Soy-isoflavone-enriched foods and inflammatory biomarkers of cardiovascular disease risk in postmenopausal women: Interactions with genotype and equol production

American Journal of Clinical Nutrition

Volumn 82, Issue 6, 2005, Pages 1260-1268

  Hall, Wendy L ^a   Vafeiadou, Katerina ^a   Hallund, Jesper ^b   Bügel, Susanne ^b   Koebnick, Corinna ^c   Reimann, Manja ^c   Ferrari, Marika ^d   Branca, Francesco ^d   Talbot, Duncan ^e   Dadd, Tony ^e   Nilsson, Maria ^f   Dahlman Wright, Karin ^f   Gustafsson, Jan Åke ^f   Minihane, Anne Marie ^a   Williams, Christine M ^a  

^a UNIVERSITY OF READING   (United Kingdom)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^d ISTITUTO NAZIONALE DELLA NUTRIZIONE   (Italy)

^e UNILEVER RESEARCH   (United Kingdom)

^f KAROLINSKA INSTITUTE   (Sweden)

Author keywords

C reactive protein; Cardiovascular disease; Cell adhesion molecules; Endothelin 1; Estrogen receptor; Gene nutrient interaction; Inflammatory factors; Isoflavones; Monocyte chemoattractant protein 1; Postmenopausal women; Soy; Von Willebrand factor

Indexed keywords

APOLIPOPROTEIN E; BIOLOGICAL MARKER; C REACTIVE PROTEIN; CELL ADHESION MOLECULE; CHOLESTEROL ESTER TRANSFER PROTEIN; DAIDZEIN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIN 1; EQUOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GENISTEIN; ISOFLAVONE; MONOCYTE CHEMOTACTIC PROTEIN 1; VASCULAR ADHESION PROTEIN 1; VON WILLEBRAND FACTOR; ISOFLAVONE DERIVATIVE; PHYTOESTROGEN; VASCULAR CELL ADHESION MOLECULE 1;

ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CONTROLLED STUDY; FEMALE; HUMAN; INFLAMMATION; NORMAL HUMAN; POSTMENOPAUSE; SINGLE NUCLEOTIDE POLYMORPHISM; AGED; BIOSYNTHESIS; BLOOD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CROSSOVER PROCEDURE; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; GENETICS; GENOTYPE; METABOLISM; MIDDLE AGED; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; SOYBEAN; URINE;

AGED; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CARDIOVASCULAR DISEASES; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ESTROGEN RECEPTOR BETA; FEMALE; FOOD, FORTIFIED; GENOTYPE; HUMANS; ISOFLAVONES; MIDDLE AGED; PHYTOESTROGENS; POLYMORPHISM, SINGLE NUCLEOTIDE; POSTMENOPAUSE; RISK FACTORS; SOY FOODS; VASCULAR CELL ADHESION MOLECULE-1;

EID: 33644693570     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/82.6.1260     Document Type: Article

References (43)

