SCOPUS 정보 검색 플랫폼

Volumn 10, Issue 7, 2015, Pages 1184-1199

Design, Synthesis, and Biological Evaluation of Novel Nonsteroidal Farnesoid X Receptor (FXR) Antagonists: Molecular Basis of FXR Antagonism

(10) Huang, Huang a Si, Pei b Wang, Lei a Xu, Yong c Xu, Xin b Zhu, Jin a Jiang, Hualiang a,b Li, Weihua a Chen, Lili b Li, Jian a

a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)

b SHANGHAI INSTITUTE OF MATERIA MEDICA (China)

c Humanwell Healthcare (Group) Co Ltd (China)

Author keywords

antagonists; mechanism of action; molecular dynamics; nonsteroidal ligands; receptors

Indexed keywords

4' [(3 [[3 (2 CHLOROPHENYL) 5 (2 THIENYL)ISOXAZOL 4 YL]METHOXY] 1 PYRAZOL 1 YL)METHYL]BIPHENYL 2 CARBOXYLIC ACID; FARNESOID X RECEPTOR; ISOXAZOLE DERIVATIVE; NONSTEROIDAL FARNESOID X RECEPTOR ANTAGONIST; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; CELL RECEPTOR; FARNESOID X-ACTIVATED RECEPTOR;

ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC50; MOLECULAR DYNAMICS; PRIORITY JOURNAL; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION; TRANSACTIVATION ASSAY; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; HEPG2 CELL LINE; SYNTHESIS;

DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HEP G2 CELLS; HUMANS; ISOXAZOLES; MOLECULAR DYNAMICS SIMULATION; MOLECULAR STRUCTURE; RECEPTORS, CYTOPLASMIC AND NUCLEAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84933517894 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.201500136 Document Type: Article

Times cited : (17)

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