Thymic CD8+ T Cell Production Strongly Influences Tumor Antigen Recognition and Age-Dependent Glioma Mortality

Journal of Immunology

Volumn 171, Issue 9, 2003, Pages 4927-4933

  Wheeler, Christopher J ^a   Black, Keith L ^a   Liu, Gentao ^a   Ying, Han ^a,b   Yu, John S ^a   Zhang, Wenxuan ^a   Lee, Paul K ^a,c  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b BAYER AG   (Germany)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER VACCINE; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; COMPLEMENTARY DNA; DNA; EPITOPE; GAMMA INTERFERON; T LYMPHOCYTE RECEPTOR; TUMOR ANTIGEN;

ADULT; AGED; AGING; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; ARTICLE; BRAIN TUMOR; CANCER MORTALITY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; FLOW CYTOMETRY; GLIOBLASTOMA; GLIOMA; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; T LYMPHOCYTE; THYMUS; TREATMENT OUTCOME; VACCINATION;

EID: 0142179258     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.171.9.4927     Document Type: Article

References (34)

1. Davis, F. G., V. Kupelian, S. Freels, B. McCarthy, and T. Surawicz. 2001. Prevalence estimates for primary brain tumors in the United States by behavior and major histology groups. Neuro-oncol. 3:152.
2. Reavey-Cantwell, J. F., R. I. Haroun, M. Zahurak, R. E. Clatterbuck, R. J. Parker, R. Mehta, J. P. Fruehauf, and H. Brem. 2001. The prognostic value of tumor markers in patients with glioblastoma multiforme: analysis of 32 patients and review of the literature. J. Neurooncol. 55:195.
3. Ries, L. A. G., M. P. Eisner, C. L. Kosary, B. F. Hankey, B. A. Miller, L. Clegg, and B. K. Edwards. 2002. SEER Cancer Statistics Review, 1973-1999. National Cancer Institute, Bethesda, MD.
4. + T cell adoptive immunotherapy. Immunity 13:265.
5. Kugler, A., G. Stuhler, P. Walden, G. Zoller, A. Zobywalski, P. Brossart, U. Trefzer, S. Ullrich, C. A. Muller, V. Becker, et al. 2000. Regression of human metastatic renal cell carcinoma after vaccination with tumor cell-dendritic cell hybrids. Nat. Med. 6:332.
6. Posnett, D. N., R. Sinha, S. Kabak, and C. Russo. 1994. Clonal populations of T cells in normal elderly humans: the T cell equivalent to "benign monoclonal gammapathy." [Published erratum appears in 1994 J. Exp. Med. 179:1077.] J. Exp. Med. 179:609.
7. Posnett, D. N., R. Sinha, S. Kabak, and C. Russo. 1994. Clonal populations of T cells in normal elderly humans: the T cell equivalent to "benign monoclonal gammapathy." [Published erratum appears in 1994 J. Exp. Med. 179:1077.] J. Exp. Med. 179:609.
8. + T cell clones in elderly humans. J. Immunol. 158:4493.
9. Douek, D. C., R. D. McFarland, P. H. Keiser, E. A. Gage, J. M. Massey, B. F. Haynes, M. A. Polis, A. T. Haase, M. B. Feinberg, J. L. Sullivan, et al. 1998. Changes in thymic function with age and during the treatment of HIV infection. Nature 396:690.
10. Jamieson, B. D., D. C. Douek, S. Killian, L. E. Hultin, D. D. Scripture-Adams, J. V. Giorgi, D. Marelli, R. A. Koup, and J. A. Zack. 1999. Generation of functional thymocytes in the human adult. Immunity 10:569.
11. Sempowski, G. D., M. E. Gooding, H. X. Liao, P. T. Le, and B. F. Haynes. 2002. T cell receptor excision circle assessment of thymopoiesis in aging mice. Mol. Immunol. 38:841.
12. Yu, J. S., C. J. Wheeler, P. M. Zeltzer, H. Ying, D. N. Finger, P. K. Lee, W. H. Yong, F. Incardona, R. C. Thompson, M. S. Riedinger, et al. 2001. Vaccination of malignant glioma patients with peptide-pulsed dendritic cells elicits systemic cytotoxicity and intracranial T-cell infiltration. Cancer Res. 61:842.
13. Douek, D. C., R. A. Vescio, M. R. Betts, J. M. Brenchley, B. J. Hill, L. Zhang, J. R. Berenson, R. H. Collins, and R. A. Koup. 2000. Assessment of thymic output in adults after haematopoietic stem-cell transplantation and prediction of T-cell reconstitution. Lancet 355:1875.
14. Kammula, U. S., K.-H. Lee, A. I. Riker, E. Wang, G. A. Ohnmacht, S. A. Rosenberg, and F. M. Marincola. 1999. Functional analysis of antigen-specific T lymphocytes by serial measurement of gene expression in peripheral blood mononuclear cells and tumor specimens. J. Immunol. 163:6867.
