메뉴 건너뛰기




Volumn 6, Issue JUN, 2015, Pages

How does thymus infection by coxsackievirus contribute to the pathogenesis of type 1 diabetes?

Author keywords

Coxsackievirus; Enterovirus; Insulin family; Insulin like growth factor 2; Self tolerance; Thymus; Type 1 diabetes

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 6; SOMATOMEDIN B;

EID: 84935139810     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2015.00338     Document Type: Short Survey
Times cited : (16)

References (62)
  • 1
    • 79551469699 scopus 로고    scopus 로고
    • Genetics of type 1 diabetes
    • Steck AK, Rewers MJ. Genetics of type 1 diabetes. Clin Chem (2011) 57:176-85. doi:10.1373/clinchem.2010.148221
    • (2011) Clin Chem , vol.57 , pp. 176-185
    • Steck, A.K.1    Rewers, M.J.2
  • 2
    • 20244384697 scopus 로고
    • A prospective role of coxsackie B and enterovirus infections in the pathogenesis of IDDM Childhood Diabetes in Finland (DiMe) Study Group
    • Hyöti H, Hiltunen M, Knip M, Laakonen M, Vähäsalo P, Karjalainen J, et al. A prospective role of coxsackie B and enterovirus infections in the pathogenesis of IDDM. Childhood Diabetes in Finland (DiMe) Study Group. Diabetes (1995) 44:652-67. doi:10.2337/diabetes.44.6.652
    • (1995) Diabetes , vol.44 , pp. 652-667
    • Hyöti, H.1    Hiltunen, M.2    Knip, M.3    Laakonen, M.4    Vähäsalo, P.5    Karjalainen, J.6
  • 3
    • 79951983776 scopus 로고    scopus 로고
    • Enterovirus infection and type 1 diabetes mellitus: systematic review and meta-analysis of observational molecular studies
    • Yeung WC, Rawlinson WD, Craig ME. Enterovirus infection and type 1 diabetes mellitus: systematic review and meta-analysis of observational molecular studies. BMJ (2011) 342:d35. doi:10.1136/bmj.d35
    • (2011) BMJ , vol.342 , pp. d35
    • Yeung, W.C.1    Rawlinson, W.D.2    Craig, M.E.3
  • 4
    • 84893045342 scopus 로고    scopus 로고
    • VirDiab Study Group. Virus antibody survey in different European populations indicates risk association between coxsackievirus B1 and type 1 diabetes
    • Oikarinen S, Tauriainen S, Hober D, Lucas B, Vazeou A, Sioofy-Khojine A, et al. VirDiab Study Group. Virus antibody survey in different European populations indicates risk association between coxsackievirus B1 and type 1 diabetes. Diabetes (2014) 63:655-62. doi:10.2337/db13-0620
    • (2014) Diabetes , vol.63 , pp. 655-662
    • Oikarinen, S.1    Tauriainen, S.2    Hober, D.3    Lucas, B.4    Vazeou, A.5    Sioofy-Khojine, A.6
  • 5
    • 57149101123 scopus 로고    scopus 로고
    • Role of coxsackievirus B4 in the pathogenesis of type 1 diabetes
    • Jaïdane H, Hober D. Role of coxsackievirus B4 in the pathogenesis of type 1 diabetes. Diabetes Metab (2008) 34:537-48. doi:10.1016/j.diabet.2008.05.008
    • (2008) Diabetes Metab , vol.34 , pp. 537-548
    • Jaïdane, H.1    Hober, D.2
  • 6
    • 77951666052 scopus 로고    scopus 로고
    • Pathogenesis of type 1 diabetes mellitus: interplay between enterovirus and host
    • Hober D, Sauter P. Pathogenesis of type 1 diabetes mellitus: interplay between enterovirus and host. Nat Rev Endocrinol (2010) 6:279-89. doi:10.1038/nrendo.2010.27
    • (2010) Nat Rev Endocrinol , vol.6 , pp. 279-289
    • Hober, D.1    Sauter, P.2
  • 7
    • 77956640135 scopus 로고    scopus 로고
    • Enteroviruses and type 1 diabetes: towards a better understanding of the relationship
    • Jaïdane H, Sauter P, Sane F, Goffard A, Gharbi J, Hober D. Enteroviruses and type 1 diabetes: towards a better understanding of the relationship. Rev Med Virol (2010) 20:265-80. doi:10.1002/rmv.647
