메뉴 건너뛰기




Volumn 1, Issue 3, 2012, Pages 326-333

Comprehensive analysis of current approaches to inhibit regulatory T cells in cancer

(20)  Pere, Helene a,b   Tanchot, Corinne a   Bayry, Jagadeesh c   Terme, Magali a   Taieb, Julien a   Badoual, Cecile a,b   Adotevi, Olivier d   Merillon, Nathalie a   Marcheteau, Elie a   Quillien, Véronique e   Banissi, Claire f   Carpentier, Alain f   Sandoval, Federico a   Nizard, Mevyn a   Quintin Colonna, Françoise a,g   Kroemer, Guido b,c,f,h,i   Fridman, Wolf H b,c   Zitvogel, Laurence i,j   Oudard, Stéphane a,b   Tartour, Eric a,b  


Author keywords

Antiangiogenic molecule; CCR4; Chemokine; Regulatory T cell

Indexed keywords

ADENOSINE RECEPTOR BLOCKING AGENT; ANGIOGENESIS INHIBITOR; BASILIXIMAB; CANCER VACCINE; CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR4; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR7; CYCLOPHOSPHAMIDE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 ANTIBODY; DACLIZUMAB; DENILEUKIN DIFTITOX; IMATINIB; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 35; MACROPHAGE DERIVED CHEMOKINE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY GITR; MONOCLONAL ANTIBODY OX40; PACLITAXEL; PROTEIN P60; PROTEIN TYROSINE KINASE INHIBITOR; SUNITINIB; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TOLL LIKE RECEPTOR 8; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

EID: 84871719877     PISSN: 21624011     EISSN: 2162402X     Source Type: Journal    
DOI: 10.4161/onci.18852     Document Type: Article
Times cited : (96)

References (80)
  • 1
    • 0015983555 scopus 로고
    • Suppressive effects of in vivo immunization on PHA responses in vitro
    • PMID:4130148
    • Gershon RK, Gery I, Waksman BH. Suppressive effects of in vivo immunization on PHA responses in vitro. J Immunol 1974; 112:215-21
    • (1974) J Immunol , vol.112 , pp. 215-221
    • Gershon, R.K.1    Gery, I.2    Waksman, B.H.3
  • 2
    • 0017076014 scopus 로고
    • Spontaneous development of autoimmune thyroiditis in neonatally thymectomized mice
    • Kojima A, Tanaka-Kojima Y, Sakakura T, Nishizuka Y. Spontaneous development of autoimmune thyroiditis in neonatally thymectomized mice. Lab Invest 1976; 34:550-7
    • (1976) Lab Invest , vol.34 , pp. 550-557
    • Kojima, A.1    Tanaka-Kojima, Y.2    Sakakura, T.3    Nishizuka, Y.4
  • 3
    • 77954141914 scopus 로고    scopus 로고
    • FOXP3+ regulatory T cells in the human immune system
    • Sakaguchi S, Miyara M, Costantino CM, Hafler DA. FOXP3+ regulatory T cells in the human immune system. Nat Rev Immunol 2010; 10:490-500; http://dx.doi.org/10.1038/nri2785
    • (2010) Nat Rev Immunol , vol.10 , pp. 490-500
    • Sakaguchi, S.1    Miyara, M.2    Costantino, C.M.3    Hafler, D.A.4
  • 4
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25), Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995; 155:1151-64
    • (1995) J Immunol , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 5
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299:1057-61; http://dx.doi.org/10.1126/science.1079490
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 7
    • 33745817085 scopus 로고    scopus 로고
    • CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells
    • Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, Zhu S, et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J ExpMed 2006; 203:1701-11; PMID:16818678; http://dx.doi.org/10.1084/jem.20060772
    • (2006) J ExpMed , vol.203 , pp. 1701-1711
    • Liu, W.1    Putnam, A.L.2    Xu-Yu, Z.3    Szot, G.L.4    Lee, M.R.5    Zhu, S.6
  • 8
    • 79951831706 scopus 로고    scopus 로고
    • Frequency of circulating Tregs with demethylated FOXP3 intron 1 in melanoma patients receiving tumor vaccines and potentially Tregdepleting agents
    • de Vries IJ, Castelli C, Huygens C, Jacobs JF, Stockis J, Schuler-Thurner B, et al. Frequency of circulating Tregs with demethylated FOXP3 intron 1 in melanoma patients receiving tumor vaccines and potentially Tregdepleting agents. Clin Cancer Res 2011; 17:841-8; http://dx.doi.org/10.1158/1078-0432.CCR-10-2227
    • (2011) Clin Cancer Res , vol.17 , pp. 841-848
    • de Vries, I.J.1    Castelli, C.2    Huygens, C.3    Jacobs, J.F.4    Stockis, J.5    Schuler-Thurner, B.6
  • 10
    • 0035903307 scopus 로고    scopus 로고
    • Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells
    • Iellem A, Mariani M, Lang R, Recalde H, Panina-Bordignon P, Sinigaglia F, et al. Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells. J Exp Med 2001; 194:847-54; http://dx.doi.org/10.1084/jem.194.6.847
    • (2001) J Exp Med , vol.194 , pp. 847-854
    • Iellem, A.1    Mariani, M.2    Lang, R.3    Recalde, H.4    Panina-Bordignon, P.5    Sinigaglia, F.6
  • 11
    • 25844504654 scopus 로고    scopus 로고
    • Tumor cells convert immature myeloid dendritic cells into TGF-beta-secreting cells inducing CD4+CD25+ regulatory T cell proliferation
    • Ghiringhelli F, Puig PE, Roux S, Parcellier A, Schmitt E, Solary E, et al. Tumor cells convert immature myeloid dendritic cells into TGF-beta-secreting cells inducing CD4+CD25+ regulatory T cell proliferation. J Exp Med 2005; 202:919-29; http://dx.doi.org/10.1084/jem.20050463
