메뉴 건너뛰기




Volumn 5, Issue JUN, 2015, Pages

Brain tumor immunotherapy: What have we learned so far?

Author keywords

Dendritic cell vaccines; Galectin 1; Immunomodulation; Immunotherapy; Malignant glioma; Oncolytic viruses

Indexed keywords


EID: 84934268827     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2015.00098     Document Type: Review
Times cited : (30)

References (173)
  • 1
    • 0030980497 scopus 로고    scopus 로고
    • Descriptive epidemiology of cerebral gliomas in France
    • Fleury A, Menegoz F, Grosclaude P, Daures JP, Henry Amar M, Raverdy N, et al. Descriptive epidemiology of cerebral gliomas in France. Cancer (1997) 79:1195-202. doi:10.1002/(SICI)1097-0142(19970315)79:6<1195::AID-CNCR19>3.0.CO;2-V.
    • (1997) Cancer , vol.79 , pp. 1195-1202
    • Fleury, A.1    Menegoz, F.2    Grosclaude, P.3    Daures, J.P.4    Henry Amar, M.5    Raverdy, N.6
  • 2
    • 2142834907 scopus 로고    scopus 로고
    • Pediatric supratentorial high-grade gliomas
    • Tamber MS, Rutka JT. Pediatric supratentorial high-grade gliomas. Neurosurg Focus (2003) 14. Available from: http://www.medscape.com/viewarticle/449870.
    • (2003) Neurosurg Focus , vol.14
    • Tamber, M.S.1    Rutka, J.T.2
  • 3
  • 4
    • 65349121788 scopus 로고    scopus 로고
    • Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial
    • Stupp R, Hegi ME, Mason WP, van den Bent MJ, Taphoorn MJ, Janzer RC, et al. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol (2009) 10:459-66. doi:10.1016/S1470-2045(09)70025-7.
    • (2009) Lancet Oncol , vol.10 , pp. 459-466
    • Stupp, R.1    Hegi, M.E.2    Mason, W.P.3    van den Bent, M.J.4    Taphoorn, M.J.5    Janzer, R.C.6
  • 6
    • 34948892058 scopus 로고    scopus 로고
    • Diffuse glioma growth: a guerilla war
    • Claes A, Idema AJ, Wesseling P. Diffuse glioma growth: a guerilla war. Acta Neuropathol (2007) 114:443-58. doi:10.1007/s00401-007-0293-7.
    • (2007) Acta Neuropathol , vol.114 , pp. 443-458
    • Claes, A.1    Idema, A.J.2    Wesseling, P.3
  • 7
    • 0035108398 scopus 로고    scopus 로고
    • Multicenter phase II trial of temozolomide in patients with glioblastoma multiforme at first relapse
    • Brada M, Hoang-Xuan K, Rampling R, Dietrich PY, Dirix LY, Macdonald D, et al. Multicenter phase II trial of temozolomide in patients with glioblastoma multiforme at first relapse. Ann Oncol (2001) 12:259-66. doi:10.1023/A:1008382516636.
    • (2001) Ann Oncol , vol.12 , pp. 259-266
    • Brada, M.1    Hoang-Xuan, K.2    Rampling, R.3    Dietrich, P.Y.4    Dirix, L.Y.5    Macdonald, D.6
  • 8
    • 84871960565 scopus 로고    scopus 로고
    • Standards of care for treatment of recurrent glioblastoma-are we there yet?
    • Weller M, Cloughesy T, Perry JR, Wick W. Standards of care for treatment of recurrent glioblastoma-are we there yet? Neuro Oncol (2013) 15:4-27. doi:10.1093/neuonc/nos273.
    • (2013) Neuro Oncol , vol.15 , pp. 4-27
    • Weller, M.1    Cloughesy, T.2    Perry, J.R.3    Wick, W.4
  • 9
    • 84897125848 scopus 로고    scopus 로고
    • Fractionated stereotactic radiosurgery with concurrent temozolomide chemotherapy for locally recurrent glioblastoma multiforme: a prospective cohort study
    • Greenspoon JN, Sharieff W, Hirte H, Overholt A, Devillers R, Gunnarsson T, et al. Fractionated stereotactic radiosurgery with concurrent temozolomide chemotherapy for locally recurrent glioblastoma multiforme: a prospective cohort study. Onco Targets Ther (2014) 7:485-90. doi:10.2147/OTT.S60358.
    • (2014) Onco Targets Ther , vol.7 , pp. 485-490
    • Greenspoon, J.N.1    Sharieff, W.2    Hirte, H.3    Overholt, A.4    Devillers, R.5    Gunnarsson, T.6
  • 10
    • 84879802033 scopus 로고    scopus 로고
    • Reirradiation in progressive high-grade gliomas: outcome, role of concurrent chemotherapy, prognostic factors and validation of a new prognostic score with an independent patient cohort
    • Scholtyssek F, Zwiener I, Schlamann A, Seidel C, Meixensberger J, Bauer M, et al. Reirradiation in progressive high-grade gliomas: outcome, role of concurrent chemotherapy, prognostic factors and validation of a new prognostic score with an independent patient cohort. Radiat Oncol (2013) 8:161. doi:10.1186/1748-717X-8-161.
    • (2013) Radiat Oncol , vol.8 , pp. 161
    • Scholtyssek, F.1    Zwiener, I.2    Schlamann, A.3    Seidel, C.4    Meixensberger, J.5    Bauer, M.6
  • 12
    • 14844330067 scopus 로고    scopus 로고
    • Years of life lost (YLL) from cancer is an important measure of population burden-and should be considered when allocating research funds
    • Burnet NG, Jefferies SJ, Benson RJ, Hunt DP, Treasure FP. Years of life lost (YLL) from cancer is an important measure of population burden-and should be considered when allocating research funds. Br J Cancer (2005) 92:241-5. doi:10.1038/sj.bjc.6602321.
    • (2005) Br J Cancer , vol.92 , pp. 241-245
    • Burnet, N.G.1    Jefferies, S.J.2    Benson, R.J.3    Hunt, D.P.4    Treasure, F.P.5
  • 13
    • 84856728163 scopus 로고    scopus 로고
    • Individualized targeted therapy for glioblastoma: fact or fiction?
    • Weller M, Stupp R, Hegi M, Wick W. Individualized targeted therapy for glioblastoma: fact or fiction? Cancer J (2012) 18:40-4. doi:10.1097/PPO.0b013e318243f6c9.
    • (2012) Cancer J , vol.18 , pp. 40-44
    • Weller, M.1    Stupp, R.2    Hegi, M.3    Wick, W.4
  • 15
  • 16
    • 34547643974 scopus 로고    scopus 로고
    • Persistent IL-10 production is required for glioma growth suppressive activity by Th1-directed effector cells after stimulation with tumor lysate-loaded dendritic cells
    • De Vleeschouwer S, Spencer L I, Ceuppens JL, Van Gool SW. Persistent IL-10 production is required for glioma growth suppressive activity by Th1-directed effector cells after stimulation with tumor lysate-loaded dendritic cells. J Neurooncol (2007) 84:131-40. doi:10.1007/s11060-007-9362-y.
    • (2007) J Neurooncol , vol.84 , pp. 131-140
    • De Vleeschouwer, S.1    Spencer, L.I.2    Ceuppens, J.L.3    Van Gool, S.W.4
  • 17
    • 57449084713 scopus 로고    scopus 로고
    • In vivo bioluminescence imaging in an experimental mouse model for dendritic cell based immunotherapy against malignant glioma
    • Maes W, Deroose C, Reumers V, Krylyshkina O, Gijsbers R, Ceuppens J, et al. In vivo bioluminescence imaging in an experimental mouse model for dendritic cell based immunotherapy against malignant glioma. J Neurooncol (2009) 91:127-39. doi:10.1007/s11060-008-9691-5.
    • (2009) J Neurooncol , vol.91 , pp. 127-139
    • Maes, W.1    Deroose, C.2    Reumers, V.3    Krylyshkina, O.4    Gijsbers, R.5    Ceuppens, J.6
  • 18
    • 69949127667 scopus 로고    scopus 로고
    • DC vaccination with anti-CD25 treatment leads to long-term immunity against experimental glioma
    • Maes W, Galicia Rosas G, Verbinnen B, Boon L, De Vleeschouwer S, Ceuppens JL, et al. DC vaccination with anti-CD25 treatment leads to long-term immunity against experimental glioma. Neuro Oncol (2009) 11:529-42. doi:10.1215/15228517-2009-004.
    • (2009) Neuro Oncol , vol.11 , pp. 529-542
    • Maes, W.1    Galicia Rosas, G.2    Verbinnen, B.3    Boon, L.4    De Vleeschouwer, S.5    Ceuppens, J.L.6
  • 19
    • 84890126632 scopus 로고    scopus 로고
    • Glioma-derived galectin-1 regulates innate and adaptive antitumor immunity
    • Verschuere T, Toelen J, Maes W, Poirier F, Boon L, Tousseyn T, et al. Glioma-derived galectin-1 regulates innate and adaptive antitumor immunity. Int J Cancer (2014) 134:873-84. doi:10.1002/ijc.28426.
    • (2014) Int J Cancer , vol.134 , pp. 873-884
    • Verschuere, T.1    Toelen, J.2    Maes, W.3    Poirier, F.4    Boon, L.5    Tousseyn, T.6
  • 20
    • 11144356171 scopus 로고    scopus 로고
    • Transient local response and persistent tumor control of recurrent malignant glioma treated with combination therapy including dendritic cell therapy
    • De Vleeschouwer S, Van Calenbergh F, Demaerel P, Flamen P, Rutkowski S, Kaempgen E, et al. Transient local response and persistent tumor control of recurrent malignant glioma treated with combination therapy including dendritic cell therapy. J Neurosurg (2004) 100:492-7.
    • (2004) J Neurosurg , vol.100 , pp. 492-497
    • De Vleeschouwer, S.1    Van Calenbergh, F.2    Demaerel, P.3    Flamen, P.4    Rutkowski, S.5    Kaempgen, E.6
  • 21
    • 9144247794 scopus 로고    scopus 로고
    • Surgery and adjuvant dendritic cell-based tumour vaccination for patients with relapsed malignant glioma, a feasibility study
    • Rutkowski S, De Vleeschouwer S, Kaempgen E, Wolff JE, Kuhl J, Demaerel P, et al. Surgery and adjuvant dendritic cell-based tumour vaccination for patients with relapsed malignant glioma, a feasibility study. Br J Cancer (2004) 91:1656-62. doi:10.1038/sj.bjc.6602195.
    • (2004) Br J Cancer , vol.91 , pp. 1656-1662
    • Rutkowski, S.1    De Vleeschouwer, S.2    Kaempgen, E.3    Wolff, J.E.4    Kuhl, J.5    Demaerel, P.6
  • 22
    • 49649113879 scopus 로고    scopus 로고
    • Postoperative adjuvant dendritic cell-based immunotherapy in patients with relapsed glioblastoma multiforme
    • De Vleeschouwer S, Fieuws S, Rutkowski S, Van Calenbergh F, Van Loon J, Goffin J, et al. Postoperative adjuvant dendritic cell-based immunotherapy in patients with relapsed glioblastoma multiforme. Clin Cancer Res (2008) 14:3098-104. doi:10.1158/1078-0432.CCR-07-4875.
    • (2008) Clin Cancer Res , vol.14 , pp. 3098-3104
    • De Vleeschouwer, S.1    Fieuws, S.2    Rutkowski, S.3    Van Calenbergh, F.4    Van Loon, J.5    Goffin, J.6
  • 24
    • 84880647032 scopus 로고    scopus 로고
    • Resection and immunotherapy for recurrent grade III glioma
    • Elens I, De Vleeschouwer S, Pauwels F, Van Gool SW. Resection and immunotherapy for recurrent grade III glioma. ISRN Immunol (2012) 2012:1-9. doi:10.5402/2012/530179.
    • (2012) ISRN Immunol , vol.2012 , pp. 1-9
    • Elens, I.1    De Vleeschouwer, S.2    Pauwels, F.3    Van Gool, S.W.4
  • 25
    • 84870982871 scopus 로고    scopus 로고
    • Stratification according to HGG-IMMUNO RPA model predicts outcome in a large group of patients with relapsed malignant glioma treated by adjuvant postoperative dendritic cell vaccination
    • De Vleeschouwer S, Ardon H, Van Calenbergh F, Sciot R, Wilms G, Van Loon J, et al. Stratification according to HGG-IMMUNO RPA model predicts outcome in a large group of patients with relapsed malignant glioma treated by adjuvant postoperative dendritic cell vaccination. Cancer Immunol Immunother (2012) 61:2105-12. doi:10.1007/s00262-012-1271-z.
