Comparative risks of aldehyde constituents in cigarette smoke using transient computational fluid dynamics/physiologically based pharmacokinetic models of the rat and human respiratory tracts

Toxicological Sciences

Volumn 146, Issue 1, 2015, Pages 65-88

  Corley, Richard A ^a   Kabilan, Senthil ^a   Kuprat, Andrew P ^a   Carson, James P ^b   Jacob, Richard E ^a   Minard, Kevin R ^a   Teeguarden, Justin G ^a   Timchalk, Charles ^a   Pipavath, Sudhakar ^c   Glenny, Robb ^c   Einstein, Daniel R ^a  

^a PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Acetaldehyde; Acrolein; CFD; Cigarette smoke; Formaldehyde; PBPK; Respiratory tract; Risk assessment

Indexed keywords

ACETALDEHYDE; ACROLEIN; ALDEHYDE; CIGARETTE SMOKE; FORMALDEHYDE; SMOKE;

AIRWAY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREATHING; COMPUTATIONAL FLUID DYNAMICS; ENVIRONMENTAL EXPOSURE; GEOMETRY; HUMAN; HUMAN EXPERIMENT; NONHUMAN; RAT; RESPIRATORY SYSTEM; RISK ASSESSMENT; SMOKING; SPECIES DIFFERENCE; ANIMAL; BIOLOGICAL MODEL; COMPARATIVE STUDY; METABOLISM; SMOKE; TOBACCO;

RATTUS;

ALDEHYDES; ANIMALS; HUMANS; MODELS, BIOLOGICAL; RATS; SMOKE; TOBACCO;

EID: 84936762079     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfv071     Document Type: Article

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