1. Hwang SJ, Ballantyne CM, Sharrett AR, et al. Circulating adhesion molecules VCAM-1, ICAM-1, and E-selectin in carotid atherosclerosis and incident coronary heart disease cases: the Atherosclerosis Risk In Communities (ARIC) study. Circulation 1997;96:4219-25.
2. Li JJ, Fang CH. C-reactive protein is not only an inflammatory marker but also a direct cause of cardiovascular diseases. Med Hypotheses 2004;62:499-506.
3. Ridker PM, Hennekens CH, During JE, Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 2000;342:836-43.
4. Venugopal SK, Devaraj S, Jialal I. Effect of C-reactive protein on vascular cells: evidence for a proinflammatory, proatherogenic role. Curr Opin Nephrol Hypertens 2005;14:33-7.
5. Blann AD. Is raised von Willebrand factor a marker of endothelial cell damage? Med Hypotheses 1993;41:419-24.
6. Kinlay S, Behrendt D, Wainstein M, et al. Role of endothelin-1 in the active constriction of human atherosclerotic coronary arteries. Circulation 2001;104:1114-8.
7. Gilligan DM, Quyyumi AA, Cannon RO 3rd. Effects of physiological levels of estrogen on coronary vasomotor function in postmenopausal women. Circulation 1994;89:2545-51.
8. Lieberman EH, Gerhard MD, Uehata A, et al. Estrogen improves endothelium-dependent, flow-mediated vasodilation in postmenopausal women. Ann Intern Med 1994;121:936-41.
9. Sullivan TR Jr, Karas RH, Aronovitz M, et al. Estrogen inhibits the response-to-injury in a mouse carotid artery model. J Clin Invest 1995; 96:2482-8.
10. Krasinski K, Spyridopoulos I, Asahara T, van der Zee R, Isner JM, Losordo DW. Estradiol accelerates functional endothelial recovery after arterial injury. Circulation 1997;95:1768-72.
11. Wilcox JG, Hatch IE, Gentzschein E, Stanczyk FZ, Lobo RA. Endothelin levels decrease after oral and nonoral estrogen in postmenopausal women with increased cardiovascular risk factors. Fertil Steril 1997;67: 273-7.
12. Koh KK, Bui MN, Mincemoyer R, Cannon RO 3rd. Effects of hormone therapy on inflammatory cell adhesion molecules in postmenopausal healthy women. Am J Cardiol 1997;80:1505-7.
13. Nelson HD, Humphrey LL, Nygren P, Teutsch SM, Allan JD. Postmenopausal hormone replacement therapy: scientific review. JAMA 2002; 288:872-81.
14. Cushman M, Legault C, Barrett-Connor E, et al. Effect of postmenopausal hormones on inflammation-sensitive proteins: the Postmenopausal Estrogen/Progestin Interventions (PEPI) Study. Circulation 1999;100:717-22.
15. Manning PJ, Sutherland WHF, Allum AR, de Jong SA, Jones SD. Effect of hormone replacement therapy on inflammation-sensitive proteins in post-menopausal women with Type 2 diabetes. Diabet Med 2002;19: 847-52.
16. Gottstein N, Ewins BA, Eccleston C, et al. Effect of genistein and daidzein on platelet aggregation and monocyte and endothelial function. Br J Nutr 2003;89:607-16.
17. Mukherjee TK, Nathan L, Dinh H, Reddy ST, Chaudhuri G. 17-epiestriol, an estrogen metabolite, is more potent than estradiol in inhibiting vascular cell adhesion molecule 1 (VCAM-1) mRNA expression. J Biol Chem 2003;278:11746-52.
18. Rimbach G, Weinberg PD, de Pascual-Teresa S, et al. Sulfation of genistein alters its antioxidant properties and its effect on platelet aggregation and monocyte and endothelial function. Biochim Biophys Acta 2004;1670:229-37.
19. Bingham M, Gibson G, Gottstein N, de Pascual-Teresa S, Minihane A-M, Rimbach G. Gut metabolism and cardioprotective effects of dietary isoflavones. Curr Top Nutraceutical Res 2003;1:31-48.
20. Rowland IR, Wisemen H, Sanders TAB, Adlercreutz H, Bowey EA. Interindividual variation in metabolism of soy isoflavones and lignans: influence of habitual diet on equol production by the gut microflora. Nutr Cancer 2000;36:27-32.
21. Setchell KD, Brown NM, Lydeking-Olsen E. The clinical importance of the metabolite equol - a clue to the effectiveness of soy and its isoflavones. J Nutr 2002;132:3577-84.
22. Herrington DM, Howard TD, Hawkins GA, et al. Estrogen-receptor polymorphisms and effects of estrogen replacement on high-density lipoprotein cholesterol in women with coronary disease. N Engl J Med 2002;346:967-74.
23. Herrington DM, Howard TD, Brosnihan KB, et al. Common estrogen receptor polymorphism augments effects of hormone replacement therapy on E-selectin but not C-reactive protein. Circulation 2002;105:1879-82.
