Type: Article

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