-
2
-
-
0037117313
-
Genetic defects in hepatobiliary transport
-
Elferink RO, Groen AK. Genetic defects in hepatobiliary transport. Biochim Biophys Acta 2002; 1586:129-145.
-
(2002)
Biochim Biophys Acta
, vol.1586
, pp. 129-145
-
-
Elferink, R.O.1
Groen, A.K.2
-
3
-
-
33847011377
-
Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regeneration
-
An exhaustive review of the role of nuclear receptors in regulating liver and biliary tract physiology and disorder
-
Geier A. Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regeneration. Biochim Biophys Acta 2007; 1773:283-308. An exhaustive review of the role of nuclear receptors in regulating liver and biliary tract physiology and disorder.
-
(2007)
Biochim Biophys Acta
, vol.1773
, pp. 283-308
-
-
Geier, A.1
-
4
-
-
0033980287
-
The molecular expression of the bile salt export pump, sister of P-glycoprotein, is selectively preserved in cholestatic liver injury
-
Lee JM, Trauner M, Soroka CJ, et al. The molecular expression of the bile salt export pump, sister of P-glycoprotein, is selectively preserved in cholestatic liver injury. Gastroenterology 2000; 118:163-172.
-
(2000)
Gastroenterology
, vol.118
, pp. 163-172
-
-
Lee, J.M.1
Trauner, M.2
Soroka, C.J.3
-
5
-
-
0035080391
-
Cellular localization and up-regulation of multidrug resistance- associated protein 3 in hepatocytes and cholangiocytes during obstructive cholestasis in rat liver
-
DOI 10.1053/jhep.2001.23501
-
Soroka CJ, Lee JM, Azzaroli F, Boyer JL. Cellular localization and up-regulation of multidrug resistance-associated protein 3 in hepatocytes and cholangiocytes during obstructive cholestasis in rat liver. Hepatology 2001; 33:783-791. (Pubitemid 32246625)
-
(2001)
Hepatology
, vol.33
, Issue.4
, pp. 783-791
-
-
Soroka, C.J.1
Lee, J.M.2
Azzaroli, F.3
Boyer, J.L.4
-
6
-
-
0036122824
-
Increased expression of multidrug resistance-associated protein 1 (mrp1) in hepatocyte basolateral membrane and renal tubular epithelia after bile duct ligation in rats
-
DOI 10.1016/S1386-6346(01)00110-3, PII S1386634601001103
-
Pei QL, Kobayashi Y, Tanaka Y, et al. Increased expression of multidrug resistance-associated protein 1 (mrp1) in hepatocyte basolateral membrane and renal tubular epithelia after bile duct ligation in rats. Hepatol Res 2002; 22:58-64. (Pubitemid 34223635)
-
(2002)
Hepatology Research
, vol.22
, Issue.1
, pp. 58-64
-
-
Pei, Q.-L.1
Kobayashi, Y.2
Tanaka, Y.3
Taguchi, Y.4
Higuchi, K.5
Kaito, M.6
Ma, N.7
Semba, R.8
Kamisako, T.9
Adachi, Y.10
-
7
-
-
0042825756
-
Role of farnesoid X receptor in determining hepatic ABC transporter expression and liver injury in bile duct-ligated mice
-
DOI 10.1016/S0016-5085(03)01068-0
-
Wagner M, Fickert P, Zollner G, et al. Role of farnesoid X receptor in determining hepatic ABC transporter expression and liver injury in bile duct-ligated mice. Gastroenterology 2003; 125:825-838. (Pubitemid 37070700)
-
(2003)
Gastroenterology
, vol.125
, Issue.3
, pp. 825-838
-
-
Wagner, M.1
