SCOPUS 정보 검색 플랫폼

Volumn 22, Issue 9, 2014, Pages 2799-2808

Structure-activity relationship-guided development of retinoic acid receptor-related orphan receptor gamma (RORγ)-selective inverse agonists with a phenanthridin-6(5H)-one skeleton from a liver X receptor ligand

(7) Nishiyama, Yuko a Nakamura, Masahiko a Misawa, Takashi a Nakagomi, Madoka b Makishima, Makoto c Ishikawa, Minoru a Hashimoto, Yuichi a

a UNIVERSITY OF TOKYO (Japan)

b Kawasaki (Japan)

c NIHON UNIVERSITY SCHOOL OF MEDICINE (Japan)

Author keywords

Inverse agonist; LXR; Phenanthridinone; ROR

Indexed keywords

ISOPROTEIN; LIGAND; LIVER X RECEPTOR; ORPHAN NUCLEAR RECEPTOR; PHENANTHRENE DERIVATIVE; PHENANTHRIDONE; PROTEIN BINDING; RETINOIC ACID RECEPTOR; RETINOIC ACID RECEPTOR GAMMA;

CHEMISTRY; HEK293 CELL LINE; HUMAN; INVERSE AGONISM; METABOLISM; PROTEIN TERTIARY STRUCTURE; SYNTHESIS;

DRUG INVERSE AGONISM; HEK293 CELLS; HUMANS; LIGANDS; ORPHAN NUCLEAR RECEPTORS; PHENANTHRENES; PROTEIN BINDING; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, RETINOIC ACID;

EID: 84899434633 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2014.03.007 Document Type: Article

Times cited : (25)

References (28)

1
- 66849099394
- A. Jetten Nucl. Recept. Signal. 7 2009 e003
- (2009) Nucl. Recept. Signal. , vol.7 , pp. 003
- Jetten, A.¹

2
- 0034254930
- T. Meyer, M. Kneissel, J. Mariani, and B. Fournier Proc. Natl. Acad. Sci. U.S.A. 97 2000 9197
- (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 9197
- Meyer, T.¹ Kneissel, M.² Mariani, J.³ Fournier, B.⁴

3
- 0032527749
- E. Andre, F. Conquet, M. Steinmayr, S.C. Stratton, V. Porciatti, and M. Becker-Andre EMBO J. 17 1998 3867
- (1998) EMBO J. , vol.17 , pp. 3867
- Andre, E.¹ Conquet, F.² Steinmayr, M.³ Stratton, S.C.⁴ Porciatti, V.⁵ Becker-Andre, M.⁶

4
- 84874222674
- A.M. Jetten, H.S. Kang, and Y. Takeda Front. Endocrinol. (Lausanne) 4 2013 1
- (2013) Front. Endocrinol. (Lausanne) , vol.4 , pp. 1
- Jetten, A.M.¹ Kang, H.S.² Takeda, Y.³

5
- 37849048599
- X. Yang, B. Pappu, R. Nurieva, A. Akimzhanov, H. Kang, Y. Chung, L. Ma, B. Shah, A. Panopoulos, K. Schluns, S. Watowich, Q. Tian, A. Jetten, and C. Dong Immunity 28 2008 29
- (2008) Immunity , vol.28 , pp. 29
- Yang, X.¹ Pappu, B.² Nurieva, R.³ Akimzhanov, A.⁴ Kang, H.⁵ Chung, Y.⁶ Ma, L.⁷ Shah, B.⁸ Panopoulos, A.⁹ Schluns, K.¹⁰ Watowich, S.¹¹ Tian, Q.¹² Jetten, A.¹³ Dong, C.¹⁴

6
- 33748588423
- I. Ivanov, B. McKenzie, L. Zhou, C. Tadokoro, A. Lepelley, J. Lafaille, D. Cua, and D. Littman Cell 126 2006 1121
- (2006) Cell , vol.126 , pp. 1121
- Ivanov, I.¹ McKenzie, B.² Zhou, L.³ Tadokoro, C.⁴ Lepelley, A.⁵ Lafaille, J.⁶ Cua, D.⁷ Littman, D.⁸

