Aerosol deposition in the human respiratory tract breathing air and 80:20 heliox

Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung

Volumn 17, Issue 3, 2004, Pages 278-285

  Darquenne, Chantal ^a   Prisk, G Kim ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Helium; Particles; Turbulent mixing

Indexed keywords

HELIOX; POLYSTYRENE;

ADULT; AEROSOL; ARTICLE; BREATHING; FEMALE; FLOW RATE; HUMAN; HUMAN EXPERIMENT; INHALATIONAL DRUG ADMINISTRATION; LUNG ALVEOLUS; MALE; NORMAL HUMAN; PARTICLE SIZE; PARTICULATE MATTER; PHOTOMETER; PNEUMOTACHYGRAPHY; TIDAL VOLUME; TURBULENT FLOW; UPPER RESPIRATORY TRACT;

ADULT; AEROSOLS; ANOXIA; FEMALE; HELIUM; HUMANS; INSPIRATORY CAPACITY; MALE; MIDDLE AGED; OXYGEN; PARTICLE SIZE; VITAL CAPACITY;

EID: 4644256226     PISSN: 08942684     EISSN: None     Source Type: Journal    
DOI: 10.1089/jam.2004.17.278     Document Type: Article

References (23)

1. Ultman, J. 1985. Gas transport in the conducting airways. In L.A. Engel and M. Paiva, eds. Gas Mixing and Distribution in the Lung. M. Dekker, New York, 63-136.
2. West, J.B., and P. Hugh-Jones. 1959. Patterns of gas flow in the upper-bronchial tree. J. Appl. Physiol. 14: 753-759.
3. Dekker, E. 1961. Transition between laminar and turbulent flow in human trachea. J. Appl. Physiol. 16: 1060-1064.
4. Svartengren, M., M. Anderson, K. Philipson, et al. 1989. Human lung deposition of particles suspended in air or in helium/oxygen mixtures. Exp. Lung Res. 15:575-585.
5. Anderson, M., M. Svartengren, K. Philipson, et al. 1990. Deposition in man of particles inhaled in air or helium-oxygen at different flow rates. J. Aerosol Med. 3:209-216.
6. Esch, J.L., D.M. Spektor, and M. Lippmann. 1988. Effect of lung airway branching pattern and gas composition on particle deposition. II. Experimental studies in human and canine lungs. Exp. Lung Res. 14: 321-348.
7. Swift, D.L., J.C. Carpin, and W. Mitzner. 1982. Pulmonary penetration and deposition of aerosols in different gases: fluid flow effects. Ann. Occup. Hyg. 26:109-117.
8. Darquenne, C., M. Paiva, J.B. West, et al. 1997. Effect of microgravity and hypergravity on deposition of 0.5- to 3-μm-diameter aerosol in the human lung. J. Appl. Physiol. 83:2029-2036.
9. Westenberger, S., J. Gebhart, S. Jaser, et al. 1992. A novel device for the generation and recording of aerosol micro-pulses in lung diagnostic. J. Aerosol Sci. 23:S449-S452.
10. Darquenne, C., J.B. West, and G.K. Prisk. 1999. Dispersion of 0.5-2 μm aerosol in micro- and hypergravity as a probe of convective inhomogeneity in the human lung. J. Appl. Physiol. 86:1402-1409.
11. Clarkson, D.P., C.L. Schatte, and J.P. Jordan. 1972. Thermal neutral temperature of rats in helium-oxygen, argon-oxygen, and air. Am. J. Physiol. 222:1494-1498.
12. Paganelli, C.V., and F.K. Kurata. 1977. Diffusion of water vapor in binary and ternary gas mixtures at increased pressures. Respir. Physiol. 30:15-26.
13. Chang, H.K. 1985. General concepts of molecular diffusion. In L.A. Engel, and M. Paiva, eds. Gas Mixing and Distribution in the Lung. M. Dekker, New York, 1-22.
14. Gebhart, J., Heigwer, G., Heyder, J., et al. 1998. The use of light scattering photometry in aerosol medicine. J. Aerosol Med. 1:89-112.
15. Heyder, J., J. Gebhart, G. Rudolf, et al. 1986. Deposition of particles in the human respiratory tract in the size range 0.0005-15 μm. J. Aerosol Sci. 17:811-825.
16. Hamill, P. 1979. Particle deposition due to turbulent diffusion in the upper respiratory system. Health Physics 36:355-369.
17. Jensen, A., H. Atileh, B. Suki, et al. 2001. Signal transduction in smooth muscle Selected Contribution: Airway caliber in healthy and asthmatic subjects: effects of bronchial challenge and deep inspirations. J. Appl. Physiol. 91:506-515.
18. Anderson, M., M. Svartengren, G. Bylin, et al. 1993. Deposition in asthmatics of particles inhaled in air or in helium-oxygen. Am. Rev. Respir. Dis. 147:524-528.
19. Schulz, H., A. Schulz, G. Eder, et al. 1995. Influence of gas composition on convective and diffusive intrapulmonary gas transport. Exp. Lung Res. 21:853-876.
20. Svartengren, M., P. Skogward, O. Nerbrink, et al. 1998. Regional deposition of inhaled Evans blue dye in mechanically ventilated rabbits with air or helium oxygen mixture. Exp. Lung Res. 24:159-172.
21. Kleinstreuer, C., and Z. Zhang. 2003. Laminar-to-turbulent fluid-particle flows in a human airway model. Int. J. Multiphase Flow 29:271-289.
22. Zhang, Z., and C. Kleinstreuer. 2003. Low-Reynolds-number turbulent flows in locally constricted conduits: a comparison study. AIAA J. 41:831-840.
23. Gemci, T., B. Shortall, G.M. Allen, et al. 2003. A CFD study of the throat during aerosol drug delivery using heliox and air. J. Aerosol Sci. 34:1175-1192.