Fickert, P.2
Zollner, G.3
Fuchsbichler, A.4
Silbert, D.5
Tsybrovskyy, O.6
Zatloukal, K.7
Guo, G.L.8
Schuetz, J.D.9
Gonzalez, F.J.10
Marschall, H.-U.11
Denk, H.12
Trauner, M.13
-
8
-
-
34547870567
-
Expression of bile acid synthesis and detoxification enzymes and the alternative bile acid efflux pump MRP4 in patients with primary biliary cirrhosis
-
DOI 10.1111/j.1478-3231.2007.01506.x
-
Zollner G, Wagner M, Fickert P, et al. Expression of bile acid synthesis and detoxification enzymes and the alternative bile acid efflux pump MRP4 in patients with primary biliary cirrhosis. Liver Int 2007; 27:920-929. A study showing the cholestasis induces the basolateral transporter MRP4. (Pubitemid 47261945)
-
(2007)
Liver International
, vol.27
, Issue.7
, pp. 920-929
-
-
Zollner, G.1
Wagner, M.2
Fickert, P.3
Silbert, D.4
Gumhold, J.5
Zatloukal, K.6
Denk, H.7
Trauner, M.8
-
9
-
-
33646871585
-
Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents
-
DOI 10.1152/ajpgi.00539.2005
-
Boyer JL, Trauner M, Mennone A, et al. Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents. Am J Physiol Gastrointest Liver Physiol 2006; 290:G1124-G1130. (Pubitemid 43788293)
-
(2006)
American Journal of Physiology - Gastrointestinal and Liver Physiology
, vol.290
, Issue.6
-
-
Boyer, J.L.1
Trauner, M.2
Mennone, A.3
Soroka, C.J.4
Cai, S.-Y.5
Moustafa, T.6
Zollner, G.7
Lee, J.Y.8
Ballatori, N.9
-
10
-
-
33645839049
-
Coordinated induction of bile acid detoxification and alternative elimination in mice: Role of FXR-regulated organic solute transporter-alpha/beta in the adaptive response to bile acids
-
Zollner G, Wagner M, Moustafa T, et al. Coordinated induction of bile acid detoxification and alternative elimination in mice: role of FXR-regulated organic solute transporter-alpha/beta in the adaptive response to bile acids. Am J Physiol Gastrointest Liver Physiol 2006; 290:G923-G932.
-
(2006)
Am J Physiol Gastrointest Liver Physiol
, vol.290
-
-
Zollner, G.1
Wagner, M.2
Moustafa, T.3
-
11
-
-
33644979579
-
The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes
-
Landrier JF, Eloranta JJ, Vavricka SR, Kullak-Ublick GA. The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes. Am J Physiol Gastrointest Liver Physiol 2006; 290:G476-G485.
-
(2006)
Am J Physiol Gastrointest Liver Physiol
, vol.290
-
-
Landrier, J.F.1
Eloranta, J.J.2
Vavricka, S.R.3
Kullak-Ublick, G.A.4
-
12
-
-
34548572892
-
Bile acid transporters: Structure, function, regulation and pathophysiological implications
-
DOI 10.1007/s11095-007-9289-1
-
Alrefai WA, Gill RK. Bile acid transporters: structure, function, regulation and pathophysiological implications. Pharm Res 2007; 24:1803-1823. (Pubitemid 47389235)
-
(2007)
Pharmaceutical Research
, vol.24
, Issue.10
, pp. 1803-1823
-
-
Alrefai, W.A.1
Gill, R.K.2
-
13
-
-
33745684373
-
Bile acid interactions with cholangiocytes
-
Xia X, Francis H, Glaser S, et al. Bile acid interactions with cholangiocytes. World J Gastroenterol 2006; 12:3553-3563.