7
- 39449101603
- I. Ivanov, L. Zhou, and D. Littman Semin. Immunol. 19 2007 409
- (2007) Semin. Immunol. , vol.19 , pp. 409
- Ivanov, I.¹ Zhou, L.² Littman, D.³

8
- 74549224652
- N. Kumar, L.A. Solt, J.J. Conkright, Y. Wang, M.A. Istrate, S.A. Busby, R.D. Garcia-Ordonez, T.P. Burris, and P.R. Griffin Mol. Pharmacol. 77 2010 228
- (2010) Mol. Pharmacol. , vol.77 , pp. 228
- Kumar, N.¹ Solt, L.A.² Conkright, J.J.³ Wang, Y.⁴ Istrate, M.A.⁵ Busby, S.A.⁶ Garcia-Ordonez, R.D.⁷ Burris, T.P.⁸ Griffin, P.R.⁹

9
- 84869489534
- L.A. Solt, and T.P. Burris Trends Endocrinol. Metab. 23 2012 619
- (2012) Trends Endocrinol. Metab. , vol.23 , pp. 619
- Solt, L.A.¹ Burris, T.P.²

10
- 79955526989
- L.A. Solt, N. Kumar, P. Nuhant, Y. Wang, J.L. Lauer, J. Liu, M.A. Istrate, T.M. Kamenecka, W.R. Roush, D. Vidovic, S. Schurer, J. Xu, G. Wagoner, P.D. Drew, and P.R. Groffin Nature 472 2011 491
- (2011) Nature , vol.472 , pp. 491
- Solt, L.A.¹ Kumar, N.² Nuhant, P.³ Wang, Y.⁴ Lauer, J.L.⁵ Liu, J.⁶ Istrate, M.A.⁷ Kamenecka, T.M.⁸ Roush, W.R.⁹ Vidovic, D.¹⁰ Schurer, S.¹¹ Xu, J.¹² Wagoner, G.¹³ Drew, P.D.¹⁴ Groffin, P.R.¹⁵

11
- 79955639493
- N. Kumar, D.J. Kojetin, L.A. Solt, K.G. Kumar, P. Nuhant, D.R. Duckett, M.D. Cameron, A.A. Butler, W.R. Roush, P.R. Griffin, and T.P. Burris ACS Chem. Biol. 6 2011 218
- (2011) ACS Chem. Biol. , vol.6 , pp. 218
- Kumar, N.¹ Kojetin, D.J.² Solt, L.A.³ Kumar, K.G.⁴ Nuhant, P.⁵ Duckett, D.R.⁶ Cameron, M.D.⁷ Butler, A.A.⁸ Roush, W.R.⁹ Griffin, P.R.¹⁰ Burris, T.P.¹¹

12
- 84860176210
- N. Kumar, B. Lyda, M.R. Chang, J.L. Lauer, L.A. Solt, T.P. Burris, T.M. Kamenecka, and P.R. Griffin ACS Chem. Biol. 7 2012 672
- (2012) ACS Chem. Biol. , vol.7 , pp. 672
- Kumar, N.¹ Lyda, B.² Chang, M.R.³ Lauer, J.L.⁴ Solt, L.A.⁵ Burris, T.P.⁶ Kamenecka, T.M.⁷ Griffin, P.R.⁸

13
- 84871720718
- P.M. Khan, E. El-Gendy, N. Kumar, R. Garcia-Ordonez, L. Lin, C.H. Ruiz, M.D. Cameron, P.R. Griffin, and T.M. Kamenecka Bioorg. Med. Chem. Lett. 23 2013 532
- (2013) Bioorg. Med. Chem. Lett. , vol.23 , pp. 532
- Khan, P.M.¹ El-Gendy, E.² Kumar, N.³ Garcia-Ordonez, R.⁴ Lin, L.⁵ Ruiz, C.H.⁶ Cameron, M.D.⁷ Griffin, P.R.⁸ Kamenecka, T.M.⁹

