Discovery of 2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide derivatives as new RORγ inhibitors using virtual screening, synthesis and biological evaluation

European Journal of Medicinal Chemistry

Volumn 78, Issue , 2014, Pages 431-441

  Zhang, Yan ^a   Xue, Xiaoqian ^a,b   Jin, Xiangyu ^a,c   Song, Yu ^a,c   Li, Jing ^a   Luo, Xiaoyu ^a   Song, Ming ^a   Yan, Weiqun ^c   Song, Hongrui ^b   Xu, Yong ^a  

^a GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^c JILIN UNIVERSITY   (China)

Author keywords

Nuclear hormone receptor; ROR inhibitor; Th17 cell differentiation; Virtual screening

Indexed keywords

1 ETHYL 2 OXO 1,2 DIHYDROBENZO[CD]INDOLE 6 SULFONYL CHLORIDE; 1 ETHYL 2 OXO N [4 (PHENYLDIAZENYL)PHENYL] 1,2 DIHYDROBENZO[CD]INDOLE 6 SUFONAMIDE; 1 ETHYL N (4' MORPHOLINOPHENYL) 2 OXO 1,2 DIHYDROBENZO[CD]INDOLE 6 SULFONAMIDE; 1 ETHYL N (ISOQUINOLIN 7 YL) 2 OXO 1,2 DIHYDROBENZO[CD]INDOLE 6 SULFONAMIDE; 1 ETHYLBENZO[CD]INDOL 2 (1H)ONE; BENZENESULFONATE 1,3 DIOXO 2,3 DIHYDRO 1H PHENALEN 2 YL 4 METHYLBENZENESULFONATE; BENZO[CD]INDOL 2 (1H)ONE; HORMONE RECEPTOR; IMMUNOLOGIC AGENT; N (2',5' DICHLOROBENZYL) 1 ETHYL 2 OXO 1,2 DIHYDROBENZO[CD]INDOLE 6 SULFONAMIDE; N (3',4' DIMETHOXYPHENYL) 1 ETHYL 2 OXO 1,2 DIHYDROBENZO[CD]INDOLE 6 SULFONAMIDE; N (4' ACETYLPHENYL) 1 ETHYL 2 OXO 1,2 DIHYDROBENZO[CD]INDOLE 6 SULFONAMIDE; RECEPTOR BLOCKING AGENT; RETINOIC ACID RECEPTOR; RETINOIC ACID RECEPTOR RELATED ORPHAN RECEPTOR GAMMA INHIBITOR; TERT BUTYL[3'(1-ETHYL 2 OXO 1,2 DIHYDROBENZO[CD]INDOLE 6 SULFONAMIDO)PHENYL]CARBAMATE; UNCLASSIFIED DRUG; INDOLE DERIVATIVE; RETINOID RELATED ORPHAN RECEPTOR GAMMA; SULFONAMIDE;

ARTICLE; CELL ASSAY; DRUG SCREENING; DRUG STRUCTURE; HYDROPHOBICITY; IC 50; LIGAND BINDING; LYMPHOCYTE DIFFERENTIATION; MOLECULAR DOCKING; REPORTER GENE; TH17 CELL; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG DEVELOPMENT; HIGH THROUGHPUT SCREENING; HUMAN; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; INDOLES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 84897480417     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.03.065     Document Type: Article

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