AKT crystal structure and AKT-specific inhibitors

Oncogene

Volumn 24, Issue 50, 2005, Pages 7493-7501

  Kumar, Chandra C ^a   Madison, Vincent ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

AKT crystal structure; Akt inhibitors; Apoptosis; ATP competitive; Chemoresistance; Peptide substrate; PH domain

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ALANYLARGINYLLYSYLARGINYLGLUTAMYLARGINYLTHREONYLTYROSYLSERYLPHENYLALANYL GLYCYLHISTIDYLHISTIDYLALANINE; ANTINEOPLASTIC AGENT; ERLOTINIB; GEFITINIB; IMATINIB; PROTEIN KINASE B BETA; PROTEIN KINASE INHIBITOR; TRASTUZUMAB; UNCLASSIFIED DRUG; VALYLGLUTAMYLLEUCYLASPARTYLPROLYLGLUTAMYLPHENYLALANYLGLUTAMYLPROLYLARGINYL ALANYLARGINYLGLUTAMYLARGINYLTHREONYLTYROSYLSERYLPHENYLALANYLGLYCYLHISTIDINE; WORTMANNIN;

AMINO ACID SEQUENCE; APOPTOSIS; BINDING SITE; COMPUTER MODEL; CRYSTAL STRUCTURE; ENZYME INHIBITION; HYDROPHOBICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN STRUCTURE; REVIEW; SEQUENCE HOMOLOGY; STRUCTURE ANALYSIS;

ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC AGENTS; APOPTOSIS; BINDING SITES; CRYSTALLIZATION; DRUG RESISTANCE, NEOPLASM; ENZYME INHIBITORS; MODELS, CHEMICAL; NEOPLASMS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-AKT; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 27844553839     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1209087     Document Type: Review

References (50)