24. Yaich L, Dupont WD, Cavener DR, Parl FF. Analysis of the PvuII restriction fragment-length polymorphism and exon structure of the estrogen receptor gene in breast cancer and peripheral blood. Cancer Res 1992;52:77-83.
25. Miyamoto Y, Saito Y, Kajiyama N, et al. Endothelial nitric oxide synthase gene is positively associated with essential hypertension. Hypertension 1998;32:3-8.
26. Corella D, Saiz C, Guillen M, et al. Association of TaqIB polymorphism in the cholesteryl ester transfer protein gene with plasma lipid levels in a healthy Spanish population. Atherosclerosis 2000;152:367-76.
27. Nilsson M, Naessen S, Dahlman I, Linden Hirschberg A, Gustafsson JA, Dahlman-Wright K. Association of estrogen receptor beta gene polymorphisms with bulimic disease in women. Mol Psychiatry 2004;9:28-34.
28. De Pascual-Teresa S, Hallund J, Talbot D, et al. Absorption of isoflavones in humans: effects of food matrix and processing. J Nutr Biochem 2005 (in press).
29. Talbot D, Ogborne R, Dadd T, et al. Development and validation of rapid monoclonal TR-FIA assays for the phytoestrogens daidzein, genistein and equol and their use in the Isoheart Framework VEU Study. Polyphenols Communications 2004 XXII International Conference on Polyphenols, 2004:699-700 (abstr). Internet: http://www.helsinki.fi/ icp2004 (accessed 05 October 2005).
30. Blum A, Lang N, Peleg A, et al. Effects of oral soy protein on markers of inflammation in postmenopausal women with mild hypercholesterolemia. Am Heart J [serial online] 2003;145:e7.
31. Steinberg FM, Guthrie NL, Villabianca AC, Kumar K, Murray MJ. Soy protein with isoflavones has favorable effects on endothelial function that are independent of lipid and antioxidant effects in healthy postmenopausal women. Am J Clin Nutr 2003;78:123-30.
32. Nikander E, Metsa-Heikkila M, Tiitinen A, Ylikorkala O. Evidence of a lack of effect of a phytoestrogen regimen on the levels of C-reactive protein, E-selectin, and nitrate in postmenopausal women. J Clin Endocrinol Metab 2003;88:5180-5.
33. Teede HJ, McGrath BP, DeSilva L, Cehun M, Fassoulakis A, Nestel PJ. Isoflavones reduce arterial stiffness: a placebo-controlled study in men and postmenopausal women. Arterioscler Thromb Vasc Biol 2003;23: 1066-71.
34. Hermansen K, Sondergaard M, Hoie L, Carstensen M, Brock B. Beneficial effects of a soy-based dietary supplement on lipid levels and cardiovascular risk markers in type 2 diabetic subjects. Diabetes Care 2001; 24:228-33.
35. Squadrito F, Altavilla D, Morabito N, et al. The effect of the phytoestrogen genistein on plasma nitric oxide concentrations, endothelin-1 levels and endothelium dependent vasodilation in postmenopausal women. Atherosclerosis 2002;163:339-47.
36. Squadrito F, Altavilla D, Crisafulli A, et al. Effect of genistein on endothelial function in postmenopausal women: a randomized, double-blind, controlled study. Am J Med 2003;114:470-6.
37. Wagner OF, Christ G, Wojta J, et al. Polar secretion of endothelin-1 by cultured endothelial cells. J Biol Chem 1992;267:16066-8.
38. Lerman A, Edwards BS, Hallett JW, Heublein DM, Sandberg SM, Burnett JC Jr. Circulating and tissue endothelin immunoreactivity in advanced atherosclerosis. N Engl J Med 1991;325:997-1001.
39. Omland T, Lie RT, Aakvaag A, Aarsland T, Dickstein K. Plasma endothelin determination as a prognostic indicator of 1-year mortality after acute myocardial infarction. Circulation 1994;89:1573-9.
40. Gardner CD, Newell KA, Cherin R, Haskell WL. The effect of soy protein with or without isoflavones relative to milk protein on plasma lipids in hypercholesterolemic postmenopausal women. Am J Clin Nutr 2001;73:728-35.
41. Mori M, Tsukahara F, Yoshioka T, Irie K, Ohta H. Suppression by 17beta-estradiol of monocyte adhesion to vascular endothelial cells is mediated by estrogen receptors. Life Sci 2004;75:599-609.
42. Rosenkranz K, Hinney A, Ziegler A, et al. Systematic mutation screening of the estrogen receptor beta gene in probands of different weight extremes: identification of several genetic variants. J Clin Endocrinol Metab 1998;83:4524-7.
43. Kreijkamp-Kaspers S, Kok L, Bots ML, Grobbee DE, Lampe JW, van der Schouw YT. Randomized controlled trial of the effects of soy protein containing isoflavones on vascular function in postmenopausal women. Am J Clin Nutr 2005;81:189-95.