Expression of the NLRP3 inflammasome in cerebral cortex after traumatic brain injury in a rat model

Neurochemical Research

Volumn 38, Issue 10, 2013, Pages 2072-2083

  Liu, Huan Dong ^a   Li, Wei ^b   Chen, Zhen Rui ^a   Hu, Yang Chun ^b   Zhang, Ding Ding ^b   Shen, Wei ^a   Zhou, Meng Liang ^b   Zhu, Lin ^b   Hang, Chun Hua ^a,b  

^a JINLING HOSPITAL   (China)

^b NANJING UNIVERSITY   (China)

Author keywords

Inflammasome; Inflammation; NLRP3; Traumatic brain injury

Indexed keywords

ADAPTOR PROTEIN; APOPTOTIC SPECK CONTAINING PROTEIN; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; PATTERN RECOGNITION RECEPTOR; UNCLASSIFIED DRUG;

AMINO ACID BRAIN LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN CELL; BRAIN CORTEX; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; INFLAMMATION; INNATE IMMUNITY; MALE; MICROGLIA; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; RAT; REAL TIME POLYMERASE CHAIN REACTION; TRAUMATIC BRAIN INJURY; UPREGULATION; WESTERN BLOTTING;

ANIMALIA; RATTUS;

ANIMALS; BRAIN INJURIES; CASPASE 1; CEREBRAL CORTEX; CYTOSKELETAL PROTEINS; IMMUNITY, INNATE; INFLAMMASOMES; INFLAMMATION; INTERLEUKIN-18; INTERLEUKIN-1BETA; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CYTOPLASMIC AND NUCLEAR;

EID: 84884905290     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-013-1115-z     Document Type: Article

References (39)