    • (2012) Cancer Immunol Immunother , vol.61 , pp. 2105-2112
    • De Vleeschouwer, S.1    Ardon, H.2    Van Calenbergh, F.3    Sciot, R.4    Wilms, G.5    Van Loon, J.6
  • 26
    • 84901984069 scopus 로고    scopus 로고
    • Development and validation of a fully GMP-compliant production process of autologous, tumor-lysate-pulsed dendritic cells
    • Eyrich M, Schreiber SC, Rachor J, Krauss J, Pauwels F, Hain J, et al. Development and validation of a fully GMP-compliant production process of autologous, tumor-lysate-pulsed dendritic cells. Cytotherapy (2014) 16:946-64. doi:10.1016/j.jcyt.2014.02.017.
    • (2014) Cytotherapy , vol.16 , pp. 946-964
    • Eyrich, M.1    Schreiber, S.C.2    Rachor, J.3    Krauss, J.4    Pauwels, F.5    Hain, J.6
  • 27
    • 77956061272 scopus 로고    scopus 로고
    • Integration of autologous dendritic cell-based immunotherapy in the primary treatment for patients with newly diagnosed glioblastoma multiforme: a pilot study
    • Ardon H, Van Gool S, Lopes IS, Maes W, Sciot R, Wilms G, et al. Integration of autologous dendritic cell-based immunotherapy in the primary treatment for patients with newly diagnosed glioblastoma multiforme: a pilot study. J Neurooncol (2010) 99:261-72. doi:10.1007/s11060-010-0131-y.
    • (2010) J Neurooncol , vol.99 , pp. 261-272
    • Ardon, H.1    Van Gool, S.2    Lopes, I.S.3    Maes, W.4    Sciot, R.5    Wilms, G.6
  • 28
    • 84870985481 scopus 로고    scopus 로고
    • Integration of autologous dendritic cell-based immunotherapy in the standard of care treatment for patients with newly diagnosed glioblastoma: results of the HGG-2006 phase I/II trial
    • Ardon H, Van Gool SW, Verschuere T, Maes W, Fieuws S, Sciot R, et al. Integration of autologous dendritic cell-based immunotherapy in the standard of care treatment for patients with newly diagnosed glioblastoma: results of the HGG-2006 phase I/II trial. Cancer Immunol Immunother (2012) 61:2033-44. doi:10.1007/s00262-012-1261-1.
    • (2012) Cancer Immunol Immunother , vol.61 , pp. 2033-2044
    • Ardon, H.1    Van Gool, S.W.2    Verschuere, T.3    Maes, W.4    Fieuws, S.5    Sciot, R.6
  • 29
    • 80054928589 scopus 로고    scopus 로고
    • MR perfusion and diffusion imaging in the follow-up of recurrent glioblastoma treated with dendritic cell immunotherapy: a pilot study
    • Vrabec M, Van Cauter S, Himmelreich U, Van Gool SW, Sunaert S, De Vleeschouwer S, et al. MR perfusion and diffusion imaging in the follow-up of recurrent glioblastoma treated with dendritic cell immunotherapy: a pilot study. Neuroradiology (2011) 53:721-31. doi:10.1007/s00234-010-0802-6.
    • (2011) Neuroradiology , vol.53 , pp. 721-731
    • Vrabec, M.1    Van Cauter, S.2    Himmelreich, U.3    Van Gool, S.W.4    Sunaert, S.5    De Vleeschouwer, S.6
  • 31
    • 84872953911 scopus 로고    scopus 로고
    • Reproducibility of rapid short echo time CSI at 3 Tesla for clinical applications
    • Van Cauter S, Sima DM, Luts J, Ter BL, Ribbens A, Peeters RR, et al. Reproducibility of rapid short echo time CSI at 3 Tesla for clinical applications. J Magn Reson Imaging (2013) 37:445-56. doi:10.1002/jmri.23820.
    • (2013) J Magn Reson Imaging , vol.37 , pp. 445-456
    • Van Cauter, S.1    Sima, D.M.2    Luts, J.3    Ter, B.L.4    Ribbens, A.5    Peeters, R.R.6
  • 32
    • 84902463812 scopus 로고    scopus 로고
    • Integrating diffusion kurtosis imaging, dynamic susceptibility-weighted contrast-enhanced MRI, and short echo time chemical shift imaging for grading gliomas
    • Van Cauter S, De Keyzer F, Sima DM, Croitor Sava A, D'Arco F, Veraart J, et al. Integrating diffusion kurtosis imaging, dynamic susceptibility-weighted contrast-enhanced MRI, and short echo time chemical shift imaging for grading gliomas. Neuro Oncol (2014) 16(7):1010-21. doi:10.1093/neuonc/not304.
    • (2014) Neuro Oncol , vol.16 , Issue.7 , pp. 1010-1021
    • Van Cauter, S.1    De Keyzer, F.2    Sima, D.M.3    Croitor Sava, A.4    D'Arco, F.5    Veraart, J.6
  • 33
    • 12444288645 scopus 로고    scopus 로고
    • Immunotherapy for malignant gliomas: emphasis on strategies of active specific immunotherapy using autologous dendritic cells
    • De Vleeschouwer S, Van Gool SW, Van Calenbergh F. Immunotherapy for malignant gliomas: emphasis on strategies of active specific immunotherapy using autologous dendritic cells. Childs Nerv Syst (2005) 21:7-18. doi:10.1007/s00381-004-0994-3.
    • (2005) Childs Nerv Syst , vol.21 , pp. 7-18
    • De Vleeschouwer, S.1    Van Gool, S.W.2    Van Calenbergh, F.3
  • 34
    • 33845218355 scopus 로고    scopus 로고
    • Dendritic cell vaccination in patients with malignant gliomas: current status and future directions
    • De Vleeschouwer S, Rapp M, Sorg RV, Steiger HJ, Stummer W, Van Gool S, et al. Dendritic cell vaccination in patients with malignant gliomas: current status and future directions. Neurosurgery (2006) 59:988-99. doi:10.1227/01.NEU.0000245595.38957.3E.
    • (2006) Neurosurgery , vol.59 , pp. 988-999
    • De Vleeschouwer, S.1    Rapp, M.2    Sorg, R.V.3    Steiger, H.J.4    Stummer, W.5    Van Gool, S.6
  • 37
    • 79151475507 scopus 로고    scopus 로고
    • Experimental immunotherapy for malignant glioma: lessons from two decades of research in the GL261 model
    • Maes W, Van Gool SW. Experimental immunotherapy for malignant glioma: lessons from two decades of research in the GL261 model. Cancer Immunol Immunother (2011) 60:153-60. doi:10.1007/s00262-010-0946-6.
    • (2011) Cancer Immunol Immunother , vol.60 , pp. 153-160
    • Maes, W.1    Van Gool, S.W.2
  • 38
    • 84867807535 scopus 로고    scopus 로고
    • Should dendritic cell-based tumor vaccination be incorporated into standard therapy for newly diagnosed glioblastoma patients?
    • Van Gool S, De Vleeschouwer S. Should dendritic cell-based tumor vaccination be incorporated into standard therapy for newly diagnosed glioblastoma patients? Expert Rev Neurother (2012) 12:1173-6. doi:10.1586/ern.12.107.
    • (2012) Expert Rev Neurother , vol.12 , pp. 1173-1176
    • Van Gool, S.1    De Vleeschouwer, S.2
  • 39
    • 84864598740 scopus 로고    scopus 로고
    • Treg infiltration in glioma: a hurdle for antiglioma immunotherapy
    • Vandenberk L, Van Gool SW. Treg infiltration in glioma: a hurdle for antiglioma immunotherapy. Immunotherapy (2012) 4:675-8. doi:10.2217/imt.12.64.
    • (2012) Immunotherapy , vol.4 , pp. 675-678
    • Vandenberk, L.1    Van Gool, S.W.2
  • 40
    • 84860915900 scopus 로고    scopus 로고
    • Severe methylenetetrahydrofolate reductase deficiency in mice results in behavioral anomalies with morphological and biochemical changes in hippocampus
    • Jadavji NM, Deng L, Leclerc D, Malysheva O, Bedell BJ, Caudill MA, et al. Severe methylenetetrahydrofolate reductase deficiency in mice results in behavioral anomalies with morphological and biochemical changes in hippocampus. Mol Genet Metab (2012) 106:149-59. doi:10.1016/j.ymgme.2012.03.020.
    • (2012) Mol Genet Metab , vol.106 , pp. 149-159
    • Jadavji, N.M.1    Deng, L.2    Leclerc, D.3    Malysheva, O.4    Bedell, B.J.5    Caudill, M.A.6
  • 41
    • 84871552831 scopus 로고    scopus 로고
    • Current status of immunotherapy and gene therapy for high-grade gliomas
    • Marsh JC, Goldfarb J, Shafman TD, Diaz AZ. Current status of immunotherapy and gene therapy for high-grade gliomas. Cancer Control (2013) 20:43-8.
    • (2013) Cancer Control , vol.20 , pp. 43-48
    • Marsh, J.C.1    Goldfarb, J.2    Shafman, T.D.3    Diaz, A.Z.4
  • 42
    • 84874065710 scopus 로고    scopus 로고
    • Vaccine strategies for glioblastoma: progress and future directions
    • Jackson C, Ruzevick J, Brem H, Lim M. Vaccine strategies for glioblastoma: progress and future directions. Immunotherapy (2013) 5:155-67. doi:10.2217/imt.12.155.
    • (2013) Immunotherapy , vol.5 , pp. 155-167
    • Jackson, C.1    Ruzevick, J.2    Brem, H.3    Lim, M.4
  • 43
    • 84883554099 scopus 로고    scopus 로고
    • Active immunotherapy using dendritic cells in the treatment of glioblastoma multiforme
    • Bregy A, Wong TM, Shah AH, Goldberg JM, Komotar RJ. Active immunotherapy using dendritic cells in the treatment of glioblastoma multiforme. Cancer Treat Rev (2013) 39:891-907. doi:10.1016/j.ctrv.2013.05.007.
    • (2013) Cancer Treat Rev , vol.39 , pp. 891-907
    • Bregy, A.1    Wong, T.M.2    Shah, A.H.3    Goldberg, J.M.4    Komotar, R.J.5
  • 44
    • 84933048332 scopus 로고    scopus 로고
    • Clinical efficacy of tumor antigen-pulsed DC treatment for high-grade glioma patients: evidence from a meta-analysis
    • Cao JX, Zhang XY, Liu JL, Li D, Li JL, Liu YS, et al. Clinical efficacy of tumor antigen-pulsed DC treatment for high-grade glioma patients: evidence from a meta-analysis. PLoS One (2014) 9:e107173. doi:10.1371/journal.pone.0107173.
    • (2014) PLoS One , vol.9
    • Cao, J.X.1    Zhang, X.Y.2    Liu, J.L.3    Li, D.4    Li, J.L.5    Liu, Y.S.6
  • 45
    • 0035059416 scopus 로고    scopus 로고
    • Cross-presentation, dendritic cells, tolerance and immunity
    • Heath WR, Carbone FR. Cross-presentation, dendritic cells, tolerance and immunity. Annu Rev Immunol (2001) 19:47-64. doi:10.1146/annurev.immunol.19.1.47.
    • (2001) Annu Rev Immunol , vol.19 , pp. 47-64
    • Heath, W.R.1    Carbone, F.R.2
  • 46
    • 0025030522 scopus 로고
    • Presentation of exogenous antigen with class I major histocompatibility complex molecules
    • Rock KL, Gamble S, Rothstein L. Presentation of exogenous antigen with class I major histocompatibility complex molecules. Science (1990) 249:918-21. doi:10.1126/science.2392683.
    • (1990) Science , vol.249 , pp. 918-921
    • Rock, K.L.1    Gamble, S.2    Rothstein, L.3
  • 47
    • 0029887715 scopus 로고    scopus 로고
    • Analysis of the role of MHC class II presentation in the stimulation ofcytotoxic T lymphocytes by antigens targeted into the exogenous antigen-MHCclass I presentation pathway
    • Rock KL, Clark K. Analysis of the role of MHC class II presentation in the stimulation ofcytotoxic T lymphocytes by antigens targeted into the exogenous antigen-MHCclass I presentation pathway. J Immunol (1996) 156:3721-6.
    • (1996) J Immunol , vol.156 , pp. 3721-3726
    • Rock, K.L.1    Clark, K.2
  • 48
    • 0033840544 scopus 로고    scopus 로고
    • The critical role of CD40/CD40L in the CD4-dependent generation of CD8+ T cell immunity
    • Clarke SR. The critical role of CD40/CD40L in the CD4-dependent generation of CD8+ T cell immunity. J Leukoc Biol (2000) 67:607-14.
    • (2000) J Leukoc Biol , vol.67 , pp. 607-614
    • Clarke, S.R.1
  • 49
    • 0028205094 scopus 로고
    • In vivo priming of two distinct antitumor effector populations: the role of MHC class I expression
    • Levitsky HI, Lazenby A, Hayashi RJ, Pardoll DM. In vivo priming of two distinct antitumor effector populations: the role of MHC class I expression. J Exp Med (1994) 179:1215-24. doi:10.1084/jem.179.4.1215.
