Novel pyrazolopyrimidine derivatives targeting COXs and iNOS enzymes; Design, synthesis and biological evaluation as potential anti-inflammatory agents

European Journal of Pharmaceutical Sciences

Volumn 62, Issue , 2014, Pages 197-211

  Abdelazeem, Ahmed H ^a   Abdelatef, Shaimaa A ^a   El Saadi, Mohammed T ^a   Omar, Hany A ^a   Khan, Shabana I ^b   McCurdy, Christopher R ^b   El Moghazy, Samir M ^c  

^a Beni Suef University   (Egypt)

^b UNIVERSITY OF MISSISSIPPI   (United States)

^c CAIRO UNIVERSITY   (Egypt)

Author keywords

Analgesic; Anti inflammatory; COX; iNOS; NF B; Pyrazolopyrimidines

Indexed keywords

1 PHENYL 1H PYRAZOLO[3,4 D]PYRIMIDIN 4 AMINE; 1 PHENYL 3 (1 PHENYL 1H PYRAZOLO[3,4 D]PYRIMIDIN 4 YL)UREA; 1 PHENYL 4 (4 PHENYLPIPERAZIN 1 YL) 1H PYRAZOLO[3,4 D]PYRIMIDINE; 1 PHENYL 4 [4 [4 (TRIFLUOROMETHYL)PHENYL]PIPERAZIN 1 YL] 1H PYRAZOLO[3,4 D]PYRIMIDINE; 1 PHENYL 5 [2 (PHENYLTHIO)ETHYL] 1H PYRAZOLO[3,4 D]PYRIMIDIN 4(5H) ONE; 1 PHENYL 5 [2 (PYRROLIDIN 1 YL)ETHYL] 1H PYRAZOLO[3,4 D]PYRIMIDIN 4(5H) ONE; 3 [2 [4 OXO 1 PHENYL 1H PYRAZOLO[3,4 D]PYRIMIDIN 5(4H) YL] ETHYL]BENZO[D]THIAZOL; 4 (4 CYCLOHEXYLPIPERAZIN 1 YL) 1 PHENYL 1H PYRAZOLO[3,4 D]PYRIMIDINE; 4 CHLORO 1 PHENYL 1H PYRAZOLO[3,4 D]PYRIMIDINE; 4 SUBSTITUTED 1 PHENYL PYRAZOLO[3,4 D ]PYRIMIDINE DERIVATIVE; 4 [4 (4 FLUOROPHENYL)PIPERAZIN 1 YL] 1 PHENYL 1H PYRAZOLO[3,4 D]PYRIMIDINE; 4 [[2 [4 OXO 1 PHENYL 1H PYRAZOLO[3,4 D]PYRIMIDIN 5(4H) YL]ETHYL]AMINO]BENZENESULFONAMIDE; 5 SUBSTITUTED 1 PHENYL PYRAZOLO[3,4 D]PYRIMIDIN 4 ONE DERIVATIVE; 5 [2 (AZEPAN 1 YL)ETHYL] 1 PHENYL 1H PYRAZOLO[3,4 D]PYRIMIDIN 4(5H) ONE; 5 [2 [BIS(2 HYDROXYETHYL)AMINO]ETHYL] 1 PHENYL 1H PYRAZOLO[3,4 D]PYRIMIDIN 4(5H) ONE; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 2; DOXORUBICIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDOMETACIN; INDUCIBLE NITRIC OXIDE SYNTHASE; KETOROLAC; N (3 PHENOXYBENZYL) 1 PHENYL 1H PYRAZOLO[3,4 D]PYRIMIDIN 4 AMINE; N (4 NITROBENZYL) 1 PHENYL 1H PYRAZOLO[3,4 D]PYRIMIDIN 4 AMINE; N (FURAN 3 YLMETHYL) 1 PHENYL 1H PYRAZOLO[3,4 D]PYRIMIDIN 4 AMINE; PARTHENOLIDE; PROSTAGLANDIN SYNTHASE; PYRAZOLOPYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; UREA DERIVATIVE; ACETIC ACID; CARRAGEENAN; CYCLOOXYGENASE 1; PROSTAGLANDIN SYNTHASE INHIBITOR; PYRIMIDINE DERIVATIVE;

ANALGESIC ACTIVITY; ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CANCER CELL LINE; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CELL SURVIVAL; CHEMICALLY INDUCED; CHEMISTRY; CHLOROCEBUS AETHIOPS; DRUG EFFECTS; EDEMA; HYPERALGESIA; LLC PK1 CELL LINE; METABOLISM; MOLECULAR DOCKING; PAIN; SWINE; SYNTHESIS; TUMOR CELL LINE; VERO CELL LINE;

ACETIC ACID; ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; CARRAGEENAN; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; DRUG DESIGN; EDEMA; HUMANS; HYPERALGESIA; LLC-PK1 CELLS; MICE; MOLECULAR DOCKING SIMULATION; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; PAIN; PYRIMIDINES; SWINE; VERO CELLS;

EID: 84903308317     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2014.05.025     Document Type: Article

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