    • (2005) J Exp Med , vol.202 , pp. 919-929
    • Ghiringhelli, F.1    Puig, P.E.2    Roux, S.3    Parcellier, A.4    Schmitt, E.5    Solary, E.6
  • 13
    • 34250351459 scopus 로고    scopus 로고
    • Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
    • Deaglio S, Dwyer KM, Gao W, Friedman D, Usheva A, Erat A, et al. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med 2007; 204:1257-65; http://dx.doi.org/10.1084/jem.20062512
    • (2007) J Exp Med , vol.204 , pp. 1257-1265
    • Deaglio, S.1    Dwyer, K.M.2    Gao, W.3    Friedman, D.4    Usheva, A.5    Erat, A.6
  • 14
    • 77149142263 scopus 로고    scopus 로고
    • Foxp3+ T cells induce perforin-dependent dendritic cell death in tumor-draining lymph nodes
    • Boissonnas A, Scholer-Dahirel A, Simon-Blancal V, Pace L, Valet F, Kissenpfennig A, et al. Foxp3+ T cells induce perforin-dependent dendritic cell death in tumor-draining lymph nodes. Immunity 2010; 32: 266-78; http://dx.doi.org/10.1016/j.immuni.2009.11.015
    • (2010) Immunity , vol.32 , pp. 266-278
    • Boissonnas, A.1    Scholer-Dahirel, A.2    Simon-Blancal, V.3    Pace, L.4    Valet, F.5    Kissenpfennig, A.6
  • 15
    • 36248976097 scopus 로고    scopus 로고
    • CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells
    • Pandiyan P, Zheng L, Ishihara S, Reed J, Lenardo MJ. CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells. Nat Immunol 2007; 8:1353-62; http://dx.doi.org/10.1038/ni1536
    • (2007) Nat Immunol , vol.8 , pp. 1353-1362
    • Pandiyan, P.1    Zheng, L.2    Ishihara, S.3    Reed, J.4    Lenardo, M.J.5
  • 17
    • 51049083609 scopus 로고    scopus 로고
    • The Wilms' tumor antigen is a novel target for human CD4+ regulatory T cells: implications for immunotherapy
    • Lehe C, Ghebeh H, Al-Sulaiman A, Al Qudaihi G, Al-Hussein K, Almohareb F, et al. The Wilms' tumor antigen is a novel target for human CD4+ regulatory T cells: implications for immunotherapy. Cancer Res 2008; 68:6350-9; http://dx.doi.org/10.1158/0008-5472.CAN-08-0050
    • (2008) Cancer Res , vol.68 , pp. 6350-6359
    • Lehe, C.1    Ghebeh, H.2    Al-Sulaiman, A.3    Al Qudaihi, G.4    Al-Hussein, K.5    Almohareb, F.6
  • 18
    • 30444443314 scopus 로고    scopus 로고
    • Amplification of tumor-specific regulatory T cells following therapeutic cancer vaccines
    • Zhou G, Drake CG, Levitsky HI. Amplification of tumor-specific regulatory T cells following therapeutic cancer vaccines. Blood 2006; 107:628-36; http://dx.doi.org/10.1182/blood-2005-07-2737
    • (2006) Blood , vol.107 , pp. 628-636
    • Zhou, G.1    Drake, C.G.2    Levitsky, H.I.3
  • 19
    • 40749107481 scopus 로고    scopus 로고
    • Analysis and characterization of antitumor T-cell response after administration of dendritic cells loaded with allogeneic tumor lysate to metastatic melanoma patients
    • Bercovici N, Haicheur N, Massicard S, Vernel-Pauillac F, Adotevi O, Landais D, et al. Analysis and characterization of antitumor T-cell response after administration of dendritic cells loaded with allogeneic tumor lysate to metastatic melanoma patients. J Immunother 2008; 31: 101-12; http://dx.doi.org/10.1097/CJI.0b013e318159f5ba
    • (2008) J Immunother , vol.31 , pp. 101-112
    • Bercovici, N.1    Haicheur, N.2    Massicard, S.3    Vernel-Pauillac, F.4    Adotevi, O.5    Landais, D.6
  • 20
    • 23044463715 scopus 로고    scopus 로고
    • CD4+ CD25+ regulatory T cells control the induction of antigen-specific CD4+ helper T cell responses in cancer patients
    • Nishikawa H, Jager E, Ritter G, Old LJ, Gnjatic S. CD4+ CD25+ regulatory T cells control the induction of antigen-specific CD4+ helper T cell responses in cancer patients. Blood 2005; 106:1008-11; http://dx.doi.org/10.1182/blood-2005-02-0607
    • (2005) Blood , vol.106 , pp. 1008-1011
    • Nishikawa, H.1    Jager, E.2    Ritter, G.3    Old, L.J.4    Gnjatic, S.5
  • 21
    • 80855156710 scopus 로고    scopus 로고
    • A CCR4 antagonist combined with vaccines induce antigen-specific CD8+ T cells and tumor immunity against self antigens
    • Pere H, Montier Y, Bayry J, Quintin-Colonna F, Merillon N, Dransart E, et al. A CCR4 antagonist combined with vaccines induce antigen-specific CD8+ T cells and tumor immunity against self antigens. Blood 2011; 118:4853-62; http://dx.doi.org/10.1182/blood-2011-01-329656
    • (2011) Blood , vol.118 , pp. 4853-4862
    • Pere, H.1    Montier, Y.2    Bayry, J.3    Quintin-Colonna, F.4    Merillon, N.5    Dransart, E.6
  • 22
    • 4644237613 scopus 로고    scopus 로고
    • Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    • Curiel TJ, Coukos G, Zou L, Alvarez X, Cheng P, Mottram P, et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med 2004; 10:942-9; http://dx.doi.org/10.1038/nm1093
    • (2004) Nat Med , vol.10 , pp. 942-949
    • Curiel, T.J.1    Coukos, G.2    Zou, L.3    Alvarez, X.4    Cheng, P.5    Mottram, P.6
  • 23
    • 62449250053 scopus 로고    scopus 로고
    • Regulatory T cells recruited through CCL22/CCR4 are selectively activated in lymphoid infiltrates surrounding primary breast tumors and lead to an adverse clinical outcome