    • (1994) J Exp Med , vol.179 , pp. 1215-1224
    • Levitsky, H.I.1    Lazenby, A.2    Hayashi, R.J.3    Pardoll, D.M.4
  • 50
    • 15444369205 scopus 로고    scopus 로고
    • Invariant natural killer T cells are preserved in patients with glioma and exhibit antitumor lytic activity following dendritic cell-mediated expansion
    • Dhodapkar KM, Cirignano B, Chamian F, Zagzag D, Miller DC, Finlay JL, et al. Invariant natural killer T cells are preserved in patients with glioma and exhibit antitumor lytic activity following dendritic cell-mediated expansion. Int J Cancer (2004) 109:893-9. doi:10.1002/ijc.20050.
    • (2004) Int J Cancer , vol.109 , pp. 893-899
    • Dhodapkar, K.M.1    Cirignano, B.2    Chamian, F.3    Zagzag, D.4    Miller, D.C.5    Finlay, J.L.6
  • 53
    • 84880721353 scopus 로고    scopus 로고
    • Dendritic-cell-based therapeutic cancer vaccines
    • Palucka K, Banchereau J. Dendritic-cell-based therapeutic cancer vaccines. Immunity (2013) 39:38-48. doi:10.1016/j.immuni.2013.07.004.
    • (2013) Immunity , vol.39 , pp. 38-48
    • Palucka, K.1    Banchereau, J.2
  • 54
    • 84880679655 scopus 로고    scopus 로고
    • Current status and future perspectives of dendritic cell-based cancer immunotherapy
    • Yi H, Appel S. Current status and future perspectives of dendritic cell-based cancer immunotherapy. Scand J Immunol (2013) 78:167-71. doi:10.1111/sji.12060.
    • (2013) Scand J Immunol , vol.78 , pp. 167-171
    • Yi, H.1    Appel, S.2
  • 55
    • 84875177588 scopus 로고    scopus 로고
    • Dendritic cells in cancer immunotherapy: vaccines and combination immunotherapies
    • Kalinski P, Muthuswamy R, Urban J. Dendritic cells in cancer immunotherapy: vaccines and combination immunotherapies. Expert Rev Vaccines (2013) 12:285-95. doi:10.1586/erv.13.22.
    • (2013) Expert Rev Vaccines , vol.12 , pp. 285-295
    • Kalinski, P.1    Muthuswamy, R.2    Urban, J.3
  • 56
    • 84916936048 scopus 로고    scopus 로고
    • Immunotherapy for primary brain tumors: no longer a matter of privilege
    • Fecci PE, Heimberger AB, Sampson JH. Immunotherapy for primary brain tumors: no longer a matter of privilege. Clin Cancer Res (2014) 20:5620-9. doi:10.1158/1078-0432.CCR-14-0832.
    • (2014) Clin Cancer Res , vol.20 , pp. 5620-5629
    • Fecci, P.E.1    Heimberger, A.B.2    Sampson, J.H.3
  • 57
    • 84904878079 scopus 로고    scopus 로고
    • Glioma-associated antigen HEATR1 induces functional cytotoxic T lymphocytes in patients with glioma
    • Wu ZB, Qiu C, Zhang AL, Cai L, Lin SJ, Yao Y, et al. Glioma-associated antigen HEATR1 induces functional cytotoxic T lymphocytes in patients with glioma. J Immunol Res (2014) 2014:131494. doi:10.1155/2014/131494.
    • (2014) J Immunol Res , vol.2014 , pp. 131494
    • Wu, Z.B.1    Qiu, C.2    Zhang, A.L.3    Cai, L.4    Lin, S.J.5    Yao, Y.6
  • 58
    • 84906518742 scopus 로고    scopus 로고
    • Cellular immunotherapy directed against human cytomegalovirus as a novel approach for glioblastoma treatment
    • Schuessler A, Walker DG, Khanna R. Cellular immunotherapy directed against human cytomegalovirus as a novel approach for glioblastoma treatment. Oncoimmunology (2014) 3:e29381. doi:10.4161/onci.29381.
    • (2014) Oncoimmunology , vol.3
    • Schuessler, A.1    Walker, D.G.2    Khanna, R.3
  • 59
    • 0031978249 scopus 로고    scopus 로고
    • Immunotherapy of cancer with dendritic-cell-based vaccines
    • Gilboa E, Nair SK, Lyerly HK. Immunotherapy of cancer with dendritic-cell-based vaccines. Cancer Immunol Immunother (1998) 46:82-7. doi:10.1007/s002620050465.
    • (1998) Cancer Immunol Immunother , vol.46 , pp. 82-87
    • Gilboa, E.1    Nair, S.K.2    Lyerly, H.K.3
  • 60
    • 78149254368 scopus 로고    scopus 로고
    • Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastoma
    • Sampson JH, Heimberger AB, Archer GE, Aldape KD, Friedman AH, Friedman HS, et al. Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastoma. J Clin Oncol (2010) 28:4722-9. doi:10.1200/JCO.2010.28.6963.
    • (2010) J Clin Oncol , vol.28 , pp. 4722-4729
    • Sampson, J.H.1    Heimberger, A.B.2    Archer, G.E.3    Aldape, K.D.4    Friedman, A.H.5    Friedman, H.S.6
  • 61
    • 84866945151 scopus 로고    scopus 로고
    • Vaccination with mRNA-electroporated dendritic cells induces robust tumor antigen-specific CD4+ and CD8+ T cells responses in stage III and IV melanoma patients
    • Aarntzen EH, Schreibelt G, Bol K, Lesterhuis WJ, Croockewit AJ, de Wilt JH, et al. Vaccination with mRNA-electroporated dendritic cells induces robust tumor antigen-specific CD4+ and CD8+ T cells responses in stage III and IV melanoma patients. Clin Cancer Res (2012) 18:5460-70. doi:10.1158/1078-0432.CCR-11-3368.
    • (2012) Clin Cancer Res , vol.18 , pp. 5460-5470
    • Aarntzen, E.H.1    Schreibelt, G.2    Bol, K.3    Lesterhuis, W.J.4    Croockewit, A.J.5    de Wilt, J.H.6
  • 62
    • 84869164521 scopus 로고    scopus 로고
    • Dendritic cell-based vaccination for renal cell carcinoma: challenges in clinical trials
    • Wang J, Liao L, Tan J. Dendritic cell-based vaccination for renal cell carcinoma: challenges in clinical trials. Immunotherapy (2012) 4:1031-42. doi:10.2217/imt.12.107.
    • (2012) Immunotherapy , vol.4 , pp. 1031-1042
    • Wang, J.1    Liao, L.2    Tan, J.3
  • 64
    • 77956384935 scopus 로고    scopus 로고
    • Induction of complete and molecular remissions in acute myeloid leukemia by Wilms' tumor 1 antigen-targeted dendritic cell vaccination
    • Van Tendeloo VF, Van De Velde AL, Van Driessche A, Cools N, Anguille S, Ladell K, et al. Induction of complete and molecular remissions in acute myeloid leukemia by Wilms' tumor 1 antigen-targeted dendritic cell vaccination. Proc Natl Acad Sci U S A (2010) 107:13824-9. doi:10.1073/pnas.1008051107.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 13824-13829
    • Van Tendeloo, V.F.1    Van De Velde, A.L.2    Van Driessche, A.3    Cools, N.4    Anguille, S.5    Ladell, K.6
  • 65
    • 77958527547 scopus 로고    scopus 로고
    • Immunological response after therapeutic vaccination with WT1 mRNA-loaded dendritic cells in end-stage endometrial carcinoma
    • Coosemans A, Wolfl M, Berneman ZN, Van Tendeloo V, Vergote I, Amant F, et al. Immunological response after therapeutic vaccination with WT1 mRNA-loaded dendritic cells in end-stage endometrial carcinoma. Anticancer Res (2010) 30:3709-14.
    • (2010) Anticancer Res , vol.30 , pp. 3709-3714
    • Coosemans, A.1    Wolfl, M.2    Berneman, Z.N.3    Van Tendeloo, V.4    Vergote, I.5    Amant, F.6
  • 66
    • 84891440852 scopus 로고    scopus 로고
    • Wilms' tumor gene 1 (WT1)-loaded dendritic cell immunotherapy in patients with uterine tumors: a phase I/II clinical trial
    • Coosemans A, Vanderstraeten A, Tuyaerts S, Verschuere T, Moerman P, Berneman ZN, et al. Wilms' tumor gene 1 (WT1)-loaded dendritic cell immunotherapy in patients with uterine tumors: a phase I/II clinical trial. Anticancer Res (2013) 33:5495-500.
    • (2013) Anticancer Res , vol.33 , pp. 5495-5500
    • Coosemans, A.1    Vanderstraeten, A.2    Tuyaerts, S.3    Verschuere, T.4    Moerman, P.5    Berneman, Z.N.6
  • 67
    • 84885015878 scopus 로고    scopus 로고
    • Immunological response after WT1 mRNA-loaded dendritic cell immunotherapy in ovarian carcinoma and carcinosarcoma
    • Coosemans A, Vanderstraeten A, Tuyaerts S, Verschuere T, Moerman P, Berneman Z, et al. Immunological response after WT1 mRNA-loaded dendritic cell immunotherapy in ovarian carcinoma and carcinosarcoma. Anticancer Res (2013) 33:3855-9.
    • (2013) Anticancer Res , vol.33 , pp. 3855-3859
    • Coosemans, A.1    Vanderstraeten, A.2    Tuyaerts, S.3    Verschuere, T.4    Moerman, P.5    Berneman, Z.6
  • 69
    • 0344076299 scopus 로고    scopus 로고
    • Generation of large numbers of fully mature and stable dendritic cells from leukapheresis products for clinical application
    • Thurner B, Roder C, Dieckmann D, Heuer H, Kruse M, Glaser A, et al. Generation of large numbers of fully mature and stable dendritic cells from leukapheresis products for clinical application. J Immunol Methods (1999) 223:1-15. doi:10.1016/S0022-1759(98)00208-7.
    • (1999) J Immunol Methods , vol.223 , pp. 1-15
    • Thurner, B.1    Roder, C.2    Dieckmann, D.3    Heuer, H.4    Kruse, M.5    Glaser, A.6
  • 70
    • 0242574478 scopus 로고    scopus 로고
    • A protocol for generation of clinical grade mRNA-transfected monocyte-derived dendritic cells for cancer vaccines
    • Mu LJ, Gaudernack G, Saeboe-Larssen S, Hammerstad H, Tierens A, Kvalheim G. A protocol for generation of clinical grade mRNA-transfected monocyte-derived dendritic cells for cancer vaccines. Scand J Immunol (2003) 58:578-86. doi:10.1046/j.1365-3083.2003.01333.x.
    • (2003) Scand J Immunol , vol.58 , pp. 578-586
    • Mu, L.J.1    Gaudernack, G.2    Saeboe-Larssen, S.3    Hammerstad, H.4    Tierens, A.5    Kvalheim, G.6
  • 71
    • 0037491839 scopus 로고    scopus 로고
    • Clinical-scale generation of dendritic cells in a closed system
    • Sorg RV, Ozcan Z, Brefort T, Fischer J, Ackermann R, Muller M, et al. Clinical-scale generation of dendritic cells in a closed system. J Immunother (2003) 26:374-83. doi:10.1097/00002371-200307000-00010.
    • (2003) J Immunother , vol.26 , pp. 374-383
    • Sorg, R.V.1    Ozcan, Z.2    Brefort, T.3    Fischer, J.4    Ackermann, R.5    Muller, M.6
  • 72
    • 0036606341 scopus 로고    scopus 로고
    • Generation of large numbers of dendritic cells in a closed system using cell factories
    • Tuyaerts S, Noppe SM, Corthals J, Breckpot K, Heirman C, De Greef C, et al. Generation of large numbers of dendritic cells in a closed system using cell factories. J Immunol Methods (2002) 264:135-51. doi:10.1016/S0022-1759(02)00099-6.
    • (2002) J Immunol Methods , vol.264 , pp. 135-151
    • Tuyaerts, S.1    Noppe, S.M.2    Corthals, J.3    Breckpot, K.4    Heirman, C.5    De Greef, C.6
  • 73
    • 0030035947 scopus 로고    scopus 로고
    • Lymphocyte targeting of the central nervous system: a review of afferent and efferent CNS-immune pathways
    • Weller RO, Engelhardt B, Phillips MJ. Lymphocyte targeting of the central nervous system: a review of afferent and efferent CNS-immune pathways. Brain Pathol (1996) 6:275-88. doi:10.1111/j.1750-3639.1996.tb00855.x.
