Memory impaired aged rats: No loss of principal hippocampal and subicular neurons

Neurobiology of Aging

Volumn 17, Issue 1, 1996, Pages 143-147

  Rasmussen, Thøger ^a,c   Schliemann, Thor ^a   SØrensen, Jens Christian ^a   Zimmer, Jens ^a   West, Mark J ^b  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

^c NOVO NORDISK A S   (Denmark)

Author keywords

Hippocampus; Morris' watermaze; Neuronal cell loss; Optical fractionator; Spatial reference memory; Stereology

Indexed keywords

AGED; AGING; AMNESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; HIPPOCAMPUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SUBICULUM;

EID: 0030053883     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/0197-4580(95)02032-2     Document Type: Article

References (28)

1. Aika, Y.; Ren, J. Q.; Kosaka, K.; Kosaka, T. Quantitative analysis of GABA-like immunoreactive and parvalbumin-containing neurons in the CA1 region of the rat hippocampus using a stereological method, the disector. Exp. Brain Res. 99:267-276; 1994.
2. Biegon, A.; Greenberger, V., Segal, M. Quantitative histochemistry of brain acetylcholinesterase and learning rate in the aged rat. Neurobiol. Aging 7:215-217; 1986.
3. Brandeis, R.; Bradys, R. Y.; Yehuda, S. The use of Morris' watermaze in the study of memory and learning. Int. J. Neurosci. 48:29-69; 1989.
4. Dunbar, G. L.; Rylett, R. J.; Schmidt, B. M.; Sinclair, R. C.; Williams, L. R. Hippocampal choline acetyltransferase activity correlates with spatial learning in aged rats. Brain Res. 604:266-272; 1993.
5. Fischer, W.; Gage, F. H.; Björklund, A. Atrophy and cell loss in forebrain cholinergic nuclei correlate with behavioral impairment in aged rats. European J. Neurosci. 1:34-35; 1989.
6. Fischer, W.; Chen, K.; Gage, F. H.; Björklund, A. Progressive decline in spatial learning and integrity of forebrain cholinergic neurons in rats during aging. Neurobiol. Aging 13:9-23; 1991.
7. Flood, D. G.; Coleman, P. D. Hippocampal plasticity in normal aging and decreased plasticity in Alzheimer's disease. Prog. Brain Res. 83:435-444; 1990.
8. Gage, F. H.; Dunnett, S. B.; Björklund, A. Spatial learning and motor deficits in aged rats. Neurobiol. Aging 5:43-48; 1984.
9. Gage, F. H.; Dunnett, S. B.; Björklund, A. Age-related impairments in spatial memory are independent of those in sensorimotor skills. Neurobiol. Aging 10:347-352; 1989.
10. Gallagher, M.; Burwell, R. D. Relationship of age-related decline across several behavioral domains. Neurobiol. Aging 10:691-708; 1989.
11. Geinisman, Y; de Toledo-Morrell, L.; Morell, F. Aged rats need a preserved complement of perforated axospinous synapses per hippocampal neuron to maintain good spatial memory. Brain Res. 398: 266-275; 1988.
12. Henriksson, B. G.; Söderström, S.; Gower, A. J.; Ebendal, T.; Winblad, B.; Mohammed, A. H. Hippocampal nerve growth factor levels are related to spatial learning ability in aged rats. Behav. Brain Res. 48:15-20; 1992.
13. Houser, C. R.; Esclapez, M. Localization of mRNA's encoding two forms of glutamatic acid decarboxylase in the rat hippocampal formation. Hippocampus 5:530-545; 1994.
14. Ishimaru, H.; Ogawa, S.; Fuji, K.; Fukuta, T.; Kameyama, T.; Nabeshima, T. Aged-related changes in learning and memory, choline acetyltransferase activity and number of neuronal cells in rats. J. Pharmacobio-Dyn. 14:321-325; 1991.
15. Janson, A. M.; Møller, A. Chronic nicotine treatment counteracts nigral cell loss induced by a partial mesodiencephalic hemitransection: An analysis of the total number and mean volume of neurons and glia in substantia nigra of the male rat. Neuroscience 57:931-941; 1993.
16. Lezak, M. D. Neuropsychological Assessment. New York: Oxford University Press; 1983.
17. Meaney, M. J.; Aitken, D. H.; van Berkel, C.; Bhatnagar, S.; Sapolsky, R. M. Effect of neonatal handling on age-related impairments associated with the hippocampus. Science 239:766-768; 1987.
18. Miettinen, R.; Riekkinen, P.; Laakso, M. P.; Riekkinen, M.; Riekkinen Jr., P. Neocortical, hippocampal and septal parvalbumin-and somatostatin-containing neurons in young and aged rats: Correlation with passive avoidance and watermaze performance. Neurosci. 2:367-378; 1993.
19. Morris, R. G. M. Developments of a watermaze procedure for studying spatial learning in the rat. J. Neurosci. Meth. 11:47-60; 1984.
20. Neurobiol. Aging 12; 1991 (Special issue: Animal Models for Aging Research).
21. Nitsch, R.; Soriano, E.; Frotscher, M. The parvalbumin-containing nonpyramidal neurons in the rat hippocampus. Anat. Embryol. (Berl.) 181:413-425; 1990.
22. Poitier, B.; Rascol, O.; Jazat, F.; Lamour, Y.; Dutar, P. Alterations in the properties of hippocampal pyramidal neurons in the aged rat. Neurosci. 48:793-806; 1992.
23. Stewart, C. A.; Morris, R. G. M. The Watermaze. In: Sahgal, A. (Ed.). Behavioural neuroscience, a practical approach. Oxford: Oxford University Press; 1993.
24. Turner, D. A.; Deupree, D. L. Functional elongation of CA1 hippocampal neurons with aging in Fischer 344 rats. Neurobiol. Aging 12:201-210; 1991.
25. West, M. J. Regionally specific loss of neurons in the aging human hippocampus. Neurobiol. Aging 14:287-293; 1993.
26. West, M. J. Differences in the pattern of hippocampal neuron loss in normal ageing and Alzheimer's disease. Lancet 344:769-772; 1994.
27. West, M. J.; Slomianka, L.; Gundersen, H. J. G. Unbiased stereological estimation of neurons in the subdivisions of the rat hippocampus using the optical fractionator. Anat. Rec. 231:482-497; 1991.
28. West, M. J.; Amaral, D. G.; Rapp, P. R. Preserved hippocampal cell number in aged monkeys with recognition memory deficits. Soc. Neurosci. Abstr 19:599; 1993.