A systematic review of the efficacy of bioactive compounds in cardiovascular disease: Phenolic compounds

Nutrients

Volumn 7, Issue 7, 2015, Pages 5177-5216

  Rangel Huerta, Oscar D ^a   Pastor Villaescusa, Belen ^a   Aguilera, Concepcion M ^a   Gil, Angel ^a  

^a UNIVERSITY OF GRANADA   (Spain)

Author keywords

Bioactive food compounds; Cardiovascular diseases; Flavonols; Phenols; Polyphenols

Indexed keywords

ADIPONECTIN; ANTHOCYANIN; BIOLOGICAL MARKER; C REACTIVE PROTEIN; CATECHIN; CATECHOL; FLAVONOL DERIVATIVE; INTERLEUKIN 1BETA; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; PHENOL DERIVATIVE; POLYPHENOL; PROCYANIDIN; PYCNOGENOL; RESVERATROL; STILBENE; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

ANGINA PECTORIS; BIOLOGICAL ACTIVITY; BLOOD PRESSURE; CARDIOVASCULAR DISEASE; CASE CONTROL STUDY; CAUSE OF DEATH; CHOLESTEROL BLOOD LEVEL; DRUG EFFICACY; FOOD; HOMEOSTASIS; HUMAN; INFORMATION PROCESSING; OXIDATIVE STRESS; PREVALENCE; PREVENTION; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RISK FACTOR; SYSTEMATIC REVIEW; BLOOD; CARDIOVASCULAR DISEASES; DRUG EFFECTS; INFLAMMATION; VASCULAR ENDOTHELIUM;

BIOMARKERS; BLOOD PRESSURE; CARDIOVASCULAR DISEASES; ENDOTHELIUM, VASCULAR; FLAVONOLS; HOMEOSTASIS; HUMANS; INFLAMMATION; OXIDATIVE STRESS; POLYPHENOLS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RISK FACTORS;

EID: 84936951125     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu7075177     Document Type: Review

References (116)

1. Martínez-Augustin, O.; Aguilera, C.M.; Gil-campos, M.; Sánchez de Medina, F.; Gil, A. Bioactive anti-obesity food components. Int. J. Vitam. Nutr. Res. 2012, 82, 148-156.
2. Organization, W.H. Obesity and overweight. Available online: http://www.who.int/mediacentre/factsheets/fs311/en/ (accessed on 14 October 2014).
3. Perk, J.; de Backer, G.; Gohlke, H.; Graham, I.; Reiner, Ž.; Verschuren, M.; Albus, C.; Benlian, P.; Boysen, G., Cifkova, R., et al. European Guidelines on cardiovascular disease prevention in clinical practice (version 2012). Eur. Heart J. 2012, 33, 1635-1701.
4. Stone, N.J.; Robinson, J.G.; Lichtenstein, A.H.; Bairey Merz, C.N.; Blum, C.B.; Eckel, R.H.; Goldberg, A.C.; Gordon, D.; Levy, D., Lloyd-Jones, D.M., et al. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: A report of the American college of cardiology/American heart association task force on practice guidelines. J. Am. Coll. Cardiol. 2014, 63, 2889-2934.
5. Kitts, D.D. Bioactive substances in food: Identification and potential uses. Can. J. Physiol. Pharmacol. 1994, 72, 423-434.
6. Kris-Etherton, P.M.; Hecker, K.D.; Bonanome, A.; Coval, S.M.; Binkoski, A.E.; Hilpert, K.F.; Griel, A.E.; Etherton, T.D. Bioactive compounds in foods: Their role in the prevention of cardiovascular disease and cancer. Am. J. Med. 2002, 113, 71S-88S.
7. Sarriá, B.; Martínez-López, S.; Sierra-Cinos, J.L.; Garcia-Diz, L.; Goya, L.; Mateos, R.; Bravo, L. Effects of bioactive constituents in functional cocoa products on cardiovascular health in humans. Food Chem. 2015, 174, 214-218.
8. Huxley, R.R.; Neil, H.A.W. The relation between dietary flavonol intake and coronary heart disease mortality: A meta-analysis of prospective cohort studies. Eur. J. Clin. Nutr. 2003, 57, 904-908.
9. Li, S.; Liu, X.; Bai, Y.; Wang, X.; Sun, K.; Chen, J.; Hui, R. Effect of oral isoflavone supplementation on vascular endothelial function in postmenopausal women: A meta-analysis of randomized placebo-controlled trials. Am. J. Clin. Nutr. 2009, 91, 480-486.
10. Wang, Z.-M.; Nie, Z.-L.; Zhou, B.; Lian, X.-Q.; Zhao, H.; Gao, W.; Wang, Y.-S.; Jia, E.-Z.; Wang, L.-S.; Yang, Z.-J. Flavonols intake and the risk of coronary heart disease: A meta-analysis of cohort studies. Atherosclerosis 2012, 222, 270-273.