    • (2010) Rev Med Virol , vol.20 , pp. 265-280
    • Jaïdane, H.1    Sauter, P.2    Sane, F.3    Goffard, A.4    Gharbi, J.5    Hober, D.6
  • 8
    • 0034120066 scopus 로고    scopus 로고
    • Increased level of interferon-alpha in blood of patients with insulin-dependent diabetes mellitus: relationship with coxsackie B virus infection
    • Chehadeh W, Weill J, Vantyghem MC, Alm G, Lefebvre J, Wattré P, et al. Increased level of interferon-alpha in blood of patients with insulin-dependent diabetes mellitus: relationship with coxsackie B virus infection. J Infect Dis (2000) 181:1929-39. doi:10.1086/315516
    • (2000) J Infect Dis , vol.181 , pp. 1929-1939
    • Chehadeh, W.1    Weill, J.2    Vantyghem, M.C.3    Alm, G.4    Lefebvre, J.5    Wattré, P.6
  • 9
    • 0033779186 scopus 로고    scopus 로고
    • Persistent infection of human pancreatic islets by coxsackievirus B is associated with alpha-interferon synthesis in beta cells
    • Chehadeh W, Kerr-Conte J, Patou F, Alm G, Lefebvre J, Wattré P, et al. Persistent infection of human pancreatic islets by coxsackievirus B is associated with alpha-interferon synthesis in beta cells. J Virol (2000) 74:10153-64. doi:10.1128/JVI.74.21.10153-10164.2000
    • (2000) J Virol , vol.74 , pp. 10153-10164
    • Chehadeh, W.1    Kerr-Conte, J.2    Patou, F.3    Alm, G.4    Lefebvre, J.5    Wattré, P.6
  • 10
    • 0036883660 scopus 로고    scopus 로고
    • Complete nucleotide sequence of a coxsackievirus B4 strain capable of establishing persistent infection in human pancreatic islets: effects on insulin release, proinsulin synthesis, and cell morphology
    • Yin H, Berg AK, Westman J, Hellerström C, Frisk G. Complete nucleotide sequence of a coxsackievirus B4 strain capable of establishing persistent infection in human pancreatic islets: effects on insulin release, proinsulin synthesis, and cell morphology. J Med Virol (2002) 68:544-7. doi:10.1002/jmv.10236
    • (2002) J Med Virol , vol.68 , pp. 544-547
    • Yin, H.1    Berg, A.K.2    Westman, J.3    Hellerström, C.4    Frisk, G.5
  • 12
    • 0036141519 scopus 로고    scopus 로고
    • Presented antigen from damaged pancreatic beta cells activates autoreactive T cells in virus-mediated autoimmune diabetes
    • Horwitz MS, Ilic A, Fine C, Rodriguez E, Sarvetnick N. Presented antigen from damaged pancreatic beta cells activates autoreactive T cells in virus-mediated autoimmune diabetes. J Clin Invest (2002) 109:79-87. doi:10.1172/JCI0211198
    • (2002) J Clin Invest , vol.109 , pp. 79-87
    • Horwitz, M.S.1    Ilic, A.2    Fine, C.3    Rodriguez, E.4    Sarvetnick, N.5
  • 13
    • 34247627376 scopus 로고    scopus 로고
    • Coxsackie B4 virus infection of b cells and natural killer cell insulitis in recent-onset type 1 diabetic patients
    • Dotta F, Censini S, van Halteren AGS, Marselli L, Masini M, Dionisi S, et al. Coxsackie B4 virus infection of β cells and natural killer cell insulitis in recent-onset type 1 diabetic patients. Proc Natl Acad Sci U S A (2007) 104:5115-20. doi:10.1073/pnas.0700442104
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 5115-5120
    • Dotta, F.1    Censini, S.2    van Halteren, A.G.S.3    Marselli, L.4    Masini, M.5    Dionisi, S.6
  • 14
    • 84935135565 scopus 로고    scopus 로고
    • Enterovrus persistence as a mechanism in the pathogenesis of type 1 diabetes
    • Alidjinou EK, Sané F, Engelmann I, Geenen V, Hober D. Enterovrus persistence as a mechanism in the pathogenesis of type 1 diabetes. Discov Med (2014) 18:273-82.
