메뉴 건너뛰기




Volumn 4, Issue 10, 2012, Pages 1031-1042

Dendritic cell-based vaccination for renal cell carcinoma: Challenges in clinical trials

Author keywords

cytokine induced killer cell; dendritic cell; immune monitoring; renal cell carcinoma; tumor vaccine

Indexed keywords

B7 ANTIGEN; CD40 ANTIGEN; CD40 LIGAND; CD83 ANTIGEN; CD86 ANTIGEN; DENDRITIC CELL VACCINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HLA ANTIGEN; HLA DR ANTIGEN; IMMUNICUM; INTERFERON; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; PROSTAGLANDIN E2; T6 ANTIGEN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84869164521     PISSN: 1750743X     EISSN: 17507448     Source Type: Journal    
DOI: 10.2217/imt.12.107     Document Type: Review
Times cited : (10)

References (95)
  • 1
    • 42649145828 scopus 로고    scopus 로고
    • Epidemiologic and socioeconomic burden of metastatic renal cell carcinoma (mRCC): A literature review
    • Gupta K, Miller JD, Li JZ, Russell MW, Charbonneau C. Epidemiologic and socioeconomic burden of metastatic renal cell carcinoma (mRCC): A literature review. Cancer Treat. Rev. 34(3), 193-205 (2008).
    • (2008) Cancer Treat. Rev. , vol.34 , Issue.3 , pp. 193-205
    • Gupta, K.1    Miller, J.D.2    Li, J.Z.3    Russell, M.W.4    Charbonneau, C.5
  • 2
    • 27744561283 scopus 로고    scopus 로고
    • Renal cell carcinoma: Current status and future prospects
    • Drucker BJ. Renal cell carcinoma: Current status and future prospects. Cancer Treat. Rev. 31(7), 536-545 (2005).
    • (2005) Cancer Treat. Rev. , vol.31 , Issue.7 , pp. 536-545
    • Drucker, B.J.1
  • 3
    • 1942437538 scopus 로고    scopus 로고
    • Safety and efficacy of subcutaneous and continuous intravenous infusion rIL-2 in patients with metastatic renal cell carcinoma
    • Geertsen PF, Gore ME, Negrier S, Tourani JM, von der Maase H. Safety and efficacy of subcutaneous and continuous intravenous infusion rIL-2 in patients with metastatic renal cell carcinoma. Br. J. Cancer. 90(6), 1156-1162 (2004).
    • (2004) Br. J. Cancer. , vol.90 , Issue.6 , pp. 1156-1162
    • Geertsen, P.F.1    Gore, M.E.2    Negrier, S.3    Tourani, J.M.4    Von Der Maase, H.5
  • 4
    • 28844487782 scopus 로고    scopus 로고
    • Tumor regression in patients with metastatic renal cancer treated with a monoclonal antibody to CTLA4 (MDX-010
    • Yang JC, Beck KE, Blansfield JA, Tran KQ, Lowy I, Rosenberg SA. Tumor regression in patients with metastatic renal cancer treated with a monoclonal antibody to CTLA4 (MDX-010). J. Clin. Oncol. 23(16S), 2501 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , Issue.16 S , pp. 2501
    • Yang, J.C.1    Beck, K.E.2    Blansfield, J.A.3    Tran, K.Q.4    Lowy, I.5    Rosenberg, S.A.6
  • 5
    • 83655193361 scopus 로고    scopus 로고
    • TroVax® vaccine therapy for renal cell carcinoma
    • Zhang RT, Bines SD, Ruby C, Kaufman HL. TroVax® vaccine therapy for renal cell carcinoma. Immunotherapy 4(1), 27-42 (2012).
    • (2012) Immunotherapy , vol.4 , Issue.1 , pp. 27-42
    • Zhang, R.T.1    Bines, S.D.2    Ruby, C.3    Kaufman, H.L.4
  • 6
    • 84863230396 scopus 로고    scopus 로고
    • Randomized study of autologous cytokine-induced killer cell immunotherapy in metastatic renal carcinoma
    • Liu L, Zhang W, Qi X et al. Randomized study of autologous cytokine-induced killer cell immunotherapy in metastatic renal carcinoma. Clin. Cancer Res. 18(6), 1751-1759 (2012).
    • (2012) Clin. Cancer Res. , vol.18 , Issue.6 , pp. 1751-1759
    • Liu, L.1    Zhang, W.2    Qi, X.3
  • 7
    • 0032784492 scopus 로고    scopus 로고
    • Multicenter, randomized, Phase III trial of CD8+ tumor-infiltrating lymphocytes in combination with recombinant interleukin-2 in metastatic renal cell carcinoma
    • Figlin RA, Thompson JA, Bukowski RM et al. Multicenter, randomized, Phase III trial of CD8+ tumor-infiltrating lymphocytes in combination with recombinant interleukin-2 in metastatic renal cell carcinoma. J. Clin. Oncol. 17(8), 2521-2529 (1999).
    • (1999) J. Clin. Oncol. , vol.17 , Issue.8 , pp. 2521-2529
    • Figlin, R.A.1    Thompson, J.A.2    Bukowski, R.M.3
  • 8
    • 0034648702 scopus 로고    scopus 로고
    • Regression of metastatic renal-cell carcinoma after nonmyeloablative allogeneic peripheralblood stem-cell transplantation
    • Childs R, Chernoff A, Contentin N et al. Regression of metastatic renal-cell carcinoma after nonmyeloablative allogeneic peripheralblood stem-cell transplantation. N. Engl. J. Med. 343(11), 750-758 (2000).
    • (2000) N. Engl. J. Med. , vol.343 , Issue.11 , pp. 750-758
    • Childs, R.1    Chernoff, A.2    Contentin, N.3
  • 9
    • 4644236156 scopus 로고    scopus 로고
    • Nonmyeloablative transplantation: An allogeneic-based immunotherapy for renal cell carcinoma
    • Takahashi Y, Childs RW. Nonmyeloablative transplantation: An allogeneic-based immunotherapy for renal cell carcinoma. Clin. Cancer Res. 10(18 Pt 2), S6353-S6359 (2004).
    • (2004) Clin. Cancer Res. , vol.10 , Issue.18 PART 2
    • Takahashi, Y.1    Childs, R.W.2
  • 10
    • 0344678389 scopus 로고    scopus 로고
    • Cellular and humoral immune responses in patients with metastatic renal cell carcinoma after vaccination with antigen pulsed dendritic cells
    • Höltl L, Rieser C, Papesh C et al. Cellular and humoral immune responses in patients with metastatic renal cell carcinoma after vaccination with antigen pulsed dendritic cells. J. Urol. 161(3), 777-782 (1999).