1. Hang CH, Chen G, Shi JX, Zhang X, Li JS (2006) Cortical expression of nuclear factor kappaB after human brain contusion. Brain Res 1109(1):14-21. doi: 10.1016/j.brainres.2006.06.045
2. Zhao JB, Zhang Y, Li GZ, Su XF, Hang CH (2011) Activation of JAK2/STAT pathway in cerebral cortex after experimental traumatic brain injury of rats. Neurosci Lett 498(2):147-152. doi: 10.1016/j.neulet.2011.05.001
3. Dinarello CA (2005) Blocking IL-1 in systemic inflammation. J Exp Med 201(9):1355-1359. doi: 10.1084/jem.20050640
4. Dinarello CA (2006) Interleukin 1 and interleukin 18 as mediators of inflammation and the aging process. Am J Clin Nutr 83(2):447S-455S
5. de Rivero Vaccari JP, Lotocki G, Alonso OF, Bramlett HM, Dietrich WD, Keane RW (2009) Therapeutic neutralization of the NLRP1 inflammasome reduces the innate immune response and improves histopathology after traumatic brain injury. J Cereb Blood Flow Metab 29(7):1251-1261. doi: 10.1038/jcbfm.2009.46
6. Li GZ, Zhang Y, Zhao JB, Wu GJ, Su XF, Hang CH (2011) Expression of myeloid differentiation primary response protein 88 (Myd88) in the cerebral cortex after experimental traumatic brain injury in rats. Brain Res 1396:96-104. doi: 10.1016/j.brainres.2011.04.014
7. Yatsiv I, Morganti-Kossmann MC, Perez D, Dinarello CA, Novick D, Rubinstein M, Otto VI, Rancan M, Kossmann T, Redaelli CA, Trentz O, Shohami E, Stahel PF (2002) Elevated intracranial IL-18 in humans and mice after traumatic brain injury and evidence of neuroprotective effects of IL-18-binding protein after experimental closed head injury. J Cereb Blood Flow Metab 22(8):971-978. doi: 10.1097/00004647-200208000-00008
8. Janeway CA Jr (1989) Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb Symp Quant Biol 54(Pt 1):1-13
9. Ishii KJ, Koyama S, Nakagawa A, Coban C, Akira S (2008) Host innate immune receptors and beyond: making sense of microbial infections. Cell Host Microbe 3(6):352-363. doi: 10.1016/j.chom.2008.05.003
10. Sansonetti PJ (2006) The innate signaling of dangers and the dangers of innate signaling. Nat Immunol 7(12):1237-1242. doi: 10.1038/ni1420
11. Trinchieri G, Sher A (2007) Cooperation of toll-like receptor signals in innate immune defence. Nat Rev Immunol 7(3):179-190. doi: 10.1038/nri2038
12. Ting JP, Lovering RC, Alnemri ES, Bertin J, Boss JM, Davis BK, Flavell RA, Girardin SE, Godzik A, Harton JA, Hoffman HM, Hugot JP, Inohara N, Mackenzie A, Maltais LJ, Nunez G, Ogura Y, Otten LA, Philpott D, Reed JC, Reith W, Schreiber S, Steimle V, Ward PA (2008) The NLR gene family: a standard nomenclature. Immunity 28(3):285-287. doi: 10.1016/j.immuni.2008.02.005
13. Martinon F, Burns K, Tschopp J (2002) The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 10(2):417-426
14. Halle A, Hornung V, Petzold GC, Stewart CR, Monks BG, Reinheckel T, Fitzgerald KA, Latz E, Moore KJ, Golenbock DT (2008) The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. Nat Immunol 9(8):857-865. doi: 10.1038/ni.1636
15. Jha S, Srivastava SY, Brickey WJ, Iocca H, Toews A, Morrison JP, Chen VS, Gris D, Matsushima GK, Ting JP (2010) The inflammasome sensor, NLRP3, regulates CNS inflammation and demyelination via caspase-1 and interleukin-18. J Neurosci 30(47):15811-15820. doi: 10.1523/JNEUROSCI.4088-10.2010
16. Hoegen T, Tremel N, Klein M, Angele B, Wagner H, Kirschning C, Pfister HW, Fontana A, Hammerschmidt S, Koedel U (2011) The NLRP3 inflammasome contributes to brain injury in pneumococcal meningitis and is activated through ATP-dependent lysosomal cathepsin B release. J Immunol 187(10):5440-5451. doi: 10.4049/jimmunol.1100790
17. Feeney DM, Boyeson MG, Linn RT, Murray HM, Dail WG (1981) Responses to cortical injury: I. Methodology and local effects of contusions in the rat. Brain Res 211(1):67-77
18. Chen G, Shi J, Jin W, Wang L, Xie W, Sun J, Hang C (2008) Progesterone administration modulates TLRs/NF-kappaB signaling pathway in rat brain after cortical contusion. Ann Clin Lab Sci 38(1):65-74
19. Hutchinson PJ, O'Connell MT, Rothwell NJ, Hopkins SJ, Nortje J, Carpenter KL, Timofeev I, Al-Rawi PG, Menon DK, Pickard JD (2007) Inflammation in human brain injury: intracerebral concentrations of IL-1alpha, IL-1beta, and their endogenous inhibitor IL-1ra. J Neurotrauma 24(10):1545-1557. doi: 10.1089/neu.2007.0295