    • (2014) Discov Med , vol.18 , pp. 273-282
    • Alidjinou, E.K.1    Sané, F.2    Engelmann, I.3    Geenen, V.4    Hober, D.5
  • 15
    • 84933544989 scopus 로고    scopus 로고
    • Detection of a low-grade enteroviral infection in the islets of Langerhans of living patients newly diagnosed with type 1 diabetes
    • Krogvold L, Bjorn E, Buanes T, Frisk G, Skog O, Anagandula M, et al. Detection of a low-grade enteroviral infection in the islets of Langerhans of living patients newly diagnosed with type 1 diabetes. Diabetes (2015) 64:1682-7. doi:10.2337/db14-1370
    • (2015) Diabetes , vol.64 , pp. 1682-1687
    • Krogvold, L.1    Bjorn, E.2    Buanes, T.3    Frisk, G.4    Skog, O.5    Anagandula, M.6
  • 16
    • 17844387429 scopus 로고    scopus 로고
    • OAS1 splice site polymorphism controlling antiviral enzyme activity influences susceptibility to type 1 diabetes
    • Field LL, Bonnevie-Nielsen V, Pociot F, Lu S, Nielsen TB, Beck-Nielsen H. OAS1 splice site polymorphism controlling antiviral enzyme activity influences susceptibility to type 1 diabetes. Diabetes (2005) 54:1588-91. doi:10.2337/diabetes.54.5.1588
    • (2005) Diabetes , vol.54 , pp. 1588-1591
    • Field, L.L.1    Bonnevie-Nielsen, V.2    Pociot, F.3    Lu, S.4    Nielsen, T.B.5    Beck-Nielsen, H.6
  • 17
    • 33745240931 scopus 로고    scopus 로고
    • A genome-vide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region
    • Smyth DJ, Cooper JD, Bailey R, Field S, Burren O, Smink LJ, et al. A genome-vide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region. Nat Genet (2006) 38:617-9. doi:10.1038/ng1800
    • (2006) Nat Genet , vol.38 , pp. 617-619
    • Smyth, D.J.1    Cooper, J.D.2    Bailey, R.3    Field, S.4    Burren, O.5    Smink, L.J.6
  • 18
    • 0027450835 scopus 로고
    • Thymus epithelium induces tissue-specific tolerance
    • Bonomo A, Matzinger P. Thymus epithelium induces tissue-specific tolerance. J Exp Med (1993) 177:1153-64. doi:10.1084/jem.177.4.1153
    • (1993) J Exp Med , vol.177 , pp. 1153-1164
    • Bonomo, A.1    Matzinger, P.2
  • 19
    • 0029898286 scopus 로고    scopus 로고
    • The thymic repertoire of neuroendocrine self-antigens: physiological implications in T-cell life and death
    • Martens H, Goxe B, Geenen V. The thymic repertoire of neuroendocrine self-antigens: physiological implications in T-cell life and death. Immunol Today (1996) 17:312-7. doi:10.1016/0167-5699(96)10023-2
    • (1996) Immunol Today , vol.17 , pp. 312-317
    • Martens, H.1    Goxe, B.2    Geenen, V.3
  • 20
    • 84888789419 scopus 로고    scopus 로고
    • Programming of neuroendocrine self in the thymus and its defect in the development of neuroendocrine autoimmunity
    • Geenen V, Bodart G, Henry S, Michaux H, Dardenne O, Charlet-Renard C, et al. Programming of neuroendocrine self in the thymus and its defect in the development of neuroendocrine autoimmunity. Front Neurosci (2013) 7:187. doi:10.3389/fnins.2013.00187
    • (2013) Front Neurosci , vol.7 , pp. 187
    • Geenen, V.1    Bodart, G.2    Henry, S.3    Michaux, H.4    Dardenne, O.5    Charlet-Renard, C.6
  • 21
    • 33646165128 scopus 로고    scopus 로고
    • The central role of central tolerance
    • Kyewski B, Klein L. The central role of central tolerance. Annu Rev Immunol (2006) 24:571-605. doi:10.1146/annurev.immunol.23.021704.115601
    • (2006) Annu Rev Immunol , vol.24 , pp. 571-605
    • Kyewski, B.1    Klein, L.2
  • 22
    • 0037112047 scopus 로고    scopus 로고
    • Projection of an immunological self shadow in the thymus by the Aire protein
    • Anderson MS, Venanzi ES, Klein L, Chen Z, Berzin SP, Turley SJ, et al. Projection of an immunological self shadow in the thymus by the Aire protein. Science (2002) 298:1395-401. doi:10.1126/science.1075958
    • (2002) Science , vol.298 , pp. 1395-1401
    • Anderson, M.S.1    Venanzi, E.S.2    Klein, L.3    Chen, Z.4    Berzin, S.P.5    Turley, S.J.6
  • 23
    • 84926680474 scopus 로고    scopus 로고
    • Promiscuous gene expression in the thymus: a matter of epigenetics, miRNA and more?