    • (1999) J. Urol. , vol.161 , Issue.3 , pp. 777-782
    • Höltl, L.1    Rieser, C.2    Papesh, C.3
  • 11
    • 68049140780 scopus 로고    scopus 로고
    • Clinical and immunologic effects of intranodal autologous tumor lysate-dendritic cell vaccine with Aldesleukin (interleukin 2) and IFN-a2a therapy in metastatic renal cell carcinoma patients
    • Schwaab T, Schwarzer A, Wolf B et al. Clinical and immunologic effects of intranodal autologous tumor lysate-dendritic cell vaccine with Aldesleukin (interleukin 2) and IFN-a2a therapy in metastatic renal cell carcinoma patients. Clin. Cancer Res. 15(15), 4986-4992 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , Issue.15 , pp. 4986-4992
    • Schwaab, T.1    Schwarzer, A.2    Wolf, B.3
  • 12
    • 84866560936 scopus 로고    scopus 로고
    • Quality of life during dendritic cell vaccination against metastatic renal cell carcinoma
    • Leonhartsberger N, Ramoner R, Falkensammer C et al. Quality of life during dendritic cell vaccination against metastatic renal cell carcinoma. Cancer Immunol. Immunother. 61(9), 1407-1413 (2012).
    • (2012) Cancer Immunol. Immunother. , vol.61 , Issue.9 , pp. 1407-1413
    • Leonhartsberger, N.1    Ramoner, R.2    Falkensammer, C.3
  • 13
    • 79955451697 scopus 로고    scopus 로고
    • Dendritic cell based tumor vaccination in prostate and renal cell cancer: A systematic review and meta-analysis
    • Draube A, Klein-González N, Mattheus S et al. Dendritic cell based tumor vaccination in prostate and renal cell cancer: A systematic review and meta-analysis. PLoS ONE 6(4), E18801 (2011).
    • (2011) PLoS ONE , vol.6 , Issue.4
    • Draube, A.1    Klein-González, N.2    Mattheus, S.3
  • 14
    • 84860188105 scopus 로고    scopus 로고
    • Therapeutic cancer vaccines: Current status and moving forward
    • Schlom J. Therapeutic cancer vaccines: Current status and moving forward. J. Natl Cancer Inst. 104(8), 599-613 (2012).
    • (2012) J. Natl Cancer Inst. , vol.104 , Issue.8 , pp. 599-613
    • Schlom, J.1
  • 15
    • 17144417748 scopus 로고    scopus 로고
    • Dendritic cells as therapeutic vaccines against cancer
    • Banchereau J, Palucka AK. Dendritic cells as therapeutic vaccines against cancer. Nat. Rev. Immunol. 5(4), 296-306 (2005).
    • (2005) Nat. Rev. Immunol. , vol.5 , Issue.4 , pp. 296-306
    • Banchereau, J.1    Palucka, A.K.2
  • 16
    • 79952441518 scopus 로고    scopus 로고
    • Targeting human dendritic cell subsets for improved vaccines
    • Ueno H, Klechevsky E, Schmitt N et al. Targeting human dendritic cell subsets for improved vaccines. Semin. Immunol. 23(1), 21-27 (2011).
    • (2011) Semin. Immunol. , vol.23 , Issue.1 , pp. 21-27
    • Ueno, H.1    Klechevsky, E.2    Schmitt, N.3
  • 17
    • 0036086102 scopus 로고    scopus 로고
    • Dendritic cells: Immune regulators in health and disease
    • Lipscomb MF, Masten BJ. Dendritic cells: Immune regulators in health and disease. Physiol. Rev. 82(1), 97-130 (2002).
    • (2002) Physiol. Rev. , vol.82 , Issue.1 , pp. 97-130
    • Lipscomb, M.F.1    Masten, B.J.2
  • 18
    • 77958454596 scopus 로고    scopus 로고
    • Designing vaccines based on biology of human dendritic cell subsets
    • Palucka K, Banchereau J, Mellman I. Designing vaccines based on biology of human dendritic cell subsets. Immunity 33(4), 464-478 (2010).
    • (2010) Immunity , vol.33 , Issue.4 , pp. 464-478
    • Palucka, K.1    Banchereau, J.2    Mellman, I.3
  • 20
    • 77956211427 scopus 로고    scopus 로고
    • Human Flt3L generates dendritic cells from canine peripheral blood precursors: Implications for a dog glioma clinical trial
    • Xiong W, Candolfi M, Liu C et al. Human Flt3L generates dendritic cells from canine peripheral blood precursors: Implications for a dog glioma clinical trial. PLoS ONE 5(6), E11074 (2010).
    • (2010) PLoS ONE , vol.5 , Issue.6
    • Xiong, W.1    Candolfi, M.2    Liu, C.3
  • 21
    • 10844279912 scopus 로고    scopus 로고
    • Serum concentration of the growth medium markedly affects monocyte-derived dendritic cells' phenotype, cytokine production profile and capacities to stimulate in MLR
    • Jakobsen MA, Møller BK, Lillevang ST. Serum concentration of the growth medium markedly affects monocyte-derived dendritic cells' phenotype, cytokine production profile and capacities to stimulate in MLR. Scand. J. Immunol. 60(6), 584-591 (2004).
    • (2004) Scand. J. Immunol. , vol.60 , Issue.6 , pp. 584-591
    • Jakobsen, M.A.1    Møller, B.K.2    Lillevang, S.T.3
  • 22
    • 3242890716 scopus 로고    scopus 로고
    • Generation of dendritic cells using cell culture bags - description of a method and review of literature
    • Büchler T, Kovárová L, Musilová R et al. Generation of dendritic cells using cell culture bags - description of a method and review of literature. Hematology 9(3), 199-205 (2004).
    • (2004) Hematology , vol.9 , Issue.3 , pp. 199-205
    • Büchler, T.1    Kovárová, L.2    Musilová, R.3
  • 23
    • 80054707651 scopus 로고    scopus 로고
    • Combination therapy of renal cell carcinoma or breast cancer patients with dendritic cell vaccine and IL-2: Results from a Phase I/II trial
    • Baek S, Kim CS, Kim SB et al. Combination therapy of renal cell carcinoma or breast cancer patients with dendritic cell vaccine and IL-2: Results from a Phase I/II trial. J. Transl. Med. 9, 178 (2011).
