Thymic expression of insulin-related genes in an animal model of autoimmune type 1 diabetes

Diabetes/Metabolism Research and Reviews

Volumn 17, Issue 2, 2001, Pages 146-152

  Kecha Kamoun, Ouafae ^a   Achour, Imane ^a   Martens, Henri ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Insulin gene family; Thymus; Type 1 diabetes

Indexed keywords

AUTOANTIGEN; INSULIN; INSULINASE; MESSENGER RNA; SOMATOMEDIN B; SOMATOMEDIN C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; BRAIN TISSUE; CELL MATURATION; CONTROLLED STUDY; GENE EXPRESSION; GENETIC TRANSCRIPTION; HYPOTHESIS; IMMUNOREACTIVITY; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; INSULIN TOLERANCE TEST; LIVER; LYMPHOCYTOPENIA; MAMMAL; NONHUMAN; PANCREAS ISLET BETA CELL; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RAT; RAT STRAIN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; T LYMPHOCYTE; THYMUS; TISSUE SPECIFICITY;

AGING; ANIMALS; ANIMALS, NEWBORN; DIABETES MELLITUS, TYPE 1; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION, DEVELOPMENTAL; IMMUNITY, NATURAL; IMMUNORADIOMETRIC ASSAY; INSULIN; INSULIN-LIKE GROWTH FACTOR I; INSULIN-LIKE GROWTH FACTOR II; PROINSULIN; RATS; RATS, INBRED BB; RATS, INBRED WF; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; THYMUS GLAND; TRANSCRIPTION, GENETIC;

EID: 0035014865     PISSN: 15207552     EISSN: None     Source Type: Journal    
DOI: 10.1002/dmrr.182     Document Type: Article

References (46)

1. Processing and presentation of insulin. III. Insulin degrading enzyme: A neutral metalloendoproteinase that is non-homologous to classical endoproteinases mediates the processing of insulin epitopes for helper T cells
2. Analysis of the spontaneous T cell response to insulin in NOD mice
3. Similar peptides from two beta cell autoantigens, proinsulin and glutamic acid decarboxylase, stimulate T cells of individuals at risk for insulin-dependent diabetes
4. Experimental autoimmune insulitis. Induction by T lymphocytes specific for a peptide of proinsulin
5. The thymic repertoire of neuroendocrine self-antigens: Physiological implications in T-cell life and death
6. The intrathymic expression of insulin-related genes: Implications for pathophysiology and prevention of type 1 diabetes
7. Thymic expression of neuroendocrine self-peptide precursors: Role in T cell survival and self-tolerance
8. Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes
9. Thymus epithelium induces tissue-specific tolerance
10. Central tolerance of T cells
11. Evidence that insulin-like growth factor 2 (IGF2) is the dominant thymic peptide of the insulin superfamily
12. Murine macrophages express abundant insulin-like growth factor-I class I Ea and Eb transcripts
13. Expression of insulin-like growth factor II (IGF-II) and histological changes in the thymus and spleen of transgenic mice overexpressing IGF-II
14. Characterization of the insulin-like growth factor axis in the human thymus
15. Involvement of insulin-like growth factors in early T cell development: A study using fetal thymic organ cultures
16. T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus
17. Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus
18. The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes
19. Pancreatic hormone expression in the murine thymus: Localization in dendritic cells and macrophages
20. Intrathymic expression of genes involved in organ specific autoimmune disease
21. The BB/Wor rat and the balance hypothesis of autoimmunity
22. Preproinsulin I and II mRNAs and insulin electron microscopic immunoreaction are present within the rat fetal nervous system
23. Pulsatile secretion of gonadotropin-releasing hormone by rat hypothalamic explants without cell bodies of GnRH neurons
24. Measurement of serum ferritin by a 2-site immunoradiometric assay
25. Insulin-dependent diabetes mellitus as an autoimmune disease
26. Thymic epithelial defects and predisposition to autoimmune disease in BB rats
27. Recapitulation of normal and abnormal BioBreeding rat T cell development in adult thymus organ culture
28. The lymphopenia (lyp) gene controls the intrathymic cytokine ratio in congenic BioBreeding rats
29. Developmental and tissue-specific expression of a family of transcripts related to rat insulin-like growth factor II mRNA
30. Rat insulin-like growth factor II gene. A single gene with two promoters expressing a multitranscript family
31. Coordinate developmental regulation of high and low molecular weight mRNAs for rat insulin-like growth factor II
32. Structure and expression of the rat insulin-like growth factor II (rIGF- II) gene. Rigf-II RNAs are transcribed from two promoters
33. Developmental regulation of insulin-like growth factor II mRNA in different rat tissues
34. Somatomedin-C/insulin-like growth factor-I and insulin-like growth factor-II mRNAs in rat fetal and adult tissues
35. Insulin-like growth factor gene expression during rat embryonic development
36. Tissue-specific and developmentally regulated transcription of the insulin-like growth factor 2 gene
37. Expression of the insulin-like growth factor II gene in the choroid plexus and the leptomeninges of the adult rat central nervous system
38. Autoimmune diabetes mellitus in the BB rat
39. Diabetes-prone and diabetes-resistant BB rats share a common major diabetes susceptibility locus, iddm4. Additional evidence for a "universal autoimmunity locus" on rat chromosome 4
40. Non-major histocompatibility complex-linked diabetes susceptibility loci on chromosomes 4 and 13 in a backcross of the DP-BB/Wor rat to the WF rat
41. Mapping of novel genes predisposing or protecting diabetes development in the BB/OK rat
42. IDDM2-VNTR-encoded susceptibility to type 1 diabetes: Dominant protection and parental transmission of alleles of the insulin gene-linked minisatellite locus
43. Divergence between genetic determinants of IGF2 transcription levels in leukocytes and of IDDM2-encoded susceptibility to type 1 diabetes
44. The INS 5′ variable number of tandem repeats is associated with IGF2 expression in humans
45. No effect of oral insulin on residual beta-cell function in recent-onset type 1 diabetes
46. Oral insulin administration and residual beta-cell function in recent-onset type 1 diabetes: A multicentre randomised controlled trial