Discovery of Biaryl Amides as Potent, Orally Bioavailable, and CNS Penetrant RORγt Inhibitors

ACS Medicinal Chemistry Letters

Volumn 6, Issue 7, 2015, Pages 787-792

  Wang, Yonghui ^a   Cai, Wei ^b   Cheng, Yaobang ^b   Yang, Ting ^b   Liu, Qian ^b   Zhang, Guifeng ^b   Meng, Qinghua ^b   Han, Fangbin ^b   Huang, Yafei ^a   Zhou, Ling ^b   Xiang, Zhijun ^b   Zhao, Yong Gang ^b   Xu, Yan ^b   Cheng, Ziqiang ^b   Lu, Sijie ^b   Wu, Qianqian ^b   Xiang, Jia Ning ^b   Elliott, John D ^b   Leung, Stewart ^b   Ren, Feng ^b   Lin, Xichen ^b   more..

^a FUDAN UNIVERSITY   (China)

^b GLAXOSMITHKLINE   (China)

Author keywords

biaryl amides; EAE; multiple sclerosis; ROR t inhibitor; Th17 cell differentiation

Indexed keywords

AMIDE; CENTRAL NERVOUS SYSTEM AGENTS;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG EFFICACY; DRUG HALF LIFE; DRUG PENETRATION; IN VIVO STUDY; LYMPHOCYTE DIFFERENTIATION; MALE; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; SUZUKI REACTION; TH17 CELL;

MUS;

EID: 84936880845     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/acsmedchemlett.5b00122     Document Type: Article

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