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Volumn 21, Issue 7, 2015, Pages 450-460

Molecular aspects of age-related cognitive decline: The role of GABA signaling

Author keywords

GABAA 5; GABAB receptor; Hippocampus; Memory; Prefrontal cortex; Tonic inhibition

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID BETA RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; ETIRACETAM; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID RECEPTOR;

EID: 84933679010     PISSN: 14714914     EISSN: 1471499X     Source Type: Journal    
DOI: 10.1016/j.molmed.2015.05.002     Document Type: Review
Times cited : (147)

References (131)
  • 2
    • 84897365914 scopus 로고    scopus 로고
    • Characterizing cognitive aging in humans with links to animal models
    • Alexander G.E., et al. Characterizing cognitive aging in humans with links to animal models. Front. Aging Neurosci. 2012, 4:21.
    • (2012) Front. Aging Neurosci. , vol.4 , pp. 21
    • Alexander, G.E.1
  • 3
    • 84870495282 scopus 로고    scopus 로고
    • Characterizing cognitive aging of working memory and executive function in animal models
    • Bizon J.L., et al. Characterizing cognitive aging of working memory and executive function in animal models. Front. Aging Neurosci. 2012, 4:19.
    • (2012) Front. Aging Neurosci. , vol.4 , pp. 19
    • Bizon, J.L.1
  • 4
    • 84897365846 scopus 로고    scopus 로고
    • Characterizing cognitive aging of spatial and contextual memory in animal models
    • Foster T.C., et al. Characterizing cognitive aging of spatial and contextual memory in animal models. Front. Aging Neurosci. 2012, 4:12.
    • (2012) Front. Aging Neurosci. , vol.4 , pp. 12
    • Foster, T.C.1
  • 5
    • 84858702953 scopus 로고    scopus 로고
    • The ageing cortical synapse: hallmarks and implications for cognitive decline
    • Morrison J.H., Baxter M.G. The ageing cortical synapse: hallmarks and implications for cognitive decline. Nat. Rev. Neurosci. 2012, 13:240-250.
    • (2012) Nat. Rev. Neurosci. , vol.13 , pp. 240-250
    • Morrison, J.H.1    Baxter, M.G.2
  • 6
    • 0030639472 scopus 로고    scopus 로고
    • The use of animal models to study the effects of aging on cognition
    • Gallagher M., Rapp P.R. The use of animal models to study the effects of aging on cognition. Annu. Rev. Psychol. 1997, 48:339-370.
    • (1997) Annu. Rev. Psychol. , vol.48 , pp. 339-370
    • Gallagher, M.1    Rapp, P.R.2
  • 7
    • 0034279244 scopus 로고    scopus 로고
    • Circuit-specific alterations in hippocampal synaptophysin immunoreactivity predict spatial learning impairment in aged rats
    • Smith T.D., et al. Circuit-specific alterations in hippocampal synaptophysin immunoreactivity predict spatial learning impairment in aged rats. J. Neurosci. 2000, 20:6587-6593.
    • (2000) J. Neurosci. , vol.20 , pp. 6587-6593
    • Smith, T.D.1
  • 8
    • 0035784703 scopus 로고    scopus 로고
    • Hypothalamic-pituitary-adrenal axis function and corticosterone receptor expression in behaviourally characterized young and aged Long-Evans rats
    • Bizon J.L., et al. Hypothalamic-pituitary-adrenal axis function and corticosterone receptor expression in behaviourally characterized young and aged Long-Evans rats. Eur. J. Neurosci. 2001, 14:1739-1751.
    • (2001) Eur. J. Neurosci. , vol.14 , pp. 1739-1751
    • Bizon, J.L.1
  • 9
    • 0042668324 scopus 로고    scopus 로고
    • Production of new cells in the rat dentate gyrus over the lifespan: relation to cognitive decline
    • Bizon J.L., Gallagher M. Production of new cells in the rat dentate gyrus over the lifespan: relation to cognitive decline. Eur. J. Neurosci. 2003, 18:215-219.
    • (2003) Eur. J. Neurosci. , vol.18 , pp. 215-219
    • Bizon, J.L.1    Gallagher, M.2
  • 10
    • 33847093516 scopus 로고    scopus 로고
    • Muscarinic receptor-mediated GTP-Eu binding in the hippocampus and prefrontal cortex is correlated with spatial memory impairment in aged rats
    • Zhang H-Y., et al. Muscarinic receptor-mediated GTP-Eu binding in the hippocampus and prefrontal cortex is correlated with spatial memory impairment in aged rats. Neurobiol. Aging 2007, 28:619-626.
    • (2007) Neurobiol. Aging , vol.28 , pp. 619-626
    • Zhang, H.-Y.1
  • 11
    • 84859508946 scopus 로고    scopus 로고
    • GABAB receptor GTP-binding is decreased in the prefrontal cortex but not the hippocampus of aged rats
    • 1124.e1-1124.e12
    • McQuail J.A., et al. GABAB receptor GTP-binding is decreased in the prefrontal cortex but not the hippocampus of aged rats. Neurobiol. Aging 2012, 33. 1124.e1-1124.e12.
    • (2012) Neurobiol. Aging , vol.33
    • McQuail, J.A.1
  • 12
    • 84870485250 scopus 로고    scopus 로고
    • Age-related changes in rostral basal forebrain cholinergic and GABAergic projection neurons: relationship with spatial impairment
    • Bañuelos C., et al. Age-related changes in rostral basal forebrain cholinergic and GABAergic projection neurons: relationship with spatial impairment. Neurobiol. Aging 2013, 34:845-862.
    • (2013) Neurobiol. Aging , vol.34 , pp. 845-862
    • Bañuelos, C.1
  • 13
    • 84876971669 scopus 로고    scopus 로고
    • Hippocampal Gαq/11 but not Gαo-coupled receptors are altered in aging
    • McQuail J.A., et al. Hippocampal Gαq/11 but not Gαo-coupled receptors are altered in aging. Neuropharmacology 2013, 70:63-73.
    • (2013) Neuropharmacology , vol.70 , pp. 63-73
    • McQuail, J.A.1
  • 14
    • 84895419110 scopus 로고    scopus 로고
    • Prefrontal cortical GABAergic dysfunction contributes to age-related working memory impairment
    • Bañuelos C., et al. Prefrontal cortical GABAergic dysfunction contributes to age-related working memory impairment. J. Neurosci. 2014, 34:3457-3466.
    • (2014) J. Neurosci. , vol.34 , pp. 3457-3466
    • Bañuelos, C.1
  • 15
    • 0005535917 scopus 로고
    • Spatial localization does not require the presence of local cues
    • Morris R.G.M. Spatial localization does not require the presence of local cues. Learn. Motiv. 1981, 12:239-260.
    • (1981) Learn. Motiv. , vol.12 , pp. 239-260
    • Morris, R.G.M.1
  • 16
    • 0019957779 scopus 로고
    • Place navigation impaired in rats with hippocampal lesions
    • Morris R.G., et al. Place navigation impaired in rats with hippocampal lesions. Nature 1982, 297:681-683.
