Isoflavones and clinical cardiovascular risk factors in obese postmenopausal women: A randomized double-blind placebo-controlled trial

Journal of Women's Health

Volumn 17, Issue 8, 2008, Pages 1363-1369

  Aubertin Leheudre, Mylène ^a   Lord, Christine ^a   Khalil, Abdelouahed ^a   Dionne, Isabelle J ^a  

^a UNIVERSITY INSTITUTE OF GERIATRICS OF SHERBROOKE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; ISOFLAVONE DERIVATIVE; LIPID; PLACEBO;

ADULT; AGED; ARTICLE; BODY COMPOSITION; CARDIOVASCULAR RISK; CHEMICAL ANALYSIS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET RESTRICTION; DIETARY INTAKE; DOUBLE BLIND PROCEDURE; ENERGY EXPENDITURE; FEMALE; HUMAN; OBESITY; POSTMENOPAUSE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SOCIAL ASPECT;

AGED; BLOOD GLUCOSE; CARDIOVASCULAR DISEASES; DOUBLE-BLIND METHOD; ENERGY METABOLISM; FEMALE; HUMANS; INSULIN; ISOFLAVONES; LIPIDS; MIDDLE AGED; OBESITY; PILOT PROJECTS; PLACEBOS; POSTMENOPAUSE; RISK FACTORS;

EID: 52749092921     PISSN: 15409996     EISSN: None     Source Type: Journal    
DOI: 10.1089/jwh.2008.0836     Document Type: Article

References (50)