-
(2006)
World J Gastroenterol
, vol.12
, pp. 3553-3563
-
-
Xia, X.1
Francis, H.2
Glaser, S.3
-
14
-
-
27744602267
-
Differential gene expression profiles in stage I primary biliary cirrhosis
-
DOI 10.1111/j.1572-0241.2005.41662.x
-
Honda M, Kawai H, Shirota Y, et al. Differential gene expression profiles in stage I primary biliary cirrhosis. Am J Gastroenterol 2005; 100:2019-2030. (Pubitemid 43919395)
-
(2005)
American Journal of Gastroenterology
, vol.100
, Issue.9
, pp. 2019-2030
-
-
Honda, M.1
Kawai, H.2
Shirota, Y.3
Yamashita, T.4
Kaneko, S.5
-
15
-
-
17744391290
-
Hepatobiliary transporter expression in percutaneous liver biopsies of patients with cholestatic liver diseases
-
DOI 10.1053/jhep.2001.22646
-
Zollner G, Fickert P, Zenz R, et al. Hepatobiliary transporter expression in percutaneous liver biopsies of patients with cholestatic liver diseases. Hepatology 2001; 33:633-646. (Pubitemid 32185226)
-
(2001)
Hepatology
, vol.33
, Issue.3
, pp. 633-646
-
-
Zollner, G.1
Fickert, P.2
Zenz, R.3
Fuchsbichler, A.4
Stumptner, C.5
Kenner, L.6
Ferenci, P.7
Stauber, R.E.8
Krejs, G.J.9
Denk, H.10
Zatloukal, K.11
Trauner, M.12
-
16
-
-
0013138711
-
Adaptive changes in hepatobiliary transporter expression in primary biliary cirrhosis
-
DOI 10.1016/S0168-8278(03)00096-5
-
Zollner G, Fickert P, Silbert D, et al. Adaptive changes in hepatobiliary transporter expression in primary biliary cirrhosis. J Hepatol 2003; 38:717-727. (Pubitemid 36613336)
-
(2003)
Journal of Hepatology
, vol.38
, Issue.6
, pp. 717-727
-
-
Zollner, G.1
Fickert, P.2
Silbert, D.3
Fuchsbichler, A.4
Marschall, H.-U.5
Zatloukal, K.6
Denk, H.7
Trauner, M.8
-
17
-
-
33847011377
-
Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regeneration
-
Andreas G, Martin W, Christoph GD, Michael T. Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regeneration. Biochim Biophys Acta Mol Cell Res 2007; 1773:283-308.
-
(2007)
Biochim Biophys Acta Mol Cell Res
, vol.1773
, pp. 283-308
-
-
Andreas, G.1
Martin, W.2
Christoph, G.D.3
Michael, T.4
-
18
-
-
0029046931
-
Identification of a nuclear receptor that is activated by farnesol metabolites
-
Forman BM, Goode E, Chen J, et al. Identification of a nuclear receptor that is activated by farnesol metabolites. Cell 1995; 8:687-693.
-
(1995)
Cell
, vol.8
, pp. 687-693
-
-
Forman, B.M.1
Goode, E.2
Chen, J.3
-
19
-
-
0037094415
-
Generation of multiple farnesoid-X-receptor isoforms through the use of alternative promoters
-
DOI 10.1016/S0378-1119(02)00557-7, PII S0378111902005577
-
Huber RM, Murphy K, Miao B, et al. Generation of multiple farnesoid-X-receptor isoforms through the use of alternative promoters. Gene 2002; 290:35-43. (Pubitemid 34615907)
-
(2002)
Gene
, vol.290
, Issue.1-2
, pp. 35-43
-
-