    • (1982) Nature , vol.297 , pp. 681-683
    • Morris, R.G.1
  • 17
    • 0027200693 scopus 로고
    • Spatial learning impairment parallels the magnitude of dorsal hippocampal lesions, but is hardly present following ventral lesions
    • Moser E., et al. Spatial learning impairment parallels the magnitude of dorsal hippocampal lesions, but is hardly present following ventral lesions. J. Neurosci. 1993, 13:3916-3925.
    • (1993) J. Neurosci. , vol.13 , pp. 3916-3925
    • Moser, E.1
  • 18
    • 12344267143 scopus 로고    scopus 로고
    • Spatial memory in the rat requires the dorsolateral band of the entorhinal cortex
    • Steffenach H-A., et al. Spatial memory in the rat requires the dorsolateral band of the entorhinal cortex. Neuron 2005, 45:301-313.
    • (2005) Neuron , vol.45 , pp. 301-313
    • Steffenach, H.-A.1
  • 19
    • 0027214025 scopus 로고
    • Severity of spatial learning impairment in aging: development of a learning index for performance in the Morris water maze
    • Gallagher M., et al. Severity of spatial learning impairment in aging: development of a learning index for performance in the Morris water maze. Behav. Neurosci. 1993, 107:618-626.
    • (1993) Behav. Neurosci. , vol.107 , pp. 618-626
    • Gallagher, M.1
  • 20
    • 61649086732 scopus 로고    scopus 로고
    • Spatial reference and working memory across the lifespan of male Fischer 344 rats
    • Bizon J.L., et al. Spatial reference and working memory across the lifespan of male Fischer 344 rats. Neurobiol. Aging 2009, 30:646-655.
    • (2009) Neurobiol. Aging , vol.30 , pp. 646-655
    • Bizon, J.L.1
  • 21
    • 84920618334 scopus 로고    scopus 로고
    • Spatial reference memory in normal aging Fischer 344×Brown Norway F1 hybrid rats
    • McQuail J.A., Nicolle M.M. Spatial reference memory in normal aging Fischer 344×Brown Norway F1 hybrid rats. Neurobiol. Aging 2015, 36:323-333.
    • (2015) Neurobiol. Aging , vol.36 , pp. 323-333
    • McQuail, J.A.1    Nicolle, M.M.2
  • 22
    • 13544276192 scopus 로고    scopus 로고
    • Virtual navigation in humans: the impact of age, sex, and hormones on place learning
    • Driscoll I., et al. Virtual navigation in humans: the impact of age, sex, and hormones on place learning. Horm. Behav. 2005, 47:326-335.
    • (2005) Horm. Behav. , vol.47 , pp. 326-335
    • Driscoll, I.1
  • 23
    • 0036785951 scopus 로고    scopus 로고
    • Effects of age on virtual environment place navigation and allocentric cognitive mapping
    • Moffat S.D., Resnick S.M. Effects of age on virtual environment place navigation and allocentric cognitive mapping. Behav. Neurosci. 2002, 116:851-859.
    • (2002) Behav. Neurosci. , vol.116 , pp. 851-859
    • Moffat, S.D.1    Resnick, S.M.2
  • 24
    • 34347260334 scopus 로고    scopus 로고
    • Extrahippocampal contributions to age differences in human spatial navigation
    • Moffat S.D., et al. Extrahippocampal contributions to age differences in human spatial navigation. Cereb. Cortex 2007, 17:1274-1282.
    • (2007) Cereb. Cortex , vol.17 , pp. 1274-1282
    • Moffat, S.D.1
  • 25
    • 0027164617 scopus 로고
    • Regionally specific loss of neurons in the aging human hippocampus
    • West M.J. Regionally specific loss of neurons in the aging human hippocampus. Neurobiol. Aging 1993, 14:287-293.
    • (1993) Neurobiol. Aging , vol.14 , pp. 287-293
    • West, M.J.1
  • 26
    • 0030053883 scopus 로고    scopus 로고
    • Memory impaired aged rats: no loss of principal hippocampal and subicular neurons
    • Rasmussen T., et al. Memory impaired aged rats: no loss of principal hippocampal and subicular neurons. Neurobiol. Aging 1996, 17:143-147.
    • (1996) Neurobiol. Aging , vol.17 , pp. 143-147
    • Rasmussen, T.1
  • 27
    • 0029821150 scopus 로고    scopus 로고
    • Preserved neuron number in the hippocampus of aged rats with spatial learning deficits
    • Rapp P.R., Gallagher M. Preserved neuron number in the hippocampus of aged rats with spatial learning deficits. Proc. Natl. Acad. Sci. U.S.A. 1996, 93:9926-9930.
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 9926-9930
    • Rapp, P.R.1    Gallagher, M.2
  • 28
    • 0036641819 scopus 로고    scopus 로고
    • Rodent models of prefrontal cortical function
    • Brown V.J., Bowman E.M. Rodent models of prefrontal cortical function. Trends Neurosci. 2002, 25:340-343.
    • (2002) Trends Neurosci. , vol.25 , pp. 340-343
    • Brown, V.J.1    Bowman, E.M.2
  • 29
    • 0345257034 scopus 로고    scopus 로고
    • Do rats have a prefrontal cortex?
    • Uylings H.B.M., et al. Do rats have a prefrontal cortex?. Behav. Brain Res. 2003, 146:3-17.
    • (2003) Behav. Brain Res. , vol.146 , pp. 3-17
    • Uylings, H.B.M.1
  • 30
    • 78649657560 scopus 로고    scopus 로고
    • Pharmacological enhancement of memory and executive functioning in laboratory animals
    • Floresco S.B., Jentsch J.D. Pharmacological enhancement of memory and executive functioning in laboratory animals. Neuropsychopharmacology 2011, 36:227-250.
    • (2011) Neuropsychopharmacology , vol.36 , pp. 227-250
    • Floresco, S.B.1    Jentsch, J.D.2
  • 31
    • 80053592197 scopus 로고    scopus 로고
    • An analysis of rat prefrontal cortex in mediating executive function
    • Kesner R.P., Churchwell J.C. An analysis of rat prefrontal cortex in mediating executive function. Neurobiol. Learn. Mem. 2011, 96:417-431.
    • (2011) Neurobiol. Learn. Mem. , vol.96 , pp. 417-431
    • Kesner, R.P.1    Churchwell, J.C.2
  • 33
    • 84867582831 scopus 로고    scopus 로고
    • Neuronal and morphological bases of cognitive decline in aged rhesus monkeys
    • Hara Y., et al. Neuronal and morphological bases of cognitive decline in aged rhesus monkeys. Age 2012, 34:1051-1073.
