A PBPK model for evaluating the impact of aldehyde dehydrogenase polymorphisms on comparative rat and human nasal tissue acetaldehyde dosimetry

Inhalation Toxicology

Volumn 20, Issue 4, 2008, Pages 375-390

  Teeguarden, Justin G ^a   Bogdanffy, Matthew S ^b   Covington, Tammie R ^c   Tan, Cecilia ^d   Jarabek, Annie M ^e  

^a PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

^b BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^c AIR FORCE RESEARCH LABORATORY   (United States)

^d HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

^e U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETALDEHYDE; ALDEHYDE DEHYDROGENASE ISOENZYME 2; PROTON;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOASSAY; CALIBRATION; CARCINOGENICITY; CHEMICAL ANALYSIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; DOSIMETRY; EVALUATION; FUNCTIONAL ANATOMY; GENETIC POLYMORPHISM; HOMOZYGOSITY; HUMAN; HUMAN TISSUE; HUMAN VERSUS ANIMAL COMPARISON; INHALATION; LONG TERM EXPOSURE; MODEL; NONHUMAN; NOSE; OLFACTORY EPITHELIUM; PHENOTYPE; PRIORITY JOURNAL; RAT; RESPIRATORY EPITHELIUM; RESPIRATORY SYSTEM; RISK ASSESSMENT; RODENT; SPECIES COMPARISON; STATISTICAL SIGNIFICANCE; TOXICOKINETICS; XENOBIOTIC METABOLISM;

ACETALDEHYDE; AIR POLLUTANTS, OCCUPATIONAL; ALDEHYDE DEHYDROGENASE; ANIMALS; COMPUTER SIMULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INHALATION EXPOSURE; MITOCHONDRIAL PROTEINS; MODELS, BIOLOGICAL; NASAL CAVITY; NASAL MUCOSA; POLYMORPHISM, GENETIC; RATS;

RATTUS; RODENTIA;

EID: 39849097295     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.1080/08958370801903750     Document Type: Article

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