20. Utagawa A, Truettner JS, Dietrich WD, Bramlett HM (2008) Systemic inflammation exacerbates behavioral and histopathological consequences of isolated traumatic brain injury in rats. Exp Neurol 211(1):283-291. doi: 10.1016/j.expneurol.2008.02.001
21. Lu KT, Wang YW, Wo YY, Yang YL (2005) Extracellular signal-regulated kinase-mediated IL-1-induced cortical neuron damage during traumatic brain injury. Neurosci Lett 386(1):40-45. doi: 10.1016/j.neulet.2005.05.057
22. Woodroofe MN, Sarna GS, Wadhwa M, Hayes GM, Loughlin AJ, Tinker A, Cuzner ML (1991) Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine production. J Neuroimmunol 33(3):227-236
23. Jander S, Schroeter M, Stoll G (2002) Interleukin-18 expression after focal ischemia of the rat brain: association with the late-stage inflammatory response. J Cereb Blood Flow Metab 22(1):62-70. doi: 10.1097/00004647-200201000- 00008
24. Hedtjarn M, Leverin AL, Eriksson K, Blomgren K, Mallard C, Hagberg H (2002) Interleukin-18 involvement in hypoxic-ischemic brain injury. J Neurosci 22(14):5910-5919
25. Ogura Y, Sutterwala FS, Flavell RA (2006) The inflammasome: first line of the immune response to cell stress. Cell 126(4):659-662. doi: 10.1016/j.cell.2006.08.002
26. Provoost S, Maes T, Pauwels NS, Vanden Berghe T, Vandenabeele P, Lambrecht BN, Joos GF, Tournoy KG (2011) NLRP3/caspase-1-independent IL-1beta production mediates diesel exhaust particle-induced pulmonary inflammation. J Immunol 187(6):3331-3337. doi: 10.4049/jimmunol.1004062
27. Schaefer L (2011) Small leucine-rich proteoglycans in kidney disease. J Am Soc Nephrol 22(7):1200-1207. doi: 10.1681/ASN.2010050570
28. Hoque R, Sohail MA, Salhanick S, Malik AF, Ghani A, Robson SC, Mehal WZ (2012) P2X7 receptor-mediated purinergic signaling promotes liver injury in acetaminophen hepatotoxicity in mice. Am J Physiol Gastrointest Liver Physiol 302(10):G1171-G1179. doi: 10.1152/ajpgi.00352.2011
29. Wang JG, Williams JC, Davis BK, Jacobson K, Doerschuk CM, Ting JP, Mackman N (2011) Monocytic microparticles activate endothelial cells in an IL-1beta-dependent manner. Blood 118(8):2366-2374. doi: 10.1182/blood-2011-01- 330878
30. Kaushik DK, Gupta M, Kumawat KL, Basu A (2012) NLRP3 inflammasome: key mediator of neuroinflammation in murine Japanese encephalitis. PLoS One 7(2):e32270. doi: 10.1371/journal.pone.0032270
31. Schroder K, Tschopp J (2010) The inflammasomes. Cell 140(6):821-832. doi: 10.1016/j.cell.2010.01.040
32. Wang JW, Wang HD, Zhong WZ, Li N, Cong ZX (2012) Expression and cell distribution of metabotropic glutamate receptor 5 in the rat cortex following traumatic brain injury. Brain Res 1464:73-81. doi: 10.1016/j.brainres.2012.05. 014
33. Philips T, Robberecht W (2011) Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease. Lancet Neurol 10(3):253-263. doi: 10.1016/S1474-4422(11)70015-1
34. Pearson VL, Rothwell NJ, Toulmond S (1999) Excitotoxic brain damage in the rat induces interleukin-1beta protein in microglia and astrocytes: correlation with the progression of cell death. Glia 25(4):311-323. doi: 10.1002/(SICI)1098-11o36(19990215)25:4<311:AID-GLIA1>3.0.CO;2-E
35. Conti B, Park LC, Calingasan NY, Kim Y, Kim H, Bae Y, Gibson GE, Joh TH (1999) Cultures of astrocytes and microglia express interleukin 18. Brain Res Mol Brain Res 67(1):46-52
36. Menge T, Jander S, Stoll G (2001) Induction of the proinflammatory cytokine interleukin-18 by axonal injury. J Neurosci Res 65(4):332-339
37. de Rivero Vaccari JP, Lotocki G, Marcillo AE, Dietrich WD, Keane RW (2008) A molecular platform in neurons regulates inflammation after spinal cord injury. J Neurosci 28(13):3404-3414. doi: 10.1523/JNEUROSCI.0157-08.2008
38. Silverman WR, de Rivero Vaccari JP, Locovei S, Qiu F, Carlsson SK, Scemes E, Keane RW, Dahl G (2009) The pannexin 1 channel activates the inflammasome in neurons and astrocytes. J Biol Chem 284(27):18143-18151. doi: 10.1074/jbc.M109.004804
39. Craven RR, Gao X, Allen IC, Gris D, Bubeck Wardenburg J, McElvania-Tekippe E, Ting JP, Duncan JA (2009) Staphylococcus aureus alpha-hemolysin activates the NLRP3-inflammasome in human and mouse monocytic cells. PLoS One 4(10):e7446. doi: 10.1371/journal.pone.0007446