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Volumn 1037, Issue , 2004, Pages 59-64

An insulin-like growth factor 2-derived self-antigen inducing a regulatory cytokine profile after presentation to peripheral blood mononuclear cells from DQ8+ type 1 diabetic adolescents: Preliminary design of a thymus-based tolerogenic self-vaccination

Author keywords

IGF 2; Self antigens; Self vaccination; Thymus; Type 1 diabetes

Indexed keywords

CD4 ANTIGEN; CYTOKINE; GAMMA INTERFERON; HLA DQ8 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; SOMATOMEDIN B;

EID: 14544305615     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1337.008     Document Type: Conference Paper
Times cited : (11)

References (30)
  • 1
    • 0026440464 scopus 로고
    • The thymic education of developing T cells in neuroendocrine self-principles
    • GEENEN, V., F. ROBERT, H. MARTENS, et al. 1992. The thymic education of developing T cells in neuroendocrine self-principles. J. Endocrinol. Invest. 15: 621-629.
    • (1992) J. Endocrinol. Invest. , vol.15 , pp. 621-629
    • Geenen, V.1    Robert, F.2    Martens, H.3
  • 2
    • 0026451748 scopus 로고
    • The recognition of hypothalamoneurohypophysial functions by developing T cells
    • ROBERT, F., H. MARTENS, N. CORMANN, et al. 1992 The recognition of hypothalamoneurohypophysial functions by developing T cells. Dev. Immunol. 2: 131-140.
    • (1992) Dev. Immunol. , vol.2 , pp. 131-140
    • Robert, F.1    Martens, H.2    Cormann, N.3
  • 3
    • 0028301977 scopus 로고
    • T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous genes in the thymus
    • JOLICŒUR, C., D. HANAHAN & K.M. SMITH. 1994. T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous genes in the thymus. Proc. Natl. Acad. Sci. USA 91: 6707-6711.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 6707-6711
    • Jolicœur, C.1    Hanahan, D.2    Smith, K.M.3
  • 5
    • 0029898286 scopus 로고    scopus 로고
    • The thymic repertoire of neuroendocrine self-peptides: Physiological implications in T-cell life and death
    • MARTENS, H., B. GOXE & V. GEENEN. 1996. The thymic repertoire of neuroendocrine self-peptides: physiological implications in T-cell life and death. Immunol. Today 17: 312-319.
    • (1996) Immunol. Today , vol.17 , pp. 312-319
    • Martens, H.1    Goxe, B.2    Geenen, V.3
  • 6
    • 0342894680 scopus 로고    scopus 로고
    • Identification of neurotensin-related peptides in human thymic epithelial cell membrane and relationship with major histocompatibility class I molecules
    • VANNESTE, Y., A. NTODOU-THOME, E. VANDERSMISSEN, et al. 1997. Identification of neurotensin-related peptides in human thymic epithelial cell membrane and relationship with major histocompatibility class I molecules. J. Neuroimmunol. 76: 161-166.
    • (1997) J. Neuroimmunol. , vol.76 , pp. 161-166
    • Vanneste, Y.1    Ntodou-Thome, A.2    Vandersmissen, E.3
  • 7
    • 0035171545 scopus 로고    scopus 로고
    • Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self
    • DERBINSKI, J., A. SCHULTE, B. KYEWSKY & L. KLEIN. 2001. Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat. Immunol. 2: 1032-1039.
    • (2001) Nat. Immunol. , vol.2 , pp. 1032-1039
    • Derbinski, J.1    Schulte, A.2    Kyewsky, B.3    Klein, L.4
  • 9
    • 0020067836 scopus 로고
    • Neonatal thymectomy prevents spontaneous diabetes mellitus in the BB:W rat
    • LIKE, A.A., E. KISLAUKIS, R.M. WILLIAMS & A.A. ROSSINI. 1982. Neonatal thymectomy prevents spontaneous diabetes mellitus in the BB:W rat. Science 216: 644-646.
    • (1982) Science , vol.216 , pp. 644-646
    • Like, A.A.1    Kislaukis, E.2    Williams, R.M.3    Rossini, A.A.4
  • 10
    • 0028816927 scopus 로고
    • Induction of insulitis in athymic (nude) mice. The effect of NOD thymus and pancreas transplantation
    • GEORGIOU, H.M. & T.E. MANDEL. 1995. Induction of insulitis in athymic (nude) mice. The effect of NOD thymus and pancreas transplantation. Diabetes 44: 49-59.
    • (1995) Diabetes , vol.44 , pp. 49-59
