Aerosol deposition in the human lung periphery is increased by reduced-density gas breathing

Journal of Aerosol Medicine and Pulmonary Drug Delivery

Volumn 21, Issue 2, 2008, Pages 159-168

  Peterson, Jonathan B ^a   Prisk, G Kim ^a   Darquenne, Chantal ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

aerosol bolus inhalation; heliox; helium

Indexed keywords

HELIOX; HELIUM; OXYGEN;

ADULT; AEROSOL; ARTICLE; CLINICAL TRIAL; FEMALE; HUMAN; INHALATIONAL DRUG ADMINISTRATION; LUNG; MALE; METABOLISM; MIDDLE AGED; PARTICLE SIZE; TISSUE DISTRIBUTION;

ADMINISTRATION, INHALATION; ADULT; AEROSOLS; FEMALE; HELIUM; HUMANS; LUNG; MALE; MIDDLE AGED; OXYGEN; PARTICLE SIZE; TISSUE DISTRIBUTION;

EID: 48249123463     PISSN: 19412711     EISSN: 19412703     Source Type: Journal    
DOI: 10.1089/jamp.2007.0651     Document Type: Article

References (20)

1. Svartengren M, Anderson M, Philipson K, and Camner P: Human lung deposition of particles suspended in air or in helium/oxygen mixtures. Exp. Lung Res. 1989;15:575-585. (Pubitemid 19188927)
2. Anderson M, Svartengren M, Philipson K, and Camner P: Deposition in man of particles inhaled in air or helium-oxygen at different flow rates. J Aerosol Med. 1990;3:209-216.
3. Darquenne C, and Prisk GK: Aerosol deposition in the human respiratoy tract breathing air and 80:20 heliox. J Aerosol Med. 2004;17:278-285. (Pubitemid 39299329)
4. Westenberger S, Gebhart J, Jaser S, Knoch M, and Köstler R: A novel device for the generation and recording of aerosol micro-pulses in lung diagnostic. J Aerosol Sci. 1992;23:S449-S452. (Pubitemid 23634509)
5. Darquenne C, West JB, and Prisk GK: Dispersion of 0.5-2 m aerosol in micro- and hypergravity as a probe of convective inhomogeneity in the human lung. J Appl Physiol. 1999;86:1402-1409. (Pubitemid 29172178)
6. Darquenne C, and Prisk GK: Effect of small flow reversals on aerosol mixing in the alveolar region of the human lung. J Appl Physiol. 2004;97:2083-2089. (Pubitemid 39552446)
7. Darquenne C, West JB, and Prisk GK: Deposition and dispersion of 1 μm aerosol boluses in the human lung: effect of micro- and hypergravity. J Appl Physiol. 1998;85:1252-1259. (Pubitemid 28465049)
8. Heyder J, Blanchard JD, Feldman HA, and Brain JD: Convective mixing in human respiratory tract: estimates with aerosol boli. J Appl Physiol. 1988;64:1273-1278. (Pubitemid 18088553)
9. Blanchard JD: Aerosol bolus dispersion and aerosolderived airway morphometry: assessment of lung pathology and response to therapy, part 1. J Aerosol Med. 1996;9:183-205. (Pubitemid 26192805)
10. Mills CN, Darquenne C, and Prisk GK: Mode shift of an inhaled aerosol bolus is correlated with flow sequencing in the human lung. J Appl Physiol. 2002;92: 1232-1238. (Pubitemid 34670984)
11. Comer JK, Kleinstreuer C, and Kim CS: Flow structures and particle deposition patterns in double-bifurcation airway models. Part 2. Aerosol transport and deposition. J Fluid Mech. 2001;435:55-80. (Pubitemid 32526774)
12. Matida EA, Finlay WH, Breuer M, and Lange CF: Improving prediction of aerosol deposition in an idealized mouth using large-eddy simulation. J Aerosol Med. 2006;19:290-300. (Pubitemid 44735387)
13. West JB: Respiratory Physiology - The Essentials. Lippincott Williams & Wilkins, Baltimore, MD; 2000.
14. Dekker E: Transition between laminar and turbulent flow in human trachea. J Appl Physiol. 1961;16: 1060-1064.
15. Darquenne C, and Prisk GK: Aerosols in the study of convective acinar mixing. Respir Physiol Neurobiol. 2005;148:207-216. (Pubitemid 41132759)
16. Christopherson SK, and Hlastala MP: Pulmonary gas exchange during altered density gas breathing. J Appl Physiol. 1982;52:221-225. (Pubitemid 12041163)
17. Anderson PJ, Hardy KG, Gann LP, Cole R, and Hiller FC: Detection of small airway dysfunction in asymptomatic smokers using aerosol bolus behavior. Am J Respir Crit Care Med. 1994;150:995-1001. (Pubitemid 24318026)
18. Kleinstreuer C, and Zhang Z: Laminar-to-turbulent fluid-particle flows in a human airway model. Int J Multiphase Flow. 2003;29:271-289. (Pubitemid 36230269)
19. Anderson M, Svartengren M, Bylin G, Philipson K, and Camner P: Deposition in asthmatics of particles inhaled in air or in helium-oxygen. Am Rev Resp Dis. 1993;147:524-528. (Pubitemid 23072636)
20. Piva JP, Menna Barreto SS, Zelmanovitz F, Amantea S, and Cox P: Heliox versus oxygen for nebulized aerosol therapy in children with lower airway obstruction. Pediatr Crit Care Med. 2002;3:6-10.