Adjuvant immunotherapy with whole-cell lysate dendritic cells vaccine for glioblastoma multiforme: A phase II clinical trial

World Neurosurgery

Volumn 77, Issue 5-6, 2012, Pages 736-744

  Cho, Der Yang ^a   Yang, Wen Kuang ^a   Lee, Han Chung ^a   Hsu, Den Mei ^a   Lin, Hung Lin ^a   Lin, Shinn Zong ^a   Chen, Chun Chung ^a   Harn, Horng Jyh ^a,b   Liu, Chun Lin ^a   Lee, Wen Yuan ^a   Ho, Li Hui ^a  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Dendritic cells; Glioblastoma multiforme; Immunotherapy; Overall survival; Progression free survival; Vaccine

Indexed keywords

DENDRITIC CELL VACCINE;

ADOLESCENT; ADULT; AGED; CANCER CHEMOTHERAPY; CANCER IMMUNOTHERAPY; CANCER RADIOTHERAPY; CANCER SURVIVAL; CELL LYSATE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FOLLOW UP; GAMMA KNIFE RADIOSURGERY; GLIOBLASTOMA; HUMAN; HUMAN CELL; INFECTION; KARNOFSKY PERFORMANCE STATUS; LIVER FUNCTION; LYMPHOCYTOPENIA; MALE; MULTIMODALITY CANCER THERAPY; NAUSEA AND VOMITING; OUTCOME ASSESSMENT; OVERALL SURVIVAL; POSTOPERATIVE CARE; PROGRESSION FREE SURVIVAL; PROSPECTIVE STUDY; QUALITY OF LIFE; REVIEW; SIDE EFFECT; SKIN DISEASE; SURVIVAL RATE; TREATMENT OUTCOME; TUMOR RECURRENCE; WHOLE CELL;

ADOLESCENT; ADULT; AGED; ANTINEOPLASTIC AGENTS; BRAIN NEOPLASMS; CANCER VACCINES; CELL LINE, TUMOR; COMBINED MODALITY THERAPY; DENDRITIC CELLS; DISEASE-FREE SURVIVAL; FEMALE; FOLLOW-UP STUDIES; GLIOBLASTOMA; HUMANS; IMMUNOTHERAPY; KAPLAN-MEIER ESTIMATE; KARNOFSKY PERFORMANCE STATUS; MALE; MIDDLE AGED; NEUROSURGICAL PROCEDURES; QUALITY OF LIFE; RADIOSURGERY; SURVIVAL; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84864151615     PISSN: 18788750     EISSN: 18788769     Source Type: Journal    
DOI: 10.1016/j.wneu.2011.08.020     Document Type: Review

References (31)