Huber, R.M.1
Murphy, K.2
Miao, B.3
Link, J.R.4
Cunningham, M.R.5
Rupar, M.J.6
Gunyuzlu, P.L.7
Haws Jr., T.F.8
Kassam, A.9
Powell, F.10
Hollis, G.F.11
Young, P.R.12
Mukherjee, R.13
Burn, T.C.14
-
20
-
-
0037414757
-
Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation
-
DOI 10.1074/jbc.M209505200
-
Zhang Y, Kast-Woelbern HR, Edwards PA. Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation. J Biol Chem 2003; 278:104-110. (Pubitemid 36043550)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.1
, pp. 104-110
-
-
Zhang, Y.1
Kast-Woelbern, H.R.2
Edwards, P.A.3
-
21
-
-
0037304716
-
Identification of farnesoid X receptor as a novel mammalian nuclear receptor sensing lanosterol
-
DOI 10.1128/MCB.23.3.864-872.2003
-
Otte K, Kranz H, Kober I, et al. Identification of farnesoid X receptor as a novel mammalian nuclear receptor sensing lanosterol. Mol Cell Biol 2003; 23: 864-872. (Pubitemid 36133505)
-
(2003)
Molecular and Cellular Biology
, vol.23
, Issue.3
, pp. 864-872
-
-
Otte, K.1
Kranz, H.2
Kober, I.3
Thompson, P.4
Hoefer, M.5
Haubold, B.6
Remmel, B.7
Voss, H.8
Kaiser, C.9
Albers, M.10
Cheruvallath, Z.11
Jackson, D.12
Casari, G.13
Koegl, M.14
Paabo, S.15
Mous, J.16
Kremoser, C.17
Deuschle, U.18
-
23
-
-
34347325158
-
Targeting farnesoid X receptor for liver and metabolic disorders
-
A review of current status of potential therapeutic applications of FXR agonsists
-
Fiorucci S, Rizzo G, Donini A, et al. Targeting farnesoid X receptor for liver and metabolic disorders. Trends Mol Med 2007; 13:298-309. A review of current status of potential therapeutic applications of FXR agonsists.
-
(2007)
Trends Mol Med
, vol.13
, pp. 298-309
-
-
Fiorucci, S.1
Rizzo, G.2
Donini, A.3
-
24
-
-
0033026760
-
Endogenous bile acids are ligands for the nuclear receptor FXR/BAR
-
DOI 10.1016/S1097-2765(00)80348-2
-
Wang H, Chen J, Hollister K, et al. Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol Cell 1999; 3:543-553. (Pubitemid 29268438)
-
(1999)
Molecular Cell
, vol.3
, Issue.5
, pp. 543-553
-
-
Wang, H.1
Chen, J.2
Hollister, K.3
Sowers, L.C.4
Forman, B.M.5
-
25
-
-
33748950271
-
FXR, a multipurpose nuclear receptor
-
Lee FY, Lee H, Hubbert ML, et al. FXR, a multipurpose nuclear receptor. Trends Biochem Sci 2006; 31:572-580.
-
(2006)
Trends Biochem Sci
, vol.31
, pp. 572-580
-
-
Lee, F.Y.1
Lee, H.2
Hubbert, M.L.3
-
26
-
-
34247491040
-
FXR: A promising target for the metabolic syndrome?
-
A review of current status of potential therapeutic applications of FXR agonists in metabolic disorders
-
Cariou B, Staels B. FXR: a promising target for the metabolic syndrome? Trends Pharmacol Sci 2007; 28:236-243. A review of current status of potential therapeutic applications of FXR agonists in metabolic disorders.
