Fluorinated 2′-hydroxychalcones as garcinol analogs with enhanced antioxidant and anticancer activities

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 19, 2010, Pages 5818-5821

  Padhye, Subhash ^a,b   Ahmad, Aamir ^a   Oswal, Nikhil ^c   Dandawate, Prasad ^d   Rub, Rukhsana A ^d   Deshpande, Jyoti ^e   Swamy, K Venkateswara ^e   Sarkar, Fazlul H ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DR DY PATIL UNIVERSITY   (India)

^c DR D Y PATIL INSTITUTE OF PHARMACEUTICAL SCIENCES AND RESEARCH   (India)

^d Allana College of Pharmacy   (India)

^e DR D Y PATIL BIOTECHNOLOGY AND BIOINFORMATICS INSTITUTE   (India)

Author keywords

Antioxidant; Antiproliferative; Breast cancer; Fluorochalcones; Hydroxychalcones; Pancreatic cancer

Indexed keywords

ANTINEOPLASTIC AGENT; ANTIOXIDANT; CARBON; CHALCONE DERIVATIVE; CYCLOOXYGENASE 2; FLUORINE; GARCINOL; UNCLASSIFIED DRUG; 2' HYDROXYCHALCONE; 2'-HYDROXYCHALCONE; PTGS2 PROTEIN, HUMAN; SUPEROXIDE DISMUTASE; TERPENE;

ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BREAST CANCER; DRUG BIOAVAILABILITY; DRUG POTENCY; FLUORINATION; HUMAN; HUMAN CELL; IC 50; MOLECULAR DOCKING; PANCREAS CANCER; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION; BINDING SITE; CHEMISTRY; COMPUTER SIMULATION; HALOGENATION; METABOLISM; PANCREAS TUMOR; PROTEIN TERTIARY STRUCTURE; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; BINDING SITES; CELL LINE, TUMOR; CHALCONES; COMPUTER SIMULATION; CYCLOOXYGENASE 2; HALOGENATION; HUMANS; PANCREATIC NEOPLASMS; PROTEIN STRUCTURE, TERTIARY; SUPEROXIDE DISMUTASE; TERPENES;

EID: 77957555080     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.07.128     Document Type: Article

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