    • (1996) Brain Pathol , vol.6 , pp. 275-288
    • Weller, R.O.1    Engelhardt, B.2    Phillips, M.J.3
  • 74
    • 84915804000 scopus 로고    scopus 로고
    • Immune responses to non-tumor antigens in the central nervous system
    • Huber AK, Duncker PC, Irani DN. Immune responses to non-tumor antigens in the central nervous system. Front Oncol (2014) 4:328. doi:10.3389/fonc.2014.00328.
    • (2014) Front Oncol , vol.4 , pp. 328
    • Huber, A.K.1    Duncker, P.C.2    Irani, D.N.3
  • 75
    • 84864267012 scopus 로고    scopus 로고
    • Cancer immunoediting in malignant glioma
    • Dunn GP, Fecci PE, Curry WT. Cancer immunoediting in malignant glioma. Neurosurgery (2012) 71:201-22. doi:10.1227/NEU.0b013e31824f840d.
    • (2012) Neurosurgery , vol.71 , pp. 201-222
    • Dunn, G.P.1    Fecci, P.E.2    Curry, W.T.3
  • 76
    • 2642631750 scopus 로고    scopus 로고
    • Proinflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal-calf serum-free conditions
    • Jonuleit H, Kuhn U, Muller G, Steinbrink K, Paragnik L, Schmitt E, et al. Proinflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal-calf serum-free conditions. Eur J Immunol (1997) 27:3135-42. doi:10.1002/eji.1830271209.
    • (1997) Eur J Immunol , vol.27 , pp. 3135-3142
    • Jonuleit, H.1    Kuhn, U.2    Muller, G.3    Steinbrink, K.4    Paragnik, L.5    Schmitt, E.6
  • 77
    • 33744984785 scopus 로고    scopus 로고
    • Th17: an effector CD4 T cell lineage with regulatory T cell ties
    • Weaver CT, Harrington LE, Mangan PR, Gavrieli M, Murphy KM. Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity (2006) 24:677-88. doi:10.1016/j.immuni.2006.06.002.
    • (2006) Immunity , vol.24 , pp. 677-688
    • Weaver, C.T.1    Harrington, L.E.2    Mangan, P.R.3    Gavrieli, M.4    Murphy, K.M.5
  • 78
    • 27944455183 scopus 로고    scopus 로고
    • Dendritic cells are essential for priming but inefficient for boosting antitumour immune response in an orthotopic murine glioma model
    • Jouanneau E, Poujol D, Gulia S, Le Mercier I, Blay JY, Belin MF, et al. Dendritic cells are essential for priming but inefficient for boosting antitumour immune response in an orthotopic murine glioma model. Cancer Immunol Immunother (2006) 55(3):254-67.
    • (2006) Cancer Immunol Immunother , vol.55 , Issue.3 , pp. 254-267
    • Jouanneau, E.1    Poujol, D.2    Gulia, S.3    Le Mercier, I.4    Blay, J.Y.5    Belin, M.F.6
  • 79
    • 0033486007 scopus 로고    scopus 로고
    • T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal
    • Kalinski P, Hilkens CM, Wierenga EA, Kapsenberg ML. T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal. Immunol Today (1999) 20:561-7. doi:10.1016/S0167-5699(99)01547-9.
    • (1999) Immunol Today , vol.20 , pp. 561-567
    • Kalinski, P.1    Hilkens, C.M.2    Wierenga, E.A.3    Kapsenberg, M.L.4
  • 80
    • 0037103366 scopus 로고    scopus 로고
    • Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells
    • Scandella E, Men Y, Gillessen S, Forster R, Groettrup M. Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells. Blood (2002) 100:1354-61. doi:10.1182/blood-2001-11-0017.
    • (2002) Blood , vol.100 , pp. 1354-1361
    • Scandella, E.1    Men, Y.2    Gillessen, S.3    Forster, R.4    Groettrup, M.5
  • 81
    • 33745622659 scopus 로고    scopus 로고
    • CD25 and indoleamine 2,3-dioxygenase are up-regulated by prostaglandin E2 and expressed by tumor-associated dendritic cells in vivo: additional mechanisms of T-cell inhibition
    • Bergwelt-Baildon MS, Popov A, Saric T, Chemnitz J, Classen S, Stoffel MS, et al. CD25 and indoleamine 2,3-dioxygenase are up-regulated by prostaglandin E2 and expressed by tumor-associated dendritic cells in vivo: additional mechanisms of T-cell inhibition. Blood (2006) 108:228-37. doi:10.1182/blood-2005-08-3507.
    • (2006) Blood , vol.108 , pp. 228-237
    • Bergwelt-Baildon, M.S.1    Popov, A.2    Saric, T.3    Chemnitz, J.4    Classen, S.5    Stoffel, M.S.6
  • 82
    • 0037769110 scopus 로고    scopus 로고
    • Dendritic cells in immunity and tolerance-do they display opposite functions?
    • Moser M. Dendritic cells in immunity and tolerance-do they display opposite functions? Immunity (2003) 19:5-8. doi:10.1016/S1074-7613(03)00182-1.
    • (2003) Immunity , vol.19 , pp. 5-8
    • Moser, M.1
  • 83
    • 0345447557 scopus 로고    scopus 로고
    • Injection of immature dendritic cells into adjuvant-treated skin obviates the need for ex vivo maturation
    • Nair S, McLaughlin C, Weizer A, Su Z, Boczkowski D, Dannull J, et al. Injection of immature dendritic cells into adjuvant-treated skin obviates the need for ex vivo maturation. J Immunol (2003) 171:6275-82. doi:10.4049/jimmunol.171.11.6275.
    • (2003) J Immunol , vol.171 , pp. 6275-6282
    • Nair, S.1    McLaughlin, C.2    Weizer, A.3    Su, Z.4    Boczkowski, D.5    Dannull, J.6
  • 84
    • 14044265101 scopus 로고    scopus 로고
    • Cutting edge: priming of CTL by transcutaneous peptide immunization with imiquimod
    • Rechtsteiner G, Warger T, Osterloh P, Schild H, Radsak MP. Cutting edge: priming of CTL by transcutaneous peptide immunization with imiquimod. J Immunol (2005) 174:2476-80. doi:10.4049/jimmunol.174.5.2476.
    • (2005) J Immunol , vol.174 , pp. 2476-2480
    • Rechtsteiner, G.1    Warger, T.2    Osterloh, P.3    Schild, H.4    Radsak, M.P.5
  • 85
    • 29644446061 scopus 로고    scopus 로고
    • The TLR-7 agonist, imiquimod, enhances dendritic cell survival and promotes tumor antigen-specific T cell priming: relation to central nervous system antitumor immunity
    • Prins RM, Craft N, Bruhn KW, Khan-Farooqi H, Koya RC, Stripecke R, et al. The TLR-7 agonist, imiquimod, enhances dendritic cell survival and promotes tumor antigen-specific T cell priming: relation to central nervous system antitumor immunity. J Immunol (2006) 176:157-64. doi:10.4049/jimmunol.176.1.157.
    • (2006) J Immunol , vol.176 , pp. 157-164
    • Prins, R.M.1    Craft, N.2    Bruhn, K.W.3    Khan-Farooqi, H.4    Koya, R.C.5    Stripecke, R.6
  • 86
    • 34250324345 scopus 로고    scopus 로고
    • Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells
    • Stary G, Bangert C, Tauber M, Strohal R, Kopp T, Stingl G. Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells. J Exp Med (2007) 204:1441-51. doi:10.1084/jem.20070021.
    • (2007) J Exp Med , vol.204 , pp. 1441-1451
    • Stary, G.1    Bangert, C.2    Tauber, M.3    Strohal, R.4    Kopp, T.5    Stingl, G.6
  • 87
    • 17444428074 scopus 로고    scopus 로고
    • Efficient elutriation of monocytes within a closed system (Elutra) for clinical-scale generation of dendritic cells
    • Berger TG, Strasser E, Smith R, Carste C, Schuler-Thurner B, Kaempgen E, et al. Efficient elutriation of monocytes within a closed system (Elutra) for clinical-scale generation of dendritic cells. J Immunol Methods (2005) 298:61-72. doi:10.1016/j.jim.2005.01.005.
    • (2005) J Immunol Methods , vol.298 , pp. 61-72
    • Berger, T.G.1    Strasser, E.2    Smith, R.3    Carste, C.4    Schuler-Thurner, B.5    Kaempgen, E.6
  • 88
    • 13444269087 scopus 로고    scopus 로고
    • Human monocyte isolation methods influence cytokine production from in vitro generated dendritic cells
    • Elkord E, Williams PE, Kynaston H, Rowbottom AW. Human monocyte isolation methods influence cytokine production from in vitro generated dendritic cells. Immunology (2005) 114:204-12. doi:10.1111/j.1365-2567.2004.02076.x.
    • (2005) Immunology , vol.114 , pp. 204-212
    • Elkord, E.1    Williams, P.E.2    Kynaston, H.3    Rowbottom, A.W.4
  • 89
    • 58649089564 scopus 로고    scopus 로고
    • Comparative evaluation of techniques for the manufacturing of dendritic cell-based cancer vaccines
    • Dohnal AM, Graffi S, Witt V, Eichstill C, Wagner D, Ul-Haq S, et al. Comparative evaluation of techniques for the manufacturing of dendritic cell-based cancer vaccines. J Cell Mol Med (2009) 13:125-35. doi:10.1111/j.1582-4934.2008.00304.x.
    • (2009) J Cell Mol Med , vol.13 , pp. 125-135
    • Dohnal, A.M.1    Graffi, S.2    Witt, V.3    Eichstill, C.4    Wagner, D.5    Ul-Haq, S.6
  • 90
    • 84871413280 scopus 로고    scopus 로고
    • Generation and validation of a prognostic score to predict outcome after re-irradiation of recurrent glioma
    • Combs SE, Edler L, Rausch R, Welzel T, Wick W, Debus J. Generation and validation of a prognostic score to predict outcome after re-irradiation of recurrent glioma. Acta Oncol (2013) 52:147-52. doi:10.3109/0284186X.2012.692882.
    • (2013) Acta Oncol , vol.52 , pp. 147-152
    • Combs, S.E.1    Edler, L.2    Rausch, R.3    Welzel, T.4    Wick, W.5    Debus, J.6
  • 91
    • 33745565415 scopus 로고    scopus 로고
    • Cellular immunity of patients with malignant glioma: prerequisites for dendritic cell vaccination immunotherapy
    • Rapp M, Ozcan Z, Steiger HJ, Wernet P, Sabel MC, Sorg RV. Cellular immunity of patients with malignant glioma: prerequisites for dendritic cell vaccination immunotherapy. J Neurosurg (2006) 105:41-50. doi:10.3171/jns.2006.105.1.41.
    • (2006) J Neurosurg , vol.105 , pp. 41-50
    • Rapp, M.1    Ozcan, Z.2    Steiger, H.J.3    Wernet, P.4    Sabel, M.C.5    Sorg, R.V.6
  • 92
  • 93
    • 0037154222 scopus 로고    scopus 로고
    • Tumor lysate-pulsed dendritic cells can elicit an effective antitumor immune response during early lymphoid recovery
    • Asavaroengchai W, Kotera Y, Mule JJ. Tumor lysate-pulsed dendritic cells can elicit an effective antitumor immune response during early lymphoid recovery. Proc Natl Acad Sci U S A (2002) 99:931-6. doi:10.1073/pnas.022634999.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 931-936
    • Asavaroengchai, W.1    Kotera, Y.2    Mule, J.J.3
  • 94
    • 21044444425 scopus 로고    scopus 로고
    • Immune responses to the 105AD7 human anti-idiotypic vaccine after intensive chemotherapy, for osteosarcoma
    • Pritchard-Jones K, Spendlove I, Wilton C, Whelan J, Weeden S, Lewis I, et al. Immune responses to the 105AD7 human anti-idiotypic vaccine after intensive chemotherapy, for osteosarcoma. Br J Cancer (2005) 92:1358-65. doi:10.1038/sj.bjc.6602500.
    • (2005) Br J Cancer , vol.92 , pp. 1358-1365
    • Pritchard-Jones, K.1    Spendlove, I.2    Wilton, C.3    Whelan, J.4    Weeden, S.5    Lewis, I.6
  • 95
    • 79955784386 scopus 로고    scopus 로고
    • Greater chemotherapy-induced lymphopenia enhances tumor-specific immune responses that eliminate EGFRvIII-expressing tumor cells in patients with glioblastoma
    • Sampson JH, Aldape KD, Archer GE, Coan A, Desjardins A, Friedman AH, et al. Greater chemotherapy-induced lymphopenia enhances tumor-specific immune responses that eliminate EGFRvIII-expressing tumor cells in patients with glioblastoma. Neuro Oncol (2011) 13:324-33. doi:10.1093/neuonc/noq157.