-
(2007)
Trends Pharmacol Sci
, vol.28
, pp. 236-243
-
-
Cariou, B.1
Staels, B.2
-
27
-
-
33745774784
-
Role of nuclear receptors in the adaptive response to bile acids and cholestasis: Pathogenetic and therapeutic considerations
-
DOI 10.1021/mp060010s
-
Zollner G, Marschall HU, Wagner M, Trauner M. Role of nuclear receptors in the adaptive response to bile acids and cholestasis: pathogenetic and therapeutic considerations. Mol Pharm 2006; 3:231-251. (Pubitemid 44021431)
-
(2006)
Molecular Pharmaceutics
, vol.3
, Issue.3
, pp. 231-251
-
-
Zollner, G.1
Marschall, H.-U.2
Wagner, M.3
Trauner, M.4
-
28
-
-
0035800772
-
Human Bile Salt Export Pump Promoter Is Transactivated by the Farnesoid X Receptor/Bile Acid Receptor
-
DOI 10.1074/jbc.M011610200
-
Ananthanarayanan M, Balasubramanian N, Makishima M, et al. Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor. J Biol Chem 2001; 276:28857-28865. (Pubitemid 37451965)
-
(2001)
Journal of Biological Chemistry
, vol.276
, Issue.31
, pp. 28857-28865
-
-
Ananthanarayanan, M.1
Balasubramanian, N.2
Makishima, M.3
Mangelsdorf, D.J.4
Suchy, F.J.5
-
29
-
-
0037169551
-
Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor
-
DOI 10.1074/jbc.M109326200
-
Kast HR, Goodwin B, Tarr PT, et al. Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. J Biol Chem 2002; 277:2908-2915. (Pubitemid 34953324)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.4
, pp. 2908-2915
-
-
Kast, H.R.1
Goodwin, B.2
Tarr, P.T.3
Jones, S.A.4
Anisfeld, A.M.5
Stoltz, C.M.6
Tontonoz, P.7
Kliewer, S.8
Willson, T.M.9
Edwards, P.A.10
-
30
-
-
0038281429
-
FXR induces the UGT2B4 enzyme in hepatocytes: A potential mechanism of negative feedback control of FXR activity
-
DOI 10.1016/S0016-5085(03)00388-3
-
Barbier O, Torra IP, Sirvent A, et al. FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity. Gastroenterology 2003; 124:1926-1940. (Pubitemid 36666787)
-
(2003)
Gastroenterology
, vol.124
, Issue.7
, pp. 1926-1940
-
-
Barbier, O.1
Torra, I.P.2
Sirvent, A.3
Claudel, T.4
Blanquart, C.5
Duran-Sandoval, D.6
Kuipers, F.7
Kosykh, V.8
Fruchart, J.-C.9
Staels, B.10
-
31
-
-
6944234902
-
Regulation of CYP3A4 by the bile acid receptor FXR: Evidence for functional binding sites in the CYP3A4 gene
-
DOI 10.1097/00008571-200410000-00001
-
Gnerre C, Blättler S, Kaufmann MR, et al. Regulation of CYP3A4 by the bile acid receptor FXR: evidence for functional binding sites in the CYP3A4 gene. Pharmacogenetics 2004; 14:635-645. (Pubitemid 39411263)
-
(2004)
Pharmacogenetics
, vol.14
, Issue.10
, pp. 635-645
-
-
Gnerre, C.1
Blattler, S.2
Kaufmann, M.R.3
Looser, R.4
Meyer, U.A.5
-
32
-
-
33644867569
-
Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor
-
DOI 10.1073/pnas.0509592103
-
Inagaki T, Moschetta A, Lee YK, et al. Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor. Proc Natl Acad Sci U S A 2006; 103:3920-3925. (Pubitemid 43376656)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.10
, pp. 3920-3925
-
-
Inagaki, T.1
Moschetta, A.2
Lee, Y.-K.3
Peng, L.4
Zhao, G.5
Downes, M.6
Yu, R.T.7
Shelton, J.M.8
Richardson, J.A.9
Repa, J.J.10
Mangelsdorf, D.J.11
Kliewer, S.A.12
-
33
-
-
27844546989
-
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
-
Inagaki T, Choi M, Moschetta A, et al. Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab 2005; 2:217-225.
-
(2005)
Cell Metab
, vol.2
, pp. 217-225
-
-
Inagaki, T.1
Choi, M.2
Moschetta, A.3
-
34
-
-
33745830106
-
Pregnane x receptor is a target of farnesoid x receptor
-
Jung D, Mangelsdorf DJ, Meyer UA. Pregnane x receptor is a target of farnesoid x receptor. J Biol Chem 2006; 281:19081-19091.
