Synthesis, cytotoxicity, anti-oxidative and anti-inflammatory activity of chalcones and influence of A-ring modifications on the pharmacological effect

European Journal of Medicinal Chemistry

Volumn 45, Issue 6, 2010, Pages 2206-2213

  Vogel, Susanne ^a   Barbic, Matej ^a   Jürgenliemk, Guido ^a   Heilmann, Jörg ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

3 Coumaroyl 2 ,4,4 trihydroxy 6 methoxychalcone; Anti inflammatory; Anti oxidative; Chalcones; Cytotoxic; Xanthohumol

Indexed keywords

2',3,4 TRIHYDROXY 6' METHOXY 2'',2'' DIMETHYLPYRANO[2'',3'':3',4']CHALCONE; 2',3,4,4' TETRAHYDROXY 3' (3'' HYDROXY METHYLBUTYL) 6' METHOXYCHALCONE; 2',4 DIHYDROXY 3,6' DIMETHOXY 2'',2'' DIMETHYLPYRANO[2'',3'':3',4']CHALCONE; 2',4' DIHYDROXY 4,6' DIMETHOXY 3' PRENYLCHALCONE; 2',4,4' TETRAHYDROXY 3' (3'' HYDROXY METHYLBUTYL) 3,6' DIMETHOXYCHALCONE; 3 HYDROXYHELICHRYSETIN; 3 HYDROXYXANTHOHUMOL H; 3 METHOXYHELICHRYSETIN; 3 METHOXYXANTHOHUMOL; 3' COUMAROYL 2',4,4' TRIHYDROXY 6' METHOXYCHALCONE; 4 ACETOXY 2',4' DIHYDROXY 6' METHOXY 3' PRENYLCHALCONE; CAFFEIC ACID; CHALCONE; FERULIC ACID; INTERCELLULAR ADHESION MOLECULE 1; UNCLASSIFIED DRUG; XANTHOHUMOL;

ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; ENDOTHELIUM CELL; HELA CELL; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; CHALCONES; HELA CELLS; HUMANS; INHIBITORY CONCENTRATION 50; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77950867081     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.01.060     Document Type: Article

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