Generation of large numbers of fully mature and stable dendritic cells from leukapheresis products for clinical application

Journal of Immunological Methods

Volumn 223, Issue 1, 1999, Pages 1-15

  Thurner, Beatrice ^a   Röder, Claudia ^a   Dieckmann, Detlef ^a   Heuer, Marion ^a   Kruse, Monika ^a   Glaser, Anke ^a   Keikavoussi, Petra ^b   Kämpgen, Eckhart ^b   Bender, Armin ^a   Schuler, Gerold ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Dendritic cells; Immunotherapy; Leukocyte apheresis; Vaccination

Indexed keywords

ACTIVE IMMUNIZATION; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; CELL SEPARATION; DENDRITIC CELL; GOOD MANUFACTURING PRACTICE; HUMAN; HUMAN CELL; IMMUNOTHERAPY; LEUKAPHERESIS; MONOCYTE; PRIORITY JOURNAL; REVIEW;

CELL ADHESION; CELL DIFFERENTIATION; CELL SEPARATION; CRYOPRESERVATION; CULTURE MEDIA, CONDITIONED; DENDRITIC CELLS; HUMANS; LEUKAPHERESIS; LEUKOCYTES, MONONUCLEAR; STEM CELLS; TIME FACTORS; VACCINATION;

EID: 0344076299     PISSN: 00221759     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-1759(98)00208-7     Document Type: Review

References (33)