    • (2011) J. Transl. Med. , vol.9 , Issue.178
    • Baek, S.1    Kim, C.S.2    Kim, S.B.3
  • 24
    • 84859746200 scopus 로고    scopus 로고
    • Cytokine-based high log-scale expansion of functional human dendritic cells from cord-blood CD34-positive cells
    • Harada Y, Okada-Nakanishi Y, Ueda Y et al. Cytokine-based high log-scale expansion of functional human dendritic cells from cord-blood CD34-positive cells. Sci. Rep. 1, 174 (2011).
    • (2011) Sci. Rep. , vol.1 , Issue.174
    • Harada, Y.1    Okada-Nakanishi, Y.2    Ueda, Y.3
  • 25
    • 84858705623 scopus 로고    scopus 로고
    • A proposal for a simple and inexpensive therapeutic cancer vaccine
    • Fahrer AM. A proposal for a simple and inexpensive therapeutic cancer vaccine. Immunol. Cell. Biol. 90(3), 310-313 (2012).
    • (2012) Immunol. Cell. Biol. , vol.90 , Issue.3 , pp. 310-313
    • Fahrer, A.M.1
  • 26
    • 78650768336 scopus 로고    scopus 로고
    • Maturation of monocyte derived dendritic cells with OK432 boosts IL-12p70 secretion and conveys strong T-cell responses
    • Hovden AO, Karlsen M, Jonsson R, Aarstad HJ, Appel S. Maturation of monocyte derived dendritic cells with OK432 boosts IL-12p70 secretion and conveys strong T-cell responses. BMC Immunol. 12, 2-10 (2011).
    • (2011) BMC Immunol. , vol.12 , pp. 2-10
    • Hovden, A.O.1    Karlsen, M.2    Jonsson, R.3    Aarstad, H.J.4    Appel, S.5
  • 27
    • 0034332994 scopus 로고    scopus 로고
    • A method for the production of cryopreserved aliquots of antigen-preloaded, mature dendritic cells ready for clinical use
    • Feuerstein B, Berger TG, Maczek C et al. A method for the production of cryopreserved aliquots of antigen-preloaded, mature dendritic cells ready for clinical use. J. Immunol. Methods 245(1-2), 15-29 (2000).
    • (2000) J. Immunol. Methods , vol.245 , Issue.1-2 , pp. 15-29
    • Feuerstein, B.1    Berger, T.G.2    Maczek, C.3
  • 28
    • 0037438274 scopus 로고    scopus 로고
    • Cryopreservation of immature monocytederived dendritic cells results in enhanced cell maturation but reduced endocytic activity and efficiency of adenoviral transduction
    • John J, Hutchinson J, Dalgleish A, Pandha H. Cryopreservation of immature monocytederived dendritic cells results in enhanced cell maturation but reduced endocytic activity and efficiency of adenoviral transduction. J. Immunol. Meth. 272(1-2), 35-48 (2003).
    • (2003) J. Immunol. Meth. , vol.272 , Issue.1-2 , pp. 35-48
    • John, J.1    Hutchinson, J.2    Dalgleish, A.3    Pandha, H.4
  • 29
    • 34447624543 scopus 로고    scopus 로고
    • Current approaches in dendritic cell generation and future implications for cancer immunotherapy
    • Tuyaerts S, Aerts JL, Corthals J et al. Current approaches in dendritic cell generation and future implications for cancer immunotherapy. Cancer Immunol. Immunother. 56(10), 1513-1537 (2007).
    • (2007) Cancer Immunol. Immunother. , vol.56 , Issue.10 , pp. 1513-1537
    • Tuyaerts, S.1    Aerts, J.L.2    Corthals, J.3
  • 30
    • 68549094461 scopus 로고    scopus 로고
    • Patientderived renal cell carcinoma cells fused with allogeneic dendritic cells elicit anti-tumor activity: In vitro results and clinical responses
    • Zhou J, Weng D, Zhou F et al. Patientderived renal cell carcinoma cells fused with allogeneic dendritic cells elicit anti-tumor activity: In vitro results and clinical responses. Cancer Immunol. Immunother. 58(10), 1587-1597 (2009).
    • (2009) Cancer Immunol. Immunother. , vol.58 , Issue.10 , pp. 1587-1597
    • Zhou, J.1    Weng, D.2    Zhou, F.3
  • 31
    • 34748846272 scopus 로고    scopus 로고
    • Phase I/II study of vaccination with electrofused allogeneic dendritic cells/autologous tumor-derived cells in patients with stage IV renal cell carcinoma
    • Avigan DE, Vasir B, George DJ et al. Phase I/II study of vaccination with electrofused allogeneic dendritic cells/autologous tumor-derived cells in patients with stage IV renal cell carcinoma. J. Immunother. 30(7), 749-761 (2007).
    • (2007) J. Immunother. , vol.30 , Issue.7 , pp. 749-761
    • Avigan, D.E.1    Vasir, B.2    George, D.J.3
  • 32
    • 21244505782 scopus 로고    scopus 로고
    • Allogeneic dendritic cell vaccination against metastatic renal cell carcinoma with or without cyclophosphamide
    • Höltl L, Ramoner R, Zelle-Rieser C et al. Allogeneic dendritic cell vaccination against metastatic renal cell carcinoma with or without cyclophosphamide. Cancer Immunol. Immunother. 54(7), 663-670 (2005).
    • (2005) Cancer Immunol. Immunother. , vol.54 , Issue.7 , pp. 663-670
    • Höltl, L.1    Ramoner, R.2    Zelle-Rieser, C.3
  • 34
    • 84868608933 scopus 로고    scopus 로고
    • New type of dendritic-cell-based cancer vaccine enters the clinic
    • New type of dendritic-cell-based cancer vaccine enters the clinic. Hum. Vaccin. Immunother. 8(2), 152-153 (2012).
    • (2012) Hum. Vaccin. Immunother. , vol.8 , Issue.2 , pp. 152-153
  • 35
    • 77951919810 scopus 로고    scopus 로고
    • NK cell patrolling and elimination of donor-derived dendritic cells favor indirect alloreactivity
    • Garrod KR, Liu FC, Forrest LE, Parker I, Kang SM, Cahalan MD. NK cell patrolling and elimination of donor-derived dendritic cells favor indirect alloreactivity. J. Immunol. 184(5), 2329-2336 (2010).
    • (2010) J. Immunol. , vol.184 , Issue.5 , pp. 2329-2336
    • Garrod, K.R.1    Liu, F.C.2    Forrest, L.E.3    Parker, I.4    Kang, S.M.5    Cahalan, M.D.6
  • 36
    • 0033105695 scopus 로고    scopus 로고
    • Interleukin-10-treated human dendritic cells induce a melanomaantigen specific anergy in CD8+ T cells resulting in a failure to lyse tumor cells
    • Steinbrink K, Jonuleit H, Muller G, Schuler G, Knop J, Enk AH. Interleukin-10-treated human dendritic cells induce a melanomaantigen specific anergy in CD8+ T cells resulting in a failure to lyse tumor cells. Blood 93(5), 1634-1642 (1999).
