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Volumn 1348, Issue 1, 2015, Pages 124-133

Direct molecular targets of resveratrol: identifying key interactions to unlock complex mechanisms

Author keywords

cancer; cardiovascular; inflammation; mechanism; protein targets; resveratrol

Indexed keywords

RESVERATROL;

EID: 84932144505     PISSN: 00778923     EISSN: 17496632     Source Type: Journal    
DOI: 10.1111/nyas.12796     Document Type: Article
Times cited : (92)

References (80)
  • 1
    • 0031561513 scopus 로고    scopus 로고
    • Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
    • Jang, M.S. et al. 1997. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275: 218–220.
    • (1997) Science , vol.275 , pp. 218-220
    • Jang, M.S.1
  • 2
    • 0035451363 scopus 로고    scopus 로고
    • Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation
    • Surh, Y.J. et al. 2001. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation. Mutat. Res. 480: 243–268.
    • (2001) Mutat. Res. , vol.480 , pp. 243-268
    • Surh, Y.J.1
  • 3
    • 4644309893 scopus 로고    scopus 로고
    • Mechanisms of cardiovascular protection by resveratrol
    • Hao, H.D. & L.R. He. 2004. Mechanisms of cardiovascular protection by resveratrol. J. Med. Food 7: 290–298.
    • (2004) J. Med. Food , vol.7 , pp. 290-298
    • Hao, H.D.1    He, L.R.2
  • 4
    • 84862777886 scopus 로고    scopus 로고
    • Cardiovascular effects and molecular targets of resveratrol
    • Li, H.G., N. Xia & U. Förstermann. 2012. Cardiovascular effects and molecular targets of resveratrol. Nitric Oxide 26: 102–110.
    • (2012) Nitric Oxide , vol.26 , pp. 102-110
    • Li, H.G.1    Xia, N.2    Förstermann, U.3
  • 5
    • 20344407841 scopus 로고    scopus 로고
    • Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications
    • de la Lastra, C.A. & I. Villegas. 2005. Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications. Mol. Nutr. Food Res. 49: 405–430.
    • (2005) Mol. Nutr. Food Res. , vol.49 , pp. 405-430
    • de la Lastra, C.A.1    Villegas, I.2
  • 6
    • 43549088782 scopus 로고    scopus 로고
    • Resveratrol—a multitargeted agent for age-associated chronic diseases
    • Harikumar, K.B. & B.B. Aggarwal. 2008. Resveratrol—a multitargeted agent for age-associated chronic diseases. Cell Cycle 7: 1020–1035.
    • (2008) Cell Cycle , vol.7 , pp. 1020-1035
    • Harikumar, K.B.1    Aggarwal, B.B.2
  • 7
    • 84867865164 scopus 로고    scopus 로고
    • Resveratrol role in cardiovascular and metabolic health and potential mechanisms of action
    • Xu, Q. & L.Y. Si. 2012. Resveratrol role in cardiovascular and metabolic health and potential mechanisms of action. Nutr. Res. 32: 648–658.
    • (2012) Nutr. Res. , vol.32 , pp. 648-658
    • Xu, Q.1    Si, L.Y.2
  • 8
    • 84863011114 scopus 로고    scopus 로고
    • Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases
    • Park, S.J. et al. 2012. Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell 148: 421–433.
    • (2012) Cell , vol.148 , pp. 421-433
    • Park, S.J.1
  • 9
    • 84870926998 scopus 로고    scopus 로고
    • Fruits and dietary phytochemicals in bone protection
    • Shen, C.L. et al. 2012. Fruits and dietary phytochemicals in bone protection. Nutr. Res. 32: 897–910.
    • (2012) Nutr. Res. , vol.32 , pp. 897-910
    • Shen, C.L.1
  • 10
    • 84878778128 scopus 로고    scopus 로고
    • Observation of human retinal remodeling in octogenarians with a resveratrol based nutritional supplement
    • Richer, S. et al. 2013. Observation of human retinal remodeling in octogenarians with a resveratrol based nutritional supplement. Nutrients 5: 1989–2005.
    • (2013) Nutrients , vol.5 , pp. 1989-2005
    • Richer, S.1
  • 11
    • 3943071801 scopus 로고    scopus 로고
    • Sirtuin activators mimic caloric restriction and delay ageing in metazoans
    • Wood, J.G. et al. 2004. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430: 686–689.