    • (2011) Neuro Oncol , vol.13 , pp. 324-333
    • Sampson, J.H.1    Aldape, K.D.2    Archer, G.E.3    Coan, A.4    Desjardins, A.5    Friedman, A.H.6
  • 96
    • 0021247642 scopus 로고
    • Gamma-irradiation facilitates the expression of adoptive immunity against established tumors by eliminating suppressor T cells
    • North RJ. Gamma-irradiation facilitates the expression of adoptive immunity against established tumors by eliminating suppressor T cells. Cancer Immunol Immunother (1984) 16:175-81. doi:10.1007/BF00205425.
    • (1984) Cancer Immunol Immunother , vol.16 , pp. 175-181
    • North, R.J.1
  • 97
    • 4143103624 scopus 로고    scopus 로고
    • Clinical responsiveness of glioblastoma multiforme to chemotherapy after vaccination
    • Wheeler CJ, Das A, Liu G, Yu JS, Black KL. Clinical responsiveness of glioblastoma multiforme to chemotherapy after vaccination. Clin Cancer Res (2004) 10:5316-26. doi:10.1158/1078-0432.CCR-04-0497.
    • (2004) Clin Cancer Res , vol.10 , pp. 5316-5326
    • Wheeler, C.J.1    Das, A.2    Liu, G.3    Yu, J.S.4    Black, K.L.5
  • 98
    • 21344462768 scopus 로고    scopus 로고
    • Cytotoxic T cell targeting of TRP-2 sensitizes human malignant glioma to chemotherapy
    • Liu G, Akasaki Y, Khong HT, Wheeler CJ, Das A, Black KL, et al. Cytotoxic T cell targeting of TRP-2 sensitizes human malignant glioma to chemotherapy. Oncogene (2005) 24:5226-34. doi:10.1038/sj.onc.1208519.
    • (2005) Oncogene , vol.24 , pp. 5226-5234
    • Liu, G.1    Akasaki, Y.2    Khong, H.T.3    Wheeler, C.J.4    Das, A.5    Black, K.L.6
  • 99
    • 33745010017 scopus 로고    scopus 로고
    • Radiotherapy and temozolomide for newly diagnosed glioblastoma: recursive partitioning analysis of the EORTC 26981/22981-NCIC CE3 phase III randomized trial
    • Mirimanoff RO, Gorlia T, Mason W, van den Bent MJ, Kortmann RD, Fisher B, et al. Radiotherapy and temozolomide for newly diagnosed glioblastoma: recursive partitioning analysis of the EORTC 26981/22981-NCIC CE3 phase III randomized trial. J Clin Oncol (2006) 24:2563-9. doi:10.1200/JCO.2005.04.5963.
    • (2006) J Clin Oncol , vol.24 , pp. 2563-2569
    • Mirimanoff, R.O.1    Gorlia, T.2    Mason, W.3    van den Bent, M.J.4    Kortmann, R.D.5    Fisher, B.6
  • 101
    • 70449711757 scopus 로고    scopus 로고
    • Genetic alterations and signaling pathways in the evolution of gliomas
    • Ohgaki H, Kleihues P. Genetic alterations and signaling pathways in the evolution of gliomas. Cancer Sci (2009) 100:2235-41. doi:10.1111/j.1349-7006.2009.01308.x.
    • (2009) Cancer Sci , vol.100 , pp. 2235-2241
    • Ohgaki, H.1    Kleihues, P.2
  • 103
    • 84885475418 scopus 로고    scopus 로고
    • Altered galectin-1 serum levels in patients diagnosed with high-grade glioma
    • Verschuere T, van WM, Fieuws S, Lefranc F, Mathieu V, Kiss R, et al. Altered galectin-1 serum levels in patients diagnosed with high-grade glioma. J Neurooncol (2013) 115:9-17. doi:10.1007/s11060-013-1201-8.
    • (2013) J Neurooncol , vol.115 , pp. 9-17
    • Verschuere, T.1    van, W.M.2    Fieuws, S.3    Lefranc, F.4    Mathieu, V.5    Kiss, R.6
  • 104
    • 80052615453 scopus 로고    scopus 로고
    • The combined effects of oncolytic reovirus plus Newcastle disease virus and reovirus plus parvovirus on U87 and U373 cells in vitro and in vivo
    • Alkassar M, Gartner B, Roemer K, Graesser F, Rommelaere J, Kaestner L, et al. The combined effects of oncolytic reovirus plus Newcastle disease virus and reovirus plus parvovirus on U87 and U373 cells in vitro and in vivo. J Neurooncol (2011) 104:715-27. doi:10.1007/s11060-011-0606-5.
    • (2011) J Neurooncol , vol.104 , pp. 715-727
    • Alkassar, M.1    Gartner, B.2    Roemer, K.3    Graesser, F.4    Rommelaere, J.5    Kaestner, L.6
  • 105
    • 84918574716 scopus 로고    scopus 로고
    • Newcastle disease virotherapy induces long-term survival and tumor-specific immune memory in orthotopic glioma through the induction of immunogenic cell death
    • Koks CA, Garg AD, Ehrhardt M, Riva M, De Vleeschouwer S, Agostinis P, et al. Newcastle disease virotherapy induces long-term survival and tumor-specific immune memory in orthotopic glioma through the induction of immunogenic cell death. Int J Cancer (2014) 136:e313-25. doi:10.1002/ijc.29202.
    • (2014) Int J Cancer , vol.136 , pp. e313-e325
    • Koks, C.A.1    Garg, A.D.2    Ehrhardt, M.3    Riva, M.4    De Vleeschouwer, S.5    Agostinis, P.6
  • 106
    • 48649096955 scopus 로고    scopus 로고
    • Vaccination elicits correlated immune and clinical responses in glioblastoma multiforme patients
    • Wheeler CJ, Black KL, Liu G, Mazer M, Zhang XX, Pepkowitz S, et al. Vaccination elicits correlated immune and clinical responses in glioblastoma multiforme patients. Cancer Res (2008) 68:5955-64. doi:10.1158/0008-5472.CAN-07-5973.
    • (2008) Cancer Res , vol.68 , pp. 5955-5964
    • Wheeler, C.J.1    Black, K.L.2    Liu, G.3    Mazer, M.4    Zhang, X.X.5    Pepkowitz, S.6
  • 107
    • 84862994725 scopus 로고    scopus 로고
    • Mechanisms of immune evasion by gliomas
    • Rolle CE, Sengupta S, Lesniak MS. Mechanisms of immune evasion by gliomas. Adv Exp Med Biol (2012) 746:53-76. doi:10.1007/978-1-4614-3146-6_5.
    • (2012) Adv Exp Med Biol , vol.746 , pp. 53-76
    • Rolle, C.E.1    Sengupta, S.2    Lesniak, M.S.3
  • 108
    • 84911018402 scopus 로고    scopus 로고
    • Immune-checkpoint blockade and active immunotherapy for glioma
    • Ahn BJ, Pollack IF, Okada H. Immune-checkpoint blockade and active immunotherapy for glioma. Cancers (Basel) (2013) 5:1379-412. doi:10.3390/cancers5041379.
    • (2013) Cancers (Basel) , vol.5 , pp. 1379-1412
    • Ahn, B.J.1    Pollack, I.F.2    Okada, H.3
  • 109
    • 33748481603 scopus 로고    scopus 로고
    • An increase in CD4+CD25+FOXP3+ regulatory T cells in tumor-infiltrating lymphocytes of human glioblastoma multiforme
    • El Andaloussi A, Lesniak MS. An increase in CD4+CD25+FOXP3+ regulatory T cells in tumor-infiltrating lymphocytes of human glioblastoma multiforme. Neuro Oncol (2006) 8:234-43. doi:10.1215/15228517-2006-006.
    • (2006) Neuro Oncol , vol.8 , pp. 234-243
    • El Andaloussi, A.1    Lesniak, M.S.2
  • 110
    • 77955658133 scopus 로고    scopus 로고
    • Prognostic significance and mechanism of Treg infiltration in human brain tumors
    • Jacobs JF, Idema AJ, Bol KF, Grotenhuis JA, de Vries IJ, Wesseling P, et al. Prognostic significance and mechanism of Treg infiltration in human brain tumors. J Neuroimmunol (2010) 225:195-9. doi:10.1016/j.jneuroim.2010.05.020.
    • (2010) J Neuroimmunol , vol.225 , pp. 195-199
    • Jacobs, J.F.1    Idema, A.J.2    Bol, K.F.3    Grotenhuis, J.A.4    de Vries, I.J.5    Wesseling, P.6
  • 111
    • 33748532939 scopus 로고    scopus 로고
    • The role of human glioma-infiltrating microglia/macrophages in mediating antitumor immune responses
    • Hussain SF, Yang D, Suki D, Aldape K, Grimm E, Heimberger AB. The role of human glioma-infiltrating microglia/macrophages in mediating antitumor immune responses. Neuro Oncol (2006) 8:261-79. doi:10.1215/15228517-2006-008.
    • (2006) Neuro Oncol , vol.8 , pp. 261-279
    • Hussain, S.F.1    Yang, D.2    Suki, D.3    Aldape, K.4    Grimm, E.5    Heimberger, A.B.6
  • 112
    • 0031278368 scopus 로고    scopus 로고
    • T cell receptor-mediated signaling is defective in T cells obtained from patients with primary intracranial tumors
    • Morford LA, Elliott LH, Carlson SL, Brooks WH, Roszman TL. T cell receptor-mediated signaling is defective in T cells obtained from patients with primary intracranial tumors. J Immunol (1997) 159:4415-25.
    • (1997) J Immunol , vol.159 , pp. 4415-4425
    • Morford, L.A.1    Elliott, L.H.2    Carlson, S.L.3    Brooks, W.H.4    Roszman, T.L.5
  • 114
    • 84877965095 scopus 로고    scopus 로고
    • Depletion of regulatory T cells in a mouse experimental glioma model through anti-CD25 treatment results in the infiltration of non-immunosuppressive myeloid cells in the brain
    • Maes W, Verschuere T, Van HA, Boon L, van GS. Depletion of regulatory T cells in a mouse experimental glioma model through anti-CD25 treatment results in the infiltration of non-immunosuppressive myeloid cells in the brain. Clin Dev Immunol (2013) 2013:952469. doi:10.1155/2013/952469.
    • (2013) Clin Dev Immunol , vol.2013 , pp. 952469
    • Maes, W.1    Verschuere, T.2    Van, H.A.3    Boon, L.4    van, G.S.5
  • 115
    • 78651062856 scopus 로고    scopus 로고
    • Phenotypic and functional switch of macrophages induced by regulatory CD4+CD25+ T cells in mice
    • Liu G, Ma H, Qiu L, Li L, Cao Y, Ma J, et al. Phenotypic and functional switch of macrophages induced by regulatory CD4+CD25+ T cells in mice. Immunol Cell Biol (2011) 89:130-42. doi:10.1038/icb.2010.70.
    • (2011) Immunol Cell Biol , vol.89 , pp. 130-142
    • Liu, G.1    Ma, H.2    Qiu, L.3    Li, L.4    Cao, Y.5    Ma, J.6
  • 116
    • 79251535018 scopus 로고    scopus 로고
    • Successful colon cancer eradication after chemoimmunotherapy is associated with profound phenotypic change of intratumoral myeloid cells
    • Medina-Echeverz J, Fioravanti J, Zabala M, Ardaiz N, Prieto J, Berraondo P. Successful colon cancer eradication after chemoimmunotherapy is associated with profound phenotypic change of intratumoral myeloid cells. J Immunol (2011) 186:807-15. doi:10.4049/jimmunol.1001483.
    • (2011) J Immunol , vol.186 , pp. 807-815
    • Medina-Echeverz, J.1    Fioravanti, J.2    Zabala, M.3    Ardaiz, N.4    Prieto, J.5    Berraondo, P.6
  • 117
    • 35748975652 scopus 로고    scopus 로고
    • Preferential migration of regulatory T cells mediated by glioma-secreted chemokines can be blocked with chemotherapy
    • Jordan JT, Sun W, Hussain SF, DeAngulo G, Prabhu SS, Heimberger AB. Preferential migration of regulatory T cells mediated by glioma-secreted chemokines can be blocked with chemotherapy. Cancer Immunol Immunother (2008) 57:123-31. doi:10.1007/s00262-007-0336-x.
    • (2008) Cancer Immunol Immunother , vol.57 , pp. 123-131
    • Jordan, J.T.1    Sun, W.2    Hussain, S.F.3    DeAngulo, G.4    Prabhu, S.S.5    Heimberger, A.B.6
  • 118
    • 33645502885 scopus 로고    scopus 로고
    • Increased regulatory T-cell fraction amidst a diminished CD4 compartment explains cellular immune defects in patients with malignant glioma
    • Fecci PE, Mitchell DA, Whitesides JF, Xie W, Friedman AH, Archer GE, et al. Increased regulatory T-cell fraction amidst a diminished CD4 compartment explains cellular immune defects in patients with malignant glioma. Cancer Res (2006) 66:3294-302. doi:10.1158/0008-5472.CAN-05-3773.
