Thrombomodulin domain 1 ameliorates diabetic nephropathy in mice via anti-NF-κB/NLRP3 inflammasome-mediated inflammation, enhancement of NRF2 antioxidant activity and inhibition of apoptosis

Diabetologia

Volumn 57, Issue 2, 2014, Pages 424-434

  Yang, Shun Min ^a   Ka, Shuk Man ^b   Wu, Hua Lin ^c   Yeh, Yu Chuan ^a   Kuo, Cheng Hsiang ^c   Hua, Kuo Feng ^d   Shi, Guey Yueh ^c   Hung, Yi Jen ^a   Hsiao, Fone Ching ^a   Yang, Sung Sen ^a   Shieh, Yi Shing ^a   Lin, Shih Hua ^a   Wei, Chyou Wei ^e   Lee, Jeng Shin ^f   Yang, Chu Yi ^b   Chen, Ann ^a  

^a TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^b NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^c NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^d NATIONAL ILAN UNIVERSITY   (Taiwan)

^e HUNGKUANG UNIVERSITY   (Taiwan)

^f HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Adeno associated virus; db db mice; Diabetic nephropathy; Gene therapy; NLRP3 inflammasome; NRF2; Thrombomodulin domain 1

Indexed keywords

CRYOPYRIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; PARVOVIRUS VECTOR; RECOMBINANT THROMBOMODULIN; RECOMBINANT THROMBOMODULIN DOMAIN 1 PROTEIN; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ALBUMINURIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL IMMORTALIZATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DIABETIC NEPHROPATHY; GENE DOSAGE; GENOME; GLOMERULOSCLEROSIS; KIDNEY FUNCTION; KIDNEY INTERSTITIUM; MALE; MITOCHONDRION; MOUSE; NEPHRITIS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; PROTEIN DOMAIN; SINGLE DRUG DOSE; THERAPY EFFECT; VIRAL GENE THERAPY;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; CARRIER PROTEINS; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DIABETIC NEPHROPATHIES; GENETIC THERAPY; INFLAMMASOMES; INFLAMMATION; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NF-KAPPA B; THROMBOMODULIN;

EID: 84893673690     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-013-3115-6     Document Type: Article

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