Synthesis of novel substituted 4H-chromenes and their antioxidant screening

Journal of Chemical and Pharmaceutical Research

Volumn 5, Issue 1, 2013, Pages 387-394

  Abdelgawad, Mohamed A ^a   Elshemy, Heba A H ^a   Abdellatif, Khaled R A ^a   Omar, Hany A ^a  

^a Beni Suef University   (Egypt)

Author keywords

Antioxidant activity; Heterocycles; Schiff bases; Substituted chromenes; Thiazoles

Indexed keywords

ANTI-OXIDANT ACTIVITIES; CHROMENES; HETEROCYCLES; SCHIFF BASIS; THIAZOLES;

ALDEHYDES; FUNCTIONAL GROUPS;

ORGANIC POLYMERS;

2 (2 AMINO 3 CYANO 4 PHENYL 4H CHROMEN 7 YLOXY) N' (4 OXO 3 ETHYLTHIAZOLIDIN 2 YLIDENE)ACETOHYDRAZIDE; 2 (2 AMINO 3 CYANO 4 PHENYL 4H CHROMEN 7 YLOXY) N' (4 OXO 3 PHENYLTHIAZOLIDIN 2 YLIDENE)ACETOHYDRAZIDE; 2 [2 (2 AMINO 3 CYANO 4 PHENYL 4H CHROMEN 7 YLOXY)ACETYL] N ETHYLHYDRAZINECARBOTHIOAMIDE; 2 [2 (2 AMINO 3 CYANO 4 PHENYL 4H CHROMEN 7 YLOXY)ACETYL] N SUBSTITUTED HYDRAZINECARBOTHIOAMIDE; [2 AMINO 4 (PHENYL) 3 CYANO 4H CHROMEN 7 YLOXY] N' 2,3 DIMETHOXYBENZYLIDENEACETOHYDRAZIDE; [2 AMINO 4 (PHENYL) 3 CYANO 4H CHROMEN 7 YLOXY] N' 4 METHOXYBENZYLIDENEACETOHYDRAZIDE; ASCORBIC ACID; CHROMENE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; CYCLIZATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; NONHUMAN;

EID: 84874407818     PISSN: None     EISSN: 09757384     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. H. V. Rensburg, P. S. V. Heerden, B. B. Bezuidenhoudt, D. Ferreira, Tetrahedron Lett. 1997, 38, 3089-3092.
2. P. O. Kennedy, R. D. Thornes (Eds.) Coumarins: Biology, Applications and Mode of Action; J. Wiley & Sons: Chichester, U. K, 1997.
3. B. S. Kumar, N. Srinivasulu, R. H. Udupi, B. Rajitha, Y. T. Reddy, P. N. Reddy, P. S. Kumarb, Russian Journal of Organic Chemistry 2006, 42, 1813-1815.
4. M. M. Khafagy, A. H. F. A. El-Wahas, F. A. Eid, A. M. El-Agrody. IL Farmaco 2002, 57, 715-722.
5. M. D. Aytemir, D. D. Erol, R. C. Hider, M. O. Zalp, Turk. J. Chem. 2003, 27, 757-764.
6. I. J. S. Fairlamb, L. R. Marrison, J. M. Dickinson, F. J. Lu, J. P. Schmidt, Bioorg. Med. Chem. 2004, 12, 4285-4299.
7. K. Mazaahir, S. Shilpi, R. Khalilur, S. Sharanjit, Bioorg. Med. Chem. Lett. 2005, 15, 429-4298.
8. G. Tangmouo, L. Meli, J. Komguem, V. Kuete, N. Ngounou, D. Lontsi, P. Beng, I. Choudhary, L. Sondengam, Tetrahedron Lett. 2006, 47, 3067-3070.
9. M. El-Saghier, B. Naili, K. Rammash, A. Saleh, M. Kreddan, Arkivoc 2007, xvi, 83-91.
10. R. Kumar, S. Perumal, P. Senthilkumar, P. Yogeeswari, D. Sriram, Bioorg. Med. Chem. Lett. 2007, 17, 6459-6462.
11. D. Kumar, B. Reddy, S. Sharad, U. Dube, S. Kapur, European Journal of Medicinal Chemistry 2009, 44, 3805-3809.
12. H. Bedair, A. El-Hady, S. Abd El-Latif, H. Fakery, M El-Agrody, IL Farmaco 2000, 55, 708-714.
13. H. Bedair, A. Emam, A. El-Hady, A. Ahmed, M. El-Agrody, IL Farmaco 2001, 56, 965-973.
14. L. Alvey, S. Prado, V. Huteau, B. Saint-Joanis, S. Michel, M. Koch, T. Cole, F. Tillequin, L. Janin,. Bioorg. Med. Chem. 2008, 16, 8264-8272.
15. T. Symeonidis, M. Chamilos, J. Hadjipavlou-Litina, M. Kallitsakis, E. Litinas,. Bioorg. Med. Chem. Lett. 2009, 19, 1139-1142.
16. L. Wang, D. Liu, J. Zhang, S. Shan, X. Han, M. Srinivasula, M. Croce, S. Alnemri, Z. Huang, Proc. Natl. Acad. Sci. U. S. A. 2000, 97, 7124-7129.
17. F Cheng, A. Ishikawa, Y. Ono, T. Arrheniusa, A. Nadzana, Bioorg. Med. Chem. Lett. 2003, 13, 3647-3650.
18. D. Greé, S. Vorin, L. Manthati, F. Caijo, G. Viault, F. Manero, P. Juin, R. Greé, Tetrahedron Lett. 2008, 49, 3276-3278.
19. W. Kemnitzer, S. Jiang, H. Zhang, S. Kasibhatla, C. Crogan-Grundy, C. Blais, G. Attardo, R. Denis, S. Lamoth, H. Gourdeau, B. Tseng, J. Drewe, X. Cai, Bioorg. Med. Chem. Lett. 2008, 18, 5571-5575.
20. K. Tandon, M. Vaish, S. Jain, S. Bhakuni, C. Srimal, Indian J. Pharm. Sci. 1991, 53, 22-23.
21. M. Longobardi, A. Bargagna, E. Mariani, P. Schenone, E. Marmo, IL Farmaco 1990, 45, 399-404.
22. M. Heravi, K. Bakhtiari, V. Zadsirjan, F. Bamoharram, M. Heravi, Bioorg. Med. Chem. Lett. 2007, 17, 4262-4265 and references therein.
23. C. Bruhlmann, F. Ooms, P. Carrupt, B. Testa, M. Catto, F. Leonetti, C. Altomare, A. Cartti, J. Med. Chem. 2001, 44, 3195-3198.
24. R. Kesten, G. Heffner, J. Johnson, A. Pugsley, L. Wright, L. Wise, J. Med. Chem. 1999, 42, 3718-3725.
25. F. Abdel-Latif,. Indian Journal of Chemistry 1990, 29B, 664-666.
26. M. Radwan, A. Bakhite, M. Kamal El-Dean, Phosphorus, Sulfur, and Silicon 1995, 101, 207-211.
27. K. Schlesier et al., Free Radic Res, 2002, 36(2), 177-187.
28. I. Aruoma, Mutat Res, 2003, 523-524, 9-20.
29. B. Liu et al., Pharm Biol, 2010, 48(12), 1432-1438.
30. J. Wu et al., FEMS Yeast Res, 2011, 11(4), 379-387.
31. S. Ravipati et al., BMC Complement Altern Med, 2012, 12(1), 173.