1. Matthews KA, Kuller LH, Sutton-Tyrrell K, Chang YF. Changes in cardiovascular risk factors during the perimenopause and postmenopause and carotid artery atherosclerosis in healthy women. Stroke 2001;32:1104-1111.
2. Ferrara CM, Lynch NA, Nicklas BJ, Ryan AS, Berman DM. Differences in adipose tissue metabolism between postmenopausal and perimenopausal women. J Clin Endocrinol Metab 2002;87:4166-4170.
3. Tufano A, Marzo P, Enrini R, Morricone L, Caviezel F, Ambrosi B. Anthropometric, hormonal and biochemical differences in lean and obese women before and after menopause. J Endocrinol Invest 2004;27:648-653.
4. Sumino H, Ichikawa S, Yoshida A, et al. Effects of hormone replacement therapy on weight, abdominal fat distribution, and lipid levels in Japanese postmenopausal women. Int J Obes Rel Metab Disord 2003;27:1044-1051.
5. Stojanovic ND, Kwong P, Byrne DJ, et al. The effects of transdermal estradiol alone or with cyclical dydrogesterone on markers of cardiovascular disease risk in postmenopausal women with type 2 diabetes: A pilot study. Angiology 2003;54:391-399.
6. Stevenson JC, Crook D, Godsland IF. Influence of age and menopause on serum lipids and lipoproteins in healthy women. Atherosclerosis 1993;98:83-90.
7. Rossouw JE, Anderson GL, Prentice RL, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results From the Women's Health Initiative randomized controlled trial. JAMA 2002;288:321-333.
8. Anderson GL, Limacher M, Assaf AR, et al. Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: The Women's Health Initiative randomized controlled trial. JAMA 2004;291:1701-1712.
9. Anderson JW, Johnstone BM, Cook-Newell ME. Meta-analysis of the effects of soy protein intake on serum lipids. N Engl J Med 1995;333:276-282.
10. Jenkins DJ, Kendall CW, Connelly PW, et al. Effects of high-and low-isoflavone (phytoestrogen) soy foods on inflammatory biomarkers and proinflammatory cytokines in middle-aged men and women. Metabolism 2002;51:919-924.
11. Kreijkamp-Kaspers S, Kok L, Bots ML, Grobbee DE, Lampe JW, van der Schouw YT. Randomized controlled trial of the effects of soy protein containing isoflavones on vascular function in postmenopausal women. Am J Clin Nutr 2005;81:189-195.
12. Kreijkamp-Kaspers S, Kok L, Bots ML, Grobbee DE, van der Schouw YT. Dietary phytoestrogens and plasma lipids in Dutch postmenopausal women: A cross-sectional study. Atherosclerosis 2005;178:95-100.
13. Kreijkamp-Kaspers S, Kok L, Grobbee DE, et al. Effect of soy protein containing isoflavones on cognitive function, bone mineral density, and plasma lipids in postmenopausal women: A randomized controlled trial. JAMA 2004;292:65-74.
14. van der Schouw YT, Kreijkamp-Kaspers S, Peeters PH, Keinan-Boker L, Rimm EB, Grobbee DE. Prospective study on usual dietary phytoestrogen intake and cardiovascular disease risk in Western women. Circulation 2005;111:465-471.
15. Teede HJ, Dalais FS, Kotsopoulos D, Liang YL, Davis S, Mc-Grath BP. Dietary soy has both beneficial and potentially adverse cardiovascular effects: A placebo-controlled study in men and postmenopausal women. J Clin Endocrinol Metab 2001;86:3053-3060.
16. Anthony MS, Clarkson TB, Williams JK. Effects of soy isoflavones on atherosclerosis: Potential mechanisms. Am J Clin Nutr 1998;68(Suppl 6):1390S-1393S.
17. Teede HJ, Dalais FS, Kotsopoulos D, et al. Dietary soy containing phytoestrogens does not activate the hemostatic system in postmenopausal women. J Clin Endocrinol Metab 2005;90:1936-1941.
18. Goodman-Gruen D, Kritz-Silverstein D. Usual dietary isoflavone intake is associated with cardiovascular disease risk factors in postmenopausal women. J Nutr 2001;131:1202-1206.
19. Goodman-Gruen D, Kritz-Silverstein D. Usual dietary isoflavone intake and body composition in postmenopausal women. Menopause 2003;10:427-432.
20. Hsu CS, Shen WW, Hsueh YM, Yeh SL. Soy isoflavone supplementation in postmenopausal women. Effects on plasma lipids, antioxidant enzyme activities and bone density. J Reprod Med 2001;46:221-226.
21. Kok L, Kreijkamp-Kaspers S, Grobbee DE, Lampe JW, van der Schouw YT. Soy isoflavones, body composition, and physical performance. Maturitas 2005;52:102-110.
22. Moeller LE, Peterson CT, Hanson KB, et al. Isoflavone-rich soy protein prevents loss of hip lean mass but does not prevent the shift in regional fat distribution in perimenopausal women. Menopause 2003;10:322-331.
23. Tjepkema M. Adult obesity. Health Rep 2006;17:9-25.
24. Sites CK, Calles-Escandon J, Brochu M, Butterfield M, Ashikaga T, Poehlman ET. Relation of regional fat distribution to insulin sensitivity in postmenopausal women. Fertil Steril 2000;73:61-65.
