Use of computational fluid dynamics models for dosimetry of inhaled gases in the nasal passages

Inhalation Toxicology

Volumn 13, Issue 5, 2001, Pages 325-334

  Kimbell, J S ^a   Subramaniam, R P ^a  

^a CIIT CENTERS FOR HEALTH RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACRYLIC ACID; FORMALDEHYDE; VINYL ACETATE;

ABSORPTION; ACCURACY; ADULT; AIRWAY; ARTICLE; DOSIMETRY; GAS TRANSPORT; HUMAN; MALE; MODEL; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY AIRFLOW; RISK ASSESSMENT; SIMULATION;

ANIMALIA; MACACA MULATTA; PRIMATES;

EID: 0035011346     PISSN: 08958378     EISSN: None     Source Type: Journal    
DOI: 10.1080/08958370151126185     Document Type: Article

References (27)

1. Inertial and gravitational deposition of particles in a square cross section bifurcating airway
2. Binding of formaldehyde to human and rat nasal mucus and bovine serum albumin
3. Analysis of vinyl acetate metabolism in rat and human nasal tissues by an in vitro gas uptake technique
4. A biologically based risk assessment for vinyl acetate-induced cancer and noncancer inhalation toxicity
5. A CFD-PBPK hybrid model for simulating gas and vapor uptake in the rat nose
6. Covalent binding of inhaled formaldehyde to DNA in the nasal mucosa of Fischer 344 rats: Analysis of formaldehyde and DNA by high-performance liquid chromatography and provisional pharmacokinetic interpretation
7. DNA-protein cross-links and cell replication at specific sites in the nose of F344 rats exposed subchronically to formaldehyde
8. Comparison of inhaled formaldehyde dosimetry predictions with DNA-protein cross-link measurements in the rat nasal passages
9. Application of a hybrid computational fluid dynamics and physiologically-based inhalation model for interspecies dosimetry extrapolation of acidic vapors in the upper airways
10. Velocity profiles measured for airflow through a large-scale model of the human nasal cavity
11. Computer simulation of inspiratory nasal airflow and inhaled gas uptake in a rhesus monkey
12. Application of computational fluid dynamics to regional dosimetry of inhaled chemicals in the upper respiratory tract of the rat
13. Computer simulation of inspiratory airflow in all regions of the F344 rat nasal passages
14. Correlation of regional formaldehyde flux predictions with the distribution of formaldehyde-induced squamous metaplasia in F344 rat nasal passages
15. Computer models of nasal airflow and inhaled gas uptake in the rat, monkey, and human: Implications for interspecies dosimetry
16. Nasal diagrams: A tool for recording the distribution of nasal lesions in rats and mice
17. Effects of formaldehyde gas on the respiratory tract of rhesus monkeys: Pathology and cell proliferation
18. Airflow, gas deposition, and lesion distribution in the nasal passages
19. Studies of inspiratory airflow patterns in the nasal passages of the F-344 rat and rhesus monkey using nasal molds: Relevance to formaldehyde toxicity
20. A physiologically-based pharmacokinetic model for nasal uptake and metabolism of nonreactive vapors
21. Retention of formaldehyde gas by the nasal passages of F-344 rats
22. Air currents in the upper respiratory tract and their clinical importance
23. Nasal dosimetry modeling for humans
24. Computational fluid dynamics simulations of inspiratory airflow in the human nose and nasopharynx