Hydrogen-Rich Saline Attenuated Subarachnoid Hemorrhage-Induced Early Brain Injury in Rats by Suppressing Inflammatory Response: Possible Involvement of NF-κB Pathway and NLRP3 Inflammasome

Molecular Neurobiology

Volumn 53, Issue 5, 2016, Pages 3462-3476

  Shao, Anwen ^a   Wu, Haijian ^a   Hong, Yuan ^a   Tu, Sheng ^b   Sun, Xuejun ^c   Wu, Qun ^a   Zhao, Qiong ^b   Zhang, Jianmin ^a,d   Sheng, Jifang ^b  

^a THE SECOND AFFILIATED HOSPITAL OF ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b ZHEJIANG UNIVERSITY   (China)

^c SECOND MILITARY MEDICAL UNIVERSITY   (China)

^d ZHEJIANG UNIVERSITY   (China)

Author keywords

Early brain injury; Hydrogen; Inflammation; NLRP3 inflammasome; Nuclear factor B; Subarachnoid hemorrhage

Indexed keywords

ANTIINFLAMMATORY AGENT; APOPTOSIS ASSOCIATED SPECK LIKE PROTEIN CONTAINING CASPASE RECRCUITMENT DOMAIN; CASPASE 3; CASPASE RECRUITMENT DOMAIN SIGNALING PROTEIN; CRYOPYRIN; HYDROGEN RICH SALINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; MESSENGER RNA; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR FAMILY PYRIN DOMAIN CONTAINING 3; PI KAPPA B ALPHA PROTEIN; REACTIVE OXYGEN METABOLITE; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIOXIDANT; AUTACOID; CYTOKINE; HYDROGEN; MALONALDEHYDE; SODIUM CHLORIDE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN EDEMA; BRAIN INJURY; BRAIN WATER; CONTROLLED STUDY; DRUG MECHANISM; EARLY BRAIN INJURY; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; LIPID PEROXIDATION; MALE; NERVE CELL LESION; NERVE CELL NECROSIS; NEUROLOGIC DISEASE; NISSL STAINING; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; RNA ANALYSIS; SUBARACHNOID HEMORRHAGE; TUNEL ASSAY; WESTERN BLOTTING; ANIMAL; APOPTOSIS; BRAIN; BRAIN CORTEX; COMPLICATION; DOWN REGULATION; DRUG EFFECTS; ENZYMOLOGY; GENETICS; INFLAMMATION; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BRAIN; BRAIN EDEMA; BRAIN INJURIES; CEREBRAL CORTEX; CYTOKINES; DOWN-REGULATION; HYDROGEN; INFLAMMASOMES; INFLAMMATION; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; LIPID PEROXIDATION; MALE; MALONDIALDEHYDE; NF-KAPPA B; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; SIGNAL TRANSDUCTION; SODIUM CHLORIDE; SUBARACHNOID HEMORRHAGE;

EID: 84931864190     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-015-9242-y     Document Type: Article

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