Use of a pharmacokinetic-driven computational fluid dynamics model to predict nasal extraction of hydrogen sulfide in rats and humans

Toxicological Sciences

Volumn 94, Issue 2, 2006, Pages 359-367

  Schroeter, Jeffry D ^a   Kimbell, Julia S ^a   Andersen, Melvin E ^a   Dorman, David C ^a  

^a CIIT CENTERS FOR HEALTH RESEARCH   (United States)

Author keywords

Computational fluid dynamics; Hydrogen sulfide; Interspecies extrapolation; Nasal passages; Olfactory; Pharmacokinetics

Indexed keywords

HYDROGEN SULFIDE;

ARTICLE; BRAIN DAMAGE; BRAIN REGION; CHEMICAL REACTION KINETICS; COMPUTATIONAL FLUID DYNAMICS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; DIFFUSION; DOSIMETRY; ETHMOID SINUS; EXTRACTION; HUMAN; HYDROGEN SULFIDE REMOVAL; INCIDENCE; NONHUMAN; NOSE; NOSE AIRFLOW; NOSE CAVITY; OLFACTORY SYSTEM; PATHOLOGICAL ANATOMY; PREDICTION; RAT; RISK ASSESSMENT; SOLUBILITY; SPECIES COMPARISON; TISSUE LEVEL; TOXICOKINETICS;

AIR POLLUTANTS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYDROGEN SULFIDE; INHALATION EXPOSURE; MODELS, BIOLOGICAL; NASAL CAVITY; NASAL MUCOSA; RATS; SPECIES SPECIFICITY;

EID: 33751395464     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfl112     Document Type: Article

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