    • Gobert M, Treilleux I, Bendriss-Vermare N, Bachelot T, Goddard-Leon S, Arfi V, et al. Regulatory T cells recruited through CCL22/CCR4 are selectively activated in lymphoid infiltrates surrounding primary breast tumors and lead to an adverse clinical outcome. Cancer Res 2009; 69:2000-9; http://dx.doi.org/10.1158/0008-5472.CAN-08-2360
    • (2009) Cancer Res , vol.69 , pp. 2000-2009
    • Gobert, M.1    Treilleux, I.2    Bendriss-Vermare, N.3    Bachelot, T.4    Goddard-Leon, S.5    Arfi, V.6
  • 24
    • 79960393113 scopus 로고    scopus 로고
    • Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells
    • Facciabene A, Peng X, Hagemann IS, Balint K, Barchetti A, Wang LP, et al. Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells. Nature 2011; 475:226-30; http://dx.doi.org/10.1038/nature10169
    • (2011) Nature , vol.475 , pp. 226-230
    • Facciabene, A.1    Peng, X.2    Hagemann, I.S.3    Balint, K.4    Barchetti, A.5    Wang, L.P.6
  • 26
    • 80052206084 scopus 로고    scopus 로고
    • Prognostic and Predictive Impact of Intra- and Peritumoral Immune Infiltrates
    • Fridman WH, Galon J, Pages F, Tartour E, Sautes-Fridman C, Kroemer G. Prognostic and Predictive Impact of Intra- and Peritumoral Immune Infiltrates. Cancer Res 2011; 71:5601-5; http://dx.doi.org/10.1158/0008-5472.CAN-11-1316
    • (2011) Cancer Res , vol.71 , pp. 5601-5605
    • Fridman, W.H.1    Galon, J.2    Pages, F.3    Tartour, E.4    Sautes-Fridman, C.5    Kroemer, G.6
  • 27
    • 31544455880 scopus 로고    scopus 로고
    • Prognostic value of tumorinfiltrating CD4+ T-cell subpopulations in head and neck cancers
    • Badoual C, Hans S, Rodriguez J, Peyrard S, Klein C, Agueznay Nel H, et al. Prognostic value of tumorinfiltrating CD4+ T-cell subpopulations in head and neck cancers. Clin Cancer Res 2006; 12:465-72; http://dx.doi.org/10.1158/1078-0432.CCR-05-1886
    • (2006) Clin Cancer Res , vol.12 , pp. 465-472
    • Badoual, C.1    Hans, S.2    Rodriguez, J.3    Peyrard, S.4    Klein, C.5    Agueznay, N.H.6
  • 28
    • 58249089749 scopus 로고    scopus 로고
    • Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer
    • Salama P, Phillips M, Grieu F, Morris M, Zeps N, Joseph D, et al. Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer. J Clin Oncol 2009; 27:186-92; http://dx.doi.org/10.1200/JCO.2008.18.7229
    • (2009) J Clin Oncol , vol.27 , pp. 186-192
    • Salama, P.1    Phillips, M.2    Grieu, F.3    Morris, M.4    Zeps, N.5    Joseph, D.6
  • 29
    • 45549100198 scopus 로고    scopus 로고
    • The soluble alpha chain of interleukin-15 receptor: a proinflammatory molecule associated with tumor progression in head and neck cancer
    • Badoual C, Bouchaud G, Agueznay Nel H, Mortier E, Hans S, Gey A, et al. The soluble alpha chain of interleukin-15 receptor: a proinflammatory molecule associated with tumor progression in head and neck cancer. Cancer Res 2008; 68:3907-14; http://dx.doi.org/10.1158/0008-5472.CAN-07-6842
    • (2008) Cancer Res , vol.68 , pp. 3907-3914
    • Badoual, C.1    Bouchaud, G.2    Agueznay, N.H.3    Mortier, E.4    Hans, S.5    Gey, A.6
  • 30
    • 77954398659 scopus 로고    scopus 로고
    • Better understanding tumor-host interaction in head and neck cancer to improve the design and development of immunotherapeutic strategies
    • Badoual C, Sandoval F, Pere H, Hans S, Gey A, Merillon N, et al. Better understanding tumor-host interaction in head and neck cancer to improve the design and development of immunotherapeutic strategies. Head Neck 2010; 32:946-58
    • (2010) Head Neck , vol.32 , pp. 946-958
    • Badoual, C.1    Sandoval, F.2    Pere, H.3    Hans, S.4    Gey, A.5    Merillon, N.6
  • 31
    • 0027054597 scopus 로고
    • Current status of interleukin-2 therapy in cancer
    • Tartour E, Mathiot C, Fridman WH. Current status of interleukin-2 therapy in cancer. Biomed Pharmacother 1992; 46:473-84; http://dx.doi.org/10.1016/0753-3322(92)90005-R
    • (1992) Biomed Pharmacother , vol.46 , pp. 473-484
    • Tartour, E.1    Mathiot, C.2    Fridman, W.H.3
  • 32
    • 58149332682 scopus 로고    scopus 로고
    • Effects of high-dose IFNalpha2b on regional lymph node metastases of human melanoma: modulation of STAT5, FOXP3, and IL-17
    • Wang W, Edington HD, Rao UN, Jukic DM, Radfar A, Wang H, et al. Effects of high-dose IFNalpha2b on regional lymph node metastases of human melanoma: modulation of STAT5, FOXP3, and IL-17. Clin Cancer Res 2008; 14:8314-20; http://dx.doi.org/10.1158/1078-0432.CCR-08-0705
    • (2008) Clin Cancer Res , vol.14 , pp. 8314-8320
    • Wang, W.1    Edington, H.D.2    Rao, U.N.3    Jukic, D.M.4    Radfar, A.5    Wang, H.6
  • 33
    • 79960706708 scopus 로고    scopus 로고
    • Randomized multicenter trial of the effects of melanoma-associated helper peptides and cyclophosphamide on the immunogenicity of a multipeptide melanoma vaccine
    • Slingluff CL, Jr., Petroni GR, Chianese-Bullock KA, Smolkin ME, Ross MI, Haas NB, et al. Randomized multicenter trial of the effects of melanoma-associated helper peptides and cyclophosphamide on the immunogenicity of a multipeptide melanoma vaccine. J Clin Oncol 2011; 29:2924-32; http://dx.doi.org/10.1200/JCO.2010.33.8053
    • (2011) J Clin Oncol , vol.29 , pp. 2924-2932
