Absorption of flavonols derived from sea buckthorn (Hippophaë rhamnoides L.) and their effect on emerging risk factors for cardiovascular disease in humans

Journal of Agricultural and Food Chemistry

Volumn 54, Issue 19, 2006, Pages 7364-7369

  Suomela, Jukka Pekka ^a   Ahotupa, Markku ^a   Yang, Baoru ^a,b   Vasankari, Tommi ^a,c   Kallio, Heikki ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b AROMTECH LTD   (Finland)

^c Sport Institute of Finland   (Finland)

Author keywords

Baseline diene conjugation; Cardiovascular disease; Flavonol absorption; Flavonols; High performance liquid chromatography; Lipid oxidation; Oxidized LDL

Indexed keywords

3-METHYLQUERCETIN; ANTIOXIDANT; ARYLDIALKYLPHOSPHATASE; C REACTIVE PROTEIN; FLAVONOL DERIVATIVE; HOMOCYSTEINE; LOW DENSITY LIPOPROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN; PLACEBO; QUERCETIN 3 METHYL ETHER; VEGETABLE OIL;

ADULT; ARTICLE; BLOOD; CARDIOVASCULAR DISEASE; CHEMISTRY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET; DOUBLE BLIND PROCEDURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOPHAE RHAMNOIDES; HUMAN; INTESTINE ABSORPTION; MALE; MIDDLE AGED; OAT; RANDOMIZED CONTROLLED TRIAL;

ADULT; ANTIOXIDANTS; ARYLDIALKYLPHOSPHATASE; AVENA SATIVA; C-REACTIVE PROTEIN; CARDIOVASCULAR DISEASES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIET; DOUBLE-BLIND METHOD; FLAVONOLS; HIPPOPHAE; HOMOCYSTEINE; HUMANS; INTESTINAL ABSORPTION; LIPOPROTEINS, LDL; MALE; MIDDLE AGED; PLACEBOS; PLANT OILS;

ANIMALIA; HIPPOPHAE RHAMNOIDES; RHAMNACEAE;

EID: 33749684014     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf061889r     Document Type: Article

References (40)