11. Hooper, L.; Kroon, P.A.; Rimm, E.B.; Cohn, J.S.; Harvey, I.; Le Cornu, K.A.; Ryder, J.J.; Hall, W.L.; Cassidy, A. Flavonoids, flavonoid-rich foods, and cardiovascular risk: A meta-analysis of randomized controlled trials. Am. J. Clin. Nutr. 2008, 88, 38-50.
12. FDA FDA Basics—Dietary Supplements. Available online: http://www.fda.gov/AboutFDA/Transparency/Basics/ucm193949.htm (accessed on 13 Feburbary 2015).
13. Lekakis, J.; Rallidis, L.S.; Andreadou, I.; Vamvakou, G.; Kazantzoglou, G.; Magiatis, P.; Skaltsounis, A.-L.; Kremastinos, D.T. Polyphenolic compounds from red grapes acutely improve endothelial function in patients with coronary heart disease. Eur. J. Cardiovasc. Prev. Rehabil. 2005, 12, 596-600.
14. Quiles, J.L.; Mesa, M.D.; Ramírez-Tortosa, C.L.; Aguilera, C.M.; Battino, M.; Gil, Á.; Ramírez-Tortosa, M.C. Curcuma longa extract supplementation reduces oxidative stress and attenuates aortic fatty streak development in rabbits. Arterioscler. Thromb. Vasc. Biol. 2002, 22, 1225-1231.
15. Corcoran, M.P.; McKay, D.L.; Blumberg, J.B. Flavonoid Basics: Chemistry, Sources, Mechanisms of Action, and Safety. J. Nutr. Gerontol. Geriatr. 2012, 31, 176-189.
16. Scottish Intercollegiate Guidelines Network. Risk Estimation and the Prevention of Cardiovascular Disease (Guideline 97); Scottish Intercollegiate Guidelines Network: Edinburgh, UK, 2007.
17. Jadad, A.R.; Moore, R.A; Carroll, D.; Jenkinson, C.; Reynolds, D.J.; Gavaghan, D.J.; McQuay, H.J. Assessing the quality of reports of randomized clinical trials: Is blinding necessary? Control Clin. Trials 1996, 17, 1-12.
18. Uauy, R.E.A. Fats and fatty acids in human nutrition, Report of an expert consultation. FAO Food Nutr. Pap. 2008, 550, 189.
19. Wong, R.H.X.; Howe, P.R.C.; Buckley, J.D.; Coates, A.M.; Kunz, I.; Berry, N.M. Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure. Nutr. Metab. Cardiovasc. Dis. 2011, 21, 851-856.
20. Wong, R.H.X.; Berry, N.M.; Coates, A.M.; Buckley, J.D.; Bryan, J.; Kunz, I.; Howe, P.R.C. Chronic resveratrol consumption improves brachial flow-mediated dilatation in healthy obese adults. J. Hypertens. 2013, 31, 1819-1827.
21. Bo, S.; Ciccone, G.; Castiglione, A.; Gambino, R.; de Michieli, F.; Villois, P.; Durazzo, M.; Cavallo-Perin, P.; Cassader, M. Anti-inflammatory and antioxidant effects of resveratrol in healthy smokers a randomized, double-blind, placebo-controlled, cross-over trial. Curr. Med. Chem. 2013, 20, 1323-1331.
22. Militaru, C.; Donoiu, I.; Craciun, A.; Scorei, I.D.; Bulearca, A.M.; Scorei, R.I. Oral resveratrol and calcium fructoborate supplementation in subjects with stable angina pectoris: Effects on lipid profiles, inflammation markers, and quality of life. Nutrition 2013, 29, 178-183.
23. Tomé-Carneiro, J.; Gonzálvez, M.; Larrosa, M.; Yáñez-Gascón, M.J.; García-Almagro, F.J.; Ruiz-Ros, J.A.; Tomás-Barberán, F.A.; García-Conesa, M.T.; Espín, J.C. Grape resveratrol increases serum adiponectin and downregulates inflammatory genes in peripheral blood mononuclear cells: A triple-blind, placebo-controlled, one-year clinical trial in patients with stable coronary artery disease. Cardiovasc. Drugs Ther. 2013, 27, 37-48.
24. Tomé-Carneiro, J.; Gonzálvez, M.; Larrosa, M.; García-Almagro, F.J.; Avilés-Plaza, F.; Parra, S.; Yáñez-Gascón, M.J.; Ruiz-Ros, J.A.; García-Conesa, M.T., Tomás-Barberán, F.A., et al. Consumption of a grape extract supplement containing resveratrol decreases oxidized LDL and ApoB in patients undergoing primary prevention of cardiovascular disease: A triple-blind, 6-month follow-up, placebo-controlled, randomized trial. Mol. Nutr. Food Res. 2012, 56, 810-821.
25. Tomé-Carneiro, J.; Larrosa, M.; Yáñez-Gascón, M.J.; Dávalos, A.; Gil-Zamorano, J.; Gonzálvez, M.; García-Almagro, F.J.; Ruiz Ros, J.A.; Tomás-Barberán, F.A., Espín, J.C., et al. One-year supplementation with a grape extract containing resveratrol modulates inflammatory-related microRNAs and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease. Pharmacol. Res. 2013, 72, 69-82.