    • (2012) Age , vol.34 , pp. 1051-1073
    • Hara, Y.1
  • 34
    • 33646553596 scopus 로고    scopus 로고
    • Double dissociation between hippocampal and prefrontal lesions on an operant delayed matching task and a water maze reference memory task
    • Sloan H.L., et al. Double dissociation between hippocampal and prefrontal lesions on an operant delayed matching task and a water maze reference memory task. Behav. Brain Res. 2006, 171:116-126.
    • (2006) Behav. Brain Res. , vol.171 , pp. 116-126
    • Sloan, H.L.1
  • 35
    • 84878947820 scopus 로고    scopus 로고
    • Distinct manifestations of executive dysfunction in aged rats
    • Beas B.S., et al. Distinct manifestations of executive dysfunction in aged rats. Neurobiol. Aging 2013, 34:2164-2174.
    • (2013) Neurobiol. Aging , vol.34 , pp. 2164-2174
    • Beas, B.S.1
  • 36
    • 0024439790 scopus 로고
    • Evidence for task-dependent memory dysfunction in the aged monkey
    • Rapp P.R., Amaral D.G. Evidence for task-dependent memory dysfunction in the aged monkey. J. Neurosci. 1989, 9:3568-3576.
    • (1989) J. Neurosci. , vol.9 , pp. 3568-3576
    • Rapp, P.R.1    Amaral, D.G.2
  • 37
    • 0025260554 scopus 로고
    • Analysis of alpha-2 adrenergic agonist effects on the delayed nonmatch-to-sample performance of aged rhesus monkeys
    • Arnsten A.F.T., Goldman-Rakic P.S. Analysis of alpha-2 adrenergic agonist effects on the delayed nonmatch-to-sample performance of aged rhesus monkeys. Neurobiol. Aging 1990, 11:583-590.
    • (1990) Neurobiol. Aging , vol.11 , pp. 583-590
    • Arnsten, A.F.T.1    Goldman-Rakic, P.S.2
  • 38
    • 0025969047 scopus 로고
    • Aged monkeys exhibit behavioral deficits indicative of widespread cerebral dysfunction
    • Bachevalier J., et al. Aged monkeys exhibit behavioral deficits indicative of widespread cerebral dysfunction. Neurobiol. Aging 1991, 12:99-111.
    • (1991) Neurobiol. Aging , vol.12 , pp. 99-111
    • Bachevalier, J.1
  • 39
    • 0032731640 scopus 로고    scopus 로고
    • Preservation of prefrontal cortical volume in behaviorally characterized aged macaque monkeys
    • O'Donnell K.A., et al. Preservation of prefrontal cortical volume in behaviorally characterized aged macaque monkeys. Exp. Neurol. 1999, 160:300-310.
    • (1999) Exp. Neurol. , vol.160 , pp. 300-310
    • O'Donnell, K.A.1
  • 40
    • 80051677168 scopus 로고    scopus 로고
    • Neuronal basis of age-related working memory decline
    • Wang M., et al. Neuronal basis of age-related working memory decline. Nature 2011, 476:210-213.
    • (2011) Nature , vol.476 , pp. 210-213
    • Wang, M.1
  • 41
    • 0029147220 scopus 로고
    • Temporal structure in spatially organized neuronal ensembles: a role for interneuronal networks
    • Buzsáki G., Chrobak J.J. Temporal structure in spatially organized neuronal ensembles: a role for interneuronal networks. Curr. Opin. Neurobiol. 1995, 5:504-510.
    • (1995) Curr. Opin. Neurobiol. , vol.5 , pp. 504-510
    • Buzsáki, G.1    Chrobak, J.J.2
  • 42
    • 46849083268 scopus 로고    scopus 로고
    • Neuronal diversity and temporal dynamics: the unity of hippocampal circuit operations
    • Klausberger T., Somogyi P. Neuronal diversity and temporal dynamics: the unity of hippocampal circuit operations. Science 2008, 321:53-57.
    • (2008) Science , vol.321 , pp. 53-57
    • Klausberger, T.1    Somogyi, P.2
  • 43
    • 4644250821 scopus 로고    scopus 로고
    • Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome
    • Kleschevnikov A.M., et al. Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome. J. Neurosci. 2004, 24:8153-8160.
    • (2004) J. Neurosci. , vol.24 , pp. 8153-8160
    • Kleschevnikov, A.M.1
  • 44
    • 81255123215 scopus 로고    scopus 로고
    • GABA neuron alterations, cortical circuit dysfunction and cognitive deficits in schizophrenia
    • Gonzalez-Burgos G., et al. GABA neuron alterations, cortical circuit dysfunction and cognitive deficits in schizophrenia. Neural Plast. 2011, 2011:723184.
    • (2011) Neural Plast. , vol.2011 , pp. 723184
    • Gonzalez-Burgos, G.1
  • 45
    • 79951682329 scopus 로고    scopus 로고
    • Reducing prefrontal gamma-aminobutyric acid activity induces cognitive, behavioral, and dopaminergic abnormalities that resemble schizophrenia
    • Enomoto T., et al. Reducing prefrontal gamma-aminobutyric acid activity induces cognitive, behavioral, and dopaminergic abnormalities that resemble schizophrenia. Biol. Psychiatry 2011, 69:432-441.
    • (2011) Biol. Psychiatry , vol.69 , pp. 432-441
    • Enomoto, T.1
  • 46
    • 84930939162 scopus 로고    scopus 로고
    • Prefrontal cortical GABA modulation of spatial reference and working memory
    • Published online October 31, 2014
    • Auger M.L., Floresco S.B. Prefrontal cortical GABA modulation of spatial reference and working memory. Int. J. Neuropsychopharmacol. 2014, Published online October 31, 2014. 10.1093/ijnp/pyu013.
    • (2014) Int. J. Neuropsychopharmacol.
    • Auger, M.L.1    Floresco, S.B.2
  • 47
    • 34547097254 scopus 로고    scopus 로고
    • The main source of ambient GABA responsible for tonic inhibition in the mouse hippocampus
    • Glykys J., Mody I. The main source of ambient GABA responsible for tonic inhibition in the mouse hippocampus. J. Physiol. 2007, 582:1163-1178.
    • (2007) J. Physiol. , vol.582 , pp. 1163-1178
    • Glykys, J.1    Mody, I.2
  • 48
    • 77951775339 scopus 로고    scopus 로고
    • GABAB receptor-dependent modulation of network activity in the rat prefrontal cortex in vitro
    • Wang Y., et al. GABAB receptor-dependent modulation of network activity in the rat prefrontal cortex in vitro. Eur. J. Neurosci. 2010, 31:1582-1594.
    • (2010) Eur. J. Neurosci. , vol.31 , pp. 1582-1594
    • Wang, Y.1
  • 49
    • 61349115539 scopus 로고    scopus 로고
    • GABA transporter GAT1 prevents spillover at proximal and distal GABA synapses onto primate prefrontal cortex neurons
    • Gonzalez-Burgos G., et al. GABA transporter GAT1 prevents spillover at proximal and distal GABA synapses onto primate prefrontal cortex neurons. J. Neurophysiol. 2009, 101:533-547.