    • (1999) Blood , vol.93 , Issue.5 , pp. 1634-1642
    • Steinbrink, K.1    Jonuleit, H.2    Muller, G.3    Schuler, G.4    Knop, J.5    Enk, A.H.6
  • 37
    • 6344285580 scopus 로고    scopus 로고
    • Mature dendritic cells are superior to immature dendritic cells in expanding antigen-specific naive and memory CD8+T cells
    • Tomiyama M, Takahara M, Egawa K, Nieda M. Mature dendritic cells are superior to immature dendritic cells in expanding antigen-specific naive and memory CD8+T cells. Anticancer Res. 24(5C), 3327-3333 (2004).
    • (2004) Anticancer Res. , vol.24 , Issue.5 C , pp. 3327-3333
    • Tomiyama, M.1    Takahara, M.2    Egawa, K.3    Nieda, M.4
  • 38
    • 0142010678 scopus 로고    scopus 로고
    • Optimizing dendritic cell-based anticancer immunotherapy: Maturation state does have clinical impact
    • McIlroy D, Gregoire M. Optimizing dendritic cell-based anticancer immunotherapy: Maturation state does have clinical impact. Cancer Immunol. Immunother. 52(10), 583-591 (2003).
    • (2003) Cancer Immunol. Immunother. , vol.52 , Issue.10 , pp. 583-591
    • McIlroy, D.1    Gregoire, M.2
  • 39
    • 10744232378 scopus 로고    scopus 로고
    • A pilot trial of tumor lysate-loaded dendritic cells for the treatment of metastatic renal cell carcinoma
    • Gitlitz BJ, Belldegrun AS, Zisman A et al. A pilot trial of tumor lysate-loaded dendritic cells for the treatment of metastatic renal cell carcinoma. J. Immunother. 26(5), 412-419 (2003).
    • (2003) J. Immunother. , vol.26 , Issue.5 , pp. 412-419
    • Gitlitz, B.J.1    Belldegrun, A.S.2    Zisman, A.3
  • 40
    • 19244365218 scopus 로고    scopus 로고
    • Vaccination of patients with metastatic renal cell carcinoma with autologous dendritic cells pulsed with autologous tumor antigens in combination with interleukin-2: A Phase 1 study
    • Oosterwijk-Wakka JC, Tiemessen DM, Bleumer I et al. Vaccination of patients with metastatic renal cell carcinoma with autologous dendritic cells pulsed with autologous tumor antigens in combination with interleukin-2: A Phase 1 study. J. Immunother. 25(6), 500-508 (2002).
    • (2002) J. Immunother. , vol.25 , Issue.6 , pp. 500-508
    • Oosterwijk-Wakka, J.C.1    Tiemessen, D.M.2    Bleumer, I.3
  • 41
    • 0038066552 scopus 로고    scopus 로고
    • Immunological and clinical responses in metastatic renal cancer patients vaccinated with tumor RNA-transfected dendritic cells
    • Su Z, Dannull J, Heiser A et al. Immunological and clinical responses in metastatic renal cancer patients vaccinated with tumor RNA-transfected dendritic cells. Cancer Res. 63(9), 2127-2133 (2003).
    • (2003) Cancer Res. , vol.63 , Issue.9 , pp. 2127-2133
    • Su, Z.1    Dannull, J.2    Heiser, A.3
  • 42
    • 34547449658 scopus 로고    scopus 로고
    • A full scale comparative study of methods for generation of functional dendritic cells for use as cancer vaccines
    • Jarnjak-Jankovic S, Hammerstad H, Saebøe-Larssen S, Kvalheim G, Gaudernack G. A full scale comparative study of methods for generation of functional dendritic cells for use as cancer vaccines. BMC Cancer 7, 119 (2007).
    • (2007) BMC Cancer , vol.7 , pp. 119
    • Jarnjak-Jankovic, S.1    Hammerstad, H.2    Saebøe-Larssen, S.3    Kvalheim, G.4    Gaudernack, G.5
  • 43
    • 4944223122 scopus 로고    scopus 로고
    • Manipulating dendritic cell biology for the active immunotherapy of cancer
    • O'Neill DW, Adams S, Bhardwaj N. Manipulating dendritic cell biology for the active immunotherapy of cancer. Blood 104(8), 2235-2246 (2004).
    • (2004) Blood , vol.104 , Issue.8 , pp. 2235-2246
    • O'Neill, D.W.1    Adams, S.2    Bhardwaj, N.3
  • 44
    • 70350009966 scopus 로고    scopus 로고
    • Dendritic cells as danger-recognizing biosensors
    • Gi M, Im W, Hong S. Dendritic cells as danger-recognizing biosensors. Sensors (Basel) 9(9), 6730-6751 (2009).
    • (2009) Sensors (Basel , vol.9 , Issue.9 , pp. 6730-6751
    • Gi, M.1    Im, W.2    Hong, S.3
  • 46
    • 77950861300 scopus 로고    scopus 로고
    • Anti-tumor effects of fusion vaccine prepared by renal cell carcinoma 786-O cell line and peripheral blood dendritic cells of healthy volunteers in vitro and in human immune reconstituted SCID mice
    • Hu Z, Liu S, Mai X, Hu Z, Liu C. Anti-tumor effects of fusion vaccine prepared by renal cell carcinoma 786-O cell line and peripheral blood dendritic cells of healthy volunteers in vitro and in human immune reconstituted SCID mice. Cell. Immunol. 262(2), 112-119 (2010).
    • (2010) Cell. Immunol. , vol.262 , Issue.2 , pp. 112-119
    • Hu, Z.1    Liu, S.2    Mai, X.3    Hu, Z.4    Liu, C.5
  • 47
    • 38449120099 scopus 로고    scopus 로고
    • Combined treatment of dendritoma vaccine and low-dose interleukin-2 in stage IV renal cell carcinoma patients induced clinical response: A pilot study
    • Wei YC, Sticca RP, Li J et al. Combined treatment of dendritoma vaccine and low-dose interleukin-2 in stage IV renal cell carcinoma patients induced clinical response: A pilot study. Oncol. Rep. 18(3), 665-671 (2007).