    • Georgiou, H.M.1    Mandel, T.E.2
  • 11
    • 0030999992 scopus 로고    scopus 로고
    • Abnormal T-cell selection on NOD thymic epithelium is sufficient to induce autoimmune manifestations in C57BL/6 athymic nude mice
    • THOMAS-VASLIN, V., D. DAMOTTE, M. COLTEY, et al. 1997. Abnormal T-cell selection on NOD thymic epithelium is sufficient to induce autoimmune manifestations in C57BL/6 athymic nude mice. Proc. Natl. Acad. Sci. USA 94: 4598-4603.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 4598-4603
    • Thomas-Vaslin, V.1    Damotte, D.2    Coltey, M.3
  • 12
    • 0035014865 scopus 로고    scopus 로고
    • Thymic expression of insulin-related genes in an animal model of type 1 diabetes
    • KECHA-KAMOUN, O., I. ACHOUR, H. MARTENS, et al. 2001. Thymic expression of insulin-related genes in an animal model of type 1 diabetes. Diabetes/Metab. Res. Rev. 17: 146-152.
    • (2001) Diabetes/Metab. Res. Rev. , vol.17 , pp. 146-152
    • Kecha-Kamoun, O.1    Achour, I.2    Martens, H.3
  • 13
    • 0031018819 scopus 로고    scopus 로고
    • Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus
    • VAFIADIS, P., S.T. BENNETT, J.A. TODD, et al. 1997. Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus. Nat. Genet. 15: 289-292.
    • (1997) Nat. Genet. , vol.15 , pp. 289-292
    • Vafiadis, P.1    Bennett, S.T.2    Todd, J.A.3
  • 14
    • 18244421874 scopus 로고    scopus 로고
    • The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes
    • PUGLIESE, A., M. ZELLER, A. FERNANDEZ, JR., et al. 1997. The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes. Nat. Genet. 15: 293-297.
    • (1997) Nat. Genet. , vol.15 , pp. 293-297
    • Pugliese, A.1    Zeller, M.2    Fernandez Jr., A.3
  • 15
    • 0037004885 scopus 로고    scopus 로고
    • Low expression of insulin in the thymus of non-obese diabetic mice
    • BRIMNES, M.K., T. JENSEN, T.N. JORGENSEN, et al. 2002. Low expression of insulin in the thymus of non-obese diabetic mice. J. Autoimmun. 19: 203-213.
    • (2002) J. Autoimmun. , vol.19 , pp. 203-213
    • Brimnes, M.K.1    Jensen, T.2    Jorgensen, T.N.3
  • 16
    • 0036315824 scopus 로고    scopus 로고
    • Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: The mechanism by which the IDDM2 locus may predispose to diabetes
    • CHENTOUFI, A.A. & C. POLYCHRONAKOS. 2002. Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: the mechanism by which the IDDM2 locus may predispose to diabetes. Diabetes 51: 1383-1390.
    • (2002) Diabetes , vol.51 , pp. 1383-1390
    • Chentoufi, A.A.1    Polychronakos, C.2
  • 17
    • 85047689216 scopus 로고    scopus 로고
    • Acceleration of type 1 diabetes in proinsulin 2 deficient mice
    • THEBAULT-BAUMONT, K., D. DUBOIS-LAFORGUE, P. KRIEF, et al. 2003. Acceleration of type 1 diabetes in proinsulin 2 deficient mice. J. Clin. Invest. 111: 851-857.
    • (2003) J. Clin. Invest. , vol.111 , pp. 851-857
    • Thebault-Baumont, K.1    Dubois-Laforgue, D.2    Krief, P.3
  • 18
    • 0041335584 scopus 로고    scopus 로고
    • Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse
    • MORIYAMA, H., N. ABIRU, J. PARONEN, et al. 2003. Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse. Proc. Natl. Acad. Sci. USA 100: 10376-10381.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 10376-10381
    • Moriyama, H.1    Abiru, N.2    Paronen, J.3
  • 19
    • 0027368141 scopus 로고
    • Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes
    • KAUFMAN, D.L., M.C. CLARE-SALZLER, J. TIAN, et al. 1993. Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature 366: 69-72.
    • (1993) Nature , vol.366 , pp. 69-72
    • Kaufman, D.L.1    Clare-Salzler, M.C.2    Tian, J.3
  • 20
    • 0942288397 scopus 로고    scopus 로고
    • Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters
    • GOTTER, J., B. BRORS, M. HERGENHAHN & B. KYEWSKI. 2004. Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters. J. Exp. Med. 199: 155-166.
    • (2004) J. Exp. Med. , vol.199 , pp. 155-166
    • Gotter, J.1    Brors, B.2    Hergenhahn, M.3    Kyewski, B.4