    • (2006) Cancer Res , vol.66 , pp. 3294-3302
    • Fecci, P.E.1    Mitchell, D.A.2    Whitesides, J.F.3    Xie, W.4    Friedman, A.H.5    Archer, G.E.6
  • 119
    • 71749115790 scopus 로고    scopus 로고
    • Technical advancement in regulatory T cell isolation and characterization using CD127 expression in patients with malignant glioma treated with autologous dendritic cell vaccination
    • Ardon H, Verbinnen B, Maes W, Beez T, Van Gool S, De Vleeschouwer S. Technical advancement in regulatory T cell isolation and characterization using CD127 expression in patients with malignant glioma treated with autologous dendritic cell vaccination. J Immunol Methods (2009) 352(1-2):169-73. doi:10.1016/j.jim.2009.10.007.
    • (2009) J Immunol Methods , vol.352 , Issue.1-2 , pp. 169-173
    • Ardon, H.1    Verbinnen, B.2    Maes, W.3    Beez, T.4    Van Gool, S.5    De Vleeschouwer, S.6
  • 120
    • 84871719877 scopus 로고    scopus 로고
    • Comprehensive analysis of current approaches to inhibit regulatory T cells in cancer
    • Pere H, Tanchot C, Bayry J, Terme M, Taieb J, Badoual C, et al. Comprehensive analysis of current approaches to inhibit regulatory T cells in cancer. Oncoimmunology (2012) 1:326-33. doi:10.4161/onci.18852.
    • (2012) Oncoimmunology , vol.1 , pp. 326-333
    • Pere, H.1    Tanchot, C.2    Bayry, J.3    Terme, M.4    Taieb, J.5    Badoual, C.6
  • 121
    • 33745851174 scopus 로고    scopus 로고
    • Toll-like receptors on regulatory T cells: expanding immune regulation
    • Sutmuller RP, Morgan ME, Netea MG, Grauer O, Adema GJ. Toll-like receptors on regulatory T cells: expanding immune regulation. Trends Immunol (2006) 27:387-93. doi:10.1016/j.it.2006.06.005.
    • (2006) Trends Immunol , vol.27 , pp. 387-393
    • Sutmuller, R.P.1    Morgan, M.E.2    Netea, M.G.3    Grauer, O.4    Adema, G.J.5
  • 122
    • 23944509107 scopus 로고    scopus 로고
    • Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function
    • Peng G, Guo Z, Kiniwa Y, Voo KS, Peng W, Fu T, et al. Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function. Science (2005) 309:1380-4. doi:10.1126/science.1113401.
    • (2005) Science , vol.309 , pp. 1380-1384
    • Peng, G.1    Guo, Z.2    Kiniwa, Y.3    Voo, K.S.4    Peng, W.5    Fu, T.6
  • 123
    • 68549112974 scopus 로고    scopus 로고
    • Treg depletion with a low-dose metronomic temozolomide regimen in a rat glioma model
    • Banissi C, Ghiringhelli F, Chen L, Carpentier AF. Treg depletion with a low-dose metronomic temozolomide regimen in a rat glioma model. Cancer Immunol Immunother (2009) 58:1627-34. doi:10.1007/s00262-009-0671-1.
    • (2009) Cancer Immunol Immunother , vol.58 , pp. 1627-1634
    • Banissi, C.1    Ghiringhelli, F.2    Chen, L.3    Carpentier, A.F.4
  • 124
    • 74549126817 scopus 로고    scopus 로고
    • Immunological factors relating to the antitumor effect of temozolomide chemoimmunotherapy in a murine glioma model
    • Kim TG, Kim CH, Park JS, Park SD, Kim CK, Chung DS, et al. Immunological factors relating to the antitumor effect of temozolomide chemoimmunotherapy in a murine glioma model. Clin Vaccine Immunol (2010) 17:143-53. doi:10.1128/CVI.00292-09.
    • (2010) Clin Vaccine Immunol , vol.17 , pp. 143-153
    • Kim, T.G.1    Kim, C.H.2    Park, J.S.3    Park, S.D.4    Kim, C.K.5    Chung, D.S.6
  • 125
    • 84876678701 scopus 로고    scopus 로고
    • Low-dose gemcitabine depletes regulatory T cells and improves survival in the orthotopic Panc02 model of pancreatic cancer
    • Shevchenko I, Karakhanova S, Soltek S, Link J, Bayry J, Werner J, et al. Low-dose gemcitabine depletes regulatory T cells and improves survival in the orthotopic Panc02 model of pancreatic cancer. Int J Cancer (2013) 133(1):98-107. doi:10.1002/ijc.27990.
    • (2013) Int J Cancer , vol.133 , Issue.1 , pp. 98-107
    • Shevchenko, I.1    Karakhanova, S.2    Soltek, S.3    Link, J.4    Bayry, J.5    Werner, J.6
  • 126
    • 58149179532 scopus 로고    scopus 로고
    • Sunitinib reverses type-1 immune suppression and decreases T-regulatory cells in renal cell carcinoma patients
    • Finke JH, Rini B, Ireland J, Rayman P, Richmond A, Golshayan A, et al. Sunitinib reverses type-1 immune suppression and decreases T-regulatory cells in renal cell carcinoma patients. Clin Cancer Res (2008) 14:6674-82. doi:10.1158/1078-0432.CCR-07-5212.
    • (2008) Clin Cancer Res , vol.14 , pp. 6674-6682
    • Finke, J.H.1    Rini, B.2    Ireland, J.3    Rayman, P.4    Richmond, A.5    Golshayan, A.6
  • 127
    • 78149281950 scopus 로고    scopus 로고
    • A decrease of regulatory T cells correlates with overall survival after sunitinib-based antiangiogenic therapy in metastatic renal cancer patients
    • Adotevi O, Pere H, Ravel P, Haicheur N, Badoual C, Merillon N, et al. A decrease of regulatory T cells correlates with overall survival after sunitinib-based antiangiogenic therapy in metastatic renal cancer patients. J Immunother (2010) 33:991-8. doi:10.1097/CJI.0b013e3181f4c208.
    • (2010) J Immunother , vol.33 , pp. 991-998
    • Adotevi, O.1    Pere, H.2    Ravel, P.3    Haicheur, N.4    Badoual, C.5    Merillon, N.6
  • 128
    • 47049127786 scopus 로고    scopus 로고
    • Sorafenib, but not sunitinib, affects function of dendritic cells and induction of primary immune responses
    • Hipp MM, Hilf N, Walter S, Werth D, Brauer KM, Radsak MP, et al. Sorafenib, but not sunitinib, affects function of dendritic cells and induction of primary immune responses. Blood (2008) 111:5610-20. doi:10.1182/blood-2007-02-075945.
    • (2008) Blood , vol.111 , pp. 5610-5620
    • Hipp, M.M.1    Hilf, N.2    Walter, S.3    Werth, D.4    Brauer, K.M.5    Radsak, M.P.6
  • 129
    • 77953134540 scopus 로고    scopus 로고
    • Metronomic chemotherapy enhances antitumor effects of cancer vaccine by depleting regulatory T lymphocytes and inhibiting tumor angiogenesis
    • Chen CA, Ho CM, Chang MC, Sun WZ, Chen YL, Chiang YC, et al. Metronomic chemotherapy enhances antitumor effects of cancer vaccine by depleting regulatory T lymphocytes and inhibiting tumor angiogenesis. Mol Ther (2010) 18:1233-43. doi:10.1038/mt.2010.34.
    • (2010) Mol Ther , vol.18 , pp. 1233-1243
    • Chen, C.A.1    Ho, C.M.2    Chang, M.C.3    Sun, W.Z.4    Chen, Y.L.5    Chiang, Y.C.6
  • 130
    • 79953059547 scopus 로고    scopus 로고
    • Cotransfection of poly(I: C) and siRNA of IL-10 into fusions of dendritic and glioma cells enhances antitumor T helper type 1 induction in patients with glioma
    • Akasaki Y, Kikuchi T, Irie M, Yamamoto Y, Arai T, Tanaka T, et al. Cotransfection of poly(I: C) and siRNA of IL-10 into fusions of dendritic and glioma cells enhances antitumor T helper type 1 induction in patients with glioma. J Immunother (2011) 34:121-8. doi:10.1097/CJI.0b013e3181e5c278.
    • (2011) J Immunother , vol.34 , pp. 121-128
    • Akasaki, Y.1    Kikuchi, T.2    Irie, M.3    Yamamoto, Y.4    Arai, T.5    Tanaka, T.6
  • 131
    • 70350496784 scopus 로고    scopus 로고
    • Clinical use of anti-CD25 antibody daclizumab to enhance immune responses to tumor antigen vaccination by targeting regulatory T cells
    • Rech AJ, Vonderheide RH. Clinical use of anti-CD25 antibody daclizumab to enhance immune responses to tumor antigen vaccination by targeting regulatory T cells. Ann N Y Acad Sci (2009) 1174:99-106. doi:10.1111/j.1749-6632.2009.04939.x.
    • (2009) Ann N Y Acad Sci , vol.1174 , pp. 99-106
    • Rech, A.J.1    Vonderheide, R.H.2
  • 132
    • 50949115267 scopus 로고    scopus 로고
    • Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines
    • Morse MA, Hobeika AC, Osada T, Serra D, Niedzwiecki D, Lyerly HK, et al. Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines. Blood (2008) 112:610-8. doi:10.1182/blood-2008-01-135319.
    • (2008) Blood , vol.112 , pp. 610-618
    • Morse, M.A.1    Hobeika, A.C.2    Osada, T.3    Serra, D.4    Niedzwiecki, D.5    Lyerly, H.K.6
  • 133
    • 79951831706 scopus 로고    scopus 로고
    • Frequency of circulating Tregs with demethylated FOXP3 intron 1 in melanoma patients receiving tumor vaccines and potentially Treg-depleting agents
    • de Vries IJ, Castelli C, Huygens C, Jacobs JF, Stockis J, Schuler-Thurner B, et al. Frequency of circulating Tregs with demethylated FOXP3 intron 1 in melanoma patients receiving tumor vaccines and potentially Treg-depleting agents. Clin Cancer Res (2011) 17:841-8. doi:10.1158/1078-0432.CCR-10-2227.
    • (2011) Clin Cancer Res , vol.17 , pp. 841-848
    • de Vries, I.J.1    Castelli, C.2    Huygens, C.3    Jacobs, J.F.4    Stockis, J.5    Schuler-Thurner, B.6
  • 134
    • 84862495613 scopus 로고    scopus 로고
    • Phase I/II randomized trial of dendritic cell vaccination with or without cyclophosphamide for consolidation therapy of advanced ovarian cancer in first or second remission
    • Chu CS, Boyer J, Schullery DS, Gimotty PA, Gamerman V, Bender J, et al. Phase I/II randomized trial of dendritic cell vaccination with or without cyclophosphamide for consolidation therapy of advanced ovarian cancer in first or second remission. Cancer Immunol Immunother (2012) 61:629-41. doi:10.1007/s00262-011-1081-8.
    • (2012) Cancer Immunol Immunother , vol.61 , pp. 629-641
    • Chu, C.S.1    Boyer, J.2    Schullery, D.S.3    Gimotty, P.A.4    Gamerman, V.5    Bender, J.6
  • 135
    • 33847368549 scopus 로고    scopus 로고
    • Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients
    • Ghiringhelli F, Menard C, Puig PE, Ladoire S, Roux S, Martin F, et al. Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients. Cancer Immunol Immunother (2007) 56:641-8. doi:10.1007/s00262-006-0225-8.
    • (2007) Cancer Immunol Immunother , vol.56 , pp. 641-648
    • Ghiringhelli, F.1    Menard, C.2    Puig, P.E.3    Ladoire, S.4    Roux, S.5    Martin, F.6
  • 136
    • 85027957593 scopus 로고    scopus 로고
    • Immunomodulatory effects of cyclophosphamide and implementations for vaccine design
    • Sistigu A, Viaud S, Chaput N, Bracci L, Proietti E, Zitvogel L. Immunomodulatory effects of cyclophosphamide and implementations for vaccine design. Semin Immunopathol (2011) 33:369-83. doi:10.1007/s00281-011-0245-0.
    • (2011) Semin Immunopathol , vol.33 , pp. 369-383
    • Sistigu, A.1    Viaud, S.2    Chaput, N.3    Bracci, L.4    Proietti, E.5    Zitvogel, L.6
  • 137
    • 84863195770 scopus 로고    scopus 로고
    • Potentiation of a p53-SLP vaccine by cyclophosphamide in ovarian cancer: a single-arm phase II study
    • Vermeij R, Leffers N, Hoogeboom BN, Hamming IL, Wolf R, Reyners AK, et al. Potentiation of a p53-SLP vaccine by cyclophosphamide in ovarian cancer: a single-arm phase II study. Int J Cancer (2012) 131(5):E670-80. doi:10.1002/ijc.27388.