    • (2007) Oncol. Rep. , vol.18 , Issue.3 , pp. 665-671
    • Wei, Y.C.1    Sticca, R.P.2    Li, J.3
  • 48
    • 27144440353 scopus 로고    scopus 로고
    • Expression of the 5T4 oncofoetal antigen in renal cell carcinoma: A potential target for T-cell-based immunotherapy
    • Griffiths RW, Gilham DE, Dangoor A et al. Expression of the 5T4 oncofoetal antigen in renal cell carcinoma: A potential target for T-cell-based immunotherapy. Br. J. Cancer 93(6), 670-677 (2005).
    • (2005) Br. J. Cancer , vol.93 , Issue.6 , pp. 670-677
    • Griffiths, R.W.1    Gilham, D.E.2    Dangoor, A.3
  • 49
    • 8744315211 scopus 로고    scopus 로고
    • Antigenic targets for renal cell carcinoma immunotherapy
    • Vieweg J, Jackson A. Antigenic targets for renal cell carcinoma immunotherapy. Expert Opin. Biol. Ther. 4(11), 1791-1801 (2004).
    • (2004) Expert Opin. Biol. Ther. , vol.4 , Issue.11 , pp. 1791-1801
    • Vieweg, J.1    Jackson, A.2
  • 50
    • 77952878558 scopus 로고    scopus 로고
    • Carbonic anhydrase IX in renal cell carcinoma: Implications for prognosis, diagnosis, and therapy
    • Stillebroer AB, Mulders PF, Boerman OC, Oyen WJ, Oosterwijk E. Carbonic anhydrase IX in renal cell carcinoma: Implications for prognosis, diagnosis, and therapy. Eur. Urol. 58(1), 75-83 (2010).
    • (2010) Eur. Urol. , vol.58 , Issue.1 , pp. 75-83
    • Stillebroer, A.B.1    Mulders, P.F.2    Boerman, O.C.3    Oyen, W.J.4    Oosterwijk, E.5
  • 51
    • 0037943937 scopus 로고    scopus 로고
    • Durable complete clinical responses in a Phase I/II trial using an autologous melanoma cell/dendritic cell vaccine
    • O'Rourke MG, Johnson M, Lanagan C et al. Durable complete clinical responses in a Phase I/II trial using an autologous melanoma cell/dendritic cell vaccine. Cancer Immunol. Immunother. 52(6), 387-395 (2003).
    • (2003) Cancer Immunol. Immunother. , vol.52 , Issue.6 , pp. 387-395
    • O'Rourke, M.G.1    Johnson, M.2    Lanagan, C.3
  • 52
    • 0141993954 scopus 로고    scopus 로고
    • Route of immunization with peptide-pulsed dendritic cells controls the distribution of memory and effector T cells in lymphoid tissues and determines the pattern of regional tumor control
    • Mullins DW, Sheasley SL, Ream RM, Bullock TN, Fu YX, Engelhard VH. Route of immunization with peptide-pulsed dendritic cells controls the distribution of memory and effector T cells in lymphoid tissues and determines the pattern of regional tumor control. J. Exp. Med. 198(7), 1023-1034 (2003).
    • (2003) J. Exp. Med. , vol.198 , Issue.7 , pp. 1023-1034
    • Mullins, D.W.1    Sheasley, S.L.2    Ream, R.M.3    Bullock, T.N.4    Fu, Y.X.5    Engelhard, V.H.6
  • 53
    • 0033565923 scopus 로고    scopus 로고
    • Biodistribution and vaccine efficiency of murine dendritic cells are dependent on the route of administration
    • Eggert AA, Schreurs MW, Boerman OC et al. Biodistribution and vaccine efficiency of murine dendritic cells are dependent on the route of administration. Cancer Res. 59(14), 3340-3345 (1999).
    • (1999) Cancer Res. , vol.59 , Issue.14 , pp. 3340-3345
    • Eggert, A.A.1    Schreurs, M.W.2    Boerman, O.C.3
  • 54
    • 59849105579 scopus 로고    scopus 로고
    • Therapeutic dendritic cell vaccination of patients with metastatic renal cell carcinoma: A clinical Phase 1/2 trial
    • Berntsen A, Trepiakas R, Wenandy L et al. Therapeutic dendritic cell vaccination of patients with metastatic renal cell carcinoma: A clinical Phase 1/2 trial. J. Immunother. 31, 771-780 (2008).
    • (2008) J. Immunother. , vol.31 , pp. 771-780
    • Berntsen, A.1    Trepiakas, R.2    Wenandy, L.3
  • 55
    • 33746910738 scopus 로고    scopus 로고
    • Phase I/II trial of melanoma therapy with dendritic cells transfected with autologous tumor-mRNA
    • Kyte JA, Mu L, Aamdal S et al. Phase I/II trial of melanoma therapy with dendritic cells transfected with autologous tumor-mRNA. Cancer Gene Ther. 13(10), 905-918 (2006).
    • (2006) Cancer Gene Ther. , vol.13 , Issue.10 , pp. 905-918
    • Kyte, J.A.1    Mu, L.2    Aamdal, S.3
  • 56
    • 0037226599 scopus 로고    scopus 로고
    • Effective migration of antigen-pulsed dendritic cells to lymph nodes in melanoma patients is determined by their maturation state
    • De Vries IJ, Krooshoop DJ, Scharenborg NM et al. Effective migration of antigen-pulsed dendritic cells to lymph nodes in melanoma patients is determined by their maturation state. Cancer Res. 63(1), 12-17 (2003).
    • (2003) Cancer Res. , vol.63 , Issue.1 , pp. 12-17
    • De Vries, I.J.1    Krooshoop, D.J.2    Scharenborg, N.M.3
  • 58
    • 0042922810 scopus 로고    scopus 로고
    • Regulation of dendritic cell migration to the draining lymph node: Impact on T lymphocyte traffic and priming
    • MartIn-Fontecha A, Sebastiani S, Hopken UE et al. Regulation of dendritic cell migration to the draining lymph node: Impact on T lymphocyte traffic and priming. J. Exp. Med. 198(4), 615-621 (2003).
    • (2003) J. Exp. Med. , vol.198 , Issue.4 , pp. 615-621
    • MartIn-Fontecha, A.1    Sebastiani, S.2    Hopken, U.E.3
  • 59
    • 29644446061 scopus 로고    scopus 로고
    • The TLR-7 agonist, imiquimod, enhances dendritic cell survival and promotes tumor antigen-specific T cell priming: Relation to central nervous system antitumor immunity
    • Prins RM, Craft N, Bruhn KW et al. The TLR-7 agonist, imiquimod, enhances dendritic cell survival and promotes tumor antigen-specific T cell priming: Relation to central nervous system antitumor immunity. J. Immunol. 176(1), 157-164 (2006).
