A phase I/II clinical trial investigating the adverse and therapeutic effects of a postoperative autologous dendritic cell tumor vaccine in patients with malignant glioma

Journal of Clinical Neuroscience

Volumn 18, Issue 8, 2011, Pages 1048-1054

  Chang, Chen Nen ^a,b,e   Huang, Yin Cheng ^a,b   Yang, Den Mei ^c,d   Kikuta, Kenichiro ^e   Wei, Kuo Jen ^a,b   Kubota, Toshihiko ^e   Yang, Wen Kuang ^c,d  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

^c INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

^e UNIVERSITY OF FUKUI   (Japan)

Author keywords

Adverse effect; cGLP cGCP; Dendritic cell vaccine; Malignant gliomas; Serum ALT AST; Survival rate

Indexed keywords

CD8 ANTIGEN; DENDRITIC CELL VACCINE;

ADJUVANT THERAPY; ADOLESCENT; ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CANCER GRADING; CANCER IMMUNOTHERAPY; CANCER RADIOTHERAPY; CANCER RELAPSE; CANCER SURVIVAL; CD8+ T LYMPHOCYTE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CRANIOTOMY; CYTOREDUCTIVE SURGERY; FEMALE; GLIOBLASTOMA; HUMAN; LYMPHOCYTE COUNT; LYMPHOCYTOPENIA; MAJOR CLINICAL STUDY; MALE; OPEN STUDY; OVERALL SURVIVAL; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; SIDE EFFECT; TREATMENT OUTCOME; TUMOR ASSOCIATED LEUKOCYTE; TUMOR VOLUME;

ADOLESCENT; ADULT; AGED; ANTIGENS, CD; BRAIN NEOPLASMS; CANCER VACCINES; DENDRITIC CELLS; FEMALE; FOLLOW-UP STUDIES; GLIAL FIBRILLARY ACIDIC PROTEIN; GLIOMA; HUMANS; IMMUNOTHERAPY, ADOPTIVE; KAPLAN-MEIER ESTIMATE; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; POSTOPERATIVE PERIOD; TIME FACTORS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 79960735609     PISSN: 09675868     EISSN: 15322653     Source Type: Journal    
DOI: 10.1016/j.jocn.2010.11.034     Document Type: Article

References (23)

1. E.R. Laws, I.F. Parney, and W. Huang Survival following surgery and prognostic factors for recently diagnosed malignant glioma: data from the Glioma Outcomes Project J Neurosurg 99 2003 467 473 (Pubitemid 37040405)
2. G. Schuler, and R.M. Steinman Dendritic cells as adjuvants for immune-mediated resistance to tumors J Exp Med 186 1997 1183 1187 (Pubitemid 27469012)
3. J.M. Timmerman, and R. Levy Dendritic cell vaccines for cancer immunotherapy Annu Rev Med 50 1999 507 529 (Pubitemid 29117080)
4. M.V. Dhodapkar, J. Krasovsky, and R.M. Steinman Mature dendritic cells boost functionally superior CD8(+) T-cell in humans without foreign helper epitopes J Clin Invest 105 2000 R9 R14
5. M.A. Morse, R.E. Coleman, and G. Akabani Migration of human dendritic cells after injection in patients with metastatic malignancies Cancer Res 59 1999 56 58 (Pubitemid 29062955)
6. S. de Vleeschouwer, M. Rapp, and R.V. Sorg Dendritic cell vaccination in patients with malignant gliomas: current status and future directions Neurosurgery 59 2006 988 999 discussion 999-1000 (Pubitemid 44852063)
7. T. Kikuchi, Y. Akasaki, and M. Irie Results of a phase I clinical trial of vaccination of glioma patients with fusions of dendritic and glioma cells Cancer Immunol Immunother 50 2001 337 344 (Pubitemid 32835343)
8. T. Kikuchi, Y. Akasaki, and T. Abe Vaccination of glioma patients with fusions of dendritic and glioma cells and recombinant human interleukin 12 J Immunother 27 2004 452 459 (Pubitemid 39447353)
9. L.M. Liau, R.M. Prins, and S.M. Kiertscher Dendritic cell vaccination in glioblastoma patients induces systemic and intracranial T-cell responses modulated by the local central nervous system tumor microenvironment Clin Cancer Res 11 2005 5515 5525 (Pubitemid 41060828)
10. R. Yamanaka, T. Abe, and N. Yajima Vaccination of recurrent glioma patients with tumour lysate-pulsed dendritic cells elicits immune responses: results of a clinical phase I/II trial Br J Cancer 89 2003 1172 1179 (Pubitemid 37363398)
11. R. Yamanaka, J. Honma, and N. Tsuchiya Tumor lysate and IL-18 loaded dendritic cells elicits Th1 response, tumor-specific CD8+ cytotoxic T cells in patients with malignant glioma J Neurooncol 72 2005 107 113 (Pubitemid 40796460)
12. J.S. Yu, G. Liu, and H. Ying Vaccination with tumor lysate-pulsed dendritic cells elicits antigen-specific, cytotoxic T-cells in patients with malignant glioma Cancer Res 64 2004 4973 4979 (Pubitemid 38924545)
13. J.S. Yu, C.J. Wheeler, and P.M. Zeltzer Vaccination of malignant glioma patients with peptide-pulsed dendritic cells elicits systemic cytotoxicity and intracranial T-cell infiltration Cancer Res 61 2001 842 847 (Pubitemid 32175145)
14. I. Boutron, D. Moher, and D.G. Altman Extending the CONSORT statement to randomized trials of nonpharmacologic treatment: explanation and elaboration Ann Intern Med 148 2008 295 309 (Pubitemid 351665487)
15. M.H. Chen, W.K. Yang, and J. Whang-Peng Differential inducibilities of GFAP expression, cytostasis and apoptosis in primary cultures of human astrocytic tumours Apoptosis 3 1998 171 182 (Pubitemid 128513160)
16. A. Bender, M. Sapp, and G. Schuler Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood J Immunol Methods 196 1996 121 135 (Pubitemid 26306734)
17. H. Jonuleit, U. Kuhn, and G. Muller Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions Eur J Immunol 27 1997 3135 3142 (Pubitemid 28018007)
18. N. Romani, D. Reider, and M. Heuer Generation of mature dendritic cells from human blood. An improved method with special regard to clinical applicability J Immunol Methods 196 1996 137 151 (Pubitemid 26306735)
19. A.J. Janckila, W.K. Yang, and R.J. Lin Flow cytoenzymology of intracellular tartrate-resistant acid phosphatase J Histochem Cytochem 51 2003 1131 1137 (Pubitemid 37059524)
20. X.Y. Wang, L. Kazim, and E.A. Repasky Characterization of heat shock protein 110 and glucose-regulated protein 170 as cancer vaccines and the effect of fever-range hyperthermia on vaccine activity J Immunol 166 2001 490 497 (Pubitemid 32038468)
21. S.N. Markovic, A.B. Dietz, and C.W. Greiner Preparing clinical-grade myeloid dendritic cells by electroporation-mediated transfection of in vitro amplified tumor-derived mRNA and safety testing in stage IV malignant melanoma J Transl Med 4 2006 35
22. A. Zobywalski, M. Javorovic, and B. Frankenberger Generation of clinical grade dendritic cells with capacity to produce biologically active IL-12p70 J Transl Med 5 2007 18
23. S. Rutkowski, S. De Vleeschouwer, and E. Kaepgen Surgery and adjuvant dendritic cell-based tumor vaccination for patients with relapsed malignant glioma, a feasibility study Br J Cancer 91 2004 1656 1662 (Pubitemid 39546137)