26. Tomé-Carneiro, J.; Gonzálvez, M.; Larrosa, M.; Yáñez-Gascón, M.J.; García-Almagro, F.J.; Ruiz-Ros, J.A.; García-Conesa, M.T.; Tomás-Barberán, F.A.; Espín, J.C. One-year consumption of a grape nutraceutical containing resveratrol improves the inflammatory and fibrinolytic status of patients in primary prevention of cardiovascular disease. Am. J. Cardiol. 2012, 110, 356-363.
27. Alwi, I.; Santoso, T.; Suyono, S.; Sutrisna, B.; Suyatna, F.D.; Kresno, S.B.; Ernie, S. The effect of curcumin on lipid level in patients with acute coronary syndrome. Acta Med. Indones. 2008, 40, 201-210.
28. Chuengsamarn, S.; Rattanamongkolgul, S.; Phonrat, B.; Tungtrongchitr, R.; Jirawatnotai, S. Reduction of atherogenic risk in patients with type 2 diabetes by curcuminoid extract: A randomized controlled trial. J. Nutr. Biochem. 2014, 25, 144-150.
29. Botden, I.P.G.; Draijer, R.; Westerhof, B.E.; Rutten, J.H.W.; Langendonk, J.G.; Sijbrands, E.J.G.; Danser, A.H.J.; Zock, P.L.; van den Meiracker, A.H. Red wine polyphenols do not lower peripheral or central blood pressure in high normal blood pressure and hypertension. Am. J. Hypertens. 2012, 25, 718-723.
30. Chiva-Blanch, G.; Condines, X.; Magraner, E.; Roth, I.; Valderas-Martínez, P.; Arranz, S.; Casas, R.; Martínez-Huélamo, M.; Vallverdú-Queralt, A., Quifer-Rada, P., et al. The non-alcoholic fraction of beer increases stromal cell derived factor 1 and the number of circulating endothelial progenitor cells in high cardiovascular risk subjects: A randomized clinical trial. Atherosclerosis 2014, 233, 518-524.
31. Chiva-Blanch, G.; Urpi-Sarda, M.; Ros, E.; Arranz, S.; Valderas-Martínez, P.; Casas, R.; Sacanella, E.; Llorach, R.; Lamuela-Raventos, R.M., Andres-Lacueva, C., et al. Dealcoholized red wine decreases systolic and diastolic blood pressure and increases plasma nitric oxide: Short communication. Circ. Res. 2012, 111, 1065-1068.
32. Chiva-Blanch, G.; Urpi-Sarda, M.; Llorach, R.; Rotches-Ribalta, M.; Guillen, M.; Casas, R.; Arranz, S.; Valderas-Martinez, P.; Portoles, O.; Corella, D. Differential effects of polyphenols and alcohol of red wine on the expression of adhesion molecules and inflammatory cytokines related to atherosclerosis: A randomized clinical trial (vol 95, pg 326, 2012). Am. J. Clin. Nutr. 2012, 95, 1506.
33. Kuntz, S.; Kunz, C.; Herrmann, J.; Borsch, C.H.; Abel, G.; Dietrich, H.; Rudloff, S.; Fröhling, B.; Dietrich, H.; Rudloff, S. Anthocyanins from fruit juices improve the antioxidant status of healthy young female volunteers without affecting anti-inflammatory parameters: Results from the randomised, double-blind, placebo-controlled, cross-over ANTHONIA (ANTHOcyanins in Nutrition Investigation Alliance) study. Br. J. Nutr. 2014, 112, 925-936.
34. Curtis, P.J.; Kroon, P.A; Hollands, W.J.; Walls, R.; Jenkins, G.; Kay, C.D.; Cassidy, A. Cardiovascular disease risk biomarkers and liver and kidney function are not altered in postmenopausal women after ingesting an elderberry extract rich in anthocyanins for 12 weeks. J. Nutr. 2009, 139, 2266-2271.
35. Hassellund, S.S.; Flaa, A.; Kjeldsen, S.E.; Seljeflot, I.; Karlsen, A.; Erlund, I.; Rostrup, M. Effects of anthocyanins on cardiovascular risk factors and inflammation in pre-hypertensive men: A double-blind randomized placebo-controlled crossover study. J. Hum. Hypertens. 2012, 27, 100-106.
36. Dohadwala, M.M.; Holbrook, M.; Hamburg, N.M.; Shenouda, S.M.; Chung, W.B.; Titas, M.; Kluge, M.A; Wang, N.; Palmisano, J., Milbury, P.E., et al. A Effects of cranberry juice consumption on vascular function in patients with coronary artery disease 1-3. Am. J. Clin. Nutr. 2011, 93, 934-940.
37. Miyazaki, R.; Kotani, K.; Ayabe, M.; Tsuzaki, K.; Shimada, J.; Sakane, N.; Takase, H.; Ichikawa, H.; Yonei, Y.; Ishii, K. Minor effects of green tea catechin supplementation on cardiovascular risk markers in active older people: A randomized controlled trial. Geriatr. Gerontol. Int. 2013, 13, 622-629.