    • (2004) Nature , vol.430 , pp. 686-689
    • Wood, J.G.1
  • 12
    • 77952549960 scopus 로고    scopus 로고
    • Resveratrol, sirtuins, and the promise of a DR mimetic
    • Baur, J.A. 2010. Resveratrol, sirtuins, and the promise of a DR mimetic. Mech. Ageing Dev. 131: 261–269.
    • (2010) Mech. Ageing Dev. , vol.131 , pp. 261-269
    • Baur, J.A.1
  • 13
    • 33845334891 scopus 로고    scopus 로고
    • Inhibitory activity of stilbenes on Alzheimer's beta-amyloid fibrils in vitro
    • Riviere, C. et al. 2007. Inhibitory activity of stilbenes on Alzheimer's beta-amyloid fibrils in vitro. Bioorg. Med. Chem. 15: 1160–1167.
    • (2007) Bioorg. Med. Chem. , vol.15 , pp. 1160-1167
    • Riviere, C.1
  • 14
    • 77955088481 scopus 로고    scopus 로고
    • Resveratrol as a therapeutic agent for neurodegenerative diseases
    • Sun, A.Y. et al. 2010. Resveratrol as a therapeutic agent for neurodegenerative diseases. Mol. Neurobiol. 41: 375–383.
    • (2010) Mol. Neurobiol. , vol.41 , pp. 375-383
    • Sun, A.Y.1
  • 15
    • 51349132313 scopus 로고    scopus 로고
    • Cancer chemopreventive and therapeutic potential of resveratrol: Mechanistic perspectives
    • Kundu, J.K. & Y.J. Surh. 2008. Cancer chemopreventive and therapeutic potential of resveratrol: Mechanistic perspectives. Cancer Lett. 269: 243–261.
    • (2008) Cancer Lett. , vol.269 , pp. 243-261
    • Kundu, J.K.1    Surh, Y.J.2
  • 16
    • 84856731505 scopus 로고    scopus 로고
    • Finding a target for resveratrol
    • Tennen, R.I., E. Michishita-Kioi & K.F. Chua. 2012. Finding a target for resveratrol. Cell 148: 387–389.
    • (2012) Cell , vol.148 , pp. 387-389
    • Tennen, R.I.1    Michishita-Kioi, E.2    Chua, K.F.3
  • 17
    • 34547684362 scopus 로고    scopus 로고
    • Chemoprevention by resveratrol: molecular mechanisms and therapeutic potential
    • Shankar, S., G. Singh & R.K. Srivastava. 2007. Chemoprevention by resveratrol: molecular mechanisms and therapeutic potential. Front. Biosci. 12: 4839–4854.
    • (2007) Front. Biosci. , vol.12 , pp. 4839-4854
    • Shankar, S.1    Singh, G.2    Srivastava, R.K.3
  • 18
    • 84914689065 scopus 로고    scopus 로고
    • Resveratrol: anti-obesity mechanisms of action
    • Aguirre, L. et al. 2014. Resveratrol: anti-obesity mechanisms of action. Molecules 19: 18632–18655.
    • (2014) Molecules , vol.19 , pp. 18632-18655
    • Aguirre, L.1
  • 19
    • 78751706756 scopus 로고    scopus 로고
    • Resveratrol and cellular mechanisms of cancer prevention
    • &, ” In, O. Vang, &, D.K. Das, Eds., Malden, Wiley-Blackwell
    • Shukla, Y. & R. Singh. 2011. “Resveratrol and cellular mechanisms of cancer prevention.” In Resveratrol and Health. Vol. 1215: O. Vang & D.K. Das, Eds.: 1–8. Malden: Wiley-Blackwell.
    • (2011) Resveratrol and Health , vol.1215 , pp. 1-8
    • Shukla, Y.1    Singh, R.2
  • 21
    • 84923063732 scopus 로고    scopus 로고
    • Regulation of microRNAs by natural agents: new strategies in cancer therapies
    • Phuah, N.H. & N.H. Nagoor. 2014. Regulation of microRNAs by natural agents: new strategies in cancer therapies. BioMed Res. Int. 2014: 804510.