1. Scalbert, A.; Manach, C.; Morand, C.; Remesy, C.; Jimenez, L. Dietary polyphenols and the prevention of diseases. Crit. Rev. Food Sci. Nutr. 2005, 45, 287-306.
2. Erlund, I. Review of the flavonoids quercetin, he naringenin. Dietary sources, bioactivities, and epidemiology. Nutr. Res. 2004, 24, 851-874.
3. Kallio, H.; Yang, B.; Halttunen, T. Flavonol glycosides of berries of three major sea buckthorn subspecies, Hippophaë rhamnoides ssp. rhamnoides, ssp. sinensis, and ssp. mongolica. Proc. Invited Speeches Second Int. Seabuckthorn Assoc. Conf. 2005, 29-35.
4. Rösch, D.; Krumbein, A.; Mugge, C.; Kroh, L. W. Structural investigations of flavonol glycosides from sea buckthorn (Hippophaë rhamnoides) pomace by NMR Spectroscopy and HPLC-ESI-MSn. J. Agric. Food Chem. 2004, 52, 4039-4046.
5. Gou, H.; Li, G. The clearing effect of total flavonoids of Hippophaë rhamnoides on active oxygen radicals. J. Pharmacol. China 1990, 6.
6. Wang, B. The effect of total flavonoids of Hippophaë rhamnoides L. (TFH) on cardiac performance and hemodynamics of normal people. J. Xian Med. Univ. 1994, 14.
7. Wang, B. Effect of total flavonoids of Hippophaë rhamnoides L. on cardiac performance and blood stream dynamics of rabbit. Hippophaë 1993, 6.
8. Wang, B. The rheological effect of sea buckthorn total flavonoids on the blood of normal rats. North-West J. Pharm. 1993, 8.
9. Wang, B.; Li, K.; Qi, Y. Effect of total flavonoids of Hippophaë rhamnoides L. on frog heart in vivo and toad heart in vitro. Hippophaë 1994, 7.
10. Wang, B.; Wang, Y. Effect of total flavonoids of Hippophaë rhamnoides L. on the cardiac function of guinea pig. Hippophaë 1993, 6.
11. Wang, J.; Zaong, M. Observation on the curative effect of sea buckthorn total flavonoids on ischemic heart disease. Shanxi Med. Res. (Sea Buckthorn) 1985.
12. Yang, B. R.; Kalimo, K. O.; Mattila, L. M.; Kallio, S. E.; Katajisto, J. K.; Peltola, O. J.; Kallio, H. P. Effects of dietary supplementation with sea buckthorn (Hippophae rhamnoides) seed and pulp oils on atopic dermatitis. J. Nutr. Biochem. 1999, 10, 622-630.
13. Johansson, A. K.; Korte, H.; Yang, B. R.; Stanley, J. C.; Kallio, H. P. Sea buckthorn berry oil inhibits platelet aggregation. J. Nutr. Biochem. 2000, 11, 491-495.
14. Hackam, D. G.; Anand, S. S. Emerging risk factors for atherosclerotic vascular disease - A critical review of the evidence. J. Am. Med. Assoc. 2003, 290, 932-940.
15. Pepys, M. B.; Baltz, M. L. Acute phase proteins with special reference to C-reactive protein and related proteins (pentaxins) and serum amyloid A-protein. Adv. Immunol. 1983, 34, 141-212.
16. Mangoni, A. A.; Jackson, S. H. D. Homocysteine and cardiovascular disease: Current evidence and future prospects. Am. J. Med. 2002, 112, 556-565.
17. Jialal, I.; Devaraj, S. Low density lipoprotein oxidation, antioxidants, and atherosclerosis: A clinical biochemistry perspective. Clin. Chem. 1996, 42, 498-506.
18. Berliner, J. A.; Heinecke, J. W. The role of oxidized lipoproteins in atherogenesis. Free Radical Biol. Med. 1996, 20, 707-727.
19. Witztum, J. L. The oxidation hypothesis of atherosclerosis. Lancet 1994, 344, 793-795.
20. Canales, A.; Sanchez-Muniz, F. J. Paraoxonase, something more than an enzyme? Med. Clin. 2003, 121, 537-548.
21. Williams, R. J.; Spencer, J. P. E.; Rice-Evans, C. Flavonoids: Antioxidants or signalling molecules? Free Radical Biol. Med. 2004, 36, 838-849.
22. Spencer, J. P. E.; Rice-Evans, C.; Williams, R. J. Modulation of pro-survival Akt/protein kinase B and ERK1/2 signaling cascades by quercetin and its in vivo metabolites underlie their action on neuronal viability. J. Biol. Chem. 2003, 278, 34783-34793.
23. Suomela, J.-P.; Ahotupa, M.; Sjövall, O.; Kurvinen, J.-P.; Kallio, H. New approach to the analysis of oxidized triacylglycerols in lipoproteins. Lipids 2004, 39, 507-512.
24. Suomela, J.-P.; Ahotupa, M.; Sjövall, O.; Kurvinen, J.-P.; Kallio, H. Diet and lipoprotein oxidation: Analysis of oxidized triacylglycerols in pig lipoproteins. Lipids 2004, 39, 639-647.
25. Harangi, M.; Seres, I.; Varga, Z.; Emri, G.; Szilvassy, Z.; Paragh, G.; Remenyik, E. Atorvastatin effect on high-density lipoprotein-associated paraoxonase activity and oxidative DNA damage. Eur. J. Clin. Pharmacol. 2004, 60, 685-691.
26. Ridker, P. M.; Rifai, N.; Pfeffer, M. A.; Sacks, F.; Braunwald, E.; Cholesterol & recurrent events CARE investigation of long-term effects of pravastatin on plasma concentration of C-reactive protein. Circulation 1999, 100, 230-235.
27. Soinio, M.; Marniemi, J.; Laakso, M.; Lehto, S.; Ronnemaa, T. Elevated plasma homocysteine level is an independent predictor of coronary heart disease events in patients with type 2 diabetes mellitus. Ann. Intern. Med. 2004, 140, 94-100.
28. Ahotupa, M.; Ruutu, M.; Mantyla, E. Simple methods of quantifying oxidation products and antioxidant potential of low density lipoproteins. Clin. Biochem. 1996, 29, 139-144.
29. Wieland, H.; Seidel, D. A simple specific method for precipitation of low density lipoproteins. J. Lipid Res. 1983, 24, 904-909.
30. Skipski, V. P.; Barclay, M. Thin-layer chromatography. Methods Enzymol. 1969, 14, 542-548.
31. Sjövall, O.; Kuksis, A.; Marai, L.; Myher, J. J. Elution factors of synthetic oxotriacylglycerols as an aid in identification of peroxidized natural triacylglycerols by reverse-phase high-performance liquid chromatography with electrospray mass spectrometry. Lipids 1997, 32, 1211-1218.
32. Erlund, I.; Alfthan, G.; Siren, H.; Ariniemi, K.; Aro, A. Validated method for the quantitation of quercetin from human plasma using high-performance liquid chromatography with electrochemical detection. J. Chromatogr. B 1999, 727, 179-189.
33. Hollman, P. C. H. Determination of flavonols in body fluids. Methods Enzymol. 2001, 335, 97-103.
34. Maki, K. C.; Shinnick, F.; Seeley, M. A.; Veith, P. E.; Quinn, L. C.; Hallissey, P. J.; Temer, A.; Davidson, M. H. Food products containing free tall oil-based phytosterols and oat beta-glucan lower serum total and LDL cholesterol in hypercholesterolemic adults. J. Nutr. 2003, 133, 808-813.
35. Hollman, P. C. H. Evidence for health benefits of plant phenols: Local or systemic effects? J. Sci. Food Agric. 2001, 81, 842-852.
36. Lesser, S.; Cermak, R.; Wolffram, S. Bioavailability of quercetin in pigs is influenced by the dietary fat content. J. Nutr. 2004, 134, 1508-1511.
37. Manach, C.; Morand, C.; Crespy, V.; Demigne, C.; Texier, O.; Regerat, F.; Remesy, C. Quercetin is recovered in human plasma as conjugated derivatives which retain antioxidant properties. FEBS Lett. 1998, 426, 331-336.
38. Williamson, G.; Manach, C. Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies. Am. J. Clin. Nutr. 2005, 81, 243S-255S.
39. Azuma, K.; Ippoushi, K.; Ito, H.; Higashio, H.; Terao, J. Combination of lipids and emulsifiers enhances the absorption of orally administered quercetin in rats. J. Agric. Food Chem. 2002, 50, 1706-1712.
40. Azuma, K.; Ippoushi, K.; Ito, H.; Horie, H.; Terao, J. Enhancing effect of lipids and emulsifiers on the accumulation of quercetin metabolites in blood plasma after the short-term ingestion of onion by rats. Biosci., Biotechnol., Biochem. 2003, 67, 2548-2555.