-
(2006)
J Biol Chem
, vol.281
, pp. 19081-19091
-
-
Jung, D.1
Mangelsdorf, D.J.2
Meyer, U.A.3
-
35
-
-
0037108916
-
Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR)
-
DOI 10.1073/pnas.212494599
-
Sonoda J, Xie W, Rosenfeld JM, et al. Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR). Proc Natl Acad Sci U S A 2002; 99:13801-13806. (Pubitemid 35215461)
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.21
, pp. 13801-13806
-
-
Sonoda, J.1
Xie, W.2
Rosenfeld, J.M.3
Barwick, J.L.4
Guzelian, P.S.5
Evans, R.M.6
-
36
-
-
10344224570
-
The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity
-
DOI 10.1074/jbc.M409041200
-
Zhang J, Huang W, Qatanani M, et al. The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity. J Biol Chem 2004; 279:49517-49522. (Pubitemid 39625839)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.47
, pp. 49517-49522
-
-
Zhang, J.1
Huang, W.2
Qatanani, M.3
Evans, R.M.4
Moore, D.D.5
-
37
-
-
39749190047
-
Regulation of transporters by nuclear hormone receptors: Implications during inflammation
-
DOI 10.1021/mp700102q
-
Teng S, Piquette-Miller M. Regulation of transporters by nuclear hormone receptors: implications during inflammation. Mol Pharm 2008; 5:67-76. A review describing the regulation of liver transporters in inflammation. (Pubitemid 351300036)
-
(2008)
Molecular Pharmaceutics
, vol.5
, Issue.1
, pp. 67-76
-
-
Teng, S.1
Piquette-Miller, M.2
-
38
-
-
34547431187
-
A common polymorphism in the bile acid receptor farnesoid X receptor is associated with decreased hepatic target gene expression
-
DOI 10.1210/me.2007-0025
-
Marzolini C, Tirona RG, Gervasini G, et al. A common polymorphism in the bile acid receptor farnesoid x receptor is associated with decreased hepatic target gene expression. Mol Endocrinol 2007; 21:1769-1780. (Pubitemid 47173790)
-
(2007)
Molecular Endocrinology
, vol.21
, Issue.8
, pp. 1769-1780
-
-
Marzolini, C.1
Tirona, R.G.2
Gervasini, G.3
Poonkuzhali, B.4
Assem, M.5
Lee, W.6
Leake, B.F.7
Schuetz, J.D.8
Schuetz, E.G.9
Kim, R.B.10
-
39
-
-
34547515667
-
Functional variants of the central bile acid sensor FXR identified in intrahepatic cholestasis of pregnancy
-
Van Mil SA, Milona P, Dixon R, et al. Functional variants of the central bile acid sensor FXR identified in intrahepatic cholestasis of pregnancy. Gastroenterology 2007; 133:507-516.
-
(2007)
Gastroenterology
, vol.133
, pp. 507-516
-
-
Van Mil, S.A.1
Milona, P.2
Dixon, R.3
-
40
-
-
36549040038
-
Variation of the gene encoding the nuclear bile salt receptor FXR and gallstone susceptibility in mice and humans
-
A study suggesting a potential role of FXR gene variations in predisposing to gallstone in mice and humans
-
Kovacs P, Kress R, Rocha J, et al. Variation of the gene encoding the nuclear bile salt receptor FXR and gallstone susceptibility in mice and humans. J Hepatol 2008; 48:116-124. A study suggesting a potential role of FXR gene variations in predisposing to gallstone in mice and humans.
-
(2008)
J Hepatol
, vol.48
, pp. 116-124
-
-
Kovacs, P.1
Kress, R.2
Rocha, J.3
-
41
-
-
33846821743
-
New perspectives for the treatment of cholestasis: Lessons from basic science applied clinically
-
Boyer JL. New perspectives for the treatment of cholestasis: lessons from basic science applied clinically. J Hepatol 2007; 46:365-371.
-
(2007)
J Hepatol
, vol.46
, pp. 365-371
-
-
Boyer, J.L.1
-
42
-
-
45849103909
-
Expression of hepatocyte transporters and nuclear receptors in children with early and late-stage biliary atresia
-
Chen HL, Liu YJ, Chen HL, et al. Expression of hepatocyte transporters and nuclear receptors in children with early and late-stage biliary atresia. Pediatr Res 2008; 63:667-673.