    • (2014) BioMed Res. Int. , vol.2014 , pp. 804510
    • Phuah, N.H.1    Nagoor, N.H.2
  • 22
    • 84866429138 scopus 로고    scopus 로고
    • Control of MicroRNA expression as a new way for resveratrol to deliver its beneficial effects
    • Lancon, A. et al. 2012. Control of MicroRNA expression as a new way for resveratrol to deliver its beneficial effects. J. Agric. Food Chem. 60: 8783–8789.
    • (2012) J. Agric. Food Chem. , vol.60 , pp. 8783-8789
    • Lancon, A.1
  • 23
    • 71749100220 scopus 로고    scopus 로고
    • AMP-activated protein kinase: a potential target for the diseases prevention by natural occurring polyphenols
    • Hwang, J.T., D.Y. Kwon & S.H. Yoon. 2009. AMP-activated protein kinase: a potential target for the diseases prevention by natural occurring polyphenols. New Biotech. 26: 17–22.
    • (2009) New Biotech. , vol.26 , pp. 17-22
    • Hwang, J.T.1    Kwon, D.Y.2    Yoon, S.H.3
  • 24
    • 5144223780 scopus 로고    scopus 로고
    • Molecular basis of chemoprevention by resveratrol: NF-kappa B and AP-1 as potential targets
    • Kundu, J.K. & Y.J. Surh. 2004. Molecular basis of chemoprevention by resveratrol: NF-kappa B and AP-1 as potential targets. Mutat. Res. 555: 65–80.
    • (2004) Mutat. Res. , vol.555 , pp. 65-80
    • Kundu, J.K.1    Surh, Y.J.2
  • 25
    • 84883340186 scopus 로고    scopus 로고
    • Resveratrol as a Pan-HDAC inhibitor alters the acetylation status of jistone proteins in human-derived hepatoblastoma cells
    • Venturelli, S. et al. 2013. Resveratrol as a Pan-HDAC inhibitor alters the acetylation status of jistone proteins in human-derived hepatoblastoma cells. PLoS One 8: 12.
    • (2013) PLoS One , vol.8
    • Venturelli, S.1
  • 26
    • 0034909129 scopus 로고    scopus 로고
    • A reappraisal of the potential chemopreventive and chemotherapeutic properties of resveratrol
    • Gusman, J., H. Malonne & G. Atassi. 2001. A reappraisal of the potential chemopreventive and chemotherapeutic properties of resveratrol. Carcinogenesis 22: 1111–1117.
    • (2001) Carcinogenesis , vol.22 , pp. 1111-1117
    • Gusman, J.1    Malonne, H.2    Atassi, G.3
  • 27
    • 0036130351 scopus 로고    scopus 로고
    • Inactivation of creatine kinase induced by stilbene derivatives
    • Miura, T., S. Muraoka & Y. Fujimoto. 2002. Inactivation of creatine kinase induced by stilbene derivatives. Pharmacol. Toxicol. 90: 66–72.
    • (2002) Pharmacol. Toxicol. , vol.90 , pp. 66-72
    • Miura, T.1    Muraoka, S.2    Fujimoto, Y.3
  • 28
    • 4644302857 scopus 로고    scopus 로고
    • Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship
    • Murias, M. et al. 2004. Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship. Bioorg. Med. Chem. 12: 5571–5578.
    • (2004) Bioorg. Med. Chem. , vol.12 , pp. 5571-5578
    • Murias, M.1
  • 29
    • 52649086870 scopus 로고    scopus 로고
    • Resveratrol directly targets COX-2 to inhibit carcinogenesis
    • Zykova, T.A. et al. 2008. Resveratrol directly targets COX-2 to inhibit carcinogenesis. Mol. Carcinog. 47: 797–805.
    • (2008) Mol. Carcinog. , vol.47 , pp. 797-805
    • Zykova, T.A.1
  • 30
    • 84903782541 scopus 로고    scopus 로고
    • COX-2 inhibition potentiates antiangiogenic cancer therapy and prevents metastasis in preclinical models
    • Xu, L.H. et al. 2014. COX-2 inhibition potentiates antiangiogenic cancer therapy and prevents metastasis in preclinical models. Sci. Transl. Med. 6: 12.