    • (2006) J. Immunol. , vol.176 , Issue.1 , pp. 157-164
    • Prins, R.M.1    Craft, N.2    Bruhn, K.W.3
  • 60
    • 27944504770 scopus 로고    scopus 로고
    • Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy
    • de Vries IJ, Lesterhuis WJ, Barentsz JO et al. Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy. Nat. Biotechnol. 23(11), 1407-1413 (2005).
    • (2005) Nat. Biotechnol. , vol.23 , Issue.11 , pp. 1407-1413
    • De Vries, I.J.1    Lesterhuis, W.J.2    Barentsz, J.O.3
  • 61
    • 55549138386 scopus 로고    scopus 로고
    • Noninvasive imaging of dendritic cell migration into lymph nodes using nearinfrared fluorescent semiconductor nanocrystals
    • Noh YW, Lim YT, Chung BH et al. Noninvasive imaging of dendritic cell migration into lymph nodes using nearinfrared fluorescent semiconductor nanocrystals. FASEB J. 22(11), 3908-3918 (2008).
    • (2008) FASEB J. , vol.22 , Issue.11 , pp. 3908-3918
    • Noh, Y.W.1    Lim, Y.T.2    Chung, B.H.3
  • 62
    • 0036448032 scopus 로고    scopus 로고
    • Therapeutic vaccination against metastatic renal cell carcinoma by autologous dendritic cells: Preclinical results and outcome of a first clinical Phase I/II trial
    • Marten A, Flieger D, Renoth S et al. Therapeutic vaccination against metastatic renal cell carcinoma by autologous dendritic cells: preclinical results and outcome of a first clinical Phase I/II trial. Cancer Immunol. Immunother. 51(11-12), 637-644 (2002).
    • (2002) Cancer Immunol. Immunother. , vol.51 , Issue.11-12 , pp. 637-644
    • Marten, A.1    Flieger, D.2    Renoth, S.3
  • 63
    • 36148941016 scopus 로고    scopus 로고
    • Phase I/II study of immunotherapy using autologous tumor lysate-pulsed dendritic cells in patients with metastatic renal cell carcinoma
    • Kim JH, Lee Y, Bae YS et al. Phase I/II study of immunotherapy using autologous tumor lysate-pulsed dendritic cells in patients with metastatic renal cell carcinoma. Clin. Immunol. 125(3), 257-267 (2007).
    • (2007) Clin. Immunol. , vol.125 , Issue.3 , pp. 257-267
    • Kim, J.H.1    Lee, Y.2    Bae, Y.S.3
  • 64
    • 30144444279 scopus 로고    scopus 로고
    • Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells
    • Dannull J, Su Z, Rizzieri D et al. Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells. J. Clin. Invest. 115(12), 3623-3633 (2005).
    • (2005) J. Clin. Invest. , vol.115 , Issue.12 , pp. 3623-3633
    • Dannull, J.1    Su, Z.2    Rizzieri, D.3
  • 65
    • 0035996525 scopus 로고    scopus 로고
    • Dendritic cell immunotherapy for patients with metastatic renal cell carcinoma: University of Tokyo experience
    • Azuma T, Horie S, Tomita K et al. Dendritic cell immunotherapy for patients with metastatic renal cell carcinoma: University of Tokyo experience. Int. J. Urol. 9(6), 340-346 (2002).
    • (2002) Int. J. Urol. , vol.9 , Issue.6 , pp. 340-346
    • Azuma, T.1    Horie, S.2    Tomita, K.3
  • 66
    • 4344637057 scopus 로고    scopus 로고
    • Dendritic cell immunotherapy for urological cancers using cryopreserved allogeneic tumour lysate-pulsed cells: A Phase I/II study
    • Pandha HS, John RJ, Hutchinson J et al. Dendritic cell immunotherapy for urological cancers using cryopreserved allogeneic tumour lysate-pulsed cells: A Phase I/II study. BJU Int. 94(3), 412-418 (2004).
    • (2004) BJU Int. , vol.94 , Issue.3 , pp. 412-418
    • Pandha, H.S.1    John, R.J.2    Hutchinson, J.3
  • 67
    • 0036845714 scopus 로고    scopus 로고
    • Immunotherapy of metastatic renal cell carcinoma with tumor lysate-pulsed autologous dendritic cells
    • Holtl L, Zelle-Rieser C, Gander H et al. Immunotherapy of metastatic renal cell carcinoma with tumor lysate-pulsed autologous dendritic cells. Clin. Cancer Res. 8(11), 3369-3376 (2002).
    • (2002) Clin. Cancer Res. , vol.8 , Issue.11 , pp. 3369-3376
    • Holtl, L.1    Zelle-Rieser, C.2    Gander, H.3
  • 69
    • 53549087527 scopus 로고    scopus 로고
    • How tumours escape mass destruction
    • Stewart TJ, Abrams SI. How tumours escape mass destruction. Oncogene 27(45), 5894-5903 (2008).
    • (2008) Oncogene , vol.27 , Issue.45 , pp. 5894-5903
    • Stewart, T.J.1    Abrams, S.I.2
  • 70
    • 29144508613 scopus 로고    scopus 로고
    • Dendritic cell dysfunction in cancer: A mechanism for immunosuppression
    • Pinzon-Charry A, Maxwell T, López JA. Dendritic cell dysfunction in cancer: A mechanism for immunosuppression. Immunol. Cell. Biol. 83(5), 451-461 (2005).
    • (2005) Immunol. Cell. Biol. , vol.83 , Issue.5 , pp. 451-461
    • Pinzon-Charry, A.1    Maxwell, T.2    López, J.A.3
  • 71
    • 10244279184 scopus 로고    scopus 로고
    • Mechanisms and functional significance of tumour-induced dendritic-cell defects
    • Gabrilovich D. Mechanisms and functional significance of tumour-induced dendritic-cell defects. Nat. Rev. Immunol. 4(12), 941-952 (2004).
    • (2004) Nat. Rev. Immunol. , vol.4 , Issue.12 , pp. 941-952
    • Gabrilovich, D.1
  • 72
    • 0031924545 scopus 로고    scopus 로고
    • Minimal recruitment and activation of dendritic cells within renal cell carcinoma
    • Troy AJ, Summers KL, Davidson PJ, Atkinson CH, Hart DN. Minimal recruitment and activation of dendritic cells within renal cell carcinoma. Clin. Cancer Res. 4(3), 585-593 (1998).
    • (1998) Clin. Cancer Res. , vol.4 , Issue.3 , pp. 585-593
    • Troy, A.J.1    Summers, K.L.2    Davidson, P.J.3    Atkinson, C.H.4    Hart, D.N.5
  • 73
    • 53549102755 scopus 로고    scopus 로고
    • The tumor microenvironment and its role in promoting tumor growth
    • Whiteside TL. The tumor microenvironment and its role in promoting tumor growth. Oncogene 27(45), 5904-5912 (2008).