14
- 79955538365
- J.R. Huh, M.W. Leung, P. Huang, D.A. Ryan, M.R. Krout, R.R. Malapaka, J. Chow, N. Manel, M. Ciofani, S.V. Kim, A. Cuesta, F.R. Santori, J.J. Lafaille, H.E. Xu, D.Y. Gin, F. Rastinejad, and D.R. Littman Nature 472 2011 486
- (2011) Nature , vol.472 , pp. 486
- Huh, J.R.¹ Leung, M.W.² Huang, P.³ Ryan, D.A.⁴ Krout, M.R.⁵ Malapaka, R.R.⁶ Chow, J.⁷ Manel, N.⁸ Ciofani, M.⁹ Kim, S.V.¹⁰ Cuesta, A.¹¹ Santori, F.R.¹² Lafaille, J.J.¹³ Xu, H.E.¹⁴ Gin, D.Y.¹⁵ Rastinejad, F.¹⁶ Littman, D.R.¹⁷

15
- 84892608180
- T. Yang, Q. Liu, Y. Cheng, W. Cai, Y. Ma, L. Yang, Q. Wu, L.A. Orband-Miller, L. Zhou, Z. Xiang, M. Huxdorf, W. Zhang, J. Zhang, J. Xiang, S. Leung, Y. Qiu, Z. Zhong, J.D. Elliott, X. Lin, and Y. Wang ACS Med. Chem. Lett. 5 2014 65
- (2014) ACS Med. Chem. Lett. , vol.5 , pp. 65
- Yang, T.¹ Liu, Q.² Cheng, Y.³ Cai, W.⁴ Ma, Y.⁵ Yang, L.⁶ Wu, Q.⁷ Orband-Miller, L.A.⁸ Zhou, L.⁹ Xiang, Z.¹⁰ Huxdorf, M.¹¹ Zhang, W.¹² Zhang, J.¹³ Xiang, J.¹⁴ Leung, S.¹⁵ Qiu, Y.¹⁶ Zhong, Z.¹⁷ Elliott, J.D.¹⁸ Lin, X.¹⁹ Wang, Y.²⁰ more..

16
- 65749104436
- S. Hosoda, D. Matsuda, H. Tomoda, and Y. Hashimoto Mini-Rev. Med. Chem. 9 2009 572
- (2009) Mini-Rev. Med. Chem. , vol.9 , pp. 572
- Hosoda, S.¹ Matsuda, D.² Tomoda, H.³ Hashimoto, Y.⁴

17
- 33646190044
- M. Kainuma, J. Kasuga, S. Hosoda, K. Wakabayashi, A. Tanatani, J. Nagasawa, H. Miyachi, M. Makishima, and Y. Hashimoto Bioorg. Med. Chem. Lett. 16 2006 3213
- (2006) Bioorg. Med. Chem. Lett. , vol.16 , pp. 3213
- Kainuma, M.¹ Kasuga, J.² Hosoda, S.³ Wakabayashi, K.⁴ Tanatani, A.⁵ Nagasawa, J.⁶ Miyachi, H.⁷ Makishima, M.⁸ Hashimoto, Y.⁹

18
- 67650077280
- K. Motoshima, T. Noguchi-Yachide, K. Sugita, Y. Hashimoto, and M. Ishikawa Bioorg. Med. Chem. 17 2009 5001
- (2009) Bioorg. Med. Chem. , vol.17 , pp. 5001
- Motoshima, K.¹ Noguchi-Yachide, T.² Sugita, K.³ Hashimoto, Y.⁴ Ishikawa, M.⁵

19
- 23944488815
- S. Hosoda, A. Tanatani, K. Wakabayashi, Y. Nakano, H. Miyachi, K. Nagasawa, and Y. Hashimoto Bioorg. Med. Chem. Lett. 15 2005 4327
- (2005) Bioorg. Med. Chem. Lett. , vol.15 , pp. 4327
- Hosoda, S.¹ Tanatani, A.² Wakabayashi, K.³ Nakano, Y.⁴ Miyachi, H.⁵ Nagasawa, K.⁶ Hashimoto, Y.⁷

20
- 33745604630
- S. Hosoda, A. Tanatani, K. Wakabayashi, M. Makishima, K. Imai, H. Miyachi, K. Nagasawa, and Y. Hashimoto Bioorg. Med. Chem. 14 2006 5489
- (2006) Bioorg. Med. Chem. , vol.14 , pp. 5489
- Hosoda, S.¹ Tanatani, A.² Wakabayashi, K.³ Makishima, M.⁴ Imai, K.⁵ Miyachi, H.⁶ Nagasawa, K.⁷ Hashimoto, Y.⁸