    • (2014) Sci. Transl. Med. , vol.6 , pp. 12
    • Xu, L.H.1
  • 31
    • 84855556537 scopus 로고    scopus 로고
    • Aspirin in the chemoprevention of colorectal neoplasia: an overview
    • Chan, A.T. et al. 2012. Aspirin in the chemoprevention of colorectal neoplasia: an overview. Cancer Prev. Res. 5: 164–178.
    • (2012) Cancer Prev. Res. , vol.5 , pp. 164-178
    • Chan, A.T.1
  • 32
    • 77953319891 scopus 로고    scopus 로고
    • COX-2 as a target for cancer chemotherapy
    • Ghosh, N. et al. 2010. COX-2 as a target for cancer chemotherapy. Pharmacol. Rep. 62: 233–244.
    • (2010) Pharmacol. Rep. , vol.62 , pp. 233-244
    • Ghosh, N.1
  • 33
    • 77954701127 scopus 로고    scopus 로고
    • Pleiotropic mechanisms facilitated by resveratrol and its metabolites
    • Calamini, B. et al. 2010. Pleiotropic mechanisms facilitated by resveratrol and its metabolites. Biochem. J. 429: 273–282.
    • (2010) Biochem. J. , vol.429 , pp. 273-282
    • Calamini, B.1
  • 34
    • 35748961720 scopus 로고    scopus 로고
    • Mechanisms of disease: Leukotrienes
    • Peters-Golden, M. & W.R. Henderson. 2007. Mechanisms of disease: Leukotrienes. N. Engl. J. Med. 357: 1841–1854.
    • (2007) N. Engl. J. Med. , vol.357 , pp. 1841-1854
    • Peters-Golden, M.1    Henderson, W.R.2
  • 35
    • 78649927272 scopus 로고    scopus 로고
    • Resveratrol, a red wine polyphenol, suppresses pancreatic cancer by inhibiting leukotriene A(4) hydrolase
    • Oi, N. et al. 2010. Resveratrol, a red wine polyphenol, suppresses pancreatic cancer by inhibiting leukotriene A(4) hydrolase. Cancer Res. 70: 9755–9764.
    • (2010) Cancer Res. , vol.70 , pp. 9755-9764
    • Oi, N.1
  • 36
    • 77957344556 scopus 로고    scopus 로고
    • A critical role for LTA(4)H in limiting chronic pulmonary neutrophilic inflammation
    • Snelgrove, R.J. et al. 2010. A critical role for LTA(4)H in limiting chronic pulmonary neutrophilic inflammation. Science 330: 90–94.
    • (2010) Science , vol.330 , pp. 90-94
    • Snelgrove, R.J.1
  • 37
    • 84875890762 scopus 로고    scopus 로고
    • Targeting cellular metabolism to improve cancer therapeutics
    • Zhao, Y., E.B. Butler & M. Tan. 2013. Targeting cellular metabolism to improve cancer therapeutics. Cell Death Dis. 4: 10.
    • (2013) Cell Death Dis. , vol.4 , pp. 10
    • Zhao, Y.1    Butler, E.B.2    Tan, M.3
  • 38
    • 77950605484 scopus 로고    scopus 로고
    • Fatty acid synthase as a potential therapeutic target in cancer
    • Flavin, R. et al. 2010. Fatty acid synthase as a potential therapeutic target in cancer. Future Oncol. 6: 551–562.
    • (2010) Future Oncol. , vol.6 , pp. 551-562
    • Flavin, R.1
  • 39
    • 33745728461 scopus 로고    scopus 로고
    • Fatty acid synthase and cancer: new application of an old pathway
    • Kuhajda, F.P. 2006. Fatty acid synthase and cancer: new application of an old pathway. Cancer Res. 66: 5977–5980.
    • (2006) Cancer Res. , vol.66 , pp. 5977-5980
    • Kuhajda, F.P.1
  • 40
    • 32944475076 scopus 로고    scopus 로고
    • Structure-activity relationship of polyphenols that inhibit fatty acid synthase
    • Li, B.H. et al. 2005. Structure-activity relationship of polyphenols that inhibit fatty acid synthase. J. Biochem. 138: 679–685.