-
(2008)
Pediatr Res
, vol.63
, pp. 667-673
-
-
Chen, H.L.1
Liu, Y.J.2
Chen, H.L.3
-
43
-
-
0036725044
-
Ursodeoxycholic acid in cholestatic liver disease: Mechanisms of action and therapeutic use revisited
-
DOI 10.1053/jhep.2002.36088
-
Paumgartner G, Beuers U. Ursodeoxycholic acid in cholestatic liver disease: mechanisms of action and therapeutic use revisited. Hepatology 2002; 36:525-531. (Pubitemid 34977162)
-
(2002)
Hepatology
, vol.36
, Issue.3
, pp. 525-531
-
-
Paumgartner, G.1
Beuers, U.2
-
44
-
-
23244465392
-
Complementary stimulation of hepatobiliary transport and detoxification systems by rifampicin and ursodeoxycholic acid in humans
-
DOI 10.1016/j.gastro.2005.05.009, PII S0016508505008796
-
Marschall HU, Wagner M, Zollner G, et al. Complementary stimulation of hepatobiliary transport and detoxification systems by rifampicin and ursodeoxycholic acid in humans. Gastroenterology 2005; 129:476-485. (Pubitemid 41096635)
-
(2005)
Gastroenterology
, vol.129
, Issue.2
, pp. 476-485
-
-
Marschall, H.-U.1
Wagner, M.2
Zollner, G.3
Fickert, P.4
Diczfalusy, U.5
Gumhold, J.6
Silbert, D.7
Fuchsbichler, A.8
Benthin, L.9
Grundstrom, R.10
Gustafsson, U.11
Sahlin, S.12
Einarsson, C.13
Trauner, M.14
-
45
-
-
0346690402
-
Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- And extrahepatic cholestasis
-
DOI 10.1172/JCI200318945
-
Liu Y, Binz J, Numerick MJ, et al. Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis. J Clin Invest 2003; 112:1678-1687. (Pubitemid 38063725)
-
(2003)
Journal of Clinical Investigation
, vol.112
, Issue.11
, pp. 1678-1687
-
-
Liu, Y.1
Binz, J.2
Numerick, M.J.3
Dennis, S.4
Luo, G.5
Desai, B.6
MacKenzie, K.I.7
Mansfield, T.A.8
Kliewer, S.A.9
Goodwin, B.10
Jones, S.A.11
-
46
-
-
20944450029
-
Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid x receptor ligand, in estrogen-induced cholestasis
-
DOI 10.1124/jpet.104.079665
-
Fiorucci S, Clerici C, Antonelli E, et al. Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor ligand, in estrogen-induced cholestasis. J Pharmacol Exp Ther 2005; 313:604-612. (Pubitemid 40604160)
-
(2005)
Journal of Pharmacology and Experimental Therapeutics
, vol.313
, Issue.2
, pp. 604-612
-
-
Fiorucci, S.1
Clerici, C.2
Antonelli, E.3
Orlandi, S.4
Goodwin, B.5
Sadeghpour, B.M.6
Sabatino, G.7
Russo, G.8
Castellani, D.9
Willson, T.M.10
Pruzanski, M.11
Pellicciari, R.12
Morelli, A.13
-
47
-
-
33746605104
-
Benefit of farnesoid X receptor inhibition in obstructive cholestasis
-
DOI 10.1073/pnas.0604772103
-
Stedman C, Liddle C, Coulter S, et al. Benefit of farnesoid X receptor inhibition in obstructive cholestasis. Proc Natl Acad Sci U S A 2006; 103:11323-11328. (Pubitemid 44156516)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.30
, pp. 11323-11328
-
-
Stedman, C.1
Liddle, C.2
Coulter, S.3
Sonoda, J.4
Alvarez, J.G.5
Evans, R.M.6
Downes, M.7
-
48
-
-
33644748143
-
-/- mice adapt to biliary obstruction by enhanced phase I detoxification and renal elimination of bile acids
-
DOI 10.1194/jlr.M500427-JLR200
