Results of a 28-month chronic inhalation toxicity study of formaldehyde in male fisher-344 rats

Journal of Toxicological Sciences

Volumn 22, Issue 3, 1997, Pages 239-254

  Kamata, Eiichi ^a   Nakadate, Masahiro ^a   Uchida, Osayuki ^a   Ogawa, Yukio ^a   Suzuki, Sachiko ^a   Kaneko, Toyozo ^a   Saito, Minoru ^a   Kurokawa, Yuji ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Benchmark dose; Fisher 344 rat; Formaldehyde; Inhalation toxicity study

Indexed keywords

FORMALDEHYDE;

ADOLESCENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CARCINOGENICITY; HISTOPATHOLOGY; INHALATION; LONG TERM EXPOSURE; MALE; NONHUMAN; NOSE TUMOR; RAT; TOXICITY TESTING;

ANIMALIA; MARTES PENNANTI;

EID: 0030773913     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.22.3_239     Document Type: Article

References (46)

1. Albert, R.E., Sellakumar, A.R., Laskin, S., Kuschneret, M., Norton, N. and Snyder, C.A. (1982) : Gaseous formaldehyde and hydrogen chloride induction of nasal cancer in the rat. J. Natl. Cancer Inst., 68, 597-603.
2. Appelman, L.M., Woultersen, R.A., Zwart, A., Falke, H.E. and Feron, V.J. (1988) : One-year inhalation toxicity study of formaldehyde in male rats with a damaged or undamaged nasal mucosa. J. Appl. Toxicol., 8, 85-90.
3. Barnes, D.G. and Dourson, M. (1988) : Reference dose (RfD):Description and use in health risk assessment. Regul. Toxicol. Pharmacol., 8, 471-486.
4. Baskerville, A., Thomas, G., Wood, M. and Harris, W.J. (1974) : histology and ultrastructure of metaplasia of alveolar epithelium following infection of mice and hamsters with influenza virus. Br. J. Exp. Path., 55, 130-137
5. Beall J.R. and Ulsamer A.G. (1984): Formaldehyde and hepatotoxicity: A Review. J. Toxicol. Environ. Health., 13. 1-21.
6. Brendel, V.R. (1964) : Untersuchungen an ratten zur Vertrablichkeit von hexamethylenetetramine. Arzneimittel. Forsch., 14, 51-53.
7. Burger, G.T., Renne, R.A., Sagartz, W.S., Ayres, P.H., Coggins, C.R.E., Mosberg, A.T. and Hayes, A.W. (1989) : Histologic changes in the respiratory tract induced by inhalation of xenobiotics: physiologic adaptation or toxicity?. Toxicol. Appl. Pharmacol., 101, 521-542.
8. Cone, J.E. and Shusterman, D. (1991) : Health effects of indoor odorants. Environ. Health Perspect., 95, 53-59.
9. Conolly, R.B., Andjelkovich. D.A., Casanova, M., Heck, H.d'A., Janszen, D.B., Kimbell, J.S., Morgan, K.T. and Recio, L. (1995) : Multidisciplinary, iterative examination of the mechanism of formaldehyde carcinogenicity: The basis for better risk assessment. CIIT Activities, 15, 2-11.
10. Cox, D.R. (1972) : regression models and life-tables. J.R. Statist.Soc., B34, 187-220.
11. Crumps, K., (1984) : A new methods for determining allowable daily intakes. Fundam. Appl. Toxicol., 4, 854-871.
12. Dalbey, W.E., Netteshelm, P., Griesemer, R., Caton, J.E. and Guerin, M. (1980) : Chronic inhalation of cigarette smoke by F344 rats. J. Natl. Cancer Inst., 64, 383-390.
13. ECETOC (1981) : Assessment of data on the effects of formaldehyde on humans. In Technical Report, No.1, pp.3, European Chemical Industry Ecology and Toxicology Center, Brussels.
14. Fishbein, L. and Henry, C.J. (1991) : introduction : Workshop on the methodology for assessing health risks from complex mixtures in indoor air. Environ. Health Perspect., 95, 3-5.
15. Fisher, R.A. (1955) : Statistical methods and scientific induction. J.R. Statist.Soc., B17, 69-78.
16. Hilton, J., Dearman, R.J., Basketter, D.A., Scholes, E.W. and Kimber, I. (1996) : Experimental assessment of the sensitizing properties of formaldehyde. Food. Chem. Toxicol., 34, 571-578.
17. JSOH (1996) : The recommendation of occupational exposure limits (1996-1997). J. Occup. Health, 38, 134-147.
18. Kamei, H., Yamamoto, T., Yoshida, T., Koroiwa, Y., Kawai, M., Kuroiwa, S., Koyama, M. and Kaneko, Y. (1981) : Toxicological studies on effects of formaldehyde on bronchial tissue. EISEI KAGAKU, 27, 356-362.
19. Kerns, W.D., Pavkov, K.L., Donofrio, D.J., Gralla, E.J. and Swenberg, J.A. (1983) : Carcinogenicity of formaldehyde in rats and mice after long-term inhalation exposure. Cancer Res., 43, 4382-4392
20. Kewitz, H. and Welsch, F. (1966) : Eingelber farbstoff aus formaldehyd und kynurenin bei hexaminbehandelten ratten. Naunyn. Schmiedebergs. Arch. Exp. Pathol. Pharmacol., 254, 101-108.
21. Kojima, S. Kaniwa, M. and Nakamura, A. (1982) : Investigation on the underlying principles of test methods for formaldehyde-release from plywoods and furnitures. EISEI KAGAKU, 28, 205-218.