    • (2012) Int J Cancer , vol.131 , Issue.5 , pp. E670-E680
    • Vermeij, R.1    Leffers, N.2    Hoogeboom, B.N.3    Hamming, I.L.4    Wolf, R.5    Reyners, A.K.6
  • 138
    • 82255167661 scopus 로고    scopus 로고
    • Phase I-II study of everolimus and low-dose oral cyclophosphamide in patients with metastatic renal cell cancer
    • Huijts CM, Santegoets SJ, van den Eertwegh AJ, Pijpers LS, Haanen JB, de Gruijl TD, et al. Phase I-II study of everolimus and low-dose oral cyclophosphamide in patients with metastatic renal cell cancer. BMC Cancer (2011) 11:505. doi:10.1186/1471-2407-11-505.
    • (2011) BMC Cancer , vol.11 , pp. 505
    • Huijts, C.M.1    Santegoets, S.J.2    van den Eertwegh, A.J.3    Pijpers, L.S.4    Haanen, J.B.5    de Gruijl, T.D.6
  • 139
    • 84860815596 scopus 로고    scopus 로고
    • Metronomic cyclophosphamide treatment in metastasized breast cancer patients: immunological effects and clinical outcome
    • Ge Y, Domschke C, Stoiber N, Schott S, Heil J, Rom J, et al. Metronomic cyclophosphamide treatment in metastasized breast cancer patients: immunological effects and clinical outcome. Cancer Immunol Immunother (2011) 61(3):353-62. doi:10.1007/s00262-011-1106-3.
    • (2011) Cancer Immunol Immunother , vol.61 , Issue.3 , pp. 353-362
    • Ge, Y.1    Domschke, C.2    Stoiber, N.3    Schott, S.4    Heil, J.5    Rom, J.6
  • 140
    • 79551514818 scopus 로고    scopus 로고
    • Cyclophosphamide induces differentiation of Th17 cells in cancer patients
    • Viaud S, Flament C, Zoubir M, Pautier P, LeCesne A, Ribrag V, et al. Cyclophosphamide induces differentiation of Th17 cells in cancer patients. Cancer Res (2011) 71:661-5. doi:10.1158/0008-5472.CAN-10-1259.
    • (2011) Cancer Res , vol.71 , pp. 661-665
    • Viaud, S.1    Flament, C.2    Zoubir, M.3    Pautier, P.4    LeCesne, A.5    Ribrag, V.6
  • 141
    • 84872523491 scopus 로고    scopus 로고
    • Suppressive effects of cyclophosphamide and gemcitabine on regulatory T-cell induction in vitro
    • Kan S, Hazama S, Maeda K, Inoue Y, Homma S, Koido S, et al. Suppressive effects of cyclophosphamide and gemcitabine on regulatory T-cell induction in vitro. Anticancer Res (2012) 32:5363-9.
    • (2012) Anticancer Res , vol.32 , pp. 5363-5369
    • Kan, S.1    Hazama, S.2    Maeda, K.3    Inoue, Y.4    Homma, S.5    Koido, S.6
  • 142
    • 84872485478 scopus 로고    scopus 로고
    • Low-dose cyclophosphamide administered as daily or single dose enhances the antitumor effects of a therapeutic HPV vaccine
    • Peng S, Lyford-Pike S, Akpeng B, Wu A, Hung CF, Hannaman D, et al. Low-dose cyclophosphamide administered as daily or single dose enhances the antitumor effects of a therapeutic HPV vaccine. Cancer Immunol Immunother (2013) 62(1):171-82. doi:10.1007/s00262-012-1322-5.
    • (2013) Cancer Immunol Immunother , vol.62 , Issue.1 , pp. 171-182
    • Peng, S.1    Lyford-Pike, S.2    Akpeng, B.3    Wu, A.4    Hung, C.F.5    Hannaman, D.6
  • 143
    • 68249084528 scopus 로고    scopus 로고
    • Steroid treatments in mice do not alter the number and function of regulatory T cells, but amplify cyclophosphamide-induced autoimmune disease
    • Moraes-Fontes MF, Rebelo M, Caramalho I, Zelenay S, Bergman ML, Coutinho A, et al. Steroid treatments in mice do not alter the number and function of regulatory T cells, but amplify cyclophosphamide-induced autoimmune disease. J Autoimmun (2009) 33:109-20. doi:10.1016/j.jaut.2009.03.008.
    • (2009) J Autoimmun , vol.33 , pp. 109-120
    • Moraes-Fontes, M.F.1    Rebelo, M.2    Caramalho, I.3    Zelenay, S.4    Bergman, M.L.5    Coutinho, A.6
  • 144
    • 84934327880 scopus 로고    scopus 로고
    • Available from: http://ec.europa.eu/health/files/advtherapies/2014_atmp/atmp_en.pdf.
  • 145
    • 84921786887 scopus 로고    scopus 로고
    • DCVax(R)-L-developed by northwest biotherapeutics
    • Polyzoidis S, Keyoumars A. DCVax(R)-L-developed by northwest biotherapeutics. Hum Vaccin Immunother (2014) 10(11):3139-45. doi:10.4161/hv.29276.
    • (2014) Hum Vaccin Immunother , vol.10 , Issue.11 , pp. 3139-3145
    • Polyzoidis, S.1    Keyoumars, A.2
  • 147
    • 84908407414 scopus 로고    scopus 로고
    • Targeting human dendritic cells in situ to improve vaccines
    • Sehgal K, Dhodapkar KM, Dhodapkar MV. Targeting human dendritic cells in situ to improve vaccines. Immunol Lett (2014) 162(1 Pt A):59-67. doi:10.1016/j.imlet.2014.07.004.
    • (2014) Immunol Lett , vol.162 , Issue.1 , pp. 59-67
    • Sehgal, K.1    Dhodapkar, K.M.2    Dhodapkar, M.V.3
  • 148
    • 0142089462 scopus 로고    scopus 로고
    • Treatment of a glioblastoma patient by vaccination with autologous dendritic cells pulsed with allogeneic major histocompatibility complex class I-matched tumor peptides: case report
    • Liau LM, Black KL, Martin NA, Sykes SN, Bronstein JM, Jouben-Steele L, et al. Treatment of a glioblastoma patient by vaccination with autologous dendritic cells pulsed with allogeneic major histocompatibility complex class I-matched tumor peptides: case report. Neurosurg Focus (2000) 9(6):e8. doi:10.3171/foc.2000.9.6.9.
    • (2000) Neurosurg Focus , vol.9 , Issue.6
    • Liau, L.M.1    Black, K.L.2    Martin, N.A.3    Sykes, S.N.4    Bronstein, J.M.5    Jouben-Steele, L.6
  • 149
    • 0035107548 scopus 로고    scopus 로고
    • Vaccination of malignant glioma patients with peptide-pulsed dendritic cells elicits systemic cytotoxicity and intracranial T-cell infiltration
    • Yu JS, Wheeler CJ, Zeltzer PM, Ying H, Finger DN, Lee PK, et al. Vaccination of malignant glioma patients with peptide-pulsed dendritic cells elicits systemic cytotoxicity and intracranial T-cell infiltration. Cancer Res (2001) 61:842-7.
    • (2001) Cancer Res , vol.61 , pp. 842-847
    • Yu, J.S.1    Wheeler, C.J.2    Zeltzer, P.M.3    Ying, H.4    Finger, D.N.5    Lee, P.K.6
  • 150
    • 0034840181 scopus 로고    scopus 로고
    • Results of a phase I clinical trial of vaccination of glioma patients with fusions of dendritic and glioma cells
    • Kikuchi T, Akasaki Y, Irie M, Homma S, Abe T, Ohno T. Results of a phase I clinical trial of vaccination of glioma patients with fusions of dendritic and glioma cells. Cancer Immunol Immunother (2001) 50:337-44. doi:10.1007/s002620100205.
    • (2001) Cancer Immunol Immunother , vol.50 , pp. 337-344
    • Kikuchi, T.1    Akasaki, Y.2    Irie, M.3    Homma, S.4    Abe, T.5    Ohno, T.6
  • 151
    • 4344560470 scopus 로고    scopus 로고
    • Results of a phase 1 study utilizing monocyte-derived dendritic cells pulsed with tumor RNA in children and young adults with brain cancer
    • Caruso DA, Orme LM, Neale AM, Radcliff FJ, Amor GM, Maixner W, et al. Results of a phase 1 study utilizing monocyte-derived dendritic cells pulsed with tumor RNA in children and young adults with brain cancer. Neuro Oncol (2004) 6:236-46. doi:10.1215/S1152851703000668.
    • (2004) Neuro Oncol , vol.6 , pp. 236-246
    • Caruso, D.A.1    Orme, L.M.2    Neale, A.M.3    Radcliff, F.J.4    Amor, G.M.5    Maixner, W.6
  • 152
    • 23044479028 scopus 로고    scopus 로고
    • Dendritic cell vaccination in glioblastoma patients induces systemic and intracranial T-cell responses modulated by the local central nervous system tumor microenvironment
    • Liau LM, Prins RM, Kiertscher SM, Odesa SK, Kremen TJ, Giovannone AJ, et al. Dendritic cell vaccination in glioblastoma patients induces systemic and intracranial T-cell responses modulated by the local central nervous system tumor microenvironment. Clin Cancer Res (2005) 11:5515-25. doi:10.1158/1078-0432.CCR-05-0464.
    • (2005) Clin Cancer Res , vol.11 , pp. 5515-5525
    • Liau, L.M.1    Prins, R.M.2    Kiertscher, S.M.3    Odesa, S.K.4    Kremen, T.J.5    Giovannone, A.J.6
  • 153
    • 40149090821 scopus 로고    scopus 로고
    • Autologous glioma cell vaccine admixed with interleukin-4 gene transfected fibroblasts in the treatment of patients with malignant gliomas
    • Okada H, Lieberman FS, Walter KA, Lunsford LD, Kondziolka DS, Bejjani GK, et al. Autologous glioma cell vaccine admixed with interleukin-4 gene transfected fibroblasts in the treatment of patients with malignant gliomas. J Transl Med (2007) 5:67. doi:10.1186/1479-5876-5-67.
    • (2007) J Transl Med , vol.5 , pp. 67
    • Okada, H.1    Lieberman, F.S.2    Walter, K.A.3    Lunsford, L.D.4    Kondziolka, D.S.5    Bejjani, G.K.6
  • 154
    • 37549021127 scopus 로고    scopus 로고
    • Results of a phase I dendritic cell vaccine trial for malignant astrocytoma: potential interaction with adjuvant chemotherapy
    • Walker DG, Laherty R, Tomlinson FH, Chuah T, Schmidt C. Results of a phase I dendritic cell vaccine trial for malignant astrocytoma: potential interaction with adjuvant chemotherapy. J Clin Neurosci (2008) 15:114-21. doi:10.1016/j.jocn.2007.08.007.
    • (2008) J Clin Neurosci , vol.15 , pp. 114-121
    • Walker, D.G.1    Laherty, R.2    Tomlinson, F.H.3    Chuah, T.4    Schmidt, C.5
  • 155
    • 48249102647 scopus 로고    scopus 로고
    • Cytomegalovirus immunity after vaccination with autologous glioblastoma lysate
    • Prins RM, Cloughesy TF, Liau LM. Cytomegalovirus immunity after vaccination with autologous glioblastoma lysate. N Engl J Med (2008) 359:539-41. doi:10.1056/NEJMc0804818.
    • (2008) N Engl J Med , vol.359 , pp. 539-541
    • Prins, R.M.1    Cloughesy, T.F.2    Liau, L.M.3
  • 156
    • 70350236627 scopus 로고    scopus 로고
    • An epidermal growth factor receptor variant III-targeted vaccine is safe and immunogenic in patients with glioblastoma multiforme
    • Sampson JH, Archer GE, Mitchell DA, Heimberger AB, Herndon JE, Lally-Goss D, et al. An epidermal growth factor receptor variant III-targeted vaccine is safe and immunogenic in patients with glioblastoma multiforme. Mol Cancer Ther (2009) 8:2773-9. doi:10.1158/1535-7163.MCT-09-0124.
    • (2009) Mol Cancer Ther , vol.8 , pp. 2773-2779
    • Sampson, J.H.1    Archer, G.E.2    Mitchell, D.A.3    Heimberger, A.B.4    Herndon, J.E.5    Lally-Goss, D.6
  • 157
    • 84859258334 scopus 로고    scopus 로고
    • Monitoring of regulatory T cell frequencies and expression of CTLA-4 on T cells, before and after DC vaccination, can predict survival in GBM patients
    • Fong B, Jin R, Wang X, Safaee M, Lisiero DN, Yang I, et al. Monitoring of regulatory T cell frequencies and expression of CTLA-4 on T cells, before and after DC vaccination, can predict survival in GBM patients. PLoS One (2012) 7:e32614. doi:10.1371/journal.pone.0032614.
