Effect of oral isoflavone supplementation on vascular endothelial function in postmenopausal women: A meta-analysis of randomized placebo-controlled trials

American Journal of Clinical Nutrition

Volumn 91, Issue 2, 2010, Pages 480-486

  Li, Shao Hua ^a,b   Liu, Xu Xia ^a   Bai, Yong Yi ^a,b   Wang, Xiao Jian ^a   Sun, Kai ^a   Chen, Jing Zhou ^a   Hui, Ru Tai ^a,b  

^a PEKING UNION MEDICAL COLLEGE   (China)

^b FUWAI HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ISOFLAVONE;

ARTICLE; CLINICAL TRIAL; DIET SUPPLEMENTATION; FLOW MEDIATED DILATION; HUMAN; HYPERCHOLESTEROLEMIA; MEASUREMENT; META ANALYSIS; POSTMENOPAUSE; SYSTEMATIC REVIEW; VASCULAR ENDOTHELIUM;

CARDIOVASCULAR DISEASES; DIETARY SUPPLEMENTS; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; ISOFLAVONES; MIDDLE AGED; PLACEBOS; POSTMENOPAUSE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; VASODILATION;

EID: 75649107841     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.3945/ajcn.2009.28203     Document Type: Article

References (47)

1. Kannel WB, Hjortland MC, McNamara PM, Gordon T. Menopause and risk of cardiovascular disease: the Framingham Study. Ann Intern Med 1976;85:447-52.
2. Nagata C. Ecological study of the association between soy product intake and mortality from cancer and heart disease in Japan. Int J Epidemiol 2000;29:832-6.
3. Cassidy A, Albertazzi P, Lise Nielsen I, et al. Critical review of health effects of soyabean phyto-oestrogens in post-menopausal women. Proc Nutr Soc 2006;65:76-92.
4. He FJ, Nowson CA, MacGregor GA. Fruit and vegetable consumption and stroke: meta-analysis of cohort studies. Lancet 2006;367:320-6.
5. Chan YH, Lau KK, Yiu KH, et al. Isoflavone intake in persons at high risk of cardiovascular events: implications for vascular endothelial function and the carotid atherosclerotic burden. Am J Clin Nutr 2007;86:938-45.
6. Hall WL, Vafeiadou K, Hallund J, et al. Soy-isoflavone-enriched foods and inflammatory biomarkers of cardiovascular disease risk in postmenopausal women: interactions with genotype and equol production. Am J Clin Nutr 2005;82:1260-8.
7. Chacko BK, Chandler RT, D'Alessandro TL, et al. Anti-inflammatory effects of isoflavones are dependent on flow and human endothelial cell PPARgamma. J Nutr 2007;137:351-6.
8. Suwaidi JA, Hamasaki S, Higano ST, Nishimura RA, Holmes DR Jr, Lerman A. Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction. Circulation 2000;101:948-54.
9. Cai H, Harrison DG. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 2000;87:840-4.
10. Squadrito F, Altavilla D, Squadrito G, et al. Genistein supplementation and estrogen replacement therapy improve endothelial dysfunction induced by ovariectomy in rats. Cardiovasc Res 2000;45:454-62.
11. Squadrito F, Altavilla D, Morabito N, et al. The effect of the phytoestrogen genistein on plasma nitric oxide concentrations, endothelin-1 levels and endothelium dependent vasodilation in postmenopausal women. Atherosclerosis 2002;163:339-47.
12. Cupisti A, Ghiadoni L, D'Alessandro C, et al. Soy protein diet improves endothelial dysfunction in renal transplant patients. Nephrol Dial Transplant 2007;22:229-34.
13. Fornaro F, Carotenuto V, Bisogni C, et al. Brachial reactivity in postmenopausal women: impact of soy isoflavone administration. Int J Gynaecol Obstet 2006;18:106-10.
14. Hermansen K, Hansen B, Jacobsen R, et al. Effects of soy supplementation on blood lipids and arterial function in hypercholesterolaemic subjects. Eur J Clin Nutr 2005;59:843-50.
15. Simons LA, von Konigsmark M, Simons J, Celermajer DS. Phytoestrogens do not influence lipoprotein levels or endothelial function in healthy, postmenopausal women. Am J Cardiol 2000;85:1297-301.
16. Teede HJ, Dalais FS, Kotsopoulos D, Liang YL, Davis S, McGrath BP. Dietary soy has both beneficial and potentially adverse cardiovascular effects: a placebo-controlled study in men and postmenopausal women. J Clin Endocrinol Metab 2001;86:3053-60.
17. Hale G, Paul-Labrador M, Dwyer JH, Merz CN. Isoflavone supplementation and endothelial function in menopausal women. Clin Endocrinol (Oxf) 2002;56:693-701.
18. Squadrito F, Altavilla D, Crisafulli A, et al. Effect of genistein on endothelial function in postmenopausal women: a randomized, doubleblind, controlled study. Am J Med 2003;114:470-6.
19. Teede HJ, McGrath BP, DeSilva L, Cehun M, Fassoulakis A, Nestel PJ. Isoflavones reduce arterial stiffness: a placebo-controlled study in men and postmenopausal women. Arterioscler Thromb Vasc Biol 2003;23:1066-71.
20. Steinberg FM, Guthrie NL, Villablanca AC, Kumar K, Murray MJ. Soy protein with isoflavones has favorable effects on endothelial function that are independent of lipid and antioxidant effects in healthy postmenopausal women. Am J Clin Nutr 2003;78:123-30.