38. De Maat, M. P.; Pijl, H.; Kluft, C.; Princen, H. M. Consumption of black and green tea had no effect on inflammation, haemostasis and endothelial markers in smoking healthy individuals. Eur. J. Clin. Nutr. 2000, 54, 757-763.
39. Widmer, R.J.; Freund, M.A; Flammer, A.J.; Sexton, J.; Lennon, R.; Romani, A.; Mulinacci, N.; Vinceri, F.F.; Lerman, L.O.; Lerman, A. Beneficial effects of polyphenol-rich olive oil in patients with early atherosclerosis. Eur. J. Nutr. 2012, 52, 1223-1231.
40. Nagao, T.; Hase, T.; Tokimitsu, I. A green tea extract high in catechins reduces body fat and cardiovascular risks in humans. Obesity (Silver Spring). 2007, 15, 1473-1483.
41. Farouque, H.M.O.; Leung, M.; Hope, S.A; Baldi, M.; Schechter, C.; Cameron, J.D.; Meredith, I.T. Acute and chronic effects of flavanol-rich cocoa on vascular function in subjects with coronary artery disease: A randomized double-blind placebo-controlled study. Clin. Sci. (Lond). 2006, 111, 71-80.
42. Berry, N.M.; Davison, K.; Coates, A.M.; Buckley, J.D.; Howe, P.R.C. Impact of cocoa flavanol consumption on blood pressure responsiveness to exercise. Br. J. Nutr. 2010, 103, 1480-1484.
43. Davison, K.; Coates, A.M.; Buckley, J.D.; Howe, P.R.C. Effect of cocoa flavanols and exercise on cardiometabolic risk factors in overweight and obese subjects. Int. J. Obes. (Lond). 2008, 32, 1289-1296.
44. West, S.G.; McIntyre, M.D.; Piotrowski, M.J.; Poupin, N.; Miller, D.L.; Preston, A.G.; Wagner, P.; Groves, L.F.; Skulas-Ray, A.C. Effects of dark chocolate and cocoa consumption on endothelial function and arterial stiffness in overweight adults. Br. J. Nutr. 2014, 111, 653-661.
45. Faridi, Z.; Njike, V.Y.; Dutta, S.; Ali, A.; Katz, D.L. Acute dark chocolate and cocoa ingestion and endothelial function: A randomized controlled crossover trial. Am. J. Clin. Nutr. 2008, 88, 58-63.
46. Davison, K.; Berry, N.M.; Misan, G.; Coates, A.M.; Buckley, J.D.; Howe, P.R.C. Dose-related effects of flavanol-rich cocoa on blood pressure. J. Hum. Hypertens. 2010, 24, 568-576.
47. Grassi, D.; Desideri, G.; Necozione, S.; Lippi, C.; Casale, R.; Properzi, G.; Blumberg, J.B.; Ferri, C. Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 15 days of consuming high-polyphenol dark chocolate. J. Nutr. 2008, 138, 1671-1676.
48. Flammer, A.J.; Sudano, I.; Wolfrum, M.; Thomas, R.; Enseleit, F.; Périat, D.; Kaiser, P.; Hirt, A.; Hermann, M., Serafini, M., et al. Cardiovascular effects of flavanol-rich chocolate in patients with heart failure. Eur. Heart J. 2012, 33, 2172-2180.
49. Heiss, C.; Jahn, S.; Taylor, M.; Real, W.M.; Angeli, F.S.; Wong, M.L.; Amabile, N.; Prasad, M.; Rassaf, T., Ottaviani, J.I., et al. Improvement of endothelial function with dietary flavanols is associated with mobilization of circulating angiogenic cells in patients with coronary artery disease. J. Am. Coll. Cardiol. 2010, 56, 218-224.
50. Horn, P.; Amabile, N.; Angeli, F.S.; Sansone, R.; Stegemann, B.; Kelm, M.; Springer, M.L.; Yeghiazarians, Y.; Schroeter, H.; Heiss, C. Dietary flavanol intervention lowers the levels of endothelial microparticles in coronary artery disease patients. Br. J. Nutr. 2013, 111, 1245-1252.
51. Balzer, J.; Rassaf, T.; Heiss, C.; Kleinbongard, P.; Lauer, T.; Merx, M.; Heussen, N.; Gross, H.B.; Keen, C.L., Schroeter, H., et al. Sustained Benefits in Vascular Function Through Flavanol-Containing Cocoa in Medicated Diabetic Patients. A Double-Masked, Randomized, Controlled Trial. J. Am. Coll. Cardiol. 2008, 51, 2141-2149.
52. Larson, A.; Witman, M.A.H.; Guo, Y.; Ives, S.; Richardson, R.S.; Bruno, R.S.; Jalili, T.; Symons, J.D. Acute, quercetin-induced reductions in blood pressure in hypertensive individuals are not secondary to lower plasma angiotensin-converting enzyme activity or endothelin-1: Nitric oxide. Nutr. Res. 2012, 32, 557-564.
