The Fifth Transmembrane Segment of Cystic Fibrosis Transmembrane Conductance Regulator Contributes to Its Anion Permeation Pathway

Biochemistry

Volumn 54, Issue 24, 2015, Pages 3839-3850

  Zhang, Jingyao ^a,b   Hwang, Tzyh Chang ^a,b  

^a UNIVERSITY OF MISSOURI   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; LIPID BILAYERS; TOPOLOGY;

ANION PERMEATION; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATORS; FUNCTIONAL DATAS; METHANETHIOSULFONATE; PORE CONSTRUCTIONS; POSITIVELY CHARGED; STRUCTURAL ARRANGEMENT; TRANSMEMBRANE SEGMENTS;

AMINO ACIDS;

ADENOSINE TRIPHOSPHATE; ANION; CYSTEINE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DITHIOTHREITOL; GLIBENCLAMIDE; PROTEIN; TRANSMEMBRANE SEGMENT 5 PROTEIN; UNCLASSIFIED DRUG; (2-SULFONATOETHYL)METHANETHIOSULFONATE; CFTR PROTEIN, HUMAN; MESYLIC ACID DERIVATIVE; MUTANT PROTEIN; PEPTIDE FRAGMENT; RECOMBINANT PROTEIN; THIOL REAGENT;

ANIMAL CELL; ANION TRANSPORT; ARTICLE; CHLORIDE CONDUCTANCE; COMPARATIVE STUDY; CONTROLLED STUDY; CYSTIC FIBROSIS; ELECTROPHYSIOLOGY; FEMALE; GENETIC TRANSFECTION; INSIDE OUT PATCH CLAMP; LIPID BILAYER; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; SUBSTITUTION REACTION; TRANSIENT EXPRESSION; WHOLE CELL PATCH CLAMP; AMINO ACID SUBSTITUTION; ANIMAL; CELL MEMBRANE PERMEABILITY; CHEMICAL STRUCTURE; CHEMISTRY; CHO CELL LINE; CRICETULUS; GENETICS; HUMAN; METABOLISM; PATCH CLAMP TECHNIQUE; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN TERTIARY STRUCTURE; SURFACE PROPERTY;

AMINO ACID SUBSTITUTION; ANIMALS; CELL MEMBRANE PERMEABILITY; CHO CELLS; CRICETULUS; CYSTEINE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; HUMANS; MESYLATES; MODELS, MOLECULAR; MUTANT PROTEINS; PATCH-CLAMP TECHNIQUES; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SULFHYDRYL REAGENTS; SURFACE PROPERTIES;

EID: 84934924925     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/acs.biochem.5b00427     Document Type: Article

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