    • (2005) J. Biochem. , vol.138 , pp. 679-685
    • Li, B.H.1
  • 41
    • 82955178161 scopus 로고    scopus 로고
    • Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase
    • Pandey, P.R. et al. 2011. Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase. Breast Cancer Res. Treat. 130: 387–398.
    • (2011) Breast Cancer Res. Treat. , vol.130 , pp. 387-398
    • Pandey, P.R.1
  • 42
    • 84885454938 scopus 로고    scopus 로고
    • Sulfate metabolites provide an intracellular pool for resveratrol generation and induce autophagy with senescence
    • Patel, K.R. et al. 2013. Sulfate metabolites provide an intracellular pool for resveratrol generation and induce autophagy with senescence. Sci. Transl. Med. 5: 12.
    • (2013) Sci. Transl. Med. , vol.5 , pp. 12
    • Patel, K.R.1
  • 43
    • 84884544164 scopus 로고    scopus 로고
    • Identification of carbonyl reductase 1 as a resveratrol-binding protein by affinity chromatography using 4′–Amino-3,5-dihydroxy-trans-stilbene
    • Ito, Y. et al. 2013. Identification of carbonyl reductase 1 as a resveratrol-binding protein by affinity chromatography using 4′–Amino-3,5-dihydroxy-trans-stilbene. J. Nutr. Sci. Vitaminol. 59: 358–364.
    • (2013) J. Nutr. Sci. Vitaminol. , vol.59 , pp. 358-364
    • Ito, Y.1
  • 44
    • 4544327822 scopus 로고    scopus 로고
    • Identification and purification of resveratrol targeting proteins using immobilized resveratrol affinity chromatography
    • Wang, Z.R. et al. 2004. Identification and purification of resveratrol targeting proteins using immobilized resveratrol affinity chromatography. Biochem. Biophys. Res. Commun. 323: 743–749.
    • (2004) Biochem. Biophys. Res. Commun. , vol.323 , pp. 743-749
    • Wang, Z.R.1
  • 45
    • 4444267291 scopus 로고    scopus 로고
    • Crystal structure of quinone reductase 2 in complex with resveratrol
    • Buryanovskyy, L. et al. 2004. Crystal structure of quinone reductase 2 in complex with resveratrol. Biochemistry 43: 11417–11426.
    • (2004) Biochemistry , vol.43 , pp. 11417-11426
    • Buryanovskyy, L.1
  • 46
    • 42449128395 scopus 로고    scopus 로고
    • Association of NRH: quinone oxidoreductase 2 gene promoter polymorphism with higher gene expression and increased susceptibility to Parkinson's disease
    • Wang, W., W-D. Le, T. Pan, et al. 2008. Association of NRH: quinone oxidoreductase 2 gene promoter polymorphism with higher gene expression and increased susceptibility to Parkinson's disease. J. Gerontol. A Biol. Sci. Med. Sci. 63: 127–134.
    • (2008) J. Gerontol. A Biol. Sci. Med. Sci. , vol.63 , pp. 127-134
    • Wang, W.1    Le, W.-D.2    Pan, T.3
  • 47
    • 43549098380 scopus 로고    scopus 로고
    • Combining computational and biochemical studies for a rationale on the anti-aromatase activity of natural polyphenols
    • Neves, M.A.C. et al. 2007. Combining computational and biochemical studies for a rationale on the anti-aromatase activity of natural polyphenols. ChemMedChem. 2: 1750–1762.
    • (2007) ChemMedChem. , vol.2 , pp. 1750-1762
    • Neves, M.A.C.1
  • 48
    • 40549083326 scopus 로고    scopus 로고
    • Identification of glutathione sulfotransferase-pi (GSTP1) as a new resveratrol targeting protein (RTP) and studies of resveratrol-responsive protein changes by resveratrol affinity chromatography
    • Hsieh, T.C. et al. 2008. Identification of glutathione sulfotransferase-pi (GSTP1) as a new resveratrol targeting protein (RTP) and studies of resveratrol-responsive protein changes by resveratrol affinity chromatography. Anticancer Res. 28: 29–36.
    • (2008) Anticancer Res. , vol.28 , pp. 29-36
    • Hsieh, T.C.1
  • 49
    • 85047685824 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma and lung cancer biology
    • Roman, J. 2008. Peroxisome proliferator-activated receptor gamma and lung cancer biology. J. Invest. Med. 56: 528–533.