-
Marschall HU, Wagner M, Bodin K, et al. Fxr(-/-) mice adapt to biliary obstruction by enhanced phase I detoxification and renal elimination of bile acids. J Lipid Res 2006; 47:582-592. (Pubitemid 43345599)
-
(2006)
Journal of Lipid Research
, vol.47
, Issue.3
, pp. 582-592
-
-
Marschall, H.-U.1
Wagner, M.2
Bodin, K.3
Zollner, G.4
Fickert, P.5
Gumhold, J.6
Silbert, D.7
Fuchsbichler, A.8
Sjovall, J.9
Trauner, M.10
-
49
-
-
1642316825
-
Multidrug resistance-associated protein 4 is up-regulated in liver but down-regulated in kidney in obstructive cholestasis in the rat
-
DOI 10.1016/j.jhep.2003.12.001, PII S0168827803006354
-
Denk GU, Soroka CJ, Takeyama Y, et al. Multidrug resistance-associated protein 4 is up-regulated in liver but down-regulated in kidney in obstructive cholestasis in the rat. J Hepatol 2004; 40:585-591. (Pubitemid 38367779)
-
(2004)
Journal of Hepatology
, vol.40
, Issue.4
, pp. 585-591
-
-
Denk, G.U.1
Soroka, C.J.2
Takeyama, Y.3
Chen, W.-S.4
Schuetz, J.D.5
Boyer, J.L.6
-
50
-
-
33646541411
-
Mrp4-/- Mice have an impaired cytoprotective response in obstructive cholestasis
-
DOI 10.1002/hep.21158
-
Mennone A, Soroka CJ, Cai SY, et al. Mrp4-/- mice have an impaired cytoprotective response in obstructive cholestasis. Hepatology 2006; 43:1013-1021. (Pubitemid 43724626)
-
(2006)
Hepatology
, vol.43
, Issue.5
, pp. 1013-1021
-
-
Mennone, A.1
Soroka, C.J.2
Cai, S.-Y.3
Harry, K.4
Adachi, M.5
Hagey, L.6
Schuetz, J.D.7
Boyer, J.L.8
-
51
-
-
0036137072
-
Organ distribution of multidrug resistance proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and hepatic induction of Mrp3 by constitutive androstane receptor activators in rats
-
Cherrington NJ, Hartley DP, Li N, et al. Organ distribution of multidrug resistance proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and hepatic induction of Mrp3 by constitutive androstane receptor activators in rats. J Pharmacol Exp Ther 2002; 300:97-104.
-
(2002)
J Pharmacol Exp Ther
, vol.300
, pp. 97-104
-
-
Cherrington, N.J.1
Hartley, D.P.2
Li, N.3
-
52
-
-
2542440464
-
Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice
-
DOI 10.1074/jbc.M314111200
-
Assem M, Schuetz EG, Leggas M, et al. Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice. J Biol Chem 2004; 279:22250-22257. (Pubitemid 38679421)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.21
, pp. 22250-22257
-
-
Assem, M.1
Schuetz, E.G.2
Leggas, M.3
Sun, D.4
Yasuda, K.5
Reid, G.6
Zelcer, N.7
Adachi, M.8
Strom, S.9
Evans, R.M.10
Moore, D.D.11
Borst, P.12
Schuetz, J.D.13
-
53
-
-
11144318237
-
Prevention of cholesterol gallstone disease by FXR agonists in a mouse model
-
DOI 10.1038/nm1138
-
Moschetta A, Bookout AL, Mangelsdorf DJ. Prevention of cholesterol gallstone disease by FXR agonists in a mouse model. Nat Med 2004; 10:1352-1358. (Pubitemid 40022717)
-
(2004)
Nature Medicine
, vol.10
, Issue.12
, pp. 1352-1358
-
-
Moschetta, A.1
Bookout, A.L.2
Mangelsdorf, D.J.3
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