    • (2009) J. Neurophysiol. , vol.101 , pp. 533-547
    • Gonzalez-Burgos, G.1
  • 50
    • 84877800385 scopus 로고    scopus 로고
    • A functional role for both γ-aminobutyric acid (GABA) transporter-1 and GABA transporter-3 in the modulation of extracellular GABA and GABAergic tonic conductances in the rat hippocampus
    • Kersanté F., et al. A functional role for both γ-aminobutyric acid (GABA) transporter-1 and GABA transporter-3 in the modulation of extracellular GABA and GABAergic tonic conductances in the rat hippocampus. J. Physiol. 2013, 591:2429-2441.
    • (2013) J. Physiol. , vol.591 , pp. 2429-2441
    • Kersanté, F.1
  • 51
    • 0142157619 scopus 로고    scopus 로고
    • The gamma 2 subunit of GABA(A) receptors is required for maintenance of receptors at mature synapses
    • Schweizer C., et al. The gamma 2 subunit of GABA(A) receptors is required for maintenance of receptors at mature synapses. Mol. Cell. Neurosci. 2003, 24:442-450.
    • (2003) Mol. Cell. Neurosci. , vol.24 , pp. 442-450
    • Schweizer, C.1
  • 52
    • 14844323722 scopus 로고    scopus 로고
    • Variations on an inhibitory theme: phasic and tonic activation of GABAA receptors
    • Farrant M., Nusser Z. Variations on an inhibitory theme: phasic and tonic activation of GABAA receptors. Nat. Rev. Neurosci. 2005, 6:215-229.
    • (2005) Nat. Rev. Neurosci. , vol.6 , pp. 215-229
    • Farrant, M.1    Nusser, Z.2
  • 53
    • 0035804244 scopus 로고    scopus 로고
    • Adaptive regulation of neuronal excitability by a voltage- independent potassium conductance
    • Brickley S.G., et al. Adaptive regulation of neuronal excitability by a voltage- independent potassium conductance. Nature 2001, 409:88-92.
    • (2001) Nature , vol.409 , pp. 88-92
    • Brickley, S.G.1
  • 54
    • 0344630208 scopus 로고    scopus 로고
    • Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by δ subunit-containing GABAA receptors
    • Stell B.M., et al. Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by δ subunit-containing GABAA receptors. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:14439-14444.
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 14439-14444
    • Stell, B.M.1
  • 55
    • 0033585996 scopus 로고    scopus 로고
    • Autoradiographic localization α subunit-containing GABAA receptors in rat brain
    • Sur C., et al. Autoradiographic localization α subunit-containing GABAA receptors in rat brain. Brain Res. 1999, 822:265-270.
    • (1999) Brain Res. , vol.822 , pp. 265-270
    • Sur, C.1
  • 56
    • 0028173236 scopus 로고
    • GABAB binding sites in early adult and aging rat brain
    • Turgeon S.M., Albin R.L. GABAB binding sites in early adult and aging rat brain. Neurobiol. Aging 1994, 15:705-711.
    • (1994) Neurobiol. Aging , vol.15 , pp. 705-711
    • Turgeon, S.M.1    Albin, R.L.2
  • 57
    • 0026612363 scopus 로고
    • The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon
    • Wisden W., et al. The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon. J. Neurosci. 1992, 12:1040-1062.
    • (1992) J. Neurosci. , vol.12 , pp. 1040-1062
    • Wisden, W.1
  • 58
    • 38949092526 scopus 로고    scopus 로고
    • Which GABAA receptor subunits are necessary for tonic inhibition in the hippocampus?
    • Glykys J., et al. Which GABAA receptor subunits are necessary for tonic inhibition in the hippocampus?. J. Neurosci. 2008, 28:1421-1426.
    • (2008) J. Neurosci. , vol.28 , pp. 1421-1426
    • Glykys, J.1
  • 59
    • 33646170001 scopus 로고    scopus 로고
    • Hippocampal network hyperactivity after selective reduction of tonic inhibition in GABAA receptor α5 subunit-deficient mice
    • Glykys J., Mody I. Hippocampal network hyperactivity after selective reduction of tonic inhibition in GABAA receptor α5 subunit-deficient mice. J. Neurophysiol. 2006, 95:2796-2807.
    • (2006) J. Neurophysiol. , vol.95 , pp. 2796-2807
    • Glykys, J.1    Mody, I.2
  • 60
    • 33646400548 scopus 로고    scopus 로고
    • Differential compartmentalization and distinct functions of GABAB receptor variants
    • Vigot R., et al. Differential compartmentalization and distinct functions of GABAB receptor variants. Neuron 2006, 50:589-601.
    • (2006) Neuron , vol.50 , pp. 589-601
    • Vigot, R.1
  • 61
    • 52449121752 scopus 로고    scopus 로고
    • Roles of GABAB receptor subtypes in presynaptic auto- and heteroreceptor function regulating GABA and glutamate release
    • Waldmeier P.C., et al. Roles of GABAB receptor subtypes in presynaptic auto- and heteroreceptor function regulating GABA and glutamate release. J. Neural Transm. 2008, 115:1401-1411.
    • (2008) J. Neural Transm. , vol.115 , pp. 1401-1411
    • Waldmeier, P.C.1
  • 62
    • 84855729789 scopus 로고    scopus 로고
    • Extrasynaptic GABAA receptors: their function in the CNS and implications for disease
    • Brickley S.G., Mody I. Extrasynaptic GABAA receptors: their function in the CNS and implications for disease. Neuron 2012, 73:23-34.
    • (2012) Neuron , vol.73 , pp. 23-34
    • Brickley, S.G.1    Mody, I.2
  • 63
    • 84901402661 scopus 로고    scopus 로고
    • Modulation of GABAergic transmission in development and neurodevelopmental disorders: investigating physiology and pathology to gain therapeutic perspectives
    • Deidda G., et al. Modulation of GABAergic transmission in development and neurodevelopmental disorders: investigating physiology and pathology to gain therapeutic perspectives. Front. Cell. Neurosci. 2014, 8:119.
    • (2014) Front. Cell. Neurosci. , vol.8 , pp. 119
    • Deidda, G.1
  • 64
    • 84875241327 scopus 로고    scopus 로고
    • Tonic GABAA receptor-mediated signalling in temporal lobe epilepsy
    • Pavlov I., Walker M.C. Tonic GABAA receptor-mediated signalling in temporal lobe epilepsy. Neuropharmacology 2013, 69:55-61.
    • (2013) Neuropharmacology , vol.69 , pp. 55-61
    • Pavlov, I.1    Walker, M.C.2
  • 65
    • 84891857314 scopus 로고    scopus 로고
    • GABAA receptor subtypes: therapeutic potential in down syndrome, affective disorders, schizophrenia, and autism
    • Rudolph U., Möhler H. GABAA receptor subtypes: therapeutic potential in down syndrome, affective disorders, schizophrenia, and autism. Annu. Rev. Pharmacol. Toxicol. 2014, 54:483-507.
