Identification of potent and selective diphenylpropanamide RORγ inhibitors

ACS Medicinal Chemistry Letters

Volumn 4, Issue 1, 2013, Pages 79-84

  Huh, Jun R ^b   Englund, Erika E ^a   Wang, Hang ^a   Huang, Ruili ^a   Huang, Pengxiang ^d   Rastinejad, Fraydoon ^d   Inglese, James ^a   Austin, Christopher P ^a   Johnson, Ronald L ^a,e   Huang, Wenwei ^a   Littman, Dan R ^b,c  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d BURNHAM INSTITUTE   (United States)

^e NATIONAL CANCER INSTITUTE   (United States)

Author keywords

diphenylpropanamide; retinoic acid related orphan receptor; ROR antagonist; TH17 related autoimmune diseases

Indexed keywords

DIPHENYLPROPANAMIDE DERIVATIVE; RETINOIC ACID DERIVATIVE; RETINOIC ACID RECEPTOR GAMMA; RETINOIC ACID RELATED ORPHAN RECEPTOR GAMMA; UNCLASSIFIED DRUG;

ARTICLE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG INHIBITION; DRUG POTENCY; DRUG SELECTIVITY; FLOW CYTOMETRY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC 50; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; TH17 CELL; TRANSCRIPTION INITIATION;

EID: 84872281985     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml300286h     Document Type: Article

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