Inhibiting RORγt/Th17 axis for autoimmune disorders

Drug Discovery Today

Volumn 19, Issue 8, 2014, Pages 1205-1211

  Isono, Fujio ^a   Fujita Sato, Saori ^a   Ito, Shuichiro ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOMODULATING AGENT; INTERLEUKIN 17 RECEPTOR; ORPHAN NUCLEAR RECEPTOR; RECEPTOR BLOCKING AGENT; RETINOIC ACID RECEPTOR; RETINOIC ACID RELATED ORPHAN NUCLEAR RECEPTOR ALPHA; RETINOIC ACID RELATED ORPHAN NUCLEAR RECEPTOR GAMMA; RETINOIC ACID RELATED ORPHAN NUCLEAR RECEPTOR GAMMA T; RETINOIC ACID RELATED ORPHAN NUCLEAR RECEPTOR GAMMA T INHIBITOR; UNCLASSIFIED DRUG; INTERLEUKIN 17; MOLECULAR LIBRARY; RETINOID RELATED ORPHAN RECEPTOR GAMMA;

AUTOIMMUNE DISEASE; DRUG STRUCTURE; HUMAN; IMMUNOMODULATION; NONHUMAN; RECEPTOR BLOCKING; RECEPTOR DOWN REGULATION; REVIEW; STRUCTURE ACTIVITY RELATION; TH17 CELL; ANIMAL; ANTAGONISTS AND INHIBITORS; AUTOIMMUNE DISEASES; DRUG EFFECTS; IMMUNOLOGY; MOLECULAR LIBRARY; PHARMACOLOGY; SIGNAL TRANSDUCTION; THERAPEUTIC USE;

ANIMALS; AUTOIMMUNE DISEASES; HUMANS; INTERLEUKIN-17; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES; TH17 CELLS;

EID: 84906316949     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2014.04.012     Document Type: Review

References (47)

