Evolutionary and functional divergence between the cystic fibrosis transmembrane conductance regulator and related ATP-binding cassette transporters

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 48, 2008, Pages 18865-18870

  Jordan, I King ^a   Kota, Karthik C ^a   Cui, Guiying ^b   Thompson, Christopher H ^a   McCarty, Nael A ^b  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

CFTR; Ion channel; Molecular evolution; Type II divergence

Indexed keywords

ABC TRANSPORTER; CHLORIDE CHANNEL; TRANSMEMBRANE CONDUCTANCE REGULATOR;

AMINO ACID SEQUENCE; ARTICLE; CONFORMATIONAL TRANSITION; HYDROLYSIS; MAMMAL; MOLECULAR EVOLUTION; MOVEMENT (PHYSIOLOGY); NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE; SEQUENCE ALIGNMENT; WASTE;

AMINO ACID SEQUENCE; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; EVOLUTION, MOLECULAR; HUMANS; ION CHANNEL GATING; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PATCH-CLAMP TECHNIQUES; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT;

MAMMALIA;

EID: 57749106719     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0806306105     Document Type: Article

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