1. H. Ardon, S. Van Gool, I.S. Lopes, W. Maes, R. Sciot, G. Wilms, P. Demaerel, P. Bijttebier, L. Claes, J. Goffin, F. Van Calenbergh, S. De Vleeschouwer Integration of autologous dendritic cell-based immunotherapy in the primary treatment for patients with newly diagnosed glioblastoma multiforme: a pilot study J Neurooncol 99 2010 261 272
2. M. Bland The Design of Experiments An Introduction to Medical Statistics 3rd ed. 2000 Oxford University Press New York 5 25
3. W.J. Curran Jr., C.B. Scott, J. Horton, J.S. Nelson, A.S. Weinstein, A.J. Fischbach, C.H. Chang, M. Rotman, S.O. Asbell, R.E. Krisch, D.F. Nelson Recursive partitioning analysis of prognostic factors in three radiation therapy oncology group trials J Natl Cancer Inst 85 1993 704 710
4. D.Y. Cho, S.Z. Lin, W.K. Yang, D.M. Hsu, H.C. Lee, W.Y. Lee, S.P. Liu Recent advances of dendritic cells (DCs)-base immunotherapy for malignant gliomas Cell Transplant 18 2009 977 983
5. F.G. Davis, S. Frees, J. Grutsch, S. Barlas, S. Brem Survival rates in patients with primary malignant brain tumors stratified by patient age and tumor histological type: an analysis base on surveillance, epidemiology, end results (SEER) data 1973-1991 J Neurosurg 88 1998 1 10
6. K.M. Dhodapkar, B. Cirignano, F. Chamian, D. Zagzag, D.C. Miller, J.L. Finlay, R.M. Steinman Invariant natural killer T cells are preserved in patients with glioma and exhibit antitumor lytic activity following dendritic cell mediated expansion Int J Cancer 109 2004 893 899
7. R.A. Fenstermaker, M.J. Ciesielski Immunotherapeutic strategies for malignant glioma Cancer Control 11 2004 181 191
8. E. Gliboa, S.K. Nair, H.K. Lyerly Immunotherapy of cancer with dendritic-cell-based vaccines Cancer Immunol Immunolother 46 1998 82 87
9. K.A. Kelly, J.M. Kirkwood, D.S. Kapp Glioblastoma multiforme: pathology, natural history and treatment Cancer Treat Rev 11 1984 1 26
10. C.H. Kim, S.J. Woo, J.S. Park, H.S. Kim, M.Y. Park, S.D. Park, Y.K. Hong, T.G. Kim Enhanced antitumor immunity by combined use of temozolomide and TAT-survivin pulsed dendritic cells in a murine glioma Immunology 122 2007 615 622
11. T. Kobayashi, R. Yamanaka, J. Homma, N. Tsuchiya, N. Yajima, S. Yoshida, R. Tanaka Tumor mRNA-loaded dendritic cells elicit tumor-specific CD8+ cytotoxic T cells in patients with malignant glioma Cancer Immune Immunotherapy 52 2003 632 637
12. J.M. Legler, L.A. Ries, M.A. Smith, J.L. Warren, E.F. Heineman, R.S. Kaplan, M.S. Linet Cancer surveillance series (corrected): brain and other central nervous system cancers: recent trends in incidence and mortality J Natl Cancer Inst 91 1999 1382 1390
13. L.M. Liau, R.M. Prins, S.M. Kiertscher, S.K. Odesa, T.J. Kremen, A.J. Giovannone, J.W. Lin, D.J. Chute, P.S. Mischel, T.F. Cloughesy, M.D. Roth Dendritic cell vaccination in glioblastoma patients induces systemic and intracranial T-cell response modulated by local central nervous tumor microenvironment Clin Cancer Res 11 2005 5515 5525
14. R.O. Mirimanoff, T. Gorlia, W. Mason, M.J. Van den Bent, R.D. Kortmann, B. Fisher, M. Reni, A.A. Brandes, J. Curschmann, S. Villa, G. Cairncross, A. Allgeier, D. Lacombe, R. Stupp Radiotherapy and temozolomide for newly diagnosed glioblastoma: recursive partitioning analysis of EORTC 26981-NCIC CE2 phase III randomized trial J Clin Oncol 24 2006 2563 2569
15. R.J. North Gamma-irradiation facilitates the expression of adoptive immunity against established tumor by eliminating suppressor T-cells Cancer Immunol Immunother 16 1984 175 181
16. M. Nouri-Shirazi, J. Banchereau, D. Bell, S. Burkeholder, E.T. Kraus, J. Davoust, K.A. Palucka Dendritic cells capture killed tumor cells and present their antigens to elicit tumor-specific immune responses J Immunol 165 2000 3797 3803