    • Slingluff Jr., C.L.1    Petroni, G.R.2    Chianese-Bullock, K.A.3    Smolkin, M.E.4    Ross, M.I.5    Haas, N.B.6
  • 34
    • 79952390627 scopus 로고    scopus 로고
    • Immune parameters affecting the efficacy of chemotherapeutic regimens
    • Zitvogel L, Kepp O, Kroemer G. Immune parameters affecting the efficacy of chemotherapeutic regimens. Nat Rev Clin Oncol 2011; 8:151-60; http://dx.doi.org/10.1038/nrclinonc.2010. 223
    • (2011) Nat Rev Clin Oncol , vol.8 , pp. 151-160
    • Zitvogel, L.1    Kepp, O.2    Kroemer, G.3
  • 35
    • 0016314602 scopus 로고
    • Reversal of immunological tolerance by cyclophosphamide through inhibition of suppressor cell activity
    • Polak L, Turk JL. Reversal of immunological tolerance by cyclophosphamide through inhibition of suppressor cell activity. Nature 1974; 249:654-6; http://dx.doi.org/10.1038/249654a0
    • (1974) Nature , vol.249 , pp. 654-656
    • Polak, L.1    Turk, J.L.2
  • 36
    • 21144454780 scopus 로고    scopus 로고
    • Recruitment of latent pools of high-avidity CD8(+) T cells to the antitumor immune response
    • Ercolini AM, Ladle BH, Manning EA, Pfannenstiel LW, Armstrong TD, Machiels JP, et al. Recruitment of latent pools of high-avidity CD8(+) T cells to the antitumor immune response. J Exp Med 2005; 201:1591-602; http://dx.doi.org/10.1084/jem.20042167
    • (2005) J Exp Med , vol.201 , pp. 1591-1602
    • Ercolini, A.M.1    Ladle, B.H.2    Manning, E.A.3    Pfannenstiel, L.W.4    Armstrong, T.D.5    Machiels, J.P.6
  • 37
    • 77953134540 scopus 로고    scopus 로고
    • Metronomic chemotherapy enhances antitumor effects of cancer vaccine by depleting regulatory T lymphocytes and inhibiting tumor angiogenesis
    • Chen CA, Ho CM, Chang MC, Sun WZ, Chen YL, Chiang YC, et al. Metronomic chemotherapy enhances antitumor effects of cancer vaccine by depleting regulatory T lymphocytes and inhibiting tumor angiogenesis. Mol Ther 2010; 18:1233-43; http://dx.doi.org/10.1038/mt.2010.34
    • (2010) Mol Ther , vol.18 , pp. 1233-1243
    • Chen, C.A.1    Ho, C.M.2    Chang, M.C.3    Sun, W.Z.4    Chen, Y.L.5    Chiang, Y.C.6
  • 38
    • 33847368549 scopus 로고    scopus 로고
    • Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients
    • Ghiringhelli F, Menard C, Puig PE, Ladoire S, Roux S, Martin F, et al. Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients. Cancer Immunol Immunother 2007; 56:641-8; http://dx.doi.org/10.1007/s00262-006-0225-8
    • (2007) Cancer Immunol Immunother , vol.56 , pp. 641-648
    • Ghiringhelli, F.1    Menard, C.2    Puig, P.E.3    Ladoire, S.4    Roux, S.5    Martin, F.6
  • 39
    • 0033571105 scopus 로고    scopus 로고
    • Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunity
    • Shimizu J, Yamazaki S, Sakaguchi S. Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunity. J Immunol 1999; 163:5211-8
    • (1999) J Immunol , vol.163 , pp. 5211-5218
    • Shimizu, J.1    Yamazaki, S.2    Sakaguchi, S.3
  • 40
    • 70350496784 scopus 로고    scopus 로고
    • Clinical use of anti-CD25 antibody daclizumab to enhance immune responses to tumor antigen vaccination by targeting regulatory T cells
    • Rech AJ, Vonderheide RH. Clinical use of anti-CD25 antibody daclizumab to enhance immune responses to tumor antigen vaccination by targeting regulatory T cells. Ann N Y Acad Sci 2009; 1174:99-106; http://dx.doi.org/10.1111/j.1749-6632. 2009.04939.x
    • (2009) Ann N Y Acad Sci , vol.1174 , pp. 99-106
    • Rech, A.J.1    Vonderheide, R.H.2
  • 41
    • 50949115267 scopus 로고    scopus 로고
    • Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines
    • Morse MA, Hobeika AC, Osada T, Serra D, Niedzwiecki D, Lyerly HK, et al. Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines. Blood 2008; 112:610-8; http://dx.doi.org/10.1182/blood-2008-01-135319
    • (2008) Blood , vol.112 , pp. 610-618
    • Morse, M.A.1    Hobeika, A.C.2    Osada, T.3    Serra, D.4    Niedzwiecki, D.5    Lyerly, H.K.6
  • 42
    • 68149155982 scopus 로고    scopus 로고
    • Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies
    • Peggs KS, Quezada SA, Chambers CA, Korman AJ, Allison JP. Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies. J Exp Med 2009; 206:1717-25; http://dx.doi.org/10.1084/jem.20082492
    • (2009) J Exp Med , vol.206 , pp. 1717-1725
    • Peggs, K.S.1    Quezada, S.A.2    Chambers, C.A.3    Korman, A.J.4    Allison, J.P.5
  • 43
    • 70349320134 scopus 로고    scopus 로고
    • Anti-CTLA-4 treatment induces IL-10-producing ICOS+ regulatory T cells displaying IDO-dependent anti-inflammatory properties in a mouse model of colitis
    • Coquerelle C, Oldenhove G, Acolty V, Denoeud J, Vansanten G, Verdebout JM, et al. Anti-CTLA-4 treatment induces IL-10-producing ICOS+ regulatory T cells displaying IDO-dependent anti-inflammatory properties in a mouse model of colitis. Gut 2009; 58:1363-73; http://dx.doi.org/10.1136/gut.2008.162842
    • (2009) Gut , vol.58 , pp. 1363-1373
    • Coquerelle, C.1    Oldenhove, G.2    Acolty, V.3    Denoeud, J.4    Vansanten, G.5    Verdebout, J.M.6
  • 44
    • 52649088779 scopus 로고    scopus 로고
    • Ctla-4 blockade confers lymphocyte resistance to regulatory T-cells in advanced melanoma: surrogate marker of efficacy of tremelimumab?