    • (2014) Annu. Rev. Pharmacol. Toxicol. , vol.54 , pp. 483-507
    • Rudolph, U.1    Möhler, H.2
  • 66
    • 84908432602 scopus 로고    scopus 로고
    • Altered expression of δGABAA receptors in health and disease
    • Whissell P.D., et al. Altered expression of δGABAA receptors in health and disease. Neuropharmacology 2015, 88:24-35.
    • (2015) Neuropharmacology , vol.88 , pp. 24-35
    • Whissell, P.D.1
  • 67
    • 1842509983 scopus 로고    scopus 로고
    • Aging in the rat hippocampus is associated with widespread reductions in the number of glutamate decarboxylase-67 positive interneurons but not interneuron degeneration
    • Stanley D.P., Shetty A.K. Aging in the rat hippocampus is associated with widespread reductions in the number of glutamate decarboxylase-67 positive interneurons but not interneuron degeneration. J. Neurochem. 2004, 89:204-216.
    • (2004) J. Neurochem. , vol.89 , pp. 204-216
    • Stanley, D.P.1    Shetty, A.K.2
  • 68
    • 0025868263 scopus 로고
    • Enhanced GABAergic inhibition preserves hippocampal structure and function in a model of epilepsy
    • Ylinen A.M., et al. Enhanced GABAergic inhibition preserves hippocampal structure and function in a model of epilepsy. Proc. Natl. Acad. Sci. U.S.A. 1991, 88:7650-7653.
    • (1991) Proc. Natl. Acad. Sci. U.S.A. , vol.88 , pp. 7650-7653
    • Ylinen, A.M.1
  • 69
    • 1642497450 scopus 로고    scopus 로고
    • Selective loss of hilar neurons and impairment of initial learning in rats after repeated administration of electroconvulsive shock seizures
    • Lukoyanov N.V., et al. Selective loss of hilar neurons and impairment of initial learning in rats after repeated administration of electroconvulsive shock seizures. Exp. Brain Res. 2004, 154:192-200.
    • (2004) Exp. Brain Res. , vol.154 , pp. 192-200
    • Lukoyanov, N.V.1
  • 70
    • 33846062827 scopus 로고    scopus 로고
    • Effect of levetiracetam on visual-spatial memory following status epilepticus
    • Zhou J-L., et al. Effect of levetiracetam on visual-spatial memory following status epilepticus. Epilepsy Res. 2007, 73:65-74.
    • (2007) Epilepsy Res. , vol.73 , pp. 65-74
    • Zhou, J.-L.1
  • 71
    • 84883004035 scopus 로고    scopus 로고
    • Hilar interneuron vulnerability distinguishes aged rats with memory impairment
    • Spiegel A.M., et al. Hilar interneuron vulnerability distinguishes aged rats with memory impairment. J. Comp. Neurol. 2013, 521:3508-3523.
    • (2013) J. Comp. Neurol. , vol.521 , pp. 3508-3523
    • Spiegel, A.M.1
  • 72
    • 35148825556 scopus 로고    scopus 로고
    • Dentate filter function is altered in a proepileptic fashion during aging
    • Patrylo P.R., et al. Dentate filter function is altered in a proepileptic fashion during aging. Epilepsia 2007, 48:1964-1978.
    • (2007) Epilepsia , vol.48 , pp. 1964-1978
    • Patrylo, P.R.1
  • 73
    • 33748485343 scopus 로고    scopus 로고
    • Age-related alterations of GABAergic input to CA1 pyramidal neurons and its control by nicotinic acetylcholine receptors in rat hippocampus
    • Potier B., et al. Age-related alterations of GABAergic input to CA1 pyramidal neurons and its control by nicotinic acetylcholine receptors in rat hippocampus. Neuroscience 2006, 142:187-201.
    • (2006) Neuroscience , vol.142 , pp. 187-201
    • Potier, B.1
  • 74
    • 0026650079 scopus 로고
    • Alterations in the properties of hippocampal pyramidal neurons in the aged rat
    • Potier B., et al. Alterations in the properties of hippocampal pyramidal neurons in the aged rat. Neuroscience 1992, 48:793-806.
    • (1992) Neuroscience , vol.48 , pp. 793-806
    • Potier, B.1
  • 75
    • 79960137052 scopus 로고    scopus 로고
    • Prominent hippocampal CA3 gene expression profile in neurocognitive aging
    • Haberman R.P., et al. Prominent hippocampal CA3 gene expression profile in neurocognitive aging. Neurobiol. Aging 2011, 32:1678-1692.
    • (2011) Neurobiol. Aging , vol.32 , pp. 1678-1692
    • Haberman, R.P.1
  • 76
    • 0037333108 scopus 로고    scopus 로고
    • Place cell rigidity correlates with impaired spatial learning in aged rats
    • Wilson I.A., et al. Place cell rigidity correlates with impaired spatial learning in aged rats. Neurobiol. Aging 2003, 24:297-305.
    • (2003) Neurobiol. Aging , vol.24 , pp. 297-305
    • Wilson, I.A.1
  • 77
    • 22544475288 scopus 로고    scopus 로고
    • Age-associated alterations of hippocampal place cells are subregion specific
    • Wilson I.A., et al. Age-associated alterations of hippocampal place cells are subregion specific. J. Neurosci. 2005, 25:6877-6886.
    • (2005) J. Neurosci. , vol.25 , pp. 6877-6886
    • Wilson, I.A.1
  • 78
    • 76749092618 scopus 로고    scopus 로고
    • Treatment strategies targeting excess hippocampal activity benefit aged rats with cognitive impairment
    • Koh M.T., et al. Treatment strategies targeting excess hippocampal activity benefit aged rats with cognitive impairment. Neuropsychopharmacology 2009, 35:1016-1025.
    • (2009) Neuropsychopharmacology , vol.35 , pp. 1016-1025
    • Koh, M.T.1
  • 79
    • 0036120515 scopus 로고    scopus 로고
    • Levetiracetam opposes the action of GABAA antagonists in hypothalamic neurones
    • Poulain P., Margineanu D.G. Levetiracetam opposes the action of GABAA antagonists in hypothalamic neurones. Neuropharmacology 2002, 42:346-352.
    • (2002) Neuropharmacology , vol.42 , pp. 346-352
    • Poulain, P.1    Margineanu, D.G.2
  • 80
    • 84993724882 scopus 로고    scopus 로고
    • Is levetiracetam different from other antiepileptic drugs? Levetiracetam and its cellular mechanism of action in epilepsy revisited
    • Surges R., et al. Is levetiracetam different from other antiepileptic drugs? Levetiracetam and its cellular mechanism of action in epilepsy revisited. Ther. Adv. Neurol. Disord. 2008, 1:13-24.