17. P. Parajuli, S. Mathupala, A.E. Sloan Systematic comparison of dendritic cell-based immunotherapeutic strategies for malignant gliomas: in vitro induction of cytolytic and natural killer-like T-cells Neurosurgery 55 2004 1194 1204
18. P. Parajuli, A.E. Sloan Dendritic cell-based immunotherapy of malignant gliomas Cancer Invest 22 2004 405 416
19. M.L. Salgaller, M. Thurnher, G. Bartsch, A.L. Boynton, G.P. Murphy Report from the International Union against Cancer (UICC) Tumor Biology Committee: UICC workshop on the use of dendritic cells in cancer clinical trials Cancer 86 1999 2674 2683
20. D.C. Shrieve, E. Alexander 3rd, P.M. Black, P.Y. Wen, H.A. Fine, H.M. Kooy, J.S. Loeffler Treatment of patients with primary glioblastoma multiforme with standard postoperative radiotherapy and radiosurgical boost: prognostic factors and long-term outcome J Neurosug 90 1999 72 77
21. R. Stupp, W.P. Mason, M.J. van den Bent, M. Weller, B. Fisher, M.J. Taphoorn, K. Belanger, A.A. Brandes, C. Marosi, U. Bogdahn, J. Curschmann, R.C. Janzer, S.K. Ludwin, T. Gorlia, A. Allgeier, D. Lacombe, J.G. Cairncross, E. Eisenhauer, R.O. Mirimanoff European Organisation for Research and Treatment of Cancer Brain Tumor and Radiotherapy Groups National Cancer Institute of Canada Clinical Trials Group Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma N Engl J Med 352 2005 987 996
22. R. Stupp, P.Y. Dietrich, S.O. Kraljevic, A. Pica, I. Maillard, P. Maeder, R.J. Miuli, G. Pizzolato, R. Miralbell, F. Parchet, L. Regli, N. Tribolet, R.O. Mirimanoff, S. Leyvraz Promising survival for patients with newly diagnosed glioblastoma multiforme treated with concomitant radiation plus temozolomide followed by adjuvant temozolomide J Clin Oncol 20 2002 1375 1382
23. T.S. Surawicz, F. Davis, S. Frells, E.R. Laws Jr., H.R. Menck Brain tumor survival: results from the National Cancer Data Base J Neurooncol 40 1998 151 160
24. S. de Vleeschouwer, M. Rapp, R.V. Sorg, H.J. Steiger, W. Stummer, S. van Gool, M. Sabel Dendritic cell vaccination in patients with malignant gliomas: current status and future directions Neurosurgery 59 2006 988 1000
25. C.J. Wheeler, A. Das, G. Liu, J.S. Yu, K.L. Black Clinical responsiveness of glioblastoma multiforme to chemotherapy after vaccination Clin Cancer Res 10 2004 5316 5326
26. R. Yamanaka, T. Abe, N. Yajima, N. Tsuchiya, J. Homma, T. Kobayashi, M. Narita, M. Takahashi, R. Tanaka Vaccination of recurrent glioma patients with tumor lysate-pulsed dendritic cells immune responses: results of a clinical phase I/II trial Br J Cancer 89 2003 1172 1179
27. R. Yamanaka, J. Homma, N. Yajima, N. Tsuchiya, M. Sano, T. Kobayashi, S. Yoshida, T. Abe, M. Narita, M. Takahashi, R. Tanaka Clinical evaluation of dendritic cell vaccination for patients with recurrent glioma: results of a clinical phase I/II trial Clin Cancer Res 11 2005 4160 4167
28. S. Yoshida, K. Morii, M. Watanabe, T. Saito, K. Yamamoto, R. Tanaka The generation of anti-tumor cells using dendritic cells from the peripheral blood of patients with malignant brain tumors Cancer Immunol Immunother 50 2001 321 327
29. J.S. Yu, G. Liu, H. Ying, W.H. Yong, K.L. Black, C.J. Wheeler Vaccination with tumor lysate-pulsed dendritic cells elicits antigen-specific cytotoxic T-cells in patients with malignant glioma Cancer Res 64 2004 4973 4979
30. J.S. Yu, A. Luptrawan, K.L. Black, G. Liu Mahaley clinical research award: chemosensitization of glioma through dendritic cell vaccination1 Clin Neurosurg 53 2006 345 351
31. J.S. Yu, C.J. Wheeler, P.M. Zeltzer, H. Ying, D.N. Finger, P.K. Lee, W.H. Yong, F. Incardona, R.C. Thompson, M.S. Riedinger, W. Zhang, R.M. Prins, K.L. Black Vaccination of malignant glioma patients with peptide-pulsed dendritic cells elicits systemic cytotoxicity and intracranial T-cell infiltration Cancer Res 61 2001 842 847