53. Conquer, J.A; Maiani, G.; Azzini, E.; Raguzzini, A.; Holub, B.J. Supplementation with quercetin markedly increases plasma quercetin concentration without effect on selected risk factors for heart disease in healthy subjects. J. Nutr. 1998, 128, 593-597.
54. Suomela, J.P.; Ahotupa, M.; Yang, B.; Vasankari, T.; Kallio, H. Absorption of flavonols derived from sea buckthorn (Hippopha?? rhamnoides L.) and their effect on emerging risk factors for cardiovascular disease in humans. J. Agric. Food Chem. 2006, 54, 7364-7369.
55. Edwards, R.L.; Lyon, T.; Litwin, S.E.; Rabovsky, A.; Symons, J.D.; Jalili, T. Quercetin reduces blood pressure in hypertensive subjects. J. Nutr. 2007, 137, 2405-2411.
56. McVeigh, B.L.; Dillingham, B.L.; Lampe, J.W.; Duncan, A.M. Effect of soy protein varying in isoflavone content on serum lipids in healthy young men. Am. J. Clin. Nutr. 2006, 83, 244-251.
57. Sanders, T.A.B.; Dean, T.S.; Grainger, D.; Miller, G.J.; Wiseman, H. Moderate intakes of intact soy protein rich in isoflavones compared with ethanol-extracted soy protein increase HDL but do not influence transforming growth factor β1 concentrations and hemostatic risk factors for coronary heart disease in healthy subjets. Am. J. Clin. Nutr. 2002, 76, 373-377.
58. Thorp, A.A.; Howe, P.R.C.; Mori, T.A.; Coates, A.M.; Buckley, J.D.; Hodgson, J.; Mansour, J.; Meyer, B.J. Soy food consumption does not lower LDL cholesterol in either equol or nonequol producers. Am. J. Clin. Nutr. 2008, 88, 298-304.
59. Atkinson, C.; Oosthuizen, W.; Scollen, S.; Loktionov, A.; Day, N.E.; Bingham, S. A Modest protective effects of isoflavones from a red clover-derived dietary supplement on cardiovascular disease risk factors in perimenopausal women, and evidence of an interaction with ApoE genotype in 49-65 year-old women. J. Nutr. 2004, 134, 1759-1764.
60. Marini, H.; Bitto, A.; Altavilla, D.; Burnett, B.P.; Polito, F.; di Stefano, V.; Minutoli, L.; Atteritano, M.; Levy, R.M., Frisina, N., et al. Efficacy of genistein aglycone on some cardiovascular risk factors and homocysteine levels: A follow-up study. Nutr. Metab. Cardiovasc. Dis. 2010, 20, 332-340.
61. Hodis, H.N.; Mack, W.J.; Kono, N.; Azen, S.P.; ShoupeJ, D.; Hwang-Levine, J.; Petitti, D.; Whitfield-Maxwell, L.; Yan, M., Franke, A.A, et al. Isoflavone Soy Protein Supplementation and Atherosclerosis in Healthy Postmenopausal Women: A Randomized Controlled Trial. Stroke 2012, 42, 3168-3175.
62. Atteritano, M.; Marini, H.; Minutoli, L.; Polito, F.; Bitto, A.; Altavilla, D.; Mazzaferro, S.; D’Anna, R.; Cannata, M.L., Gaudio, A., et al. Effects of the phytoestrogen genistein on some predictors of cardiovascular risk in osteopenic, postmenopausal women: A two-year randomized, double-blind, placebo-controlled study. J. Clin. Endocrinol. Metab. 2007, 92, 3068-3075.
63. Garrido, A.; de la Maza, M.P.; Hirsch, S.; Valladares, L. Soy isoflavones affect platelet thromboxane A2 receptor density but not plasma lipids in menopausal women. Maturitas 2006, 54, 270-276.
64. Hall, W.L.; Vafeiadou, K.; Hallund, J.; Bügel, S.; Koebnick, C.; Reimann, M.; Ferrari, M.; Branca, F.; Talbot, D., Dadd, T., et al. Soy-isoflavone-enriched foods and inflammatory biomarkers of cardiovascular disease risk in postmenopausal women: Interactions with genotype and equol production. Am. J. Clin. Nutr. 2005, 82, 1260-1268.
65. Rios, D.R.A.; Rodrigues, E.T.; Cardoso, A.P.Z.; Montes, M.B.A; Franceschini, S.A.; Toloi, M.R.T. Effects of isoflavones on the coagulation and fibrinolytic system of postmenopausal women. Nutrition 2008, 24, 120-126.
66. Villa, P.; Costantini, B.; Suriano, R.; Perri, C.; Macrì, F.; Ricciardi, L.; Panunzi, S.; Lanzone, A. The differential effect of the phytoestrogen genistein on cardiovascular risk factors in postmenopausal women: Relationship with the metabolic status. J. Clin. Endocrinol. Metab. 2009, 94, 552-558.