    • Ménard C, Ghiringhelli F, Roux S, Chaput N, Mateus C, Grohmann U, et al. Ctla-4 blockade confers lymphocyte resistance to regulatory T-cells in advanced melanoma: surrogate marker of efficacy of tremelimumab?. Clin Cancer Res 2008; 14:5242-9; http://dx.doi.org/10.1158/1078-0432.CCR-07-4797
    • (2008) Clin Cancer Res , vol.14 , pp. 5242-5249
    • Ménard, C.1    Ghiringhelli, F.2    Roux, S.3    Chaput, N.4    Mateus, C.5    Grohmann, U.6
  • 45
    • 4644342928 scopus 로고    scopus 로고
    • Concomitant tumor immunity to a poorly immunogenic melanoma is prevented by regulatory T cells
    • Turk MJ, Guevara-Patino JA, Rizzuto GA, Engelhorn ME, Sakaguchi S, Houghton AN. Concomitant tumor immunity to a poorly immunogenic melanoma is prevented by regulatory T cells. J Exp Med 2004; 200:771-82; http://dx.doi.org/10.1084/jem.20041130
    • (2004) J Exp Med , vol.200 , pp. 771-782
    • Turk, M.J.1    Guevara-Patino, J.A.2    Rizzuto, G.A.3    Engelhorn, M.E.4    Sakaguchi, S.5    Houghton, A.N.6
  • 46
    • 25844517914 scopus 로고    scopus 로고
    • Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells
    • Ko K, Yamazaki S, Nakamura K, Nishioka T, Hirota K, Yamaguchi T, et al. Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells. J Exp Med 2005; 202:885-91; http://dx.doi.org/10.1084/jem.20050940
    • (2005) J Exp Med , vol.202 , pp. 885-891
    • Ko, K.1    Yamazaki, S.2    Nakamura, K.3    Nishioka, T.4    Hirota, K.5    Yamaguchi, T.6
  • 47
    • 6344279933 scopus 로고    scopus 로고
    • Engagement of glucocorticoid-induced TNFR family-related receptor on effector T cells by its ligand mediates resistance to suppression by CD4+CD25+ T cells
    • Stephens GL, McHugh RS, Whitters MJ, Young DA, Luxenberg D, Carreno BM, et al. Engagement of glucocorticoid-induced TNFR family-related receptor on effector T cells by its ligand mediates resistance to suppression by CD4+CD25+ T cells. J Immunol 2004; 173:5008-20
    • (2004) J Immunol , vol.173 , pp. 5008-5020
    • Stephens, G.L.1    McHugh, R.S.2    Whitters, M.J.3    Young, D.A.4    Luxenberg, D.5    Carreno, B.M.6
  • 48
    • 14744285671 scopus 로고    scopus 로고
    • Triggering of OX40 (CD134) on CD4(+)CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR
    • Valzasina B, Guiducci C, Dislich H, Killeen N, Weinberg AD, Colombo MP. Triggering of OX40 (CD134) on CD4(+)CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR. Blood 2005; 105: 2845-51; http://dx.doi.org/10.1182/blood-2004-07-2959
    • (2005) Blood , vol.105 , pp. 2845-2851
    • Valzasina, B.1    Guiducci, C.2    Dislich, H.3    Killeen, N.4    Weinberg, A.D.5    Colombo, M.P.6
  • 49
    • 42249097689 scopus 로고    scopus 로고
    • OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection
    • Piconese S, Valzasina B, Colombo MP. OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection. J Exp Med 2008; 205:825-39; http://dx.doi.org/10.1084/jem.20071341
    • (2008) J Exp Med , vol.205 , pp. 825-839
    • Piconese, S.1    Valzasina, B.2    Colombo, M.P.3
  • 50
    • 66049113612 scopus 로고    scopus 로고
    • OX40 engagement and chemotherapy combination provides potent antitumor immunity with concomitant regulatory T cell apoptosis
    • Hirschhorn-Cymerman D, Rizzuto GA, Merghoub T, Cohen AD, Avogadri F, Lesokhin AM, et al. OX40 engagement and chemotherapy combination provides potent antitumor immunity with concomitant regulatory T cell apoptosis. J Exp Med 2009; 206:1103-16; http://dx.doi.org/10.1084/jem.20082205
    • (2009) J Exp Med , vol.206 , pp. 1103-1116
    • Hirschhorn-Cymerman, D.1    Rizzuto, G.A.2    Merghoub, T.3    Cohen, A.D.4    Avogadri, F.5    Lesokhin, A.M.6
  • 52
    • 33745851174 scopus 로고    scopus 로고
    • Toll-like receptors on regulatory T cells: expanding immune regulation
    • Sutmuller RP, Morgan ME, Netea MG, Grauer O, Adema GJ. Toll-like receptors on regulatory T cells: expanding immune regulation. Trends Immunol 2006; 27:387-93; http://dx.doi.org/10. 1016/j.it.2006.06.005
    • (2006) Trends Immunol , vol.27 , pp. 387-393
    • Sutmuller, R.P.1    Morgan, M.E.2    Netea, M.G.3    Grauer, O.4    Adema, G.J.5
  • 53
    • 23944509107 scopus 로고    scopus 로고
    • Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function
    • Peng G, Guo Z, Kiniwa Y, Voo KS, Peng W, Fu T, et al. Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function. Science 2005; 309:1380-4; http://dx.doi.org/10.1126/science.1113401
    • (2005) Science , vol.309 , pp. 1380-1384
    • Peng, G.1    Guo, Z.2    Kiniwa, Y.3    Voo, K.S.4    Peng, W.5    Fu, T.6
  • 54