    • (2008) J. Invest. Med. , vol.56 , pp. 528-533
    • Roman, J.1
  • 50
    • 33751072349 scopus 로고    scopus 로고
    • Resveratrol improves health and survival of mice on a high-calorie diet
    • Baur, J.A. et al. 2006. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444: 337–342.
    • (2006) Nature , vol.444 , pp. 337-342
    • Baur, J.A.1
  • 51
    • 84901507127 scopus 로고    scopus 로고
    • Resveratrol and its metabolites bind to PPARs
    • Calleri, E. et al. 2014. Resveratrol and its metabolites bind to PPARs. ChemBioChem. 15: 1154–1160.
    • (2014) ChemBioChem. , vol.15 , pp. 1154-1160
    • Calleri, E.1
  • 52
    • 84925758089 scopus 로고    scopus 로고
    • Phosphodiesterase inhibitors as a target for cognition enhancement in aging and Alzheimer's disease: a translational overview
    • Heckman, P.R.A., C. Wouters & J. Prickaerts. 2015. Phosphodiesterase inhibitors as a target for cognition enhancement in aging and Alzheimer's disease: a translational overview. Curr. Pharm. Design 21: 317–331.
    • (2015) Curr. Pharm. Design , vol.21 , pp. 317-331
    • Heckman, P.R.A.1    Wouters, C.2    Prickaerts, J.3
  • 53
    • 70449109739 scopus 로고    scopus 로고
    • Phosphodiesterase inhibition in heart failure
    • Movsesian, M. et al. 2009. Phosphodiesterase inhibition in heart failure. Heart Fail. Rev. 14: 255–263.
    • (2009) Heart Fail. Rev. , vol.14 , pp. 255-263
    • Movsesian, M.1
  • 54
    • 84890686350 scopus 로고    scopus 로고
    • Roflumilast: the new orally active, selective phophodiesterase-4 inhibitor, for the treatment of COPD
    • Tashkin, D.P. 2014. Roflumilast: the new orally active, selective phophodiesterase-4 inhibitor, for the treatment of COPD. Expert Opin. Pharmacother. 15: 85–96.
    • (2014) Expert Opin. Pharmacother. , vol.15 , pp. 85-96
    • Tashkin, D.P.1
  • 55
    • 67349128956 scopus 로고    scopus 로고
    • Multiple molecular targets of resveratrol: anti-carcinogenic mechanisms
    • Athar, M. et al. 2009. Multiple molecular targets of resveratrol: anti-carcinogenic mechanisms. Arch. Biochem. Biophys. 486: 95–102.
    • (2009) Arch. Biochem. Biophys. , vol.486 , pp. 95-102
    • Athar, M.1
  • 56
    • 33645765580 scopus 로고    scopus 로고
    • Catalytic inhibition of human DNA topoisomerase II by interactions of grape cell culture polyphenols
    • Jo, J.Y., E.G. De Mejia & M.A. Lila. 2006. Catalytic inhibition of human DNA topoisomerase II by interactions of grape cell culture polyphenols. J. Agric. Food Chem. 54: 2083–2087.
    • (2006) J. Agric. Food Chem. , vol.54 , pp. 2083-2087
    • Jo, J.Y.1    De Mejia, E.G.2    Lila, M.A.3
  • 57
    • 0037295102 scopus 로고    scopus 로고
    • Molecular mechanism of the chemopreventive effect of resveratrol
    • Dong, Z. 2003. Molecular mechanism of the chemopreventive effect of resveratrol. Mutat. Res. 523: 145–150.
    • (2003) Mutat. Res. , vol.523 , pp. 145-150
    • Dong, Z.1
  • 58
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: Navigating downstream
    • Manning, B.D. & L.C. Cantley. 2007. AKT/PKB signaling: Navigating downstream. Cell 129: 1261–1274.
    • (2007) Cell , vol.129 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 59
    • 84903388632 scopus 로고    scopus 로고
    • Biochemical and cellular evidence demonstrating AKT-1 as a binding partner for resveratrol targeting protein NQO2
    • Hsieh, T.C. et al. 2014. Biochemical and cellular evidence demonstrating AKT-1 as a binding partner for resveratrol targeting protein NQO2. PLoS One 9: 1.