67. Liu, Z.M.; Ho, S.C.; Chen, Y.M.; Ho, Y.P. The effects of isoflavones combined with soy protein on lipid profiles, C-reactive protein and cardiovascular risk among postmenopausal Chinese women. Nutr. Metab. Cardiovasc. Dis. 2012, 22, 712-719.
68. Yang, T.S.; Wang, S.Y.; Yang, Y.C.; Su, C.H.; Lee, F.K.; Chen, S.C.; Tseng, C.Y.; Jou, H.J.; Huang, J.P.; Huang, K.E. Effects of standardized phytoestrogen on Taiwanese menopausal women. Taiwan J. Obstet. Gynecol. 2012, 51, 229-235.
69. Aubertin-Leheudre, M.; Lord, C.; Khalil, A.; Dionne, I.J. Isoflavones and clinical cardiovascular risk factors in obese postmenopausal women: A randomized double-blind placebo-controlled trial. J. Womens Health (Larchmt) 2008, 17, 1363-1369.
70. Choquette, S.; Riesco, É.; Cormier, É.; Dion, T.; Aubertin-Leheudre, M.; Dionne, I.J. Effects of soya isoflavones and exercise on body composition and clinical risk factors of cardiovascular diseases in overweight postmenopausal women: A 6-month double-blind controlled trial. Br. J. Nutr. 2011, 105, 1199-1209.
71. Aubertin-Leheudre, M.; Lord, C.; Khalil, A.; Dionne, I.J. Effect of 6 months of exercise and isoflavone supplementation on clinical cardiovascular risk factors in obese postmenopausal women: A randomized, double-blind study. Menopause 2007, 14, 624-629.
72. Hodgson, J.M.; Puddey, I.B.; Croft, K.D.; Mori, T.A.; Rivera, J.; Beilin, L.J. Isoflavonoids do not inhibit in vivo lipid peroxidation in subjects with high-normal blood pressure. Atherosclerosis 1999, 145, 167-172.
73. Sagara, M.; Kanda, T.; NJelekera, M.; Teramoto, T.; Armitage, L.; Birt, N.; Birt, C.; Yamori, Y. Effects of dietary intake of soy protein and isoflavones on cardiovascular disease risk factors in high risk, middle-aged men in Scotland. J. Am. Coll. Nutr. 2004, 23, 85-91.
74. Clerici, C.; Setchell, K.D.R.; Battezzati, P.M.; Pirro, M.; Giuliano, V.; Asciutti, S.; Castellani, D.; Nardi, E.; Sabatino, G., Orlandi, S., et al. Pasta naturally enriched with isoflavone aglycons from soy germ reduces serum lipids and improves markers of cardiovascular risk. J. Nutr. 2007, 137, 2270-2278.
75. Meyer, B.J.; Larkin, T.A.; Owen, A.J.; Astheimer, L.B.; Tapsell, L.C.; Howe, P.R.C. Limited lipid-lowering effects of regular consumption of whole soybean foods. Ann. Nutr. Metab. 2004, 48, 67-78.
76. Jenkins, D.J.A; Kendall, C.W.C.; Jackson, C.J.C.; Connelly, P.W.; Parker, T.; Faulkner, D.; Vidgen, E.; Cunnane, S.C.; Leiter, L.A.; Josse, R.G. Effects of high- and low-isoflavone soyfoods on blood lipids, oxidized LDL, homocysteine, and blood pressure in hyperlipidemic men and women. Am. J. Clin. Nutr. 2002, 76, 365-372.
77. Blum, A.; Lang, N.; Peleg, A.; Vigder, F.; Israeli, P.; Gumanovsky, M.; Lupovitz, S.; Elgazi, A.; Ben-Ami, M. Effects of oral soy protein on markers of inflammation in postmenopausal women with mild hypercholesterolemia. Am. Heart J. 2003, 145, e7.
78. Teede, H.J.; Giannopoulos, D.; Dalais, F.S.; Hodgson, J.; McGrath, B.P. Randomised, controlled, cross-over trial of soy protein with isoflavones on blood pressure and arterial function in hypertensive subjects. J. Am. Coll. Nutr. 2006, 25, 533-540.
79. Cicero, A.F.G.; Tartagni, E.; Ferroni, A.; de Sando, V.; Grandi, E.; Borghi, C. Combined nutraceutical approach to postmenopausal syndrome and vascular remodeling biomarkers. J. Altern. Complement. Med. 2013, 19, 582-587.
80. Curtis, P.J.; Potter, J.; Kroon, P.A.; Wilson, P.; Dhatariya, K.; Sampson, M.; Cassidy, A. Vascular function and atherosclerosis progression after 1 y of flavonoid intake in statin-treated postmenopausal women with type 2 diabetes: A double-blind randomized controlled trial. Am. J. Clin. Nutr. 2013, 97, 936-942.
81. Chan, Y.H.; Lau, K.K.; Yiu, K.H.; Li, S.W.; Chan, H.T.; Fong, D.Y.T.; Tam, S.; Lau, C.P.; Tse, H.F. Reduction of C-reactive protein with isoflavone supplement reverses endothelial dysfunction in patients with ischaemic stroke. Eur. Heart J. 2008, 29, 2800-2807.