  • 21
    • 0035083648 scopus 로고    scopus 로고
    • Differential splicing of the IA-2 mRNA in pancreas and lymphoid organs as a permissive genetic mechanism for autoimmunity against the IA-2 type 1 diabetes autoantigen
    • DIEZ, J., Y. PARK, M. ZELLER, et al. Differential splicing of the IA-2 mRNA in pancreas and lymphoid organs as a permissive genetic mechanism for autoimmunity against the IA-2 type 1 diabetes autoantigen. Diabetes 50: 895-900.
    • Diabetes , vol.50 , pp. 895-900
    • Diez, J.1    Park, Y.2    Zeller, M.3
  • 22
    • 0025054350 scopus 로고
    • Expression of preprotachykinin-A and neuropeptide-Y messenger RNA in the thymus
    • ERICSSON, A., V. GEENEN, F. ROBERT, et al. 1990. Expression of preprotachykinin-A and neuropeptide-Y messenger RNA in the thymus. Mol. Endocr. 4: 1211-1218.
    • (1990) Mol. Endocr. , vol.4 , pp. 1211-1218
    • Ericsson, A.1    Geenen, V.2    Robert, F.3
  • 23
    • 0035668779 scopus 로고    scopus 로고
    • A choice of death: The signal-transduction of immune-mediated beta-cell apoptosis
    • EIZIRIK, D.L. & T. MANDRUP-PAULSEN. 2001. A choice of death: the signal-transduction of immune-mediated beta-cell apoptosis. Diabetologia 44: 2115-2133.
    • (2001) Diabetologia , vol.44 , pp. 2115-2133
    • Eizirik, D.L.1    Mandrup-Paulsen, T.2
  • 24
    • 17444437590 scopus 로고    scopus 로고
    • Oral insulin administration and residual beta-cell function in recent-onset type 1 diabetes: A multicentre randomized controlled trial
    • Diabetes Insulin Oral Group
    • CHAILLOUS, L., H. LEFEVRE, C. THIVOLET, et al. 2000. Oral insulin administration and residual beta-cell function in recent-onset type 1 diabetes: a multicentre randomized controlled trial. Diabetes Insulin Oral Group. Lancet 356: 545-549.
    • (2000) Lancet , vol.356 , pp. 545-549
    • Chaillous, L.1    Lefevre, H.2    Thivolet, C.3
  • 25
    • 0033846982 scopus 로고    scopus 로고
    • No effect of oral insulin on residual beta-cell function in recent-onset type 1 diabetes
    • POZZILLI, P., D. PITOCCO, N. VISALLI, et al. 2000. No effect of oral insulin on residual beta-cell function in recent-onset type 1 diabetes. Diabetologia 43: 1000-1004.
    • (2000) Diabetologia , vol.43 , pp. 1000-1004
    • Pozzilli, P.1    Pitocco, D.2    Visalli, N.3
  • 26
    • 0037198427 scopus 로고    scopus 로고
    • Effects of insulin in relatives of patients with type 1 diabetes
    • DPT-TYPE 1 DIABETES STUDY GROUP. 2002. Effects of insulin in relatives of patients with type 1 diabetes. N. Engl. J. Med. 346: 1685-1691.
    • (2002) N. Engl. J. Med. , vol.346 , pp. 1685-1691
  • 27
    • 0036148871 scopus 로고    scopus 로고
    • Insulin-specific tolerance in diabetes
    • GOTTLIEB, P.A. & G.S. EISENBARTH. 2002. Insulin-specific tolerance in diabetes. Clin. Immunol. 102: 2-11.
    • (2002) Clin. Immunol. , vol.102 , pp. 2-11
    • Gottlieb, P.A.1    Eisenbarth, G.S.2
  • 28
    • 0033001488 scopus 로고    scopus 로고
    • The NOD mouse model of type 1 diabetes: As good as it gets?
    • ATKINSON, M.A. & E.H. LEITER. 1999. The NOD mouse model of type 1 diabetes: as good as it gets? Nat. Med. 5: 601-604.
    • (1999) Nat. Med. , vol.5 , pp. 601-604
    • Atkinson, M.A.1    Leiter, E.H.2
  • 29
    • 2942692039 scopus 로고    scopus 로고
    • CD25+ CD4+ T cells expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes
    • TARBELL, K.V., S. YAMAZAKI, K. OLSON, et al. 2004. CD25+ CD4+ T cells expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes. J. Exp. Med. 199: 1467-1477.
    • (2004) J. Exp. Med. , vol.199 , pp. 1467-1477
    • Tarbell, K.V.1    Yamazaki, S.2    Olson, K.3
  • 30
    • 2942642383 scopus 로고    scopus 로고
    • In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes
    • TANG, Q., K.J. HENRIKSEN, M. BI, et al. 2004. In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J. Exp. Med. 199: 1455-1465.
    • (2004) J. Exp. Med. , vol.199 , pp. 1455-1465
    • Tang, Q.1    Henriksen, K.J.2    Bi, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.