15. Kammula, U. S., F. M. Marincola, and S. A. Rosenberg. 2000. Real-time quantitative polymerase chain reaction assessment of immune reactivity in melanoma patients after tumor peptide vaccination. J. Natl. Cancer Inst. 92:1336.
16. Steffens, C. M., L. Al-Harthi, S. Shott, R. Yogev, and A. Landay. 2000. Evaluation of thymopoiesis using T cell receptor excision circles (TRECs): differential correlation between adult and pediatric TRECs and naive phenotypes. Clin. Immunol. 97:95.
17. Burger, P. C., F. S. Vogel, S. B. Green, and T. A. Strike. 1985. Glioblastoma multiforme and anaplastic astrocytoma: pathologic criteria and prognostic implications. Cancer 56:1106.
18. Lote, K., T. Egeland, B. Hager, B. Stenwig, K. Skullerud, J. Berg-Johnsen, I. Storm-Mathisen, and H. Hirschberg. 1997. Survival, prognostic factors, and therapeutic efficacy in low-grade glioma: a retrospective study in 379 patients. J. Clin. Oncol. 15:3129.
19. Hazenberg, M. D., S. A. Otto, J. W. Cohen Stuart, M. C. Verschuren, J. C. Borleffs, C. A. Boucher, R. A. Coutinho, J. M. Lange, T. F. Rinke de Wit, A. Tsegaye, et al. 2000. Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection. Nat. Med. 6:1036.
20. McFarland, R. D., D. C. Douek, R. A. Koup, and L. J. Picker. 2000. Identification of a human recent thymic emigrant phenotype. Proc. Natl. Acad. Sci. USA 97:4215.
21. E (CD103)-deficient mice. J. Immunol. 162:6641.
22. Howie, D., J. Spencer, D. DeLord, C. Pitzalis, N. C. Wathen, A. Dogan, A. Akbar, and T. T. MacDonald. 1998. Extrathymic T cell differentiation in the human intestine early in life. J. Immunol. 161:5862.
23. Siesjo, P., E. Visse, and H. O. Sjogren. 1996. Cure of established, intracerebral rat gliomas induced by therapeutic immunizations with tumor cells and purified APC or adjuvant IFN-γ treatment. J. Immunother. Emphasis Tumor Immunol. 19:334.
24. Liau, L. M., K. L. Black, R. M. Prins, S. N. Sykes, P. L. DiPatre, T. F. Cloughesy, D. P. Becker, and J. M. Bronstein. 1999. Treatment of intracranial gliomas with bone marrow-derived dendritic cells pulsed with tumor antigens. J. Neurosurg. 90:1115.
25. Ni, H. T., S. R. Spellman, W. C. Jean, W. A. Hall, and W. C. Low. 2001. Immunization with dendritic cells pulsed with tumor extract increases survival of mice bearing intracranial gliomas. J. Neurooncol. 51:1.
26. Crooks, M. E., and D. R. Littman. 1994. Disruption of T lymphocyte positive and negative selection in mice lacking the CD8 β chain. Immunity 1:277.
27. + T cells in CD8 β gene-targeted mice. J. Exp. Med. 180:959.
28. Miller, E. E. 1980. Immunity and drug resistance in a mouse glioma. J. Surg. Oncol. 14:125.
29. Pili, R., Y. Guo, J. Chang, H. Nakanishi, G. R. Martin, and A. Passaniti. 1994. Altered angiogenesis underlying age-dependent changes in tumor growth. J. Natl. Cancer Inst. 86:1303.
30. Prins, R. M., M. R. Graf, R. E. Merchant, K. L. Black, and C. J. Wheeler. 2003. Deficits in thymic function and output of recent thymic emigrant T cells during intracranial glioma progression. J. Neurooncol. 64:45.
31. Disis, M. L., J. W. Smith, A. E. Murphy, W. Chen, and M. A. Cheever. 1994. In vitro generation of human cytolytic T-cells specific for peptides derived from the HER-2/neu protooncogene protein. Cancer Res. 54:1071.
32. Bakker, A. B., M. W. Schreurs, G. Tafazzul, A. J. de Boer, Y. Kawakami, G. J. Adema, and C. G. Figdor. 1995. Identification of a novel peptide derived from the melanocyte-specific gp100 antigen as the dominant epitope recognized by an HLA-A2. I-restricted anti-melanoma CTL line. Int. J. Cancer 62:97.
33. Van den Eynde, B., O. Peeters, O. De Backer, B. Gaugler, S. Lucas, and T. Boon. 1995. A new fami]y of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma. J. Exp. Med. 182:689.
34. Lupetti, R., P. Pisarra, A. Verrecchia, C. Farina, G. Nicolini, A. Anichini. C. Bordignon, M. Sensi, G. Parmiani, and C. Traversari. 1998. Translation of a retained intron in tyrosinase-related protein (TRP) 2 mRNA generates a new cytotoxic T lymphocyte (CTL)-defined and shared human melanoma antigen not expressed in normal cells of the melanocytic lineage. J. Exp. Med. 188:1005.