Identification of tertiary sulfonamides as RORc inverse agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 9, 2014, Pages 2182-2187

  Fauber, Benjamin P ^a   René, Olivier ^a   Burton, Brenda ^b   Everett, Christine ^a   Gobbi, Alberto ^a   Hawkins, Julie ^b   Johnson, Adam R ^a   Liimatta, Marya ^a   Lockey, Peter ^b   Norman, Maxine ^b   Wong, Harvey ^a  

^a GENENTECH INC   (United States)

^b Argenta Discovery Ltd   (United Kingdom)

Author keywords

Autoimmune; IL 17; Inflammation; RORc; ROR

Indexed keywords

AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; LIVER X RECEPTOR ALPHA; LIVER X RECEPTOR BETA; RETINOID RELATED ORPHAN RECEPTOR GAMMA; SULFONAMIDE; LIGAND; RORC PROTEIN, HUMAN;

ARTICLE; BINDING ASSAY; CELL STRAIN HEK293; CHEMICAL STRUCTURE; EMBRYO; HUMAN; HUMAN CELL; INVERSE AGONISM; LIGAND BINDING; STRUCTURE ACTIVITY RELATION; AGONISTS; CHEMISTRY; METABOLISM; MOLECULAR DOCKING; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; EC50; HEK293 CELL LINE;

HUMANS; LIGANDS; MOLECULAR DOCKING SIMULATION; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 84899108449     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.03.038     Document Type: Article

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