Application of a new dosimetry program TAOCS to assess transient vapour absorption in the upper airways

Inhalation Toxicology

Volumn 22, Issue 13, 2010, Pages 1047-1063

  Tian, Geng ^a   Longest, P Worth ^a,b  

^a Virginia Commonwealth University   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Absorption of vapours; dosimetry codes; mucus absorption; multilayer diffusion; transient diffusion; transient flow fields; uptake of gases

Indexed keywords

ACETALDEHYDE; BENZENE;

ABSORPTION; ANALYTIC METHOD; ANALYTICAL EQUIPMENT; ARTICLE; BLOOD; COMPUTATIONAL FLUID DYNAMICS; DOSIMETRY; GEOMETRY; HUMAN; HUMAN TISSUE; MUCUS; PRIORITY JOURNAL; RESPIRATORY AIRFLOW; STEADY STATE; TISSUE; TRANSIENT ABSORPTION OF CHEMICAL SPECIES; UPPER RESPIRATORY TRACT; VAPOR;

ABSORPTION; AIR; BIOLOGICAL TRANSPORT; COMPUTER SIMULATION; DIFFUSION; GASES; HUMANS; HYDRODYNAMICS; MODELS, BIOLOGICAL; MUCUS; RADIOMETRY; RESPIRATORY SYSTEM;

EID: 78649279345     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.3109/08958378.2010.521783     Document Type: Article

References (39)