    • (2008) Oncogene , vol.27 , Issue.45 , pp. 5904-5912
    • Whiteside, T.L.1
  • 74
    • 79959334978 scopus 로고    scopus 로고
    • Immunologic monitoring of cellular responses by dendritic/tumor cell fusion vaccines
    • Koido S, Homma S, Takahara A et al. Immunologic monitoring of cellular responses by dendritic/tumor cell fusion vaccines. J. Biomed. Biotechnol. 2011, 910836 (2011).
    • (2011) J. Biomed. Biotechnol. 2011 , pp. 910836
    • Koido, S.1    Homma, S.2    Takahara, A.3
  • 75
    • 0035201489 scopus 로고    scopus 로고
    • Interactions between dendritic cells and cytokine-induced killer cells lead to an activation of both populations
    • Märten A, Ziske C, Schöttker B et al. Interactions between dendritic cells and cytokine-induced killer cells lead to an activation of both populations. J. Immunother. 24(6), 502-510 (2001).
    • (2001) J. Immunother. , vol.24 , Issue.6 , pp. 502-510
    • Märten, A.1    Ziske, C.2    Schöttker, B.3
  • 76
    • 0348109413 scopus 로고    scopus 로고
    • Telomerase pulsed dendritic cells for immunotherapy for renal cell carcinoma
    • Sievers E, Albers P, Schmidt-Wolf IG, Märten A. Telomerase pulsed dendritic cells for immunotherapy for renal cell carcinoma. J. Urol. 171(1), 114-119 (2004).
    • (2004) J. Urol. , vol.171 , Issue.1 , pp. 114-119
    • Sievers, E.1    Albers, P.2    Schmidt-Wolf, I.G.3    Märten, A.4
  • 77
    • 5644253039 scopus 로고    scopus 로고
    • Dendritic cells reduce number and function of CD4+CD25+ cells in cytokine-induced killer cells derived from patients with pancreatic carcinoma
    • Schmidt J, Eisold S, Büchler MW, Märten A. Dendritic cells reduce number and function of CD4+CD25+ cells in cytokine-induced killer cells derived from patients with pancreatic carcinoma. Cancer Immunol. Immunother. 53(11), 1018-1026 (2004).
    • (2004) Cancer Immunol. Immunother. , vol.53 , Issue.11 , pp. 1018-1026
    • Schmidt, J.1    Eisold, S.2    Büchler, M.W.3    Märten, A.4
  • 78
    • 33845993628 scopus 로고    scopus 로고
    • A clinical development paradigm for cancer vaccines and related biologics
    • Hoos A, Parmiani G, Hege K et al. A clinical development paradigm for cancer vaccines and related biologics. J. Immunother. 30(1), 1-15 (2007).
    • (2007) J. Immunother. , vol.30 , Issue.1 , pp. 1-15
    • Hoos, A.1    Parmiani, G.2    Hege, K.3
  • 79
    • 33846021299 scopus 로고    scopus 로고
    • Preliminary analysis of patients with progressive renal cell carcinoma vaccinated with CA9-peptide-pulsed mature dendritic cells
    • Bleumer I, Tiemessen DM, Oosterwijk-Wakka JC et al. Preliminary analysis of patients with progressive renal cell carcinoma vaccinated with CA9-peptide-pulsed mature dendritic cells. J. Immunother. 30(1), 116-122 (2007).
    • (2007) J. Immunother. , vol.30 , Issue.1 , pp. 116-122
    • Bleumer, I.1    Tiemessen, D.M.2    Oosterwijk-Wakka, J.C.3
  • 80
    • 0037457018 scopus 로고    scopus 로고
    • Allogeneic dendritic cells fused with tumor cells: preclinical results and outcome of a clinical Phase I/II trial in patients with metastatic renal cell carcinoma
    • Marten A, Renoth S, Heinicke T et al. Allogeneic dendritic cells fused with tumor cells: preclinical results and outcome of a clinical Phase I/II trial in patients with metastatic renal cell carcinoma. Hum. Gene Ther. 14(5), 483-494 (2003).
    • (2003) Hum. Gene Ther. , vol.14 , Issue.5 , pp. 483-494
    • Marten, A.1    Renoth, S.2    Heinicke, T.3
  • 81
    • 33745247366 scopus 로고    scopus 로고
    • Immunologic and clinical responses after vaccinations with peptide-pulsed dendritic cells in metastatic renal cancer patients
    • Wierecky J, Muller MR, Wirths S et al. Immunologic and clinical responses after vaccinations with peptide-pulsed dendritic cells in metastatic renal cancer patients. Cancer Res. 66(11), 5910-5918 (2006).
    • (2006) Cancer Res. , vol.66 , Issue.11 , pp. 5910-5918
    • Wierecky, J.1    Muller, M.R.2    Wirths, S.3
  • 82
    • 49549107094 scopus 로고    scopus 로고
    • Dendritic cell therapy in combination with interferon - A for the treatment of metastatic renal cell carcinoma
    • Tatsugami K, Eto M, Harano M et al. Dendritic cell therapy in combination with interferon-a for the treatment of metastatic renal cell carcinoma. Int. J. Urol. 15(8), 694-698 (2008).
    • (2008) Int. J. Urol. , vol.15 , Issue.8 , pp. 694-698
    • Tatsugami, K.1    Eto, M.2    Harano, M.3
  • 83
    • 50649093779 scopus 로고    scopus 로고
    • The use of TLR7 and TLR8 ligands for the enhancement of cancer immunotherapy
    • Smits EL, Ponsaerts P, Berneman ZN, Van Tendeloo VF. The use of TLR7 and TLR8 ligands for the enhancement of cancer immunotherapy. Oncologist 13(8), 859-875 (2008).
    • (2008) Oncologist , vol.13 , Issue.8 , pp. 859-875
    • Smits, E.L.1    Ponsaerts, P.2    Berneman, Z.N.3    Van Tendeloo, V.F.4
  • 84
    • 37848999304 scopus 로고    scopus 로고
    • TLR7 and TLR8 as targets in cancer therapy
    • Schön MP, Schön M. TLR7 and TLR8 as targets in cancer therapy. Oncogene 27(2), 190-199 (2008).