22. Matsumura, T., Muramatsu, S. and Kametani, K. (1983) : Studies on indoor air pollution (III) - the concentration of formaldehyde in indoor air-, Japanese J. Public. Health, 30, 303-308.
23. NIOSH/OSHA (1980) : FOLMALDEHYDE: Evidence of Carcinogenicity. Current Intelligence Bulletin, 34, 5-6.
24. Oba, T., Nakamura, A., Kojima, S. and Mori, J. (1975) : The testing of chemical substances in household products. IYAKUHIN KENKYU, 6, 196-205.
25. Oishi, S., Oishi, H. and Hiraga, K. (1974) : The effect of food restriction for 4 weeks on common toxicity parameters in male rats. Toxicol. Appl. Pharmacol., 47, 15-22.
26. Rebell, G. (1966) : Kynurenine in rat hair. Nature, 26, 913-914.
27. Rusch G.M., Clary, J.J., Rinehart, W.E. and Boite, H.F. (1983) : A 26-week inhalation toxicity study with formaldehyde in the monkey, rat, and hamster. Toxicol. Appl. Pharmacol., 68, 329-343.
28. Sellakumar, A.R., Snyder C.A., Solomon, J.J. and Albert, R.E. (1985) : Carcinogenicity of formaldehyde and hydrogen chloride in rats. Toxicol. Appl. Pharmacol., 81, 401-406.
29. Sellakumar, A.R., Snyder C.A., Solomon, J.J. and Albert, R.E. (1985) : Carcinogenicity of formaldehyde and hydrogen chloride in rats. Toxicol. Appl. Pharmacol., 81, 401-406.
30. Shields, P.A. and jeffery, P.K. (1987) : The combined effects of vitamin A-deficiency and cigarette smoke on rat tracheal epithelium. Br. J. Exp. Path., 68, 705-717.
31. Strubelt, O., Younes, M., Pentz. R. and Kuhnel, W. (1989) : Mechanistic study on formaldehyde induced hepatotoxicity. J. Toxicol. Environ. Health, 27, 351-366.
32. Swenberg, J.A., Kerns, W.D., Mitchell, R.I., Gralla, E.J. and Pavkov, K.L. (1980) : Induction of squamous cell carcinomas of the rat nasal cavity by inhalation exposure to formaldehyde vapor. Cancer Res., 40, 3398-3402.
33. Til, H.P., Woutersen, R.A. and Feron, V.J. (1988) : Evaluation of the oral toxicity of acetaldehyde and formaldehyde in a 4-week drinking-water study in rats. Fd. Chem. Toxic., 26, 447-452.
34. Til, H.P., Woutersen, R.A., Feron, V.J., Hollanders, H.M. and Falke, H.E. (1989) : Two-year drinking-water study of formaldehyde in rats. Fd. Chem. Toxic., 27, 77-78.
35. Tobe. M., Naito. K. and Kurokawa. Y. (1989): Chronic toxicity study on formaldehyde administered orally to rats. Toxicology, 56, 79-86.
36. Watanabe, F., Matsunaga, T., Soejima, T. and Iwata, Y. (1954) : Study on the Carcinogenicity of aldehyde. 1st report. Experimentally produced rat sarcomas by repeated injections of aqueous solution of formaldehyde. GANN, 45, 451-452.
37. White, L.R., Marthinsen, A.B.L., Richards, R.J., Eik-nes, K.B. and Nilsen, O.G. (1983) : Biochemical and cytological studies of rat lung after inhalation of methanol vapour. Toxicology Letters, 17, 1-5.
38. WHO (1987): Air quality guidelines for Europe. In Regional Publications, European Series No.23, pp.91-104, World Health Organization, Copenhagen.
39. WHO (1994): Assessing human health risks of chemicals : derivation of guidance values for health-based exposure limits. In IPCS Environmental Health Criteria 170, pp.1-73, World Health Organization, Geneva.
40. WHO (1995): Application of risk analysis to food standards issues. In Report of the joint FAOAVHO Expert Consultation, pp. 17-18, World Health Organization, Geneva.
41. WHO (1996): Wood dust and formaldehyde. In IARC monographs on the evaluation of carcinogenic risks to humans 62, pp.217-362, World Health Organization, Lyon.
42. Woutersen, R.A., Appelman, L.M., Wilmer J.W.G.M., Falke, H.E. and Feron, V.J. (1987) : Subchronic (13-week) inhalation toxicity study of formaldehyde in rats. J. Appl. Toxicol., 7, 43-49.
43. Woutersen, R.A., Garderen-Hoetmer. A., Bruijntjes. J.P., Zwart, A. and Feron V.J. (1989) : Nasal tumours in rats after severe injury to the nasal mucosa and prolonged exposure to 10 ppm formaldehyde. J. Appl. Toxicol., 9, 39-46.
44. Yamate, N., Matsumura, T. and Tonomura, M. (1968) : Continuous determination of formaldehyde in the atmosphere. EISHI HOUKOKU, 86, 58-64.
45. Yamazaki, M., Noguchi, Y., Tanda, M. and Shintani, S. (1981) : Statistical methods appropriate for general toxicological studies in rats. Algorithms for multiple comparisons of treatment groups with control. J.Takeda Rec.Lab, 40, 163-187.
46. Yoshida, T. and Kayama, F. (1997) : Modulating effects of low dose of formaldehyde exposure on experimentally induced allergic responses in mice. Toxicologist, 36, 195.