    • Ucar O, Rattay K. Promiscuous gene expression in the thymus: a matter of epigenetics, miRNA and more? Front Immunol (2015) 6:93. doi:10.3389/fimmu.2015.00093
    • (2015) Front Immunol , vol.6 , pp. 93
    • Ucar, O.1    Rattay, K.2
  • 24
    • 0020067836 scopus 로고
    • Neonatal thymectomy prevents spontaneous diabetes in the BB:W rat
    • Like AA, Kislaukis E, Williams RM, Rossini AA. Neonatal thymectomy prevents spontaneous diabetes in the BB:W rat. Science (1982) 216:644-6. doi:10.1126/science.7041259
    • (1982) Science , vol.216 , pp. 644-646
    • Like, A.A.1    Kislaukis, E.2    Williams, R.M.3    Rossini, A.A.4
  • 25
    • 0028816927 scopus 로고
    • Induction of insulitis in athymic (nude) mice The effect of NOD thymus and pancreas transplantation
    • Georgiou HM, Bellgrau D. Induction of insulitis in athymic (nude) mice. The effect of NOD thymus and pancreas transplantation. Diabetes (1995) 44:49-59. doi:10.2337/diabetes.44.1.49
    • (1995) Diabetes , vol.44 , pp. 49-59
    • Georgiou, H.M.1    Bellgrau, D.2
  • 26
    • 0030999992 scopus 로고    scopus 로고
    • Abnormal T cell selection on nod thymic epithelium is sufficient to induce autoimmune manifestations in C57BL/6 athymic nude mice
    • Thomas-Vaslin V, Damotte D, Coltey M, Le Douarin NM, Coutinho A, Salaün J. Abnormal T cell selection on nod thymic epithelium is sufficient to induce autoimmune manifestations in C57BL/6 athymic nude mice. Proc Natl Acad Sci U S A (1997) 94:4598-603. doi:10.1073/pnas.94.9.4598
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 4598-4603
    • Thomas-Vaslin, V.1    Damotte, D.2    Coltey, M.3    Le Douarin, N.M.4    Coutinho, A.5    Salaün, J.6
  • 27
    • 0035175577 scopus 로고    scopus 로고
    • A defect in central tolerance in NOD mice
    • Kishimoto H, Sprent J. A defect in central tolerance in NOD mice. Nat Immunol (2001) 2:1025-31. doi:10.1038/ni726
    • (2001) Nat Immunol , vol.2 , pp. 1025-1031
    • Kishimoto, H.1    Sprent, J.2
  • 28
    • 15244338878 scopus 로고    scopus 로고
    • Defective central tolerance induction in NOD mice: genomics and genetics
    • Zucchelli S, Holler P, Yamagata T, Roy M, Benoist C, Mathis D. Defective central tolerance induction in NOD mice: genomics and genetics. Immunity (2005) 22:385-96. doi:10.1016/j.immuni.2005.01.015
    • (2005) Immunity , vol.22 , pp. 385-396
    • Zucchelli, S.1    Holler, P.2    Yamagata, T.3    Roy, M.4    Benoist, C.5    Mathis, D.6
  • 29
    • 84860387854 scopus 로고    scopus 로고
    • Thymic negative selection is functional in NOD mice
    • Mingueneau M, Jiand W, Feuerer M, Mathis D, Benoist C. Thymic negative selection is functional in NOD mice. J Exp Med (2012) 209:623-37. doi:10.1084/jem.20112593
    • (2012) J Exp Med , vol.209 , pp. 623-637
    • Mingueneau, M.1    Jiand, W.2    Feuerer, M.3    Mathis, D.4    Benoist, C.5
  • 31
    • 0031018819 scopus 로고    scopus 로고
    • Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus
    • Vafiadis P, Bennett ST, Todd JA, Nadeau J, Grabs R, Goodyer CG, et al. Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus. Nat Genet (1997) 15:289-92. doi:10.1038/ng0397-289
    • (1997) Nat Genet , vol.15 , pp. 289-292
    • Vafiadis, P.1    Bennett, S.T.2    Todd, J.A.3    Nadeau, J.4    Grabs, R.5    Goodyer, C.G.6
  • 32
    • 18244421874 scopus 로고    scopus 로고
    • The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes
    • Pugliese A, Zeller M, Fernandez A Jr, Zalcberg LJ, Bartlett RJ, Ricordi C, et al. The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes. Nat Genet (1997) 15:293-7. doi:10.1038/ng0397-293
    • (1997) Nat Genet , vol.15 , pp. 293-297