82. Webb, C.M.; Hayward, C.S.; Mason, M.J.; Ilsley, C.D.; Collins, P. Coronary vasomotor and blood flow responses to isoflavone-intact soya protein in subjects with coronary heart disease or risk factors for coronary heart disease. Clin. Sci. 2008, 115, 353.
83. Fanti, P.; Asmis, R.; Stephenson, T.J.; Sawaya, B.P.; Franke, A.A. Positive effect of dietary soy in ESRD patients with systemic inflammation—Correlation between blood levels of the soy isoflavones and the acute-phase reactants. Nephrol. Dial. Transplant. 2006, 21, 2239-2246.
84. Ras, R.T.; Zock, P.L.; Zebregs, Y.E.M.P.; Johnston, N.R.; Webb, D.J.; Draijer, R. Effect of polyphenol-rich grape seed extract on ambulatory blood pressure in subjects with pre- and stage I hypertension. Br. J. Nutr. 2013, 110, 2234-2241.
85. Yubero, N.; Sanz-Buenhombre, M.; Guadarrama, A.; Villanueva, S.; Carrión, J.M.; Larrarte, E.; Moro, C. LDL cholesterol-lowering effects of grape extract used as a dietary supplement on healthy volunteers. Int. J. Food Sci. Nutr. 2013, 64, 400-406.
86. Asher, G.N.; Viera, A.J.; Weaver, M.A; Dominik, R.; Caughey, M.; Hinderliter, A.L. Effect of hawthorn standardized extract on flow mediated dilation in prehypertensive and mildly hypertensive adults: A randomized, controlled cross-over trial. BMC Complement. Altern. Med. 2012, 12, 26.
87. ® French maritime pine bark extract in patients with diabetes type II. Life Sci. 2004, 75, 2505-2513.
88. Enseleit, F.; Sudano, I.; Périat, D.; Winnik, S.; Wolfrum, M.; Flammer, A.J.; Fröhlich, G.M.; Kaiser, P.; Hirt, A., Haile, S.R., et al. Effects of Pycnogenol on endothelial function in patients with stable coronary artery disease: A double-blind, randomized, placebo-controlled, cross-over study. Eur. Heart J. 2012, 33, 1589-1597.
89. Mellen, P.B.; Daniel, K.R.; Brosnihan, K.B.; Hansen, K.J.; Herrington, D.M. Effect of muscadine grape seed supplementation on vascular function in subjects with or at risk for cardiovascular disease: A randomized crossover trial. J. Am. Coll. Nutr. 2010, 29, 469-475.
90. Tauchert, M. Efficacy and safety of crataegus extract WS 1442 in comparison with placebo in patients with chronic stable New York Heart Association class-III heart failure. Am. Heart J. 2002, 143, 910-915.
91. Tang, P.C.-T.; Ng, Y.-F.; Ho, S.; Gyda, M.; Chan, S.-W. Resveratrol and cardiovascular health—Promising therapeutic or hopeless illusion? Pharmacol. Res. 2014, 90, 88-115.
92. Shechter, M.; Issachar, A.; Marai, I.; Koren-Morag, N.; Freinark, D.; Shahar, Y.; Shechter, A.; Feinberg, M.S. Long-term association of brachial artery flow-mediated vasodilation and cardiovascular events in middle-aged subjects with no apparent heart disease. Int. J. Cardiol. 2009, 134, 52-58.
93. Yeboah, J.; Crouse, J.R.; Hsu, F.C.; Burke, G.L.; Herrington, D.M. Brachial flow-mediated dilation predicts incident cardiovascular events in older adults: The cardiovascular health study. Circulation 2007, 115, 2390-2397.
94. Rossi, R.; Nuzzo, A.; Origliani, G.; Modena, M.G. Prognostic Role of Flow-Mediated Dilation and Cardiac Risk Factors in Post-Menopausal Women. J. Am. Coll. Cardiol. 2008, 51, 997-1002.
95. Williams, I.L.; Chowienczyk, P.J.; Wheatcroft, S.B.; Patel, A.G.; Sherwood, R.A.; Momin, A.; Shah, A.M.; Kearney, M.T. Endothelial function and weight loss in obese humans. Obes. Surg. 2005, 15, 1055-1060.
96. Widlansky, M.E.; Duffy, S.J.; Hamburg, N.M.; Gokce, N.; Warden, B.A.; Wiseman, S.; Keaney, J.F.; Frei, B.; Vita, J.A. Effects of black tea consumption on plasma catechins and markers of oxidative stress and inflammation in patients with coronary artery disease. Free Radic. Biol. Med. 2005, 38, 499-506.
97. Shenouda, S.M.; Widlansky, M.E.; Chen, K.; Xu, G.; Holbrook, M.; Tabit, C.E.; Hamburg, N.M.; Frame, A.A.; Caiano, T.L., Kluge, M.A., et al. Altered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitus. Circulation 2011, 124, 444-453.