    • 2442655250 scopus 로고    scopus 로고
    • Persistent Toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance
    • Yang Y, Huang CT, Huang X, Pardoll DM. Persistent Toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance. Nat Immunol 2004; 5:508-15; http://dx.doi.org/10.1038/ni1059
    • (2004) Nat Immunol , vol.5 , pp. 508-515
    • Yang, Y.1    Huang, C.T.2    Huang, X.3    Pardoll, D.M.4
  • 55
    • 77951196379 scopus 로고    scopus 로고
    • Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance
    • Cherfils-Vicini J, Platonova S, Gillard M, Laurans L, Validire P, Caliandro R, et al. Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance. J Clin Invest 2010; 120:1285-97; http://dx.doi.org/10.1172/JCI36551
    • (2010) J Clin Invest , vol.120 , pp. 1285-1297
    • Cherfils-Vicini, J.1    Platonova, S.2    Gillard, M.3    Laurans, L.4    Validire, P.5    Caliandro, R.6
  • 56
    • 37849046096 scopus 로고    scopus 로고
    • TLR ligand suppression or enhancement of Treg cells? A doubleedged sword in immunity to tumours
    • Conroy H, Marshall NA, Mills KH. TLR ligand suppression or enhancement of Treg cells? A doubleedged sword in immunity to tumours. Oncogene 2008; 27:168-80; http://dx.doi.org/10.1038/sj.onc.1210910
    • (2008) Oncogene , vol.27 , pp. 168-180
    • Conroy, H.1    Marshall, N.A.2    Mills, K.H.3
  • 58
    • 83755181759 scopus 로고    scopus 로고
    • Autophagy dictates anticancer immune responses induced by chemotherapeutic agents in mice
    • Michaud M, Martins I, Sukkurwala A, Adjemian S, Ma Y, Rello-Varona S, et al. Autophagy dictates anticancer immune responses induced by chemotherapeutic agents in mice. Science 2011; 334:1573-7; http://dx.doi.org/10.1126/science.1208347
    • (2011) Science , vol.334 , pp. 1573-1577
    • Michaud, M.1    Martins, I.2    Sukkurwala, A.3    Adjemian, S.4    Ma, Y.5    Rello-Varona, S.6
  • 59
    • 78149486215 scopus 로고    scopus 로고
    • A peptide inhibitor of FOXP3 impairs regulatory T cell activity and improves vaccine efficacy in mice
    • Casares N, Rudilla F, Arribillaga L, Llopiz D, Riezu-Boj JI, Lozano T, et al. A peptide inhibitor of FOXP3 impairs regulatory T cell activity and improves vaccine efficacy in mice. J Immunol 2010; 185:5150-9; http://dx.doi.org/10.4049/jimmunol.1001114
    • (2010) J Immunol , vol.185 , pp. 5150-5159
    • Casares, N.1    Rudilla, F.2    Arribillaga, L.3    Llopiz, D.4    Riezu-Boj, J.I.5    Lozano, T.6
  • 60
    • 33749144742 scopus 로고    scopus 로고
    • The majority of human peripheral blood CD4+CD25highFoxp3+ regulatory T cells bear functional skin-homing receptors
    • Hirahara K, Liu L, Clark RA, Yamanaka K, Fuhlbrigge RC, Kupper TS. The majority of human peripheral blood CD4+CD25highFoxp3+ regulatory T cells bear functional skin-homing receptors. J Immunol 2006; 177:4488-94
    • (2006) J Immunol , vol.177 , pp. 4488-4494
    • Hirahara, K.1    Liu, L.2    Clark, R.A.3    Yamanaka, K.4    Fuhlbrigge, R.C.5    Kupper, T.S.6
  • 61
    • 33947655511 scopus 로고    scopus 로고
    • Human dendritic cells acquire a semimature phenotype and lymph node homing potential through interaction with CD4+CD25+ regulatory T cells
    • Bayry J, Triebel F, Kaveri SV, Tough DF. Human dendritic cells acquire a semimature phenotype and lymph node homing potential through interaction with CD4+CD25+ regulatory T cells. J Immunol 2007; 178:4184-93
    • (2007) J Immunol , vol.178 , pp. 4184-4193
    • Bayry, J.1    Triebel, F.2    Kaveri, S.V.3    Tough, D.F.4
  • 62
    • 34250321683 scopus 로고    scopus 로고
    • CCR4-dependent regulatory T cell function in inflammatory bowel disease
    • Yuan Q, Bromley SK, Means TK, Jones KJ, Hayashi F, Bhan AK, et al. CCR4-dependent regulatory T cell function in inflammatory bowel disease. J Exp Med 2007; 204:1327-34; http://dx.doi.org/10.1084/jem.20062076
    • (2007) J Exp Med , vol.204 , pp. 1327-1334
    • Yuan, Q.1    Bromley, S.K.2    Means, T.K.3    Jones, K.J.4    Hayashi, F.5    Bhan, A.K.6
  • 63
    • 48249150707 scopus 로고    scopus 로고
    • In silico identified CCR4 antagonists target regulatory T cells and exert adjuvant activity in vaccination
    • Bayry J, Tchilian EZ, Davies MN, Forbes EK, Draper SJ, Kaveri SV, et al. In silico identified CCR4 antagonists target regulatory T cells and exert adjuvant activity in vaccination. Proc Natl Acad Sci USA 2008; 105:10221-6; http://dx.doi.org/10.1073/pnas.0803453105
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 10221-10226
    • Bayry, J.1    Tchilian, E.Z.2    Davies, M.N.3    Forbes, E.K.4    Draper, S.J.5    Kaveri, S.V.6