    • Pugliese, A.1    Zeller, M.2    Fernandez Jr, A.3    Zalcberg, L.J.4    Bartlett, R.J.5    Ricordi, C.6
  • 33
    • 27844563909 scopus 로고    scopus 로고
    • Insulin alleles and autoimmune regulator (AIRE) gene both influence insulin expression in the thymus
    • Sabater L, Ferrer-Francesch X, Sospedra M, Caro P, Juan M, Pujol-Borrell R. Insulin alleles and autoimmune regulator (AIRE) gene both influence insulin expression in the thymus. J Autoimmun (2005) 25:312-8. doi:10.1016/j.aut.2005.08.006
    • (2005) J Autoimmun , vol.25 , pp. 312-318
    • Sabater, L.1    Ferrer-Francesch, X.2    Sospedra, M.3    Caro, P.4    Juan, M.5    Pujol-Borrell, R.6
  • 35
    • 0041335584 scopus 로고    scopus 로고
    • Evidence for a primary islet autoantigen (proinsulin 1) for insulitis and diabetes in the nonobese diabetic mice
    • Moriyama H, Abiru N, Paronen J, Sikora K, Liu E, Miao D, et al. Evidence for a primary islet autoantigen (proinsulin 1) for insulitis and diabetes in the nonobese diabetic mice. Proc Natl Acad Sci U S A (2003) 100:10376-81. doi:10.1073/pnas.1834450100
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 10376-10381
    • Moriyama, H.1    Abiru, N.2    Paronen, J.3    Sikora, K.4    Liu, E.5    Miao, D.6
  • 36
    • 18744366947 scopus 로고    scopus 로고
    • Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice
    • Nakayama M, Abiru N, Moriyama H, Babaya N, Liu E, Miao D, et al. Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice. Nature (2005) 435:220-3. doi:10.1038/nature03523
    • (2005) Nature , vol.435 , pp. 220-223
    • Nakayama, M.1    Abiru, N.2    Moriyama, H.3    Babaya, N.4    Liu, E.5    Miao, D.6
  • 37
    • 18744385526 scopus 로고    scopus 로고
    • Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope
    • Kent SC, Chen Y, Bregoli L, Clemmings SM, Kenyon NS, Ricordi C, et al. Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope. Nature (2005) 435:224-8. doi:10.1038/nature03625
    • (2005) Nature , vol.435 , pp. 224-228
    • Kent, S.C.1    Chen, Y.2    Bregoli, L.3    Clemmings, S.M.4    Kenyon, N.S.5    Ricordi, C.6
  • 38
    • 70349194383 scopus 로고    scopus 로고
    • Thymus-specific deletion of insulin induces autoimmune diabetes
    • Fan Y, Rudert WA, Grupillo M, He J, Sisino G, Trucco M. Thymus-specific deletion of insulin induces autoimmune diabetes. EMBO J (2009) 28:2812-24. doi:10.1038/emboj.2009.212
    • (2009) EMBO J , vol.28 , pp. 2812-2824
    • Fan, Y.1    Rudert, W.A.2    Grupillo, M.3    He, J.4    Sisino, G.5    Trucco, M.6
  • 39
    • 77957584132 scopus 로고    scopus 로고
    • Insulin transactivator MafA regulates intrathymic transcription of insulin and affects susceptibility to type 1 diabetes
    • Noso S, Kataoka K, Kawabata Y, Babaya N, Hiromine Y, Yamaji K, et al. Insulin transactivator MafA regulates intrathymic transcription of insulin and affects susceptibility to type 1 diabetes. Diabetes (2010) 59:2579-87. doi:10.2337/db10-0476
    • (2010) Diabetes , vol.59 , pp. 2579-2587
    • Noso, S.1    Kataoka, K.2    Kawabata, Y.3    Babaya, N.4    Hiromine, Y.5    Yamaji, K.6
  • 41
    • 84885130819 scopus 로고    scopus 로고
    • Autoimmunity against INS-IGF2 protein expressed in human pancreatic islets
    • Kanatsuma N, Taneera J, Vaziri-Sani F, Wierup N, Larsson HE, Delli A, et al. Autoimmunity against INS-IGF2 protein expressed in human pancreatic islets. J Biol Chem (2013) 288:29013-23. doi:10.1074/jbc.M113.478222
    • (2013) J Biol Chem , vol.288 , pp. 29013-29023
    • Kanatsuma, N.1    Taneera, J.2    Vaziri-Sani, F.3    Wierup, N.4    Larsson, H.E.5    Delli, A.6
  • 42
    • 33645779272 scopus 로고    scopus 로고