    • (2008) Ther. Adv. Neurol. Disord. , vol.1 , pp. 13-24
    • Surges, R.1
  • 81
    • 84866431674 scopus 로고    scopus 로고
    • Selective GABAA α5 positive allosteric modulators improve cognitive function in aged rats with memory impairment
    • Koh M.T., et al. Selective GABAA α5 positive allosteric modulators improve cognitive function in aged rats with memory impairment. Neuropharmacology 2013, 64:145-152.
    • (2013) Neuropharmacology , vol.64 , pp. 145-152
    • Koh, M.T.1
  • 82
    • 84856690726 scopus 로고    scopus 로고
    • Aging reduces total neuron number in the dorsal component of the rodent prefrontal cortex
    • Stranahan A.M., et al. Aging reduces total neuron number in the dorsal component of the rodent prefrontal cortex. J. Comp. Neurol. 2012, 520:1318-1326.
    • (2012) J. Comp. Neurol. , vol.520 , pp. 1318-1326
    • Stranahan, A.M.1
  • 83
    • 46349094529 scopus 로고    scopus 로고
    • Regional variability in age-related loss of neurons from the primary visual cortex and medial prefrontal cortex of male and female rats
    • Yates M.A., et al. Regional variability in age-related loss of neurons from the primary visual cortex and medial prefrontal cortex of male and female rats. Brain Res. 2008, 1218:1-12.
    • (2008) Brain Res. , vol.1218 , pp. 1-12
    • Yates, M.A.1
  • 84
    • 2342612629 scopus 로고    scopus 로고
    • Memory impairment in aged primates is associated with focal death of cortical neurons and atrophy of subcortical neurons
    • Smith D.E., et al. Memory impairment in aged primates is associated with focal death of cortical neurons and atrophy of subcortical neurons. J. Neurosci. 2004, 24:4373-4381.
    • (2004) J. Neurosci. , vol.24 , pp. 4373-4381
    • Smith, D.E.1
  • 85
    • 41549167594 scopus 로고    scopus 로고
    • Synapses are lost during aging in the primate prefrontal cortex
    • Peters A., et al. Synapses are lost during aging in the primate prefrontal cortex. Neuroscience 2008, 152:970-981.
    • (2008) Neuroscience , vol.152 , pp. 970-981
    • Peters, A.1
  • 86
    • 0035142769 scopus 로고    scopus 로고
    • Aging alters regional multichemical profile of the human brain: an in vivo1H-MRS study of young versus middle-aged subjects
    • Grachev I.D., Apkarian A.V. Aging alters regional multichemical profile of the human brain: an in vivo1H-MRS study of young versus middle-aged subjects. J. Neurochem. 2001, 76:582-593.
    • (2001) J. Neurochem. , vol.76 , pp. 582-593
    • Grachev, I.D.1    Apkarian, A.V.2
  • 87
    • 84872740598 scopus 로고    scopus 로고
    • Differential balance of prefrontal synaptic activity in successful versus unsuccessful cognitive aging
    • Bories C., et al. Differential balance of prefrontal synaptic activity in successful versus unsuccessful cognitive aging. J. Neurosci. 2013, 33:1344-1356.
    • (2013) J. Neurosci. , vol.33 , pp. 1344-1356
    • Bories, C.1
  • 88
    • 1642421135 scopus 로고    scopus 로고
    • Normal aging results in decreased synaptic excitation and increased synaptic inhibition of layer 2/3 pyramidal cells in the monkey prefrontal cortex
    • Luebke J.I., et al. Normal aging results in decreased synaptic excitation and increased synaptic inhibition of layer 2/3 pyramidal cells in the monkey prefrontal cortex. Neuroscience 2004, 125:277-288.
    • (2004) Neuroscience , vol.125 , pp. 277-288
    • Luebke, J.I.1
  • 89
    • 84933685805 scopus 로고    scopus 로고
    • Age-related changes in GABA-B receptor mediated inhibitory tone in the medial prefrontal cortex.
    • November 9-13, 2013, A91.02.
    • Carpenter, H.E. et al. (2013) Age-related changes in GABA-B receptor mediated inhibitory tone in the medial prefrontal cortex. In Society Proceedings Neuroscience Meeting, November 9-13, 2013, A91.02.
    • (2013) In Society Proceedings Neuroscience Meeting
    • Carpenter, H.E.1
  • 90
    • 0035887699 scopus 로고    scopus 로고
    • GABA(B2) is essential for G-protein coupling of the GABA(B) receptor heterodimer
    • Robbins M.J., et al. GABA(B2) is essential for G-protein coupling of the GABA(B) receptor heterodimer. J. Neurosci. 2001, 21:8043-8052.
    • (2001) J. Neurosci. , vol.21 , pp. 8043-8052
    • Robbins, M.J.1
  • 91
    • 0033667466 scopus 로고    scopus 로고
    • A trafficking checkpoint controls GABA(B) receptor heterodimerization
    • Margeta-Mitrovic M., et al. A trafficking checkpoint controls GABA(B) receptor heterodimerization. Neuron 2000, 27:97-106.
    • (2000) Neuron , vol.27 , pp. 97-106
    • Margeta-Mitrovic, M.1
  • 92
    • 0345447640 scopus 로고    scopus 로고
    • Agonist-induced desensitization and endocytosis of heterodimeric GABAB receptors in CHO-K1 cells
    • González-Maeso J., et al. Agonist-induced desensitization and endocytosis of heterodimeric GABAB receptors in CHO-K1 cells. Eur. J. Pharmacol. 2003, 481:15-23.
    • (2003) Eur. J. Pharmacol. , vol.481 , pp. 15-23
    • González-Maeso, J.1
  • 93
    • 80051937468 scopus 로고    scopus 로고
    • Pattern separation deficits associated with increased hippocampal CA3 and dentate gyrus activity in nondemented older adults
    • Yassa M.A., et al. Pattern separation deficits associated with increased hippocampal CA3 and dentate gyrus activity in nondemented older adults. Hippocampus 2011, 21:968-979.
    • (2011) Hippocampus , vol.21 , pp. 968-979
    • Yassa, M.A.1
  • 94
    • 79957738688 scopus 로고    scopus 로고
    • Age-related memory deficits linked to circuit-specific disruptions in the hippocampus
    • Yassa M.A., et al. Age-related memory deficits linked to circuit-specific disruptions in the hippocampus. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:8873-8878.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 8873-8878
    • Yassa, M.A.1
  • 95
    • 3042714810 scopus 로고    scopus 로고
    • Medial temporal lobe function and structure in mild cognitive impairment
    • Dickerson B.C., et al. Medial temporal lobe function and structure in mild cognitive impairment. Ann. Neurol. 2004, 56:27-35.
    • (2004) Ann. Neurol. , vol.56 , pp. 27-35
    • Dickerson, B.C.1
  • 96
    • 23244445918 scopus 로고    scopus 로고
    • Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD
    • Dickerson B.C., et al. Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD. Neurology 2005, 65:404-411.