  • 64
    • 77951239027 scopus 로고    scopus 로고
    • Toward the discovery of vaccine adjuvants: coupling in silico screening and in vitro analysis of antagonist binding to human and mouse CCR4 receptors
    • Davies MN, Bayry J, Tchilian EZ, Vani J, Shaila MS, Forbes EK, et al. Toward the discovery of vaccine adjuvants: coupling in silico screening and in vitro analysis of antagonist binding to human and mouse CCR4 receptors. PLoS ONE 2009; 4:e8084; http://dx.doi.org/10.1371/journal.pone.0008084
    • (2009) PLoS ONE , vol.4
    • Davies, M.N.1    Bayry, J.2    Tchilian, E.Z.3    Vani, J.4    Shaila, M.S.5    Forbes, E.K.6
  • 65
    • 35548950221 scopus 로고    scopus 로고
    • Regulatory-T-cell inhibition versus depletion: the right choice in cancer immunotherapy
    • Colombo MP, Piconese S. Regulatory-T-cell inhibition versus depletion: the right choice in cancer immunotherapy. Nat Rev Cancer 2007; 7:880-7; http://dx.doi.org/10.1038/nrc2250
    • (2007) Nat Rev Cancer , vol.7 , pp. 880-887
    • Colombo, M.P.1    Piconese, S.2
  • 66
    • 63149148047 scopus 로고    scopus 로고
    • Disruption of CCR5-dependent homing of regulatory T cells inhibits tumor growth in a murine model of pancreatic cancer
    • Tan MC, Goedegebuure PS, Belt BA, Flaherty B, Sankpal N, Gillanders WE, et al. Disruption of CCR5-dependent homing of regulatory T cells inhibits tumor growth in a murine model of pancreatic cancer. J Immunol 2009; 182:1746-55
    • (2009) J Immunol , vol.182 , pp. 1746-1755
    • Tan, M.C.1    Goedegebuure, P.S.2    Belt, B.A.3    Flaherty, B.4    Sankpal, N.5    Gillanders, W.E.6
  • 67
    • 76549123625 scopus 로고    scopus 로고
    • Opposing effects of toll-like receptor (TLR3) signaling in tumors can be therapeutically uncoupled to optimize the anticancer efficacy of TLR3 ligands
    • Conforti R, Ma Y, Morel Y, Paturel C, Terme M, Viaud S, et al. Opposing effects of toll-like receptor (TLR3) signaling in tumors can be therapeutically uncoupled to optimize the anticancer efficacy of TLR3 ligands. Cancer Res 2010; 70:490-500; http://dx.doi.org/10.1158/0008-5472.CAN-09-1890
    • (2010) Cancer Res , vol.70 , pp. 490-500
    • Conforti, R.1    Ma, Y.2    Morel, Y.3    Paturel, C.4    Terme, M.5    Viaud, S.6
  • 68
    • 79952281184 scopus 로고    scopus 로고
    • Angiogenesis and immunity: a bidirectional link potentially relevant for the monitoring of antiangiogenic therapy and the development of novel therapeutic combination with immunotherapy
    • Tartour E, Pere H, Maillere B, Terme M, Merillon N, Taieb J, et al. Angiogenesis and immunity: a bidirectional link potentially relevant for the monitoring of antiangiogenic therapy and the development of novel therapeutic combination with immunotherapy. Cancer Metastasis Rev 2011; 30:83-95; http://dx.doi.org/10.1007/s10555-011-9281-4
    • (2011) Cancer Metastasis Rev , vol.30 , pp. 83-95
    • Tartour, E.1    Pere, H.2    Maillere, B.3    Terme, M.4    Merillon, N.5    Taieb, J.6
  • 69
    • 58149179532 scopus 로고    scopus 로고
    • Sunitinib reverses type-1 immune suppression and decreases T-regulatory cells in renal cell carcinoma patients
    • Finke JH, Rini B, Ireland J, Rayman P, Richmond A, Golshayan A, et al. Sunitinib reverses type-1 immune suppression and decreases T-regulatory cells in renal cell carcinoma patients. Clin Cancer Res 2008; 14:6674-82; http://dx.doi.org/10.1158/1078-0432.CCR-07-5212
    • (2008) Clin Cancer Res , vol.14 , pp. 6674-6682
    • Finke, J.H.1    Rini, B.2    Ireland, J.3    Rayman, P.4    Richmond, A.5    Golshayan, A.6
  • 70
    • 78149281950 scopus 로고    scopus 로고
    • A decrease of regulatory T cells correlates with overall survival after sunitinib-based antiangiogenic therapy in metastatic renal cancer patients
    • Adotevi O, Pere H, Ravel P, Haicheur N, Badoual C, Merillon N, et al. A decrease of regulatory T cells correlates with overall survival after sunitinib-based antiangiogenic therapy in metastatic renal cancer patients. J Immunother 2010; 33:991-8; http://dx.doi.org/10.1097/CJI.0b013e3181f4c208
    • (2010) J Immunother , vol.33 , pp. 991-998
    • Adotevi, O.1    Pere, H.2    Ravel, P.3    Haicheur, N.4    Badoual, C.5    Merillon, N.6
  • 71
    • 47049127786 scopus 로고    scopus 로고
    • Sorafenib, but not sunitinib, affects function of dendritic cells and induction of primary immune responses
    • Hipp MM, Hilf N, Walter S, Werth D, Brauer KM, Radsak MP, et al. Sorafenib, but not sunitinib, affects function of dendritic cells and induction of primary immune responses. Blood 2008; 111:5610-20; http://dx.doi.org/10.1182/blood-2007-02-075945