    • Dendritic cell differentiation and tolerance to insulin-related peptides in Igf2-deficient mice
    • Hansenne I, Charlet-Renard C, Greimers R, Geenen V. Dendritic cell differentiation and tolerance to insulin-related peptides in Igf2-deficient mice. J Immunol (2006) 176:4651-7. doi:10.4049/jimmunol.176.8.4651
    • (2006) J Immunol , vol.176 , pp. 4651-4657
    • Hansenne, I.1    Charlet-Renard, C.2    Greimers, R.3    Geenen, V.4
  • 43
    • 14544305615 scopus 로고    scopus 로고
    • The Belgian diabetes registry. An insulin-like growth factor 2-derived self-antigen inducing a regulatory cytokine profile to peripheral blood mononuclear cells from DQ8+ type 1 diabetic adolescents: preliminary design of a thymus-based tolerogenic self-vaccination
    • Geenen V, Louis C, Martens H. The Belgian diabetes registry. An insulin-like growth factor 2-derived self-antigen inducing a regulatory cytokine profile to peripheral blood mononuclear cells from DQ8+ type 1 diabetic adolescents: preliminary design of a thymus-based tolerogenic self-vaccination. Ann N Y Acad Sci (2004) 1037:59-64. doi:10.1196/annals.1337.008
    • (2004) Ann N Y Acad Sci , vol.1037 , pp. 59-64
    • Geenen, V.1    Louis, C.2    Martens, H.3
  • 44
    • 84901782665 scopus 로고    scopus 로고
    • Insulin-like growth factor 2 enhances regulatory T-cell functions and suppresses food allergy in an experimental model
    • Yang G, Geng XR, Song JP, Wu Y, Yan H, Zhan Z, et al. Insulin-like growth factor 2 enhances regulatory T-cell functions and suppresses food allergy in an experimental model. J Allergy ClinImmunol (2014) 133:1702-8. doi:10.1016/j.jaci.2014.02.019
    • (2014) J Allergy ClinImmunol , vol.133 , pp. 1702-1708
    • Yang, G.1    Geng, X.R.2    Song, J.P.3    Wu, Y.4    Yan, H.5    Zhan, Z.6
  • 45
    • 84903444205 scopus 로고    scopus 로고
    • Insulin-like growth factor 2 enhances functions of antigen (Ag)-specific regulatory B cells
    • Geng XR, Yang G, Li M, Song JP, Liu ZQ, Qiu S, et al. Insulin-like growth factor 2 enhances functions of antigen (Ag)-specific regulatory B cells. J Biol Chem (2014) 289:17941-50. doi:10.1074/jbc.M113.515262
    • (2014) J Biol Chem , vol.289 , pp. 17941-17950
    • Geng, X.R.1    Yang, G.2    Li, M.3    Song, J.P.4    Liu, Z.Q.5    Qiu, S.6
  • 46
    • 0034463082 scopus 로고    scopus 로고
    • Involvement of insulin-like growth factors in early T cell development: a study using fetal thymic organ cultures
    • Kecha O, Brilot F, Martens H, Franchimont N, Renard C, Greimers R, et al. Involvement of insulin-like growth factors in early T cell development: a study using fetal thymic organ cultures. Endocrinology (2000) 141:1209-17. doi:10.210/en.141.3.1209
    • (2000) Endocrinology , vol.141 , pp. 1209-1217
    • Kecha, O.1    Brilot, F.2    Martens, H.3    Franchimont, N.4    Renard, C.5    Greimers, R.6
  • 47
    • 84907075824 scopus 로고    scopus 로고
    • The late endosomal transporter CD222 directs the spatial distribution and activity of Lck
    • Pfister K, Forster F, Paster W, Supper V, Ohradanova-Repic A, Eckerstorfer P, et al. The late endosomal transporter CD222 directs the spatial distribution and activity of Lck. J Immunol (2014) 193:2718-32. doi:10.4049/jimmunol.1303349
    • (2014) J Immunol , vol.193 , pp. 2718-2732
    • Pfister, K.1    Forster, F.2    Paster, W.3    Supper, V.4    Ohradanova-Repic, A.5    Eckerstorfer, P.6
  • 48
    • 77955282695 scopus 로고    scopus 로고
    • Thymic self-antigens for the design of a negative/tolerogenic self-vaccination against type 1 diabetes