    • (2005) Neurology , vol.65 , pp. 404-411
    • Dickerson, B.C.1
  • 97
    • 33749522545 scopus 로고    scopus 로고
    • Alterations in memory networks in mild cognitive impairment and Alzheimer's disease: an independent component analysis
    • Celone K.A., et al. Alterations in memory networks in mild cognitive impairment and Alzheimer's disease: an independent component analysis. J. Neurosci. 2006, 26:10222-10231.
    • (2006) J. Neurosci. , vol.26 , pp. 10222-10231
    • Celone, K.A.1
  • 98
    • 77952496309 scopus 로고    scopus 로고
    • Functional alterations in memory networks in early Alzheimer's disease
    • Sperling R.A., et al. Functional alterations in memory networks in early Alzheimer's disease. Neuromolecular Med. 2010, 12:27-43.
    • (2010) Neuromolecular Med. , vol.12 , pp. 27-43
    • Sperling, R.A.1
  • 99
    • 84860659903 scopus 로고    scopus 로고
    • Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment
    • Bakker A., et al. Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment. Neuron 2012, 74:467-474.
    • (2012) Neuron , vol.74 , pp. 467-474
    • Bakker, A.1
  • 100
    • 77955068362 scopus 로고    scopus 로고
    • Chemistry and pharmacology of GABAB receptor ligands
    • Froestl W. Chemistry and pharmacology of GABAB receptor ligands. Adv. Pharmacol. 2010, 58:19-62.
    • (2010) Adv. Pharmacol. , vol.58 , pp. 19-62
    • Froestl, W.1
  • 101
    • 4644312295 scopus 로고    scopus 로고
    • SGS742: the first GABA(B) receptor antagonist in clinical trials
    • Froestl W., et al. SGS742: the first GABA(B) receptor antagonist in clinical trials. Biochem. Pharmacol. 2004, 68:1479-1487.
    • (2004) Biochem. Pharmacol. , vol.68 , pp. 1479-1487
    • Froestl, W.1
  • 103
    • 78751692575 scopus 로고    scopus 로고
    • Anti-Aβ therapeutics in Alzheimer's disease: the need for a paradigm shift
    • Golde T.E., et al. Anti-Aβ therapeutics in Alzheimer's disease: the need for a paradigm shift. Neuron 2011, 69:203-213.
    • (2011) Neuron , vol.69 , pp. 203-213
    • Golde, T.E.1
  • 104
    • 84863706212 scopus 로고    scopus 로고
    • Considerations in the design of clinical trials for cognitive aging
    • Reiman E.M., et al. Considerations in the design of clinical trials for cognitive aging. J. Gerontol. A. Biol. Sci. Med. Sci. 2012, 67:766-772.
    • (2012) J. Gerontol. A. Biol. Sci. Med. Sci. , vol.67 , pp. 766-772
    • Reiman, E.M.1
  • 105
    • 14844307038 scopus 로고    scopus 로고
    • Protein kinase A as a therapeutic target for memory disorders: rationale and challenges
    • Arnsten A.F.T., et al. Protein kinase A as a therapeutic target for memory disorders: rationale and challenges. Trends Mol. Med. 2005, 11:121-128.
    • (2005) Trends Mol. Med. , vol.11 , pp. 121-128
    • Arnsten, A.F.T.1
  • 106
    • 24944520099 scopus 로고    scopus 로고
    • Phosphodiesterase inhibitors for cognitive enhancement
    • Rose G.M., et al. Phosphodiesterase inhibitors for cognitive enhancement. Curr. Pharm. Des. 2005, 11:3329-3334.
    • (2005) Curr. Pharm. Des. , vol.11 , pp. 3329-3334
    • Rose, G.M.1
  • 107
    • 0242460552 scopus 로고    scopus 로고
    • Dysregulation of protein kinase a signaling in the aged prefrontal cortex: new strategy for treating age-related cognitive decline
    • Ramos B.P., et al. Dysregulation of protein kinase a signaling in the aged prefrontal cortex: new strategy for treating age-related cognitive decline. Neuron 2003, 40:835-845.
    • (2003) Neuron , vol.40 , pp. 835-845
    • Ramos, B.P.1
  • 108
    • 33845299524 scopus 로고    scopus 로고
    • α2A-adrenoceptor stimulation improves prefrontal cortical regulation of behavior through inhibition of cAMP signaling in aging animals
    • Ramos B.P., et al. α2A-adrenoceptor stimulation improves prefrontal cortical regulation of behavior through inhibition of cAMP signaling in aging animals. Learn. Mem. 2006, 13:770-776.
    • (2006) Learn. Mem. , vol.13 , pp. 770-776
    • Ramos, B.P.1
  • 109
    • 34147105096 scopus 로고    scopus 로고
    • α2A-adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signaling in prefrontal cortex
    • Wang M., et al. α2A-adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signaling in prefrontal cortex. Cell 2007, 129:397-410.
    • (2007) Cell , vol.129 , pp. 397-410
    • Wang, M.1
  • 110
    • 0024239064 scopus 로고
    • The alpha-2 adrenergic agonist guanfacine improves memory in aged monkeys without sedative or hypotensive side effects: evidence for alpha-2 receptor subtypes
    • Arnsten A.F., et al. The alpha-2 adrenergic agonist guanfacine improves memory in aged monkeys without sedative or hypotensive side effects: evidence for alpha-2 receptor subtypes. J. Neurosci. 1988, 8:4287-4298.
    • (1988) J. Neurosci. , vol.8 , pp. 4287-4298
    • Arnsten, A.F.1
  • 112
    • 0025874406 scopus 로고
    • The effects of guanfacine, alpha-2 agonist, on the performance of young and aged rats in spatial navigation task
    • Sirviö J., et al. The effects of guanfacine, alpha-2 agonist, on the performance of young and aged rats in spatial navigation task. Behav. Neural Biol. 1991, 56:101-107.
    • (1991) Behav. Neural Biol. , vol.56 , pp. 101-107
    • Sirviö, J.1
  • 113
    • 18044396542 scopus 로고    scopus 로고
    • GABAB receptor antagonist SGS742 improves spatial memory and reduces protein binding to the cAMP response element (CRE) in the hippocampus
    • Helm K.A., et al. GABAB receptor antagonist SGS742 improves spatial memory and reduces protein binding to the cAMP response element (CRE) in the hippocampus. Neuropharmacology 2005, 48:956-964.
    • (2005) Neuropharmacology , vol.48 , pp. 956-964
    • Helm, K.A.1
  • 114
    • 70350560327 scopus 로고    scopus 로고
    • Blockade of GABA(B) receptors completely reverses age-related learning impairment
    • LaSarge C.L., et al. Blockade of GABA(B) receptors completely reverses age-related learning impairment. Neuroscience 2009, 164:941-947.