    • (2014) PLoS One , vol.9
    • Hsieh, T.C.1
  • 60
    • 27844553839 scopus 로고    scopus 로고
    • AKT crystal structure and AKT-specific inhibitors
    • Kumar, C.C. & V. Madison. 2005. AKT crystal structure and AKT-specific inhibitors. Oncogene 24: 7493–7501.
    • (2005) Oncogene , vol.24 , pp. 7493-7501
    • Kumar, C.C.1    Madison, V.2
  • 61
    • 67650073265 scopus 로고    scopus 로고
    • Cell cycle kinases as therapeutic targets for cancer
    • Lapenna, S. & A. Giordano. 2009. Cell cycle kinases as therapeutic targets for cancer. Nat. Rev. Drug Discov. 8: 547–566.
    • (2009) Nat. Rev. Drug Discov. , vol.8 , pp. 547-566
    • Lapenna, S.1    Giordano, A.2
  • 62
    • 84903220507 scopus 로고    scopus 로고
    • Direct activation of ATM by resveratrol under oxidizing conditions
    • Lee, J.H. et al. 2014. Direct activation of ATM by resveratrol under oxidizing conditions. PLoS One 9: 10.
    • (2014) PLoS One , vol.9
    • Lee, J.H.1
  • 63
    • 0035933774 scopus 로고    scopus 로고
    • Specific structural determinants are responsible for the antioxidant activity and the cell cycle effects of resveratrol
    • Stivala, L.A. et al. 2001. Specific structural determinants are responsible for the antioxidant activity and the cell cycle effects of resveratrol. J. Biol. Chem. 276: 22586–22594.
    • (2001) J. Biol. Chem. , vol.276 , pp. 22586-22594
    • Stivala, L.A.1
  • 65
    • 0037454696 scopus 로고    scopus 로고
    • Inhibition of protein kinase C by resveratrol
    • Slater, S.J. et al. 2003. Inhibition of protein kinase C by resveratrol. Biochim. Biophys. Acta-Mol. Basis Dis. 1637: 59–69.
    • (2003) Biochim. Biophys. Acta-Mol. Basis Dis. , vol.1637 , pp. 59-69
    • Slater, S.J.1
  • 66
    • 0034333325 scopus 로고    scopus 로고
    • Effects of resveratrol on the autophosphorylation of phorbol ester-responsive protein kinases—inhibition of protein kinase D but not protein kinase C isozyme autophosphorylation
    • Stewart, J.R., K.L. Christman & C.A. O'Brian. 2000. Effects of resveratrol on the autophosphorylation of phorbol ester-responsive protein kinases—inhibition of protein kinase D but not protein kinase C isozyme autophosphorylation. Biochem. Pharmacol. 60: 1355–1359.
    • (2000) Biochem. Pharmacol. , vol.60 , pp. 1355-1359
    • Stewart, J.R.1    Christman, K.L.2    O'Brian, C.A.3
  • 68
    • 80051986980 scopus 로고    scopus 로고
    • Emerging roles of protein kinase D1 in cancer
    • Sundram, V., S.C. Chauhan & M. Jaggi. 2011. Emerging roles of protein kinase D1 in cancer. Mol. Cancer Res. 9: 985–996.
    • (2011) Mol. Cancer Res. , vol.9 , pp. 985-996
    • Sundram, V.1    Chauhan, S.C.2    Jaggi, M.3
  • 69
    • 0035894173 scopus 로고    scopus 로고
    • Inhibition of protein kinase D by resveratrol
    • Haworth, R.S. & M. Avkiran. 2001. Inhibition of protein kinase D by resveratrol. Biochem. Pharmacol. 62: 1647–1651.
    • (2001) Biochem. Pharmacol. , vol.62 , pp. 1647-1651
    • Haworth, R.S.1    Avkiran, M.2
  • 70
    • 84925503952 scopus 로고    scopus 로고
    • A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol
    • Sajish, M. & P. Schimmel. 2015. A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol. Nature 519: 370–373.
    • (2015) Nature , vol.519 , pp. 370-373
    • Sajish, M.1    Schimmel, P.2
  • 71
    • 84908530414 scopus 로고    scopus 로고
    • Chemical con artists foil drug discovery
    • Baell, J. & M.A. Walters. 2014. Chemical con artists foil drug discovery. Nature 513: 481–483.