21. Howes JB, Tran D, Brillante D, Howes LG. Effects of dietary supplementation with isoflavones from red clover on ambulatory blood pressure and endothelial function in postmenopausal type 2 diabetes. Diabetes Obes Metab 2003;5:325-32.
22. Nikander E, Metsa-Heikkila M, Tiitinen A, Ylikorkala O. Evidence of a lack of effect of a phytoestrogen regimen on the levels of C-reactive protein, E-selectin, and nitrate in postmenopausal women. J Clin Endocrinol Metab 2003;88:5180-5.
23. Lissin LW, Oka R, Lakshmi S, Cooke JP. Isoflavones improve vascular reactivity in post-menopausal women with hypercholesterolemia. Vasc Med 2004;9:26-30.
24. Kreijkamp-Kaspers S, Kok L, Bots ML, Grobbee DE, Lampe JW, van der Schouw YT. Randomized controlled trial of the effects of soy protein containing isoflavones on vascular function in postmenopausal women. Am J Clin Nutr 2005;81:189-95.
25. Teede HJ, Dalais FS, Kotsopoulos D, et al. Dietary soy containing phytoestrogens does not activate the hemostatic system in postmenopausal women. J Clin Endocrinol Metab 2005;90:1936-41.
26. Colacurci N, Chiàntera A, Fornaro F, et al. Effects of soy isoflavones on endothelial function in healthy postmenopausal women. Menopause 2005;12:299-307.
27. Hall WL, Vafeiadou K, Hallund J, et al. Soy-isoflavone-enriched foods and markers of lipid and glucose metabolism in postmenopausal women: interactions with genotype and equol production. Am J Clin Nutr 2006;83:592-600.
28. Hallund J, Bugel S, Tholstrup T, et al. Soya isoflavone-enriched cereal bars affect markers of endothelial function in postmenopausal women. Br J Nutr 2006;95:1120-6.
29. Evans M, Njike VY, Hoxley M, Pearson M, Katz DL. Effect of soy isoflavone protein and soy lecithin on endothelial function in healthy postmenopausal women. Menopause 2007;14:141-9.
30. Katz DL, Evans MA, Njike VY, et al. Raloxifene, soy phytoestrogens and endothelial function in postmenopausal women. Climacteric 2007; 10:500-7.
31. Hall WL, Formanuik NL, Harnpanich D, et al. A meal enriched with soy isoflavones increases nitric oxide-mediated vasodilation in healthy postmenopausal women. J Nutr 2008;138:1288-92.
32. Chan YH, Lau KK, Yiu KH, et al. Reduction of C-reactive protein with isoflavone supplement reverses endothelial dysfunction in patients with ischaemic stroke. Eur Heart J 2008;29:2800-7.
33. Cuevas AM, Irribarra VL, Castillo OA, Yañez MD, Germain AM. Isolated soy protein improves endothelial function in postmenopausal hypercholesterolemic women. Eur J Clin Nutr 2003;57:889-94.
34. Moens AL, Goovaerts I, Claeys MJ, Vrints CJ. Flow-mediated vasodilation: a diagnostic instrument, or an experimental tool? Chest 2005; 127:2254-63.
35. Yeboah J, Crouse JR, Hsu FC, Burke GL, Herrington DM. Brachial flow-mediated dilation predicts incident cardiovascular events in older adults: the Cardiovascular Health Study. Circulation 2007;115:2390-7.
36. Moher D, Cook DJ, Eastwood S, Olkin I, Rennie D, Stroup DF. Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement. Quality of Reporting of Meta-analyses. Lancet 1999;354:1896-900.
37. Moher D, Pham B, Jones A, et al. Does quality of reports of randomized trials affect estimates of intervention efficacy reported in meta-analyses? Lancet 1998;352:609-13.
38. Follmann D, Elliott P, Suh I, Cutler J. Variance imputation for overviews of clinical trials with continuous response. J Clin Epidemiol 1992;45: 769-73.
39. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986;7:177-88.
40. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ 2003;327:557-60.
41. Celermajer DS, Sorensen KE, Spiegelhalter DJ, Georgakopoulos D, Robinson J, Deanfield JE. Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women. J Am Coll Cardiol 1994;24:471-6.
42. Egger M, Davey Smith G, Schneider M, Minder C. Bias in metaanalysis detected by a simple, graphical test. BMJ 1997;315:629-34.
43. Witteman JC, Grobbee DE, Kok FJ, Hofman A, Valkenburg HA. Increased risk of atherosclerosis in women after the menopause. BMJ 1989;298:642-4.
44. Nevala R, Korpela R, Vapaatalo H. Plant derived estrogens relax rat mesenteric artery in vitro. Life Sci 1998;63:95-100.
45. Meng QH, Lewis P, Wahala K, Adlercreutz H, Tikkanen MJ. Incorporation of esterified soybean isoflavones with antioxidant activity into low density lipoprotein. Biochim Biophys Acta 1999;1438:369-76.
46. Nakagami H, Kaneda Y, Ogihara T, Morishita R. Endothelial dysfunction in hyperglycemia as a trigger of atherosclerosis. Curr Diabetes Rev 2005;1:59-63.
47. Taku K, Umegaki K, Sato Y, Taki Y, Endoh K, Watanabe S. Soy iso-flavones lower serum total and LDL cholesterol in humans: a metaanalysis of 11 randomized controlled trials. Am J Clin Nutr 2007;85: 1148-56.