1. Aharonson EF, Menkes H, Gurtner G, Swift DL, Proctor DF. 1974. Efect of respiratory airfow rate on removal of soluble vapors by the nose. J Appl Physiol 37:654-657.
2. Anderson JC, Babb AL, Hlastala MP. 2003. Modeling soluble gas exchange in the airways and alveoli. Ann Biomed Eng 31:1402-1422.
3. Chang JC, Gross EA, Swenberg JA, Barrow CS. 1983. Nasal cavity deposition, histopathology, and cell proliferation after single or repeated formaldehyde exposures in B6C3F1 mice and F-344 rats. Toxicol Appl Pharmacol 68:161-176.
4. Hubal EA, Kimbell JS, Fedkiw PS. 1996a. Incorporation of nasal-lining mass-transfer resistance into a CFD model for prediction of ozone dosimetry in the upper respiratory tract. Inhal Toxicol 8:831-857.
5. Hubal EA, Fedkiw PS, Kimbell JS. 1996b. Mass-transport models to predict toxicity of inhaled gases in the upper respiratory tract. J Appl Physiol 80:1415-1427.
6. Hubal EA, Schlosser PM, Conolly RB, Kimbell JS. 1997. Comparison of inhaled formaldehyde dosimetry predictions with DNA-protein cross-link measurements in the rat nasal passages. Toxicol Appl Pharmacol 143:47-55.
7. Dahl AR, Snipes MB, Gerde P. 1991. Sites for uptake of inhaled vapors in beagle dogs. Toxicol Appl Pharmacol 109:263-275.
8. Frederick CB, Bush ML, Lomax LG, Black KA, Finch L, Kimbell JS, Morgan KT, Subramaniam RP, Morris JB, Ultman JS. 1998. Application of a hybrid computational fuid dynamics and physiologically based inhalation model for interspecies dosimetry extrapolation of acidic vapors in the upper airways. Toxicol Appl Pharmacol 152:211-231.
9. ICRP. 1994. Human Respiratory Tract Model for Radiological Protection, Elsevier Science Ltd., New York.
10. Karch SB, Peat M. 2007. Drug Abuse Handbook, CRC Press.
11. Keyhani K, Scherer PW, Mozell MM. 1997. A numerical model of nasal odorant transport for the analysis of human olfaction. J Teor Biol 186:279-301.
12. Kimbell JS, Gross EA, Joyner DR, Godo MN, Morgan KT. 1993. Application of computational fuid dynamics to regional dosimetry of inhaled chemicals in the upper respiratory tract of the rat. Toxicol Appl Pharmacol 121:253-263.
13. Kimbell JS, Overton JH, Subramaniam RP, Schlosser PM, Morgan KT, Conolly RB, Miller FJ. 2001. Dosimetry modeling of inhaled formaldehyde: binning nasal fux predictions for quantitative risk assessment. Toxicol Sci 64:111-121.
14. Kumagai S, Matsunaga I. 1995. Physiologically based pharmacokinetic model for acetone. Occup Environ Med 52:344-352.
15. La Belle CW, Long JE, Christofano EE. 1955. Synergistic efects of aerosols; par-ticulates as carriers of toxic vapors. AMA Arch Ind Health 11:297-304.
16. Longest PW, Xi J. 2007. Computational investigation of particle inertia efects on submicron aerosol deposition in the respiratory tract. J Aerosol Sci 38:111-130.
17. Madasu S, Borhan A, Ultman J. 2007. Gas uptake in a three-generation model geometry with a fat inlet velocity during steady inspiration: comparison of axisymmetric and three-dimensional models. Inhal Toxicol 19:495-503. (Pubitemid 46748126)
18. Martonen TB, Yang Y, Hwang D. 1994. Hygroscopic behaviour of secondary cigarette smoke in human nasal passages. S.T.P. Pharma Sci 4:69-76.
19. McClellan RO, Henderson RF. 1995. Concepts in Inhalation Toxicology, Taylor and Francis Ltd.
20. Miller FJ, Overton JH Jr, Jaskot RH, Menzel DB. 1985. A model of the regional uptake of gaseous pollutants in the lung. I. Te sensitivity of the uptake of ozone in the human lung to lower respiratory tract secretions and exercise. Toxicol Appl Pharmacol 79:11-27.
21. Morris JB, Cavanagh DG. 1986. Deposition of ethanol and acetone vapors in the upper respiratory tract of the rat. Fundam Appl Toxicol 6:78-88.
22. Morris JB, Cavanagh DG. 1987. Metabolism and deposition of propanol and acetone vapors in the upper respiratory tract of the hamster. Fundam Appl Toxicol 9:34-40.
23. Morris JB, Blanchard KT. 1992. Upper respiratory tract deposition of inspired acetaldehyde. Toxicol Appl Pharmacol 114:140-146.
24. NIST. 2008. NIST. Chemistry WebBook. http://webbook.NIST.gov/ chemistry/.
25. Overton JH, Graham RC, Miller FJ. 1987. A model of the regional uptake of gaseous pollutants in the lung. II. Te sensitivity of ozone uptake in laboratory animal lungs to anatomical and ventilatory parameters. Toxicol Appl Pharmacol 88:418-432.
26. Overton JH, Kimbell JS, Miller FJ. 2001. Dosimetry modeling of inhaled formaldehyde: the human respiratory tract. Toxicol Sci 64:122-134.
27. Padaki A, Ultman JS, Borhan A. 2009. Ozone uptake during inspiratory fow in a model of the larynx, trachea and primary bronchial bifurcation. Chem Eng Sci 64:4640-4648.
28. Press WH, Teukolsky SA, Vetterling W T, Flannery BP. 1996. Numerical Recipes in Fortran 77: Te Art of Scientifc Computing, Cambridge.University Press, Cambridge.
29. Scherer PW, Keyhani K, Mozell MM. 1994. Nasal dosimetry modeling for humans. Inhal Toxicol 6:85-97.
30. Taylor AB, Borhan A, Ultman JS. 2007. Tree-dimensional simulations of reactive gas uptake in single airway bifurcations. Ann Biomed Eng 35:235-249.
31. Tian G, Longest PW. 2010a. Transient absorption of inhaled vapors into a multilayer mucus-tissue-blood system. Ann Biomed Eng 38:517-536.
32. Tian G, Longest PW. 2010b. Development of a CFD boundary condition to model transient vapor absorption in the respiratory airways. J Biomech Eng 132:051003.
33. US Department of Environmental Quality. 1994. DEQ Remediation and Redevelopment Operational Memorandum. http://www.deq.state.mi.us/ documents/deq-rrd-OpMemo-1-Attachment1Table4ChemicalPhysical. pdf.
34. US Department of Health and Human Services. 2004. Te Health Consequences of Smoking: A Report of the Surgeon General, U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, Coordination Center for Health Promotion, National Center for Chronic Disease Prevention and Health Promotion, Ofce on Smoking and Health.
35. US Department of Health and Human Services. 2006. Te Health Consequences of Involuntary Exposure to Tobacco Smoke: A Report of the Surgeon General - Executive Summary, U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, Coordination Center for Health Promotion, National Center for Chronic Disease Prevention and Health Promotion, Ofce on Smoking and Health.
36. Weibel ER. 1963. Morphometry of the Human Lung, Springer Verlag, Berlin.
37. Wilcox DC. 1998. Turbulence Modeling for CFD, 2nd Ed., DCW Industries, Inc., California.
38. Xi J, Longest PW. 2007. Transport and deposition of micro-aerosols in realistic and simplifed models of the oral airway. Ann Biomed Eng 35:560-581.
39. Zhang Z, Kleinstreuer C, Kim CS. 2006. Transport and uptake of MTBE and eth-anol vapors in a human upper airway model. Inhal Toxicol 18:169-184.