    • (2014) Nature , vol.513 , pp. 481-483
    • Baell, J.1    Walters, M.A.2
  • 72
    • 85006291818 scopus 로고    scopus 로고
    • Accessed May 28, 2015
    • MRC. 2014. Kinase Inhibitor Database. Vol. 2014 http://www.kinase-screen.mrc.ac.uk/screening-compounds/345920. Accessed May 28, 2015.
    • (2014) Kinase Inhibitor Database , vol.2014
  • 73
    • 36048958965 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: overview and perspectives
    • Dokmanovic, M., C. Clarke & P.A. Marks. 2007. Histone deacetylase inhibitors: overview and perspectives. Mol. Cancer Res. 5: 981–989.
    • (2007) Mol. Cancer Res. , vol.5 , pp. 981-989
    • Dokmanovic, M.1    Clarke, C.2    Marks, P.A.3
  • 74
    • 84861852370 scopus 로고    scopus 로고
    • Are sirtuins viable targets for improving healthspan and lifespan
    • Baur, J.A. et al. 2012. Are sirtuins viable targets for improving healthspan and lifespan? Nat. Rev. Drug Discov. 11: 443–461.
    • (2012) Nat. Rev. Drug Discov. , vol.11 , pp. 443-461
    • Baur, J.A.1
  • 75
    • 70350524083 scopus 로고    scopus 로고
    • Resveratrol is not a direct activator of SIRT1 enzyme activity
    • Beher, D. et al. 2009. Resveratrol is not a direct activator of SIRT1 enzyme activity. Chem. Biol. Drug Des. 74: 619–624.
    • (2009) Chem. Biol. Drug Des. , vol.74 , pp. 619-624
    • Beher, D.1
  • 76
    • 20444444649 scopus 로고    scopus 로고
    • Mechanism of human SIRT1 activation by resveratrol
    • Borra, M.T., B.C. Smith & J.M. Denu. 2005. Mechanism of human SIRT1 activation by resveratrol. J. Biol. Chem. 280: 17187–17195.
    • (2005) J. Biol. Chem. , vol.280 , pp. 17187-17195
    • Borra, M.T.1    Smith, B.C.2    Denu, J.M.3
  • 77
    • 84890257356 scopus 로고    scopus 로고
    • Inhibitory effects of grape skin extract and resveratrol on fatty acid synthase
    • Liang, Y., W.X. Tian & X.F. Ma. 2013. Inhibitory effects of grape skin extract and resveratrol on fatty acid synthase. BMC Complement Altern. Med. 13: 8.
    • (2013) BMC Complement Altern. Med. , vol.13 , pp. 8
    • Liang, Y.1    Tian, W.X.2    Ma, X.F.3
  • 78
    • 20444485396 scopus 로고    scopus 로고
    • Interaction of resveratrol and genistein with nucleic acids
    • Usha, S., I.M. Johnson & R. Malathi. 2005. Interaction of resveratrol and genistein with nucleic acids. J. Biochem. Mol. Biol. 38: 198–205.
    • (2005) J. Biochem. Mol. Biol. , vol.38 , pp. 198-205
    • Usha, S.1    Johnson, I.M.2    Malathi, R.3
  • 79
    • 0032520665 scopus 로고    scopus 로고
    • Interaction of transresveratrol with plasma lipoproteins
    • Belguendouz, L., L. Fremont & M.T. Gozzelino. 1998. Interaction of transresveratrol with plasma lipoproteins. Biochem. Pharmacol. 55: 811–816.
    • (1998) Biochem. Pharmacol. , vol.55 , pp. 811-816
    • Belguendouz, L.1    Fremont, L.2    Gozzelino, M.T.3
  • 80
    • 35348865444 scopus 로고    scopus 로고
    • Mechanism of inhibition of bovine F-1-ATPase by resveratrol and related polyphenols
    • Gledhill, J.R. et al. 2007. Mechanism of inhibition of bovine F-1-ATPase by resveratrol and related polyphenols. Proc. Natl. Acad. Sci. U. S. A. 104: 13632–13637.
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 13632-13637
    • Gledhill, J.R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.