Design, synthesis and cytotoxicity of a new series of isoxazolidines derived from substituted chalcones

European Journal of Medicinal Chemistry

Volumn 46, Issue 4, 2011, Pages 1382-1389

  Piotrowska, Dorota G ^a   Cieślak, Marcin ^b   Królewska, Karolina ^b   Wróblewski, Andrzej E ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

^b CENTRE OF MOLECULAR AND MACROMOLECULAR STUDIES   (Poland)

Author keywords

Chalcones; Cytotoxicity; Isoxazolidines; Phosphonates; Synthesis

Indexed keywords

4 (2 HYDROXY 4 METHOXYBENZOYL) 2 METHYL 5 PHENYLISOXAZOLIDIN 3 YL 3 PHOSPHONIC ACID; 4 (2 HYDROXYBENZOYL) 5 (3,4,5 TRIMETHOXYPHENYL) 2 METHYLISOXAZOLIDIN 3 YL 3 PHOSPHONIC ACID; 4 (2 HYDROXYBENZOYL) 5 (4 METHOXYPHENYL) 2 METHYLISOXAZOLIDIN 3 YL 3 PHOSPHONIC ACID; 4 (2 HYDROXYBENZOYL) 5 PHENYL 2 METHYLISOXAZOLIDIN 3 YL 3 PHOSPHINIC ACID; 4 (2,5 DIHYDROXYBENZOYL) 2 METHYL 5 PHENYLISOXAZOLIDIN 3 YL 3 PHOSPHONIC ACID; 4 BENZOYL 2 METHYL 5 PHENYLISOXAZOLIDIN 3 YL 3 PHOSPHONIC ACID; 4 HYDROXYDERRICIN; 4 METHYL 2',3',5' TRIHYDROXYCHALCONE; 4' ETHOXY 2' HYDROXY 4,6' DIMETHOXY CHALCONE; 4' HYDROXYCHALCONE; 5 (2 METHOXYBENZOYL) 4 (4 METHOXYPHENYL) 2 METHYLISOXAZOLIDIN 3 YL 3 PHOSPHONIC ACID; BROMINE DERIVATIVE; CHALCONE DERIVATIVE; COLCHICINE; DIETHYL 4 (2 HYDROXY 4 METHOXYBENZOYL) 2 METHYL 5 PHENYL ISOXAZOLIDIN 3 YL 3 PHOSPHONATE; DIETHYL 4 (2 HYDROXYBENZOYL) 5 (3,4,5 TRIMETHOXYPHENYL) 2 METHYLISOXAZOLIDIN 3 YL 3 PHOSPHONATE; DIETHYL 4 (2 HYDROXYBENZOYL) 5 (4 METHOXYPHENYL) 2 METHYLISOXAZOLIDIN 3 YL 3 PHOSPHONATE; DIETHYL 4 (2 METHOXYBENZOYL) 5 (4 METHOXYPHENYL) 2 METHYL ISOXAZOLIDIN 3 YL 3 PHOSPHONATE; DIETHYL 4 (2,5 DIHYDROXYBENZOYL) 2 METHYL 5 PHENYLISOXAZOLIDIN 3 YL 3 PHOSPHONATE; DIETHYL 5 (2 METHOXYBENZOYL) 4 (4 METHOXYPHENYL) 2 METHYL ISOXAZOLIDIN 3 YL 3 PHOSPHONATE; ISOLIQUIRITIGENIN; ISOXAZOLIDIN 3 YL 3 PHOSPHONATE; ISOXAZOLIDINE DERIVATIVE; LICOCHALCONE A; N METHYL C DIETHOXYPHOSPHORYLNITRONE; NITRONE DERIVATIVE; PEDICIN; PHOSPHONIC ACID DERIVATIVE; PHOSPHONIC ACID ESTER; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CELL STRAIN K 562; CONTROLLED STUDY; DEALKYLATION; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; HELA CELL; HUMAN; HUMAN CELL; IC 50; ISOMER;

ANTINEOPLASTIC AGENTS; CHALCONES; DRUG DESIGN; HELA CELLS; HUMANS; ISOXAZOLES; K562 CELLS; WATER;

EID: 79952282973     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.01.067     Document Type: Article

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