25. Folsom AR, Kushi LH, Anderson KE, et al. Associations of general and abdominal obesity with multiple health outcomes in older women: The Iowa Women's Health Study. Arch Intern Med 2000;160:2117-2128.
26. Sanderson WC, Scherbov S. Average remaining lifetimes can increase as human populations age. Nature 2005;435:811-813.
27. Faure ED, Chantre P, Mares P. Effects of a standardized soy extract on hot flushes: A multicenter, double-blind, randomized, placebo-controlled study. Menopause 2002;9:329-334.
28. Fox AA, Thompson JL, Butterfield GE, Gylfadottir U, Moynihan S, Spiller G. Effects of diet and exercise on common cardiovascular disease risk factors in moderately obese older women. Am J Clin Nutr 1996;63:225-233.
29. Sipila S, Taaffe DR, Cheng S, Puolakka J, Toivanen J, Suominen H. Effects of hormone replacement therapy and high-impact physical exercise on skeletal muscle in post-menopausal women: A randomized placebo-controlled study. Clin Sci (Lond) 2001;101:147-157.
30. Dionne IJ, Melancon MO, Brochu M, Ades PA, Poelhman ET. Age-related differences in metabolic adaptations following resistance training in women. Exp Gerontol 2004;39:133-138.
31. Reynolds K, Chin A, Lees KA, Nguyen A, Bujnowski D, He J. A meta-analysis of the effect of soy protein supplementation on serum lipids. Am J Cardiol 2006;98:633-640.
32. Aubertin-Leheudre M, Audet M, Goulet ED, Dionne IJ. HRT provides no additional beneficial effect on sarcopenia in physically active postmenopausal women: A cross-sectional, observational study. Maturitas 2005;51:140-145.
33. Bertin E, Marcus C, Ruiz JC, Eschard JP, Leutenegger M. Measurement of visceral adipose tissue by DXA combined with anthropometry in obese humans. Int J Obes Rel Metab Disord 2000;24:263-270.
34. Weir JB. New methods for calculating metabolic rate with special reference to protein metabolism. Nutrition 1990;6:213-221.
35. Tudor-Locke C, Ainsworth BE, Thompson RW, Matthews CE. Comparison of pedometer and accelerometer measures of free-living physical activity. Med Sci Sports Exerc 2002;34:2045-2051.
36. Starling RD, Matthews DE, Ades PA, Poehlman ET. Assessment of physical activity in older individuals: A doubly labeled water study. J Appl Physiol 1999;86:2090-2096.
37. Nichols JF, Patterson P, Early T. A validation of a physical activity monitor for young and older adults. Can J Sport Sci 1992;17:299-303.
38. Luhrmann PM, Herbert BM, Gaster C, Neuhauser-Berthold M. Validation of a self-administered 3-day estimated dietary record for use in the elderly. Eur J Nutr 1999;38:235-240.
39. Wallace TM, Levy JC, Matthews DR. Use and abuse of HOMA modeling. Diabetes Care 2004;27:1487-1495.
40. Lorenzo C, Williams K, Hunt KJ, Haffner SM. The National Cholesterol Education Program - Adult Treatment Panel III, International Diabetes Federation, and World Health Organization definitions of the metabolic syndrome as predictors of incident cardiovascular disease and diabetes. Diabetes Care 2007;30:8-13.
41. Wing RR, Matthews KA, Kuller LH, Meilahn EN, Plantinga PL. Weight gain at the time of menopause. Arch Intern Med 1991;151:97-102.
42. de Kleijn MJ, van der Schouw YT, Wilson PW, Grobbee DE, Jacques PF. Dietary intake of phytoestrogens is associated with a favorable metabolic cardiovascular risk profile in postmenopausal U.S. women: The Framingham Study. J Nutr 2002;132:276-282.
43. Dewell A, Hollenbeck CB, Bruce B. The effects of soy-derived phytoestrogens on serum lipids and lipoproteins in moderately hypercholesterolemic postmenopausal women. J Clin Endocrinol Metab 2002;87:118-121.
44. Dewell A, Hollenbeck PL, Hollenbeck CB. Clinical review: A critical evaluation of the role of soy protein and isoflavone supplementation in the control of plasma cholesterol concentrations. J Clin Endocrinol Metab 2006;91:772-780.
45. Weggemans RM, Trautwein EA. Relation between soy-associated isoflavones and LDL and HDL cholesterol concentrations in humans: A meta-analysis. Eur J Clin Nutr 2003;57:940-946.
46. Zhan S, Ho SC. Meta-analysis of the effects of soy protein containing isoflavones on the lipid profile. Am J Clin Nutr 2005;81:397-408.
47. Taku K, Umegaki K, Sato Y, Taki Y, Endoh K, Watanabe S. Soy isoflavones lower serum total and LDL cholesterol in humans: A meta-analysis of 11 randomized controlled trials. Am J Clin Nutr 2007;85:1148-1156.
48. Setchell KD. Phytoestrogens: The biochemistry, physiology, and implications for human health of soy isoflavones. Am J Clin Nutr 1998;68(Suppl 6):1333S-1346S.
49. Crisafulli A, Altavilla D, Marini H, et al. Effects of the phytoestrogen genistein on cardiovascular risk factors in postmenopausal women. Menopause 2005;12:186-192.
50. Dragan I, Stroescu V, Stoian I, Georgescu E, Baloescu R. Studies regarding the efficiency of Supro isolated soy protein in Olympic athletes. Rev Roum Physiol 1992;29:63-70.