1. Banchereau J., Steinman R.M. Dendritic cells and the control of immunity. Nature. 392:1998;245.
2. + cytolytic T cell responses. J. Exp. Med. 182:1995;1663.
3. Bender A., Sapp M., Schuler G., Steinman R.M., Bhardwaj N. Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood. J. Immunol. Methods. 196:1996;121.
4. Bhardwaj N., Bender A., Gonzalez N., Bui L.K., Garrett M.C., Steinman R.M. Influenza virus-infected dendritic cells stimulate strong proliferative and cytolytic responses from human CD8+ T cells. J. Clin. Invest. 94:1994;797.
5. Caux C., Dezutter-Dambuyant C., Schmitt D., Banchereau J. GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells. Nature. 360:1992;258.
6. Cella M., Engering A., Pinet V., Pieters J., Lanzavecchia A. Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells. Nature. 388:1997;782.
7. Dummer W., Becker J.C., Schwaaf A., Leverkus M., Moll T., Bröcker E.B. Elevated serum levels of interleukin-10 in patients with metastatic malignant melanoma. Melanoma Research. 5:1995;67.
8. Gabrilovich D.I., Chen H.L., Cunningham H.T., Meny G.M., Nadaf S., Kavanaugh D., Carbone D.P. Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells. Nature Med. 2:1996;1096.
9. Heufler C., Koch F., Stanzl U., Topar G., Wysocka M., Trinchieri G., Enk A., Steinman R.M., Romani N., Schuler G. Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells. Eur. J. Immunol. 26:1996;659.
10. Hsu F.J., Benike C., Fagnoni F., Liles T.M., Czerwinski D., Taidi B., Engleman E.G., Levy R. Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells. Nature Med. 2:1996;52.
11. Inaba K., Metlay J.P., Crowley M.T., Witmer-Pack M., Steinman R.M. Dendritic cells as antigen presenting cells in vivo. Int. Rev. Immunol. 6:1990;197.
12. Inaba K., Steinman R.M., Pack M.W., Aya H., Inaba M., Sudo T., Wolpe S., Schuler G. Identification of proliferating dendritic cell precursors in mouse blood. J. Exp. Med. 175:1992;1157.
13. Inaba K., Inaba M., Romani N., Aya H., Deguchi M., Ikehara S., Muramatsu S., Steinman R.M. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 176:1992;1693.
14. Inaba K., Inaba M., Naito M., Steinman R.M. Dendritic cell progenitors phagocytose particulates, including bacillus Calmette-Guerin organisms, and sensitize mice to mycobacterial antigens in vivo. J. Exp. Med. 178:1993;479.
15. Jonuleit H., Kühn U., Müller G., Steinbrink K., Paragnik L., Schmitt E., Knop J., Enk A.H. Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions. Eur. J. Immunol. 27:1997;3135.
16. Jonuleit, H., Schmitt, E., Steinbrink, K., Müller, G., Szalma, C., Schuler, G., Knop, J., Enk, A.H. (1998) Induction of different Th-subpopulations by immature and mature human dendritic cells. submitted.
17. Jullien D., Stenger S., Ernst W.A., Modlin R.L. CD1 presentation of microbial nonpeptide antigens to T cells. J. Clin. Invest. 99:1997;2071.
18. Miltenyi S., Müller W., Weichel W., Radbruch A. High gradient magnetic cell separation with MACS. Cytometry. 11:1990;231.
19. Mosialos G., Birkenbach M., Ayehunie S., Matsumura F., Pinkus G.S., Kieff E., Langhoff E. Circulating human dendritic cells differentially express high levels of a 55-kd actin-bundling protein. Am. J. Pathol. 148:1996;593.
20. Pickl W.F., Majdic O., Kohl P., Stöckl J., Riedl E., Scheinecker C., Bello-Fernandez C., Knapp W. Molecular and functional characteristics of dendritic cells generated from highly purified CD14+ peripheral blood monocytes. J. Immunol. 157:1996;3850.
21. Porcelli S.A., Modlin R.L. CD1 and the expanding universe of T cell antigens. J. Immunol. 155:1995;3709.
22. Reddy A., Sapp M., Feldman M., Subklewe M., Bhardwaj N. A monocyte conditioned medium is more effective than defined cytokines in mediating the terminal maturation of human dendritic cells. Blood. 90:1997;3640.
23. Rieser C., Böck G., Klocker H., Bartsch G., Thurnher M. Prostaglandin E2 and tumor necrosis factor a cooperate to activate human dendritic cells: synergistic activation of interleukin 12 production. J. Exp. Med. 186:1997;1603.
24. Romani N., Gruner S., Brang D., Kämpgen E., Lenz A., Trockenbacher B., Konwalinka G., Fritsch P.O., Steinman R.M., Schuler G. Proliferating dendritic cell progenitors in human blood. J. Exp. Med. 180:1994;83.
25. Romani N., Reider D., Heuer M., Ebner S., Kämpgen E., Eibl B., Niederwieser D., Schuler G. Generation of mature dendritic cells from human blood - an improved method with special regard to clinical applicability. J. Immunol. Methods. 196:1996;137.
26. Sallusto F., Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor-α J. Exp. Med. 179:1994;1109.
27. Sallusto F., Cella M., Danieli C., Lanzavecchia A. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products. J. Exp. Med. 182:1995;389.
28. Schuler G., Steinman R.M. Dendritic cells as adjuvants for immune-mediated resistance to tumors. J. Exp. Med. 186:1997;1183.
29. + blood progenitors for anticancer therapy. Exp. Hematol. 23:1995;1463.
30. Steinbrink K., Wölfl M., Jonuleit H., Knop J., Enk A.H. Induction of tolerance by IL-10-treated dendritic cells. J. Immunol. 159:1997;4772.
31. Steinbrink, K., Jonuleit, H., Müller, G., Schuler, G., Knop, J., Enk, A.H. (1998) IL-10-treated human dendritic cells induce a melanoma-antigen-specific anergy in CD8+ T cells resulting in a failure to lyse tumor cells (submitted).
32. Tsai V., Southwood S., Sidney J., Sakaguchi K., Kawakami Y., Appella E., Sette A., Celis E. Identification of subdominant CTL epitopes of the GP100 melanoma-associated tumor antigen by primary in vitro immunization with peptide-pulsed dendritic cells. J. Immunol. 158:1997;1796.
33. Young J.W., Inaba K. Dendritic cells as adjuvants for class I major histocompatibility complex-restricted antitumor immunity. J. Exp. Med. 183:1996;7.