1. Alessi DR, Caudwell FB, Andjelkovic M, Hemmings BA and Cohen P. (1996). FEBS Lett., 399, 333-338.
2. Altomare DA and Testa JR. (2005). Oncogene Rev., 24, 7455-7464.
3. Auguin D, Barthe P, Auge-Senegas MT, Stern MH, Noguchi M and Roumestand C. (2004). J. Biomol. NMR, 28, 137-155.
4. Bacus SS, Altomare DA, Lyass L, Chin DM, Farrell MP, Gurova K, Gudkov A and Testa JR. (2002). Oncogene, 21, 3532-3540.
5. Barnett SF, Bilodeau MT, Lindsley CW, DeFeo-Jones D, Fu S, Hancock PJ, Haskell KM, Leander KR, McAvoy E, Robinson RG, Duggan ME, Zhao Z, Huber HE, Jones RE, Leister WH, Hartman GD, Huff JR, Kahana JA, Kral AM, Leander K, Lee LL, Malinowski J, McAvoy EM and Nahas DD. (2005). Curr. Top. Med. Chem., 5, 109-125.
6. Bellacosa A, Kumar CC, Di Cristafano A and Testa JR. (2005). Advances in Cancer Research. Vande Woude G and Klein G (eds). Vol. 94.Academic press: New York, pp. 29-87.
7. Breitenlechner CB, Friebe WG, Brunet E, Werner G, Graul K, Thomas LJ, Kunkele KP, Schafer W, Gassel M, Bossemeyer D, Huber R, Engh RA and Masjost B. (2005). J. Med. Chem., 48, 163-170.
8. Breitenlechner CB, Wegge T, Berillon L, Graul K, Marzenell K, Friebe WG, Thomas U, Schumacher R, Huber R, Engh RA and Masjost B. (2004). J. Med. Chem., 47, 1375-1390.
9. Brognard J, Clark AS, Ni Y and Dennis PA. (2001). Cancer Res., 61, 3986-3997.
10. Castillo SS, Brognard J, Petukhov PA, Zhang C, Tsurutani J, Granville CA, Li M, Jung M, West KA, Gills JG, Kozikowski AP and Dennis PA. (2004). Cancer Res., 64, 2782-2792.
11. Cheng JQ, Ruggeri B, Klein WM, Sonoda G, Altomare DA, Watson DK and Testa JR. (1996). Proc. Natl. Acad. Sci. USA, 93, 3636-3641.
12. Cheng JQ, Lindsley CW, Cheng GZ, Yang H and Nicosia SV. (2005). Oncogene Rev., 24, 7428-7492.
13. Clark AS, West K, Streicher S and Dennis PA. (2002). Mol. Cancer Ther., 1, 707-717.
14. DeFeo-Jones D, Barnett SF, Fu S, Hancock PJ, Haskell KM, Leander KR, McAvoy E, Robinson RG, Duggan ME, Lindsley CW, Zhao Z, Huber HE and Jones RE. (2005). Mol. Cancer Ther., 4, 271-279.
15. Di Cristofano A and Pandolfi PP. (2000). Cell, 100, 387-390.
16. Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao R, Cooper GM, Segal RA, Kaplan DR and Greenberg ME. (1997). Science, 275, 661-665.
17. Frolov A, Chahwan S, Ochs M, Arnoletti JP, Pan ZZ, Favorova O, Fletcher J, von Mehren M, Eisenberg B and Godwin AK. (2003). Mol. Cancer Ther., 2, 699-709.
18. Gao T, Furnari F and Newton AC. (2005). Mol. Cell, 18, 13-24.
19. Garrett M. (2004). Eur. J. Cancer (Suppl.16th EORTC-NCI-AACR Symp. Mol. Targets Cancer Ther. Sept 28-Oct 1, Geneva 2004), 2, Abstr 322.
20. Gills JJ and Dennis PA. (2004). Expert Opin. Invest. Drugs, 13, 787-797.
21. Hiromura M, Okada F, Obata T, Auguin D, Shibata T, Roumestand C and Noguchi M. (2004). J. Biol. Chem., 279, 53407-53418.
22. Huang X, Begley M, Morgenstern KA, Gu Y, Rose P, Zhao H and Zhu X. (2003). Structure (Camb), 11, 21-30.
23. Jetzt A, Howe JA, Horn MT, Maxwell E, Yin Z, Johnson D and Kumar CC. (2003). Cancer Res., 63, 6697-6706.
24. Kawauchi K, Ogasawara T, Yasuyama M and Ohkawa S. (2003). Blood Cells Mol. Dis., 31, 11-17.
25. Knighton DR, Zheng JH, Ten Eyck LF, Ashford VA, Xuong NH, Taylor SS and Sowadski JM. (1991). Science, 253, 407-414.
26. Kulik G and Weber MJ. (1998). Mol. Cell Biol., 18, 6711-6718.
27. Kumar CC, Diao R, Yin Z, Liu Y, Samatar AA, Madison V and Xiao L. (2001). Biochim. Biophys. Acta, 1526, 257-268.
28. Li J, Simpson L, Takahashi M, Miliaresis C, Myers MP, Tonks N and Parsons R. (1998). Cancer Res., 58, 5667-5672.
29. Lindsley CW, Zhao Z, Leister WH, Robinson RG, Barnett SF, Defeo-Jones D, Jones RE, Hartman GD, Huff JR, Huber HE, Duggan ME, Fu S, Hancock PJ, Haskell KM, Kahana JA, Kral AM, Leander K, Lee LL, Malinowski J, McAvoy EM and Nahas DD. (2005). Bioorg. Med. Chem. Lett., 15, 761-764.
30. Luo Y, Shoemaker AR, Liu X, Woods KW, Thomas SA, de Jong R, Han EK, Li T, Stoll VS, Powlas JA, Oleksijew A, Mitten MJ, Shi Y, Guan R, McGonigal TP, Klinghofer V, Johnson EF, Leverson JD, Bouska JJ, Mamo M, Smith RA, Gramling-Evans EE, Zinker BA, Mika AK, Nguyen PT, Oltersdorf T, Rosenberg SH, Li Q, Giranda VL, Shen J, Hutchins C, Richardson P and Holzman T. (2005). Mol. Cancer Ther., 4, 977-986.
31. Luo Y, Smith RA, Guan R, Liu X, Klinghofer V, Shen J, Hutchins C, Richardson P, Holzman T, Rosenberg SH and Giranda VL. (2004). Biochemistry, 43, 1254-1263.
32. Milburn CC, Deak M, Kelly SM, Price NC, Alessi DR and Van Aalten DM. (2003). Biochem. J., 375, 531-538.
33. Ohashi A, Kinoshita K, Isozaki K, Nishida T, Shinomura Y, Kitamura Y and Hirota S. (2004). Int. J. Cancer, 111, 317-321.
34. Paez JG, Janne PA, Lee JC, Tracy S, Greulich H, Gabriel S, Herman P, Kaye FJ, Lindeman N, Boggon TJ, Naoki K, Sasaki H, Fujii Y, Eck MJ, Sellers WR, Johnson BE and Meyerson M. (2004). Science, 304, 1497-1500.
35. Pandolfi PP. (2004). N. Engl. J. Med., 351, 2337-2338.
36. Pearl LH and Barford D. (2002). Curr. Opin. Struct. Biol., 12, 761-767.
37. Reuveni H, Livnah N, Geiger T, Klein S, Ohne O, Cohen I, Benhar M, Gellerman G and Levitzki A. (2002). Biochemistry, 41, 10304-10314.
38. Saito Y, Swanson X, Mhashilkar AM, Oida Y, Schrock R, Branch CD, Chada S, Zumstein L and Ramesh R. (2003). Gene Therapy, 10, 1961-1969.
39. Scheid M and Woodgett J. (2003). FEBS Lett., 27349, 1-5.
40. She QB, Solit D, Basso A and Moasser MM. (2003). Clin. Cancer Res., 9, 4340-4346.
41. Shin I, Edl J, Biswas S, Lin PC, Mernaugh R and Arteaga CL. (2005). Cancer Res., 65, 2815-2824.
42. Sordella R, Bell DW, Haber DA and Settleman J. (2004). Science, 305, 1163-1167.
43. Thomas CC, Deak M, Alessi DR and van Aalten DM. (2002). Curr. Biol., 12, 1256-1262.
44. Thomas CC, Dowler S, Deak M, Alessi DR and van Aalten DM. (2001). Biochem. J., 358, 287-294.
45. Xu Z, Stokoe D, Kane LP and Weiss A. (2002). Cell Growth Differ, 13, 285-296.
46. Xu ZB, Chaudhary D, Olland S, Wolfrom S, Czerwinski R, Malakian K, Lin L, Stahl ML, Joseph-McCarthy D, Benander C, Fitz L, Greco R, Somers WS and Mosyak L. (2004). J. Biol. Chem., 279, 50401-50409.
47. Yakes FM, Chinratanalab W, Ritter CA, King W, Seelig S and Arteaga CL. (2002). Cancer Res., 62, 4132-4141.
48. Yang J, Cron P, Good VM, Thompson V, Hemmings BA and Barford D. (2002a). Nat. Struct. Biol., 9, 940-944.
49. Yang J, Cron P, Thompson V, Good VM, Hess D, Hemmings BA and Barford D. (2002b). Mol. Cell, 9, 1227-1240.
50. Zhao Z, Leister WH, Robinson RG, Barnett SF, Defeo-Jones D, Jones RE, Hartman GD, Huff JR, Huber HE, Duggan ME and Lindsley CW. (2005). Bioorg. Med. Chem. Lett., 15, 905-909.