    • (2008) Blood , vol.111 , pp. 5610-5620
    • Hipp, M.M.1    Hilf, N.2    Walter, S.3    Werth, D.4    Brauer, K.M.5    Radsak, M.P.6
  • 72
    • 79961125367 scopus 로고    scopus 로고
    • Sorafenib reduces the percentage of tumour infiltrating regulatory T cells in renal cell carcinoma patients
    • Desar IM, Jacobs JFM, Hulsbergen-vandeKaa CA, Oyen WJ, Mulders PF, van der Graaf WT, et al. Sorafenib reduces the percentage of tumour infiltrating regulatory T cells in renal cell carcinoma patients. Int J Cancer 2011; 129:507-12; http://dx.doi.org/10.1002/ijc.25674
    • (2011) Int J Cancer , vol.129 , pp. 507-512
    • Desar, I.M.1    Jacobs, J.F.M.2    Hulsbergen-vandeKaa, C.A.3    Oyen, W.J.4    Mulders, P.F.5    van der Graaf, W.T.6
  • 73
    • 79952101899 scopus 로고    scopus 로고
    • Immunomodulatory effects of sorafenib on peripheral immune effector cells in metastatic renal cell carcinoma
    • Busse A, Asemissen AM, Nonnenmacher A, Braun F, Ochsenreither S, Stather D, et al. Immunomodulatory effects of sorafenib on peripheral immune effector cells in metastatic renal cell carcinoma. Eur J Cancer 2011; 47:690-6; http://dx.doi.org/10.1016/j.ejca.2010.11.021
    • (2011) Eur J Cancer , vol.47 , pp. 690-696
    • Busse, A.1    Asemissen, A.M.2    Nonnenmacher, A.3    Braun, F.4    Ochsenreither, S.5    Stather, D.6
  • 74
    • 51349095960 scopus 로고    scopus 로고
    • Tuning microenvironments: induction of regulatory T cells by dendritic cells
    • Belkaid Y, Oldenhove G. Tuning microenvironments: induction of regulatory T cells by dendritic cells. Immunity 2008; 29:362-71; http://dx.doi.org/10.1016/j.immuni.2008.08.005
    • (2008) Immunity , vol.29 , pp. 362-371
    • Belkaid, Y.1    Oldenhove, G.2
  • 75
    • 0032741283 scopus 로고    scopus 로고
    • Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function
    • Gabrilovich DI, Ishida T, Nadaf S, Ohm JE, Carbone DP. Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function. Clin Cancer Res 1999; 5:2963-70
    • (1999) Clin Cancer Res , vol.5 , pp. 2963-2970
    • Gabrilovich, D.I.1    Ishida, T.2    Nadaf, S.3    Ohm, J.E.4    Carbone, D.P.5
  • 76
    • 74249123434 scopus 로고    scopus 로고
    • VEGFR2 is selectively expressed by FOXP3high CD4+ Treg
    • Suzuki H, Onishi H, Wada J, Yamasaki A, Tanaka H, Nakano K, et al. VEGFR2 is selectively expressed by FOXP3high CD4+ Treg. Eur J Immunol 2010; 40:197-203; http://dx.doi.org/10.1002/eji.200939887
    • (2010) Eur J Immunol , vol.40 , pp. 197-203
    • Suzuki, H.1    Onishi, H.2    Wada, J.3    Yamasaki, A.4    Tanaka, H.5    Nakano, K.6
  • 77
    • 84857506147 scopus 로고    scopus 로고
    • Consequence of dose scheduling of sunitinib on host immune response elements and vaccine combination therapy
    • Farsaci B, Higgins JP, Hodge JW. Consequence of dose scheduling of sunitinib on host immune response elements and vaccine combination therapy. Int J Cancer 2011; 130:1948-59; http://dx.doi.org/10.1002/ijc.26219
    • (2011) Int J Cancer , vol.130 , pp. 1948-1959
    • Farsaci, B.1    Higgins, J.P.2    Hodge, J.W.3
  • 78
    • 80052493233 scopus 로고    scopus 로고
    • Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido
    • Balachandran VP, Cavnar MJ, Zeng S, Bamboat ZM, Ocuin LM, Obaid H, et al. Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido. Nat Med 2011; 17:1094-100; http://dx.doi.org/10.1038/nm.2438
    • (2011) Nat Med , vol.17 , pp. 1094-1100
    • Balachandran, V.P.1    Cavnar, M.J.2    Zeng, S.3    Bamboat, Z.M.4    Ocuin, L.M.5    Obaid, H.6
  • 79
    • 68549112974 scopus 로고    scopus 로고
    • Treg depletion with a low-dose metronomic temozolomide regimen in a rat glioma model
    • Banissi C, Ghiringhelli F, Chen L, Carpentier AF. Treg depletion with a low-dose metronomic temozolomide regimen in a rat glioma model. Cancer Immunol Immunother 2009; 58:1627-34; http://dx.doi.org/10.1007/s00262-009-0671-1
    • (2009) Cancer Immunol Immunother , vol.58 , pp. 1627-1634
    • Banissi, C.1    Ghiringhelli, F.2    Chen, L.3    Carpentier, A.F.4
  • 80
    • 79958118266 scopus 로고    scopus 로고
    • Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors
    • Delahaye NF, Rusakiewicz S, Martins I, Menard C, Roux S, Lyonnet L, et al. Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors. Nat Med 2011; 17:700-7; http://dx.doi.org/10.1038/nm.2366
    • (2011) Nat Med , vol.17 , pp. 700-707
    • Delahaye, N.F.1    Rusakiewicz, S.2    Martins, I.3    Menard, C.4    Roux, S.5    Lyonnet, L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.