98. Hartman, M.-L.; Shirihai, O.S.; Holbrook, M.; Xu, G.; Kocherla, M.; Shah, A.; Fetterman, J.L.; Kluge, M.A.; Frame, A.A., Hamburg, N.M., et al. A Relation of mitochondrial oxygen consumption in peripheral blood mononuclear cells to vascular function in type 2 diabetes mellitus. Vasc. Med. 2014, 19, 67-74.
99. Sahebkar, A. A systematic review and meta-analysis of randomized controlled trials investigating the effects of curcumin on blood lipid levels. Clin. Nutr. 2013, 33, 406-414.
100. Ramírez-Boscá, A.; Soler, A.; Carrión, M.A.; Díaz-Alperi, J.; Bernd, A.; Quintanilla, C.; Quintanilla Almagro, E.; Miquel, J. An hydroalcoholic extract of Curcuma longa lowers the apo B/apo A ratio. Implications for atherogenesis prevention. Mech. Ageing Dev. 2000, 119, 41-47.
101. Weisberg, S.P.; Leibel, R.; Tortoriello, D.V. Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity. Endocrinology 2008, 149, 3549-3558.
102. Tang, Y.; Zheng, S.; Chen, A. Curcumin eliminates leptin’s effects on hepatic stellate cell activation via interrupting leptin signaling. Endocrinology 2009, 150, 3011-3020.
103. Rotondo, S.; di Castelnuovo, A.; de Gaetano, G. The relationship between wine consumption and cardiovascular risk: From epidemiological evidence to biological plausibility. Ital. Heart J. 2001, 2, 1-8.
104. Wang, X.; Ouyang, Y.Y.; Liu, J.; Zhao, G. Flavonoid intake and risk of CVD: A systematic review and meta-analysis of prospective cohort studies. Br. J. Nutr. 2013, 111, 1-11.
105. Johnson, R.; Bryant, S.; Huntley, A.L. Green tea and green tea catechin extracts: An overview of the clinical evidence. Maturitas 2012, 73, 280-287.
106. Khawaja, O.; Gaziano, J.M.; Djoussé, L. Chocolate and coronary heart disease: A systematic review. Curr. Atheroscler. Rep. 2011, 13, 447-452.
107. Wang, Z.M.; Zhao, D.; Nie, Z.L.; Zhao, H.; Zhou, B.; Gao, W.; Wang, L.S.; Yang, Z.J. Flavonol intake and stroke risk: A meta-analysis of cohort studies. Nutrition 2014, 30, 518-523.
108. Hollman, P.C.H.; Geelen, A.; Kromhout, D. Dietary flavonol intake may lower stroke risk in men and women. J. Nutr. 2010, 140, 600-604.
109. Liu, Z.M.; Ho, S.C.; Chen, Y.M.; Woo, J. A six-month randomized controlled trial of whole soy and isoflavones daidzein on body composition in equol-producing postmenopausal women with prehypertension. J. Obes. 2013, 2013, doi:10.1155/2013/359763.
110. Curtis, P.J.; Sampson, M.; Potter, J.; Dhatariya, K.; Kroon, P.A.; Cassidy, A. Chronic Ingestion of Flavan-3-ols and and Lipoprotein Status and Attenuates With Type 2 Diabetes. Diabetes Care 2012, 35, 226-232.
111. Azadbakht, L.; Atabak, S.; Esmaillzadeh, A. Soy protein intake, cardiorenal indices, and C-reactive protein in type 2 diabetes with nephropathy: A longitudinal randomized clinical trial. Diabetes Care 2008, 31, 648-654.
112. Li, Z.; Hong, K.; Saltsman, P.; DeShields, S.; Bellman, M.; Thames, G.; Liu, Y.; Wang, H.-J.; Elashoff, R.; Heber, D. Long-term efficacy of soy-based meal replacements vs an individualized diet plan in obese type II DM patients: Relative effects on weight loss, metabolic parameters, and C-reactive protein. Eur. J. Clin. Nutr. 2005, 59, 411-418.
113. Kokubo, Y.; Iso, H.; Ishihara, J.; Okada, K.; Inoue, M.; Tsugane, S. Association of dietary intake of soy, beans, and isoflavones with risk of cerebral and myocardial infarctions in Japanese populations: The Japan Public Health Center-based (JPHC) study cohort I. Circulation 2007, 116, 2553-2562.
114. Dong, J.-Y.; Wang, P.; He, K.; Qin, L.-Q. Effect of soy isoflavones on circulating C-reactive protein in postmenopausal women: Meta-analysis of randomized controlled trials. Menopause 2011, 18, 1256-1262.
115. Vanhoutte, P.M.; Shimokawa, H.; Tang, E.H.C.; Feletou, M. Endothelial dysfunction and vascular disease. Acta Physiol. (Oxf). 2009, 196, 193-222.
116. Pase, M.P.; Grima, N.A.; Sarris, J. The effects of dietary and nutrient interventions on arterial stiffness: A systematic review. Am. J. Clin. Nutr. 2011, 93, 446-454.