21
- 77958067460
- K. Maruyama, T. Noguchi-Yachide, K. Sugita, Y. Hashimoto, and M. Ishikawa Bioorg. Med. Chem. Lett. 20 2010 6661
- (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 6661
- Maruyama, K.¹ Noguchi-Yachide, T.² Sugita, K.³ Hashimoto, Y.⁴ Ishikawa, M.⁵

22
- 84879419936
- K. Maruyama, M. Nakamura, S. Tomoshige, K. Sugita, M. Makishima, Y. Hashimoto, and M. Ishikawa Bioorg. Med. Chem. Lett. 23 2013 4031
- (2013) Bioorg. Med. Chem. Lett. , vol.23 , pp. 4031
- Maruyama, K.¹ Nakamura, M.² Tomoshige, S.³ Sugita, K.⁴ Makishima, M.⁵ Hashimoto, Y.⁶ Ishikawa, M.⁷

23
- 75849160939
- A. Aoyama, H. Aoyama, K. Dodo, M. Makishima, Y. Hashimoto, and H. Miyachi Heterocycles 76 2008 137
- (2008) Heterocycles , vol.76 , pp. 137
- Aoyama, A.¹ Aoyama, H.² Dodo, K.³ Makishima, M.⁴ Hashimoto, Y.⁵ Miyachi, H.⁶

24
- 77950141363
- M. Nakamura, A. Aoyama, M. Salim, M. Okamoto, M. Baba, H. Miyachi, Y. Hashimoto, and H. Aoyama Bioorg. Med. Chem. 18 2010 2402
- (2010) Bioorg. Med. Chem. , vol.18 , pp. 2402
- Nakamura, M.¹ Aoyama, A.² Salim, M.³ Okamoto, M.⁴ Baba, M.⁵ Miyachi, H.⁶ Hashimoto, Y.⁷ Aoyama, H.⁸

25
- 79954422198
- H. Aoyama, K. Sugita, M. Nakamura, A. Aoyama, M. Salim, M. Okamoto, M. Baba, and Y. Hashimoto Bioorg. Med. Chem. 19 2011 2675
- (2011) Bioorg. Med. Chem. , vol.19 , pp. 2675
- Aoyama, H.¹ Sugita, K.² Nakamura, M.³ Aoyama, A.⁴ Salim, M.⁵ Okamoto, M.⁶ Baba, M.⁷ Hashimoto, Y.⁸

26
- 84888857603
- B.P. Fauber, G. Boenig, B. Burton, C. Eidenschenk, C. Everett, A. Gobbi, S.G. Hymowitz, A.R. Johnson, M. Liimatta, P. Lockey, M. Norman, W. Ouyang, O. Rene, and H. Wong Bioorg. Med. Chem. Lett. 23 2013 6604
- (2013) Bioorg. Med. Chem. Lett. , vol.23 , pp. 6604
- Fauber, B.P.¹ Boenig, G.² Burton, B.³ Eidenschenk, C.⁴ Everett, C.⁵ Gobbi, A.⁶ Hymowitz, S.G.⁷ Johnson, A.R.⁸ Liimatta, M.⁹ Lockey, P.¹⁰ Norman, M.¹¹ Ouyang, W.¹² Rene, O.¹³ Wong, H.¹⁴

27
- 84863718816
- T.J. Auvil, and A.E. Mattson Synthesis 44 2012 2173
- (2012) Synthesis , vol.44 , pp. 2173
- Auvil, T.J.¹ Mattson, A.E.²

28
- 84866306958
- A. Aoyama, K. Endo-Umeda, K. Kishida, K. Ohgane, T. Noguchi-Yachide, H. Aoyama, M. Ishikawa, H. Miyachi, M. Makishima, and Y. Hashimoto J. Med. Chem. 55 2012 7360
- (2012) J. Med. Chem. , vol.55 , pp. 7360
- Aoyama, A.¹ Endo-Umeda, K.² Kishida, K.³ Ohgane, K.⁴ Noguchi-Yachide, T.⁵ Aoyama, H.⁶ Ishikawa, M.⁷ Miyachi, H.⁸ Makishima, M.⁹ Hashimoto, Y.¹⁰

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.