Autoradiographic localization of α5 subunit-containing GABA(A) receptors in rat brain

Brain Research

Volumn 822, Issue 1-2, 1999, Pages 265-270

  Sur, Cyrille ^a   Fresu, Luigia ^b   Howell, Owain ^a   McKernan, Ruth M ^a   Atack, John R ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^b Università Degli Studi di Sabari   (Italy)

Author keywords

3H L 655,708; 3H Ro15 1788; Benzodiazepine; GABA; GABA(A) receptor; Hippocampus

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; BENZODIAZEPINE; FLUMAZENIL; L 655708; RADIOLIGAND; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG; BENZODIAZEPINE RECEPTOR AFFECTING AGENT; DIAGNOSTIC AGENT; IMIDAZOLE DERIVATIVE; L 655,708; LIGAND; TRITIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING SITE; BRAIN; BRAIN REGION; GABAERGIC SYSTEM; HIPPOCAMPUS; MALE; NONHUMAN; OLFACTORY BULB; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; RECEPTOR DENSITY; ANIMAL; BRAIN LEVEL; CHEMISTRY; PHYSIOLOGY; RADIOASSAY; SPRAGUE DAWLEY RAT;

ANIMALS; AUTORADIOGRAPHY; BRAIN CHEMISTRY; FLUMAZENIL; GABA MODULATORS; HIPPOCAMPUS; IMIDAZOLES; LIGANDS; MALE; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; TRITIUM;

EID: 0033585996     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(99)01152-X     Document Type: Article

References (20)

1. A receptors containing the α4-subunit: prevalence, distribution, pharmacology, and subunit architecture in situ, J. Neurochem. 69 (1997) 806-814.
2. A receptor heterogeneity in the adult rat brain: differential regional and cellular distribution of seven major subunits, J. Comp. Neurol. 359 (1995) 154-194.
3. A-receptor subunit composition in the circadian timing system, Brain Res. 700 (1995) 142-156.
4. A.M. Graybiel, C.W. Ragsdale, E.S. Yoneoka, R.P. Eide, An immunohistochemical study of enkephalins and other neuropeptides in the striatum of the cat with evidence that the opiate peptides are arranged to form mosaic patterns in register with the striosomal compartments visible by acetylcholinesterase staining, Neuroscience 6 (1981) 377-397.
5. A receptors from rat brain and retina, Neuropharmacology 35 (1996) 1315-1322.
6. A receptor subunit mRNAs in the rat brain: II. Olfactory bulb and cerebellum, J. Neurosci. 12 (1992) 1063-1076.
7. A receptor subtypes immunopurified from rat brain with α subunit-specific antibodies have unique pharmacological properties, Neuron 7 (1991) 667-676.
8. A receptor subtypes really occur in the brain?, Trends Neurosci. 19 (1996) 139-143.
9. A receptor populations with novel subunit combinations and drug binding profiles identified in brain by α5- and δ-subunit-specific immunopurification, J. Biol. Chem. 268 (1993) 5965-5973.
10. Z. Nusser, W. Sieghart, D. Benke, J.-M. Fritschy, P. Somogyi, Differential synaptic localization of two major γ-aminobutyric acid type A receptor α subunits on hippocampal pyramidal cells, Proc. Natl. Acad. Sci. USA 93 (1996) 11939-11944.
11. G. Paxinos, C. Watson (Eds.), The rat brain in stereotaxic coordinates. Academic Press, San Diego, 1986.
12. A-benzodiazepine receptors produced in transfected cells, Science 245 (1989) 1389-1392.
13. A receptor α5-subunit creates novel type II benzodiazepine receptor pharmacology, J. Neurochem. 54 (1990) 1802-1804.
14. A receptors which contain the α5 subunit, Neuropharmacology 35 (1996) 1331-1335.
15. A complex, J. Pharmacol. Exp. Ther. 270 (1994) 362-370.
16. A receptor subtypes, Pharmacol. Rev. 47 (1995) 181-234.
17. A receptor subunits in the rat hippocampus: I. Immunocytochemical distribution of 13 subunits, Neuroscience 80 (1997) 987-1000.
18. A receptor γ2 subunit in the rat spinal cord, Eur. J. Neurosci. 7 (1995) 1323-1332.
19. A receptor subunit mRNAs in the rat brain: I. Telencephalon, diencephalon, mesencephalon, J. Neurosci. 12 (1992) 1040-1062.
20. W.S. Young, M.J. Kuhar, Radiohistochemical localization of benzodiazepine receptors in rat brain, J. Pharmacol. Exp. Ther. 212 (1980) 337-346.