1. J. Lin et al. TNFα blockade in human diseases: an overview of efficacy and safety Clin. Immunol. 126 2008 13 30
2. G.M. Bell et al. Biologic therapies in non-rheumatic diseases: lessons for rheumatologists? Nat. Rev. Rheumatol. 7 2011 507 516
3. J.K. Kolls, and A. Lindén Interleukin-17 family members and inflammation Immunity 21 2004 467 476
4. P. Miossec et al. Interleukin-17 and Type 17 helper T cells N. Engl. J. Med. 361 2009 888 898
5. C. Leonardi et al. Anti-interleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis N. Engl. J. Med. 366 2012 1190 1199
6. K.A. Papp et al. Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis N. Engl. J. Med. 366 2012 1181 1189
7. G. Eberl, and D.R. Littman The role of the nuclear hormone receptor RORγt in the development of lymph nodes and Peyer's patches Immunol. Rev. 195 2003 81 90
8. J.R. Huh, and D.R. Littman Small molecule inhibitors of RORγt: targeting Th17 cells and other applications Eur. J. Immunol. 42 2012 2232 2237
9. H17 cells in chronic inflammation Nat. Rev. Drug Discov. 11 2012 763 776
10. C.T. Weaver et al. The Th17 pathway and inflammatory diseases of the intestines, lungs, and skin Ann. Rev. Pathol. Mech. Dis. 8 2013 477 512
11. B. Pöllinger IL-17 producing T cells in mouse models of multiple sclerosis and rheumatoid arthritis J. Mol. Med. 90 2012 613 624
12. D.J. Cua et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain Nature 421 2003 744 748
13. C.A. Murphy et al. Divergent pro- and anti-inflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation J. Exp. Med. 198 2003 1951 1957
14. D. Yen et al. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6 J. Clin. Invest. 116 2006 1310 1318
15. J.C. Knight Genomic modulators of the immune response Trends Genet. 29 2013 74 83
16. I.I. Ivanov et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells Cell 126 2006 1121 1133
17. F. Annunziato et al. Phenotype and functional features of human Th17 cells J. Exp. Med. 204 2007 1849 1861
18. L.A. Solt, and T.P. Burris Action of RORs and their ligands in (patho)physiology Trends Endocrinol. Metab. 23 2012 619 627
19. G. Eberl et al. An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells Nat. Immunol. 5 2004 64 73
20. Z. Sun et al. Requirement for RORgamma in thymocyte survival and lymphoid organ development Science 288 2000 2369 2373
21. X.O. Yang et al. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs Immunity 29 2008 44 56
22. Y. Wang et al. A second class of nuclear receptors for oxysterols: regulation of RORα and RORγ activity by 24S-hydroxycholesterol (cerebrosterol) Biochim. Biophys. Acta 1801 2010 917 923
23. Y. Wang et al. Modulation of retinoic acid receptor-related orphan receptor α and γ activity by 7-oxygenated sterol ligands J. Biol. Chem. 285 2010 5013 5025
24. N. Kumar et al. The benzenesulfoamide T0901317 [N-(2,2,2-trifluoroethyl)- N-{4-{2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl}phenyl} -benzenesulfonamide] is a novel retinoic acid receptor-related orphan receptor-α/γ inverse agonist Mol. Pharmacol. 77 2010 228 236
25. H17 cell differentiation by antagonizing RORγt activity Nature 472 2011 486 490
26. S. Fujita-Sato et al. Structural basis of digoxin that antagonizes RORγt receptor activity and suppress Th17 cell differentiation and interleukin-17 production J. Biol. Chem. 286 2011 31409 31417
27. T. Xu et al. Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORγt protein J. Biol. Chem. 286 2011 22707 22710
28. A.R. de Lera et al. Design of selective nuclear receptor modulators: RAR and RXR as a case study Nat. Rev. Drug Discov. 6 2007 811 820
29. L. Jin et al. Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma Mol. Endocrinol. 24 2010 923 929
30. M.M. Hann, and G.M. Keserü Finding the sweet spot: the role of nature and nurture in medicinal chemistry Nat. Rev. Drug Discov. 11 2012 355 365
31. H17 differentiation and autoimmunity by a synthetic ROR ligand Nature 472 2011 491 494
32. N. Kumar et al. Identification of SR 2211, a potent synthetic RORγ-selective modulator ACS Chem. Biol. 7 2012 672 677
33. H17 cells and stimulates T regulatory cells ACS Chem. Biol. 7 2012 1515 1519
34. P.M. Khan et al. Small molecule amides as potent ROR-γ selective modulators Bioorg. Med. Chem. Lett. 23 2013 532 536
35. J.R. Huh et al. Identification of potent and selective diphenylpropanamide RORγ inhibitors ACS Med. Chem. Lett. 4 2013 79 84
36. B. Meissburger et al. Adipogenesis and insulin sensitivity in obesity are regulated by retinoid-related orphan receptor gamma EMBO Mol. Med. 3 2011 637 651
37. H-17 cells in human autoimmune diseases Nat. Immunol. 11 2010 41 44
38. R.S. Blumberg et al. Unraveling the autoimmune translational research process layer by layer Nat. Med. 18 2012 35 41
39. L. Steinman et al. Optimization of current and future therapy for autoimmune diseases Nat. Med. 18 2012 59 65
40. C. Cotsapas, and D.A. Hafler Immune-mediated disease genetics: the shared basis of pathogenesis Trends Immunol. 34 2013 22 26
41. S. Rutz et al. IL-22, not simply a Th17 cytokine Immnol. Rev. 252 2013 116 132
42. + innate lymphocytes and γδ T cells initiate psoriasiform plaque formation in mice J. Clin. Invest. 122 2012 2252 2256
43. M. Ciofani et al. A validated regulatory network for Th17 cell specification Cell 151 2012 289 303
44. C. Wang et al. The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90 Nat. Immunol. 14 2013 72 81
45. A.V. Garg et al. The deubiquitinase A20 mediates feedback inhibition of interleukin-17 receptor signaling Sci. Signal. 6 2013 ra44
46. A. Ma, and B.A. Malynn A20: linking a complex regulator of ubiquitylation to immunity and human disease Nat. Rev. Immunol. 12 2012 774 785
47. W.H. Robinson et al. Mechanistic biomarkers for clinical decision making in rheumatic diseases Nat. Rev. Rheumatol. 9 2013 267 276