    • (2009) Neuroscience , vol.164 , pp. 941-947
    • LaSarge, C.L.1
  • 115
    • 5344271854 scopus 로고    scopus 로고
    • Memory and executive function in aging and AD: multiple factors that cause decline and reserve factors that compensate
    • Buckner R.L. Memory and executive function in aging and AD: multiple factors that cause decline and reserve factors that compensate. Neuron 2004, 44:195-208.
    • (2004) Neuron , vol.44 , pp. 195-208
    • Buckner, R.L.1
  • 116
    • 79959752652 scopus 로고    scopus 로고
    • A review of functional brain imaging correlates of successful cognitive aging
    • Eyler L.T., et al. A review of functional brain imaging correlates of successful cognitive aging. Biol. Psychiatry 2011, 70:115-122.
    • (2011) Biol. Psychiatry , vol.70 , pp. 115-122
    • Eyler, L.T.1
  • 117
    • 77953557625 scopus 로고    scopus 로고
    • Stress impairs GABAergic network function in the hippocampus by activating nongenomic glucocorticoid receptors and affecting the integrity of the parvalbumin-expressing neuronal network
    • Hu W., et al. Stress impairs GABAergic network function in the hippocampus by activating nongenomic glucocorticoid receptors and affecting the integrity of the parvalbumin-expressing neuronal network. Neuropsychopharmacology 2010, 35:1693-1707.
    • (2010) Neuropsychopharmacology , vol.35 , pp. 1693-1707
    • Hu, W.1
  • 118
    • 84887215433 scopus 로고    scopus 로고
    • Chronic stress alters inhibitory networks in the medial prefrontal cortex of adult mice
    • Gilabert-Juan J., et al. Chronic stress alters inhibitory networks in the medial prefrontal cortex of adult mice. Brain Struct. Funct. 2013, 218:1591-1605.
    • (2013) Brain Struct. Funct. , vol.218 , pp. 1591-1605
    • Gilabert-Juan, J.1
  • 119
    • 0028325890 scopus 로고
    • Basal cortisol levels and cognitive deficits in human aging
    • Lupien S., et al. Basal cortisol levels and cognitive deficits in human aging. J. Neurosci. 1994, 14:2893-2903.
    • (1994) J. Neurosci. , vol.14 , pp. 2893-2903
    • Lupien, S.1
  • 120
    • 33344478060 scopus 로고    scopus 로고
    • Lifelong corticosterone level determines age-related decline in neurogenesis and memory
    • Montaron M.F., et al. Lifelong corticosterone level determines age-related decline in neurogenesis and memory. Neurobiol. Aging 2006, 27:645-654.
    • (2006) Neurobiol. Aging , vol.27 , pp. 645-654
    • Montaron, M.F.1
  • 121
    • 84902491069 scopus 로고    scopus 로고
    • Adrenocortical status predicts the degree of age-related deficits in prefrontal structural plasticity and working memory
    • Anderson R.M., et al. Adrenocortical status predicts the degree of age-related deficits in prefrontal structural plasticity and working memory. J. Neurosci. 2014, 34:8387-8397.
    • (2014) J. Neurosci. , vol.34 , pp. 8387-8397
    • Anderson, R.M.1
  • 122
    • 84863611022 scopus 로고    scopus 로고
    • Hilar GABAergic interneuron activity controls spatial learning and memory retrieval
    • Andrews-Zwilling Y., et al. Hilar GABAergic interneuron activity controls spatial learning and memory retrieval. PLoS ONE 2012, 7:e40555.
    • (2012) PLoS ONE , vol.7 , pp. e40555
    • Andrews-Zwilling, Y.1
  • 123
    • 77958023983 scopus 로고    scopus 로고
    • Apolipoprotein E4 vauses age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice
    • Andrews-Zwilling Y., et al. Apolipoprotein E4 vauses age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice. J. Neurosci. 2010, 30:13707-13717.
    • (2010) J. Neurosci. , vol.30 , pp. 13707-13717
    • Andrews-Zwilling, Y.1
  • 124
    • 34548264782 scopus 로고    scopus 로고
    • Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease
    • Palop J.J., et al. Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease. Neuron 2007, 55:697-711.
    • (2007) Neuron , vol.55 , pp. 697-711
    • Palop, J.J.1
  • 125
    • 84907969845 scopus 로고    scopus 로고
    • Apolipoprotein E4 produced in GABAergic interneurons causes learning and memory deficits in mice
    • Knoferle J., et al. Apolipoprotein E4 produced in GABAergic interneurons causes learning and memory deficits in mice. J. Neurosci. 2014, 34:14069-14078.
    • (2014) J. Neurosci. , vol.34 , pp. 14069-14078
    • Knoferle, J.1
  • 126
    • 0028028130 scopus 로고
    • Inhibitory CA1-CA3-hilar region feedback in the hippocampus
    • Sik A., et al. Inhibitory CA1-CA3-hilar region feedback in the hippocampus. Science 1994, 265:1722-1724.
    • (1994) Science , vol.265 , pp. 1722-1724
    • Sik, A.1
  • 127
    • 0028938076 scopus 로고
    • Cellular basis of working memory
    • Goldman-Rakic P.S. Cellular basis of working memory. Neuron 1995, 14:477-485.
    • (1995) Neuron , vol.14 , pp. 477-485
    • Goldman-Rakic, P.S.1
  • 128
    • 84867125875 scopus 로고    scopus 로고
    • Neuromodulation of thought: flexibilities and vulnerabilities in prefrontal cortical network synapses
    • Arnsten A.F.T., et al. Neuromodulation of thought: flexibilities and vulnerabilities in prefrontal cortical network synapses. Neuron 2012, 76:223-239.
    • (2012) Neuron , vol.76 , pp. 223-239
    • Arnsten, A.F.T.1
  • 129
    • 0842320990 scopus 로고    scopus 로고
    • Division of labor among distinct subtypes of inhibitory neurons in a cortical microcircuit of working memory
    • Wang X-J., et al. Division of labor among distinct subtypes of inhibitory neurons in a cortical microcircuit of working memory. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:1368-1373.
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 1368-1373
    • Wang, X.-J.1
  • 130
    • 0028922024 scopus 로고
    • Physiological subgroups of nonpyramidal cells with specific morphological characteristics in layer II/III of rat frontal cortex
    • Kawaguchi Y. Physiological subgroups of nonpyramidal cells with specific morphological characteristics in layer II/III of rat frontal cortex. J. Neurosci. 1995, 15:2638-2655.
    • (1995) J. Neurosci. , vol.15 , pp. 2638-2655
    • Kawaguchi, Y.1
  • 131
    • 0030794494 scopus 로고    scopus 로고
    • GABAergic cell subtypes and their synaptic connections in rat frontal cortex
    • Kawaguchi Y., Kubota Y. GABAergic cell subtypes and their synaptic connections in rat frontal cortex. Cereb. Cortex 1997, 7:476-486.
    • (1997) Cereb. Cortex , vol.7 , pp. 476-486
    • Kawaguchi, Y.1    Kubota, Y.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.