    • Geenen V, Mottet M, Dardenne O, Kermani H, Martens H, Francois JM, et al. Thymic self-antigens for the design of a negative/tolerogenic self-vaccination against type 1 diabetes. Curr Opin Pharmacol (2010) 10:461-72. doi:10.1016/j.coph.2010.04.005
    • (2010) Curr Opin Pharmacol , vol.10 , pp. 461-472
    • Geenen, V.1    Mottet, M.2    Dardenne, O.3    Kermani, H.4    Martens, H.5    Francois, J.M.6
  • 49
    • 0036232787 scopus 로고    scopus 로고
    • Persistent infection of human thymic epithelial cells by coxsackievirus B4
    • Brilot F, Chehadeh W, Charlet-Renard C, Martens H, Geenen V, Hober D. Persistent infection of human thymic epithelial cells by coxsackievirus B4. J Virol (2002) 76:5260-5. doi:10.1128/JVI.76.10.5260-5265.2002
    • (2002) J Virol , vol.76 , pp. 5260-5265
    • Brilot, F.1    Chehadeh, W.2    Charlet-Renard, C.3    Martens, H.4    Geenen, V.5    Hober, D.6
  • 50
    • 1342342922 scopus 로고    scopus 로고
    • Massive thymic deletion results in systemic autoimmunity through elimination of CD4+CD25+ T regulatory cells
    • Shih FF, Mandik-Nayak L, Wipke BT, Allen PM. Massive thymic deletion results in systemic autoimmunity through elimination of CD4+CD25+ T regulatory cells. J Exp Med (2004) 199:323-35. doi:10.1084/jem.20031137
    • (2004) J Exp Med , vol.199 , pp. 323-335
    • Shih, F.F.1    Mandik-Nayak, L.2    Wipke, B.T.3    Allen, P.M.4
  • 51
    • 4444348507 scopus 로고    scopus 로고
    • Coxsackievirus B4 infection of human fetal thymus cells
    • Brilot F, Geenen V, Hober D, Stoddart C. Coxsackievirus B4 infection of human fetal thymus cells. J Virol (2004) 78:9854-61. doi:10.1128/JVI.78.18.9854-9861.2004
    • (2004) J Virol , vol.78 , pp. 9854-9861
    • Brilot, F.1    Geenen, V.2    Hober, D.3    Stoddart, C.4
  • 52
    • 40549112341 scopus 로고    scopus 로고
    • Coxsackievirus B4 infection of murine fetal thymus organ cultures
    • Brilot F, Jaïdane H, Geenen V, Hober D. Coxsackievirus B4 infection of murine fetal thymus organ cultures. J Med Virol (2008) 80:659-66. doi:10.1002/jmv.21016
    • (2008) J Med Virol , vol.80 , pp. 659-666
    • Brilot, F.1    Jaïdane, H.2    Geenen, V.3    Hober, D.4
  • 53
    • 0026761212 scopus 로고
    • Coxsackievirus B4 infection alters thymic, splenic, and peripheral lymphocyte repertoire preceding onset of hyperglycemia in mice
    • Chatterjee NK, Hou J, Dockstader P, Charbonneau T. Coxsackievirus B4 infection alters thymic, splenic, and peripheral lymphocyte repertoire preceding onset of hyperglycemia in mice. J Med Virol (1992) 38:124-31. doi:10.1002/jmv.1890380210
    • (1992) J Med Virol , vol.38 , pp. 124-131
    • Chatterjee, N.K.1    Hou, J.2    Dockstader, P.3    Charbonneau, T.4
  • 54
    • 33845790704 scopus 로고    scopus 로고
    • Prolonged viral RNA detection in blood and lymphoid tissues from coxsackievirus B4-E2 orally-inoculated mice
    • Jaïdane H, Gharbi J, Lobert PE, Lucas B, Hiar R, M'Hadheb MB, et al. Prolonged viral RNA detection in blood and lymphoid tissues from coxsackievirus B4-E2 orally-inoculated mice. Microbiol Immunol (2006) 50:971-4. doi:10.1111/j.1348-0421.2006.tb03874.x
    • (2006) Microbiol Immunol , vol.50 , pp. 971-974
    • Jaïdane, H.1    Gharbi, J.2    Lobert, P.E.3    Lucas, B.4    Hiar, R.5    M'Hadheb, M.B.6
  • 55
    • 84869051823 scopus 로고    scopus 로고
    • Persistent infection of thymic epithelial cells with coxsackievirus B4 results in decreased expression of type 2 insulin-like growth factor
    • Jaïdane H, Caloone D, Lobert PE, Sané F, Dardenne O, Naquet P, et al. Persistent infection of thymic epithelial cells with coxsackievirus B4 results in decreased expression of type 2 insulin-like growth factor. J Virol (2012) 86:11151-62. doi:10.1128/JVI.00726-12