    • (2008) Oncogene , vol.27 , Issue.2 , pp. 190-199
    • Schön, M.P.1    Schön, M.2
  • 85
    • 44349173032 scopus 로고    scopus 로고
    • Enhancing the T-cell stimulatory capacity of human dendritic cells by co-electroporation with CD40L CD70 and constitutively active TLR4 encoding mRNA
    • Bonehill A, Tuyaerts S, Van Nuffel AM et al. Enhancing the T-cell stimulatory capacity of human dendritic cells by co-electroporation with CD40L, CD70 and constitutively active TLR4 encoding mRNA. Mol. Ther. 16(6), 1170-1180 (2008).
    • (2008) Mol. Ther. , vol.16 , Issue.6 , pp. 1170-1180
    • Bonehill, A.1    Tuyaerts, S.2    Van Nuffel, A.M.3
  • 86
    • 8544249166 scopus 로고    scopus 로고
    • Anti-CD137 monoclonal antibody administration augments the antitumor efficacy of dendritic cell-based vaccines
    • Ito F, Li Q, Shreiner AB et al. Anti-CD137 monoclonal antibody administration augments the antitumor efficacy of dendritic cell-based vaccines. Cancer Res. 64(22), 8411-8419 (2004).
    • (2004) Cancer Res. , vol.64 , Issue.22 , pp. 8411-8419
    • Ito, F.1    Li, Q.2    Shreiner, A.B.3
  • 87
    • 70349680756 scopus 로고    scopus 로고
    • Dendritic cell vaccination combined with CTLA4 blockade in patients with metastatic melanoma
    • Ribas A, Comin-Anduix B, Chmielowski B et al. Dendritic cell vaccination combined with CTLA4 blockade in patients with metastatic melanoma. Clin. Cancer Res. 15(19), 6267-6276 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , Issue.19 , pp. 6267-6276
    • Ribas, A.1    Comin-Anduix, B.2    Chmielowski, B.3
  • 88
    • 25144522150 scopus 로고    scopus 로고
    • B7-H1 glycoprotein blockade: A novel strategy to enhance immunotherapy in patients with renal cell carcinoma
    • Suppl.
    • Thompson RH, Webster WS, Cheville JC et al. B7-H1 glycoprotein blockade: A novel strategy to enhance immunotherapy in patients with renal cell carcinoma. Urology 66(5 Suppl.), S10-S14 (2005).
    • (2005) Urology , vol.66 , Issue.5
    • Thompson, R.H.1    Webster, W.S.2    Cheville, J.C.3
  • 89
    • 77955561177 scopus 로고    scopus 로고
    • Combining allogeneic immunotherapy with an mTOR inhibitor for advanced renal cell carcinoma
    • Tykodi SS, Voong LN, Warren EH. Combining allogeneic immunotherapy with an mTOR inhibitor for advanced renal cell carcinoma. Bone Marrow Transplant. 45(8), 1360-1362 (2010).
    • (2010) Bone Marrow Transplant. , vol.45 , Issue.8 , pp. 1360-1362
    • Tykodi, S.S.1    Voong, L.N.2    Warren, E.H.3
  • 90
    • 41049089064 scopus 로고    scopus 로고
    • Enhancement of dendritic cell-tumor fusion vaccine potency by indoleamine-pyrrole 2,3-dioxygenase inhibitor, 1-MT
    • Ou X, Cai S, Liu P et al. Enhancement of dendritic cell-tumor fusion vaccine potency by indoleamine-pyrrole 2,3-dioxygenase inhibitor, 1-MT. J. Cancer Res. Clin. Oncol. 134(5), 525-533 (2008).
    • (2008) J. Cancer Res. Clin. Oncol. , vol.134 , Issue.5 , pp. 525-533
    • Ou, X.1    Cai, S.2    Liu, P.3
  • 91
    • 68249159577 scopus 로고    scopus 로고
    • Modulation of dendritic cell maturation and function with mono- and bifunctional small interfering RNAs targeting indoleamine 2,3-dioxygenase
    • Flatekval GF, Sioud M. Modulation of dendritic cell maturation and function with mono- and bifunctional small interfering RNAs targeting indoleamine 2,3-dioxygenase. Immunology 128(Suppl. 1), E837-E848 (2009).
    • (2009) Immunology , vol.128 , Issue.SUPPL. 1
    • Flatekval, G.F.1    Sioud, M.2
  • 92
    • 78349285473 scopus 로고    scopus 로고
    • Adjuvant effects of formalininactivated HSV through activation of dendritic cells and inactivation of myeloidderived suppressor cells in cancer immunotherapy
    • Ohkusu-Tsukada K, Ohta S, Kawakami Y, Toda M. Adjuvant effects of formalininactivated HSV through activation of dendritic cells and inactivation of myeloidderived suppressor cells in cancer immunotherapy. Int. J. Cancer 128(1), 119-131 (2011).
    • (2011) Int. J. Cancer , vol.128 , Issue.1 , pp. 119-131
    • Ohkusu-Tsukada, K.1    Ohta, S.2    Kawakami, Y.3    Toda, M.4
  • 93
    • 34447639113 scopus 로고    scopus 로고
    • Single administration of low dose cyclophosphamide augments the antitumor effect of dendritic cell vaccine
    • Liu JY, Wu Y, Zhang XS et al. Single administration of low dose cyclophosphamide augments the antitumor effect of dendritic cell vaccine. Cancer Immunol. Immunother. 56(10), 1597-1604 (2007).
    • (2007) Cancer Immunol. Immunother. , vol.56 , Issue.10 , pp. 1597-1604
    • Liu, J.Y.1    Wu, Y.2    Zhang, X.S.3
  • 94
    • 23244458246 scopus 로고    scopus 로고
    • Therapy targeted at vascular endothelial growth factor in metastatic renal cell carcinoma: Biology, clinical results and future development
    • Rini BI, Sosman JA, Motzer RJ. Therapy targeted at vascular endothelial growth factor in metastatic renal cell carcinoma: biology, clinical results and future development. BJU Int. 96, 286-290 (2005).
    • (2005) BJU Int. , vol.96 , pp. 286-290
    • Rini, B.I.1    Sosman, J.A.2    Motzer, R.J.3
  • 95
    • 70350494714 scopus 로고    scopus 로고
    • Immune responses in patients with metastatic renal cell carcinoma treated with dendritic cells pulsed with tumor lysate
    • Soleimani A, Berntsen A, Svane IM, Pedersen AE. Immune responses in patients with metastatic renal cell carcinoma treated with dendritic cells pulsed with tumor lysate. Scand. J. Immunol. 70(5), 481-489 (2009).
    • (2009) Scand. J. Immunol. , vol.70 , Issue.5 , pp. 481-489
    • Soleimani, A.1    Berntsen, A.2    Svane, I.M.3    Pedersen, A.E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.