    • (2012) PLoS One , vol.7
    • Fong, B.1    Jin, R.2    Wang, X.3    Safaee, M.4    Lisiero, D.N.5    Yang, I.6
  • 158
    • 84878194097 scopus 로고    scopus 로고
    • Autologous tumor lysate-pulsed dendritic cell immunotherapy for pediatric patients with newly diagnosed or recurrent high-grade gliomas
    • Lasky JL III, Panosyan EH, Plant A, Davidson T, Yong WH, Prins RM, et al. Autologous tumor lysate-pulsed dendritic cell immunotherapy for pediatric patients with newly diagnosed or recurrent high-grade gliomas. Anticancer Res (2013) 33:2047-56.
    • (2013) Anticancer Res , vol.33 , pp. 2047-2056
    • Lasky J.L, I.I.I.1    Panosyan, E.H.2    Plant, A.3    Davidson, T.4    Yong, W.H.5    Prins, R.M.6
  • 159
    • 84883458285 scopus 로고    scopus 로고
    • Therapeutic vaccination against autologous cancer stem cells with mRNA-transfected dendritic cells in patients with glioblastoma
    • Vik-Mo EO, Nyakas M, Mikkelsen BV, Moe MC, Due-Tonnesen P, Suso EM, et al. Therapeutic vaccination against autologous cancer stem cells with mRNA-transfected dendritic cells in patients with glioblastoma. Cancer Immunol Immunother (2013) 62(9):1499-509. doi:10.1007/s00262-013-1453-3.
    • (2013) Cancer Immunol Immunother , vol.62 , Issue.9 , pp. 1499-1509
    • Vik-Mo, E.O.1    Nyakas, M.2    Mikkelsen, B.V.3    Moe, M.C.4    Due-Tonnesen, P.5    Suso, E.M.6
  • 160
    • 84871546020 scopus 로고    scopus 로고
    • Alpha-type-1 polarized dendritic cell-based vaccination in recurrent high-grade glioma: a phase I clinical trial
    • Akiyama Y, Oshita C, Kume A, Iizuka A, Miyata H, Komiyama M, et al. Alpha-type-1 polarized dendritic cell-based vaccination in recurrent high-grade glioma: a phase I clinical trial. BMC Cancer (2012) 12:623. doi:10.1186/1471-2407-12-623.
    • (2012) BMC Cancer , vol.12 , pp. 623
    • Akiyama, Y.1    Oshita, C.2    Kume, A.3    Iizuka, A.4    Miyata, H.5    Komiyama, M.6
  • 161
    • 84886943535 scopus 로고    scopus 로고
    • The natural killer cell response and tumor debulking are associated with prolonged survival in recurrent glioblastoma patients receiving dendritic cells loaded with autologous tumor lysates
    • Pellegatta S, Eoli M, Frigerio S, Antozzi C, Bruzzone MG, Cantini G, et al. The natural killer cell response and tumor debulking are associated with prolonged survival in recurrent glioblastoma patients receiving dendritic cells loaded with autologous tumor lysates. Oncoimmunology (2013) 2:e23401. doi:10.4161/onci.23401.
    • (2013) Oncoimmunology , vol.2
    • Pellegatta, S.1    Eoli, M.2    Frigerio, S.3    Antozzi, C.4    Bruzzone, M.G.5    Cantini, G.6
  • 162
    • 0242329784 scopus 로고    scopus 로고
    • Vaccination of recurrent glioma patients with tumour lysate-pulsed dendritic cells elicits immune responses: results of a clinical phase I/II trial
    • Yamanaka R, Abe T, Yajima N, Tsuchiya N, Homma J, Kobayashi T, et al. Vaccination of recurrent glioma patients with tumour lysate-pulsed dendritic cells elicits immune responses: results of a clinical phase I/II trial. Br J Cancer (2003) 89:1172-9. doi:10.1038/sj.bjc.6601268.
    • (2003) Br J Cancer , vol.89 , pp. 1172-1179
    • Yamanaka, R.1    Abe, T.2    Yajima, N.3    Tsuchiya, N.4    Homma, J.5    Kobayashi, T.6
  • 163
    • 0142179258 scopus 로고    scopus 로고
    • Thymic CD8(+) T cell production strongly influences tumor antigen recognition and age-dependent glioma mortality
    • Wheeler CJ, Black KL, Liu G, Ying H, Yu JS, Zhang W, et al. Thymic CD8(+) T cell production strongly influences tumor antigen recognition and age-dependent glioma mortality. J Immunol (2003) 171:4927-33. doi:10.4049/jimmunol.171.9.4927.
    • (2003) J Immunol , vol.171 , pp. 4927-4933
    • Wheeler, C.J.1    Black, K.L.2    Liu, G.3    Ying, H.4    Yu, J.S.5    Zhang, W.6
  • 164
    • 3142692559 scopus 로고    scopus 로고
    • Vaccination with tumor lysate-pulsed dendritic cells elicits antigen-specific, cytotoxic T-cells in patients with malignant glioma
    • Yu JS, Liu G, Ying H, Yong WH, Black KL, Wheeler CJ. Vaccination with tumor lysate-pulsed dendritic cells elicits antigen-specific, cytotoxic T-cells in patients with malignant glioma. Cancer Res (2004) 64:4973-9. doi:10.1158/0008-5472.CAN-03-3505.
    • (2004) Cancer Res , vol.64 , pp. 4973-4979
    • Yu, J.S.1    Liu, G.2    Ying, H.3    Yong, W.H.4    Black, K.L.5    Wheeler, C.J.6
  • 165
    • 7444220033 scopus 로고    scopus 로고
    • Vaccination of glioma patients with fusions of dendritic and glioma cells and recombinant human interleukin 12
    • Kikuchi T, Akasaki Y, Abe T, Fukuda T, Saotome H, Ryan JL, et al. Vaccination of glioma patients with fusions of dendritic and glioma cells and recombinant human interleukin 12. J Immunother (2004) 27:452-9. doi:10.1097/00002371-200411000-00005.
    • (2004) J Immunother , vol.27 , pp. 452-459
    • Kikuchi, T.1    Akasaki, Y.2    Abe, T.3    Fukuda, T.4    Saotome, H.5    Ryan, J.L.6
  • 166
    • 20344372430 scopus 로고    scopus 로고
    • Clinical evaluation of dendritic cell vaccination for patients with recurrent glioma: results of a clinical phase I/II trial
    • Yamanaka R, Homma J, Yajima N, Tsuchiya N, Sano M, Kobayashi T, et al. Clinical evaluation of dendritic cell vaccination for patients with recurrent glioma: results of a clinical phase I/II trial. Clin Cancer Res (2005) 11:4160-7. doi:10.1158/1078-0432.CCR-05-0120.
    • (2005) Clin Cancer Res , vol.11 , pp. 4160-4167
    • Yamanaka, R.1    Homma, J.2    Yajima, N.3    Tsuchiya, N.4    Sano, M.5    Kobayashi, T.6
  • 167
    • 79951978155 scopus 로고    scopus 로고
    • Induction of CD8+ T-cell responses against novel glioma-associated antigen peptides and clinical activity by vaccinations with {alpha}-type 1 polarized dendritic cells and polyinosinic-polycytidylic acid stabilized by lysine and carboxymethylcellulose in patients with recurrent malignant glioma
    • Okada H, Kalinski P, Ueda R, Hoji A, Kohanbash G, Donegan TE, et al. Induction of CD8+ T-cell responses against novel glioma-associated antigen peptides and clinical activity by vaccinations with {alpha}-type 1 polarized dendritic cells and polyinosinic-polycytidylic acid stabilized by lysine and carboxymethylcellulose in patients with recurrent malignant glioma. J Clin Oncol (2011) 29:330-6. doi:10.1200/JCO.2010.30.7744.
    • (2011) J Clin Oncol , vol.29 , pp. 330-336
    • Okada, H.1    Kalinski, P.2    Ueda, R.3    Hoji, A.4    Kohanbash, G.5    Donegan, T.E.6
  • 168
    • 79960735609 scopus 로고    scopus 로고
    • A phase I/II clinical trial investigating the adverse and therapeutic effects of a postoperative autologous dendritic cell tumor vaccine in patients with malignant glioma
    • Chang CN, Huang YC, Yang DM, Kikuta K, Wei KJ, Kubota T, et al. A phase I/II clinical trial investigating the adverse and therapeutic effects of a postoperative autologous dendritic cell tumor vaccine in patients with malignant glioma. J Clin Neurosci (2011) 18:1048-54. doi:10.1016/j.jocn.2010.11.034.
    • (2011) J Clin Neurosci , vol.18 , pp. 1048-1054
    • Chang, C.N.1    Huang, Y.C.2    Yang, D.M.3    Kikuta, K.4    Wei, K.J.5    Kubota, T.6
  • 169
    • 79955591522 scopus 로고    scopus 로고
    • Immune response in patients with newly diagnosed glioblastoma multiforme treated with intranodal autologous tumor lysate-dendritic cell vaccination after radiation chemotherapy
    • Fadul CE, Fisher JL, Hampton TH, Lallana EC, Li Z, Gui J, et al. Immune response in patients with newly diagnosed glioblastoma multiforme treated with intranodal autologous tumor lysate-dendritic cell vaccination after radiation chemotherapy. J Immunother (2011) 34:382-9. doi:10.1097/CJI.0b013e318215e300.
    • (2011) J Immunother , vol.34 , pp. 382-389
    • Fadul, C.E.1    Fisher, J.L.2    Hampton, T.H.3    Lallana, E.C.4    Li, Z.5    Gui, J.6
  • 170
    • 84855597498 scopus 로고    scopus 로고
    • Clinical application of a dendritic cell vaccine raised against heat-shocked glioblastoma
    • Jie X, Hua L, Jiang W, Feng F, Feng G, Hua Z. Clinical application of a dendritic cell vaccine raised against heat-shocked glioblastoma. Cell Biochem Biophys (2012) 62:91-9. doi:10.1007/s12013-011-9265-6.
    • (2012) Cell Biochem Biophys , vol.62 , pp. 91-99
    • Jie, X.1    Hua, L.2    Jiang, W.3    Feng, F.4    Feng, G.5    Hua, Z.6
  • 171
    • 84862205027 scopus 로고    scopus 로고
    • Peptide-pulsed dendritic cell vaccination targeting interleukin-13 receptor alpha2 chain in recurrent malignant glioma patients with HLA-A*24/A*02 allele
    • Iwami K, Shimato S, Ohno M, Okada H, Nakahara N, Sato Y, et al. Peptide-pulsed dendritic cell vaccination targeting interleukin-13 receptor alpha2 chain in recurrent malignant glioma patients with HLA-A*24/A*02 allele. Cytotherapy (2012) 14(6):733-42. doi:10.3109/14653249.2012.666633.
    • (2012) Cytotherapy , vol.14 , Issue.6 , pp. 733-742
    • Iwami, K.1    Shimato, S.2    Ohno, M.3    Okada, H.4    Nakahara, N.5    Sato, Y.6
  • 172
    • 84864151615 scopus 로고    scopus 로고
    • Adjuvant immunotherapy with whole-cell lysate dendritic cells vaccine for glioblastoma multiforme: a phase II clinical trial
    • Cho DY, Yang WK, Lee HC, Hsu DM, Lin HL, Lin SZ, et al. Adjuvant immunotherapy with whole-cell lysate dendritic cells vaccine for glioblastoma multiforme: a phase II clinical trial. World Neurosurg (2011) 77(5-6):736-44. doi:10.1016/j.wneu.2011.08.020.
    • (2011) World Neurosurg , vol.77 , Issue.5-6 , pp. 736-744
    • Cho, D.Y.1    Yang, W.K.2    Lee, H.C.3    Hsu, D.M.4    Lin, H.L.5    Lin, S.Z.6
  • 173
    • 84872498982 scopus 로고    scopus 로고
    • Phase I trial of a multi-epitope-pulsed dendritic cell vaccine for patients with newly diagnosed glioblastoma
    • Phuphanich S, Wheeler CJ, Rudnick JD, Mazer M, Wang H, Nuno MA, et al. Phase I trial of a multi-epitope-pulsed dendritic cell vaccine for patients with newly diagnosed glioblastoma. Cancer Immunol Immunother (2013) 62:125-35. doi:10.1007/s00262-012-1319-0.
    • (2013) Cancer Immunol Immunother , vol.62 , pp. 125-135
    • Phuphanich, S.1    Wheeler, C.J.2    Rudnick, J.D.3    Mazer, M.4    Wang, H.5    Nuno, M.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.