    • (2012) J Virol , vol.86 , pp. 11151-11162
    • Jaïdane, H.1    Caloone, D.2    Lobert, P.E.3    Sané, F.4    Dardenne, O.5    Naquet, P.6
  • 56
    • 0035522332 scopus 로고    scopus 로고
    • Maternal antibodies, childhood infections, and autoimmune diseases
    • Zinkernagel RM. Maternal antibodies, childhood infections, and autoimmune diseases. N Engl J Med (2001) 345:1331-5. doi:10.1056/NEJMra012493
    • (2001) N Engl J Med , vol.345 , pp. 1331-1335
    • Zinkernagel, R.M.1
  • 57
    • 0036326325 scopus 로고    scopus 로고
    • Maternal first-trimester enterovirus infection and future risk of type 1 diabetes in the exposed fetus
    • Viskari HR, Roivainen M, Reunanen A, Pitkäniemi J, Sadeharju K, Koskela P, et al. Maternal first-trimester enterovirus infection and future risk of type 1 diabetes in the exposed fetus. Diabetes (2002) 51:2568-71. doi:10.2337/diabetes.51.8.2568
    • (2002) Diabetes , vol.51 , pp. 2568-2571
    • Viskari, H.R.1    Roivainen, M.2    Reunanen, A.3    Pitkäniemi, J.4    Sadeharju, K.5    Koskela, P.6
  • 58
    • 56149127682 scopus 로고    scopus 로고
    • Maternal enterovirus infection during pregnancy as a risk factor in offspring diagnosed with type 1 diabetes between 15 and 30 years of age
    • Elfving M, Svensson J, Oikarinen S, Jonsson B, Olofsson P, Sundkvist G, et al. Maternal enterovirus infection during pregnancy as a risk factor in offspring diagnosed with type 1 diabetes between 15 and 30 years of age. Exp Diabetes Res (2008) 2008:271958. doi:10.1155/2008/271958
    • (2008) Exp Diabetes Res , vol.2008 , pp. 271958
    • Elfving, M.1    Svensson, J.2    Oikarinen, S.3    Jonsson, B.4    Olofsson, P.5    Sundkvist, G.6
  • 59
    • 84856957723 scopus 로고    scopus 로고
    • Outcome of challenge with coxsackievirus B4 in young mice after maternal infection with the same virus during gestation
    • Bopegamage S, Precechtelova J, Marosova L, Stipalova D, Sojka M, Borsanyiova M, et al. Outcome of challenge with coxsackievirus B4 in young mice after maternal infection with the same virus during gestation. FEMS Immunol Med Microbiol (2012) 64:184-90. doi:10.1111/j.1574-695X.2011.00886.x
    • (2012) FEMS Immunol Med Microbiol , vol.64 , pp. 184-190
    • Bopegamage, S.1    Precechtelova, J.2    Marosova, L.3    Stipalova, D.4    Sojka, M.5    Borsanyiova, M.6
  • 60
    • 2942519183 scopus 로고    scopus 로고
    • A piece of nucleic acid surrounded by controversy: coxsackievirus and the cause of type 1 diabetes
    • Gale EAM, Atkinson M. A piece of nucleic acid surrounded by controversy: coxsackievirus and the cause of type 1 diabetes. Diabet Med (2004) 21:503-6. doi:10.1111/j.1464-5491.2004.01181.x
    • (2004) Diabet Med , vol.21 , pp. 503-506
    • Gale, E.A.M.1    Atkinson, M.2
  • 61
    • 0036852231 scopus 로고    scopus 로고
    • Viral interference with antigen presentation
    • Yewdell JY, Hill AB. Viral interference with antigen presentation. Nat Immunol (2002) 3:1019-25. doi:10.1038/ni1102-1019
    • (2002) Nat Immunol , vol.3 , pp. 1019-1025
    • Yewdell, J.Y.1    Hill, A.B.2
  • 62
    • 0033808399 scopus 로고    scopus 로고
    • Incidence of childhood type 1 diabetes worldwide Diabetes Mondiale (DiaMond) Project Group
    • Karvonen M, Viik-Kajander M, Moltchanova E, Libman I, LaPorte R, Tuomilehto J. Incidence of childhood type 1 diabetes worldwide. Diabetes Mondiale (DiaMond) Project Group. Diabetes Care (2000) 23:1516-26. doi:10.2337/diacare.23.10.1516
    • (2000) Diabetes Care , vol.23 , pp. 1516-1526
    • Karvonen, M.1    Viik-Kajander, M.2    Moltchanova, E.3    